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4WUY
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CRYSTAL STRUCTURE OF PROTEIN LYSINE METHYLTRANSFERASE SMYD2 IN COMPLEX WITH LLY-507, A CELL-ACTIVE, POTENT AND SELECTIVE INHIBITOR
分子名称:N-lysine methyltransferase SMYD2, 5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl]biphenyl-3-carboxamide, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Nguyen, H., Allali-Hassani, A., Antonysamy, S., Chang, S., Chen, L.H., Curtis, C., Emtage, S., Fan, L., Gheyi, T., Li, F., Liu, S., Martin, J.R., Mendel, D., Olsen, J.B., Pelletier, L., Shatseva, T., Wu, S., Zhang, F.F., Arrowsmith, C.H., Brown, P.J., Campbell, R.M., Garcia, B.A., Barsyte-Lovejoy, D., Mader, M., Vedadi, M.
登録日2014-11-04
公開日2015-04-08
最終更新日2015-06-10
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.
J.Biol.Chem., 290, 2015
5F3B
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STRUCTURE OF MYOSTATIN IN COMPLEX WITH CHIMERIC RK35 ANTIBODY
分子名称:RK35 Chimeric antibody heavy chain, RK35 Chimeric antibody light chain, Growth/differentiation factor 8, ...
著者Parris, K.D., Mosyak, L.
登録日2015-12-02
公開日2016-09-28
最終更新日2016-10-12
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.
Mabs, 8, 2016
5F3H
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STRUCTURE OF MYOSTATIN IN COMPLEX WITH HUMANIZED RK35 ANTIBODY
分子名称:humanized RK35 antibody heavy chain, humanized RK35 antibody light chain, Growth/differentiation factor 8
著者Parris, K.D., Mosyak, L.
登録日2015-12-02
公開日2016-09-28
最終更新日2016-10-12
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.
Mabs, 8, 2016