Author results

6DVR
  • Download 6dvr
  • View 6dvr
Molmil generated image of 6dvr
CRYSTAL STRUCTURE OF HUMAN CARM1 WITH (R)-SKI-72
Descriptor:Histone-arginine methyltransferase CARM1, (2R,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-methoxyphenyl)ethyl]hexanamide (non-preferred name), 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ...
Authors:Dong, A., Zeng, H., Hutchinson, A., Seitova, A., Luo, M., Cai, X.C., Ke, W., Wang, J., Shi, C., Zheng, W., Lee, J.P., Ibanez, G., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2018-06-25
Release date:2018-07-25
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Crystal structure of human CARM1 with (R)-SKI-72
to be published
6D2L
  • Download 6d2l
  • View 6d2l
Molmil generated image of 6d2l
CRYSTAL STRUCTURE OF HUMAN CARM1 WITH (S)-SKI-72
Descriptor:Histone-arginine methyltransferase CARM1, (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-hydroxyphenyl)ethyl]hexanamide, SULFATE ION, ...
Authors:DONG, A., ZENG, H., WALKER, J.R., Hutchinson, A., Seitova, A., LUO, M., CAI, X.C., KE, W., WANG, J., SHI, C., ZHENG, W., LEE, J.P., IBANEZ, G., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
Deposit date:2018-04-13
Release date:2018-05-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human CARM1 with (S)-SKI-72
to be published
6CP3
  • Download 6cp3
  • View 6cp3
Molmil generated image of 6cp3
MONOMER YEAST ATP SYNTHASE (F1FO) RECONSTITUTED IN NANODISC WITH INHIBITOR OF OLIGOMYCIN BOUND.
Descriptor:ATP synthase subunit 9, mitochondrial, ATP synthase subunit 5, ...
Authors:Srivastava, A.P., Luo, M., Symersky, J., Liao, M.F., Mueller, D.M.
Deposit date:2018-03-13
Release date:2018-04-11
Last modified:2018-05-23
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane.
Science, 360, 2018
6CP5
  • Download 6cp5
  • View 6cp5
Molmil generated image of 6cp5
MONOMER YEAST ATP SYNTHASE FO RECONSTITUTED IN NANODISC WITH INHIBITOR OF OLIGOMYCIN BOUND GENERATED FROM FOCUSED REFINEMENT.
Descriptor:ATP synthase subunit 9, mitochondrial, ATP synthase protein 8, ...
Authors:Srivastava, A.P., Luo, M., Symersky, J., Liao, M.F., Mueller, D.M.
Deposit date:2018-03-13
Release date:2018-04-11
Last modified:2018-05-23
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane.
Science, 360, 2018
6CP6
  • Download 6cp6
  • View 6cp6
Molmil generated image of 6cp6
MONOMER YEAST ATP SYNTHASE (F1FO) RECONSTITUTED IN NANODISC.
Descriptor:ATP synthase subunit 9, mitochondrial, ATP synthase subunit 5, ...
Authors:Srivastava, A.P., Luo, M., Symersky, J., Liao, M.F., Mueller, D.M.
Deposit date:2018-03-13
Release date:2018-04-11
Last modified:2018-05-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane.
Science, 360, 2018
6CP7
  • Download 6cp7
  • View 6cp7
Molmil generated image of 6cp7
MONOMER YEAST ATP SYNTHASE FO RECONSTITUTED IN NANODISC GENERATED FROM MASKED REFINEMENT.
Descriptor:ATP synthase subunit 9, mitochondrial, ATP synthase protein 8, ...
Authors:Srivastava, A.P., Luo, M., Symersky, J., Liao, M.F., Mueller, D.M.
Deposit date:2018-03-13
Release date:2018-04-11
Last modified:2018-05-23
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane.
Science, 360, 2018
6C66
  • Download 6c66
  • View 6c66
Molmil generated image of 6c66
CRISPR RNA-GUIDED SURVEILLANCE COMPLEX, PRE-NICKING
Descriptor:CRISPR-associated helicase, Cas3 family, CRISPR-associated protein, ...
Authors:Xiao, Y., Luo, M., Liao, M., Ke, A.
Deposit date:2018-01-17
Release date:2018-06-27
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Structure basis for RNA-guided DNA degradation by Cascade and Cas3.
Science, 361, 2018
6BWX
  • Download 6bwx
  • View 6bwx
Molmil generated image of 6bwx
ATOMIC RESOLUTION STRUCTURE OF HUMAN BUFAVIRUS 1
Descriptor:VP2
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2017-12-15
Release date:2018-01-24
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy.
Viruses, 10, 2018
6BX0
  • Download 6bx0
  • View 6bx0
Molmil generated image of 6bx0
ATOMIC RESOLUTION STRUCTURE OF HUMAN BUFAVIRUS 2
Descriptor:VP2
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2017-12-15
Release date:2018-01-24
Method:ELECTRON MICROSCOPY (3.79 Å)
Cite:Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy.
Viruses, 10, 2018
6BX1
  • Download 6bx1
  • View 6bx1
Molmil generated image of 6bx1
ATOMIC RESOLUTION STRUCTURE OF HUMAN BUFAVIRUS 3
Descriptor:VP2
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2017-12-15
Release date:2018-01-24
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy.
Viruses, 10, 2018
6BJY
  • Download 6bjy
  • View 6bjy
Molmil generated image of 6bjy
VSV NUCLEOCAPSID WITH POLYAMIDE BOUND
Descriptor:RNA (45-MER), Nucleoprotein, 4-{[4-(acetylamino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-N-{4-[(1-methyl-1H-pyrrol-3-yl)amino]-4-oxobutyl}-1H-imidazole-2-carboxamide, ...
Authors:Gumpper, R.H., Luo, M.
Deposit date:2017-11-07
Release date:2018-02-28
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (3.46 Å)
Cite:A Polyamide Inhibits Replication of Vesicular Stomatitis Virus by Targeting RNA in the Nucleocapsid.
J. Virol., 92, 2018
6BB5
  • Download 6bb5
  • View 6bb5
Molmil generated image of 6bb5
HUMAN OXY-HEMOGLOBIN
Descriptor:Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Gumpper, R.H., Terrell, J.R., Luo, M.
Deposit date:2017-10-16
Release date:2018-01-10
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Hemoglobin crystals immersed in liquid oxygen reveal diffusion channels.
Biochem. Biophys. Res. Commun., 495, 2018
5WOG
  • Download 5wog
  • View 5wog
Molmil generated image of 5wog
HUMAN HEMOGLOBIN IMMERSED IN LIQUID OXYGEN FOR 1 MINUTE
Descriptor:Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE
Authors:Gumpper, R.H., Terrell, J.R., Luo, M.
Deposit date:2017-08-02
Release date:2018-01-10
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Hemoglobin crystals immersed in liquid oxygen reveal diffusion channels.
Biochem. Biophys. Res. Commun., 495, 2018
5WOH
  • Download 5woh
  • View 5woh
Molmil generated image of 5woh
HUMAN HEMOGLOBIN IMMERSED IN LIQUID OXYGEN FOR 20 SECONDS
Descriptor:Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE
Authors:Gumpper, R.H., Terrell, J.R., Luo, M.
Deposit date:2017-08-02
Release date:2018-01-10
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Hemoglobin crystals immersed in liquid oxygen reveal diffusion channels.
Biochem. Biophys. Res. Commun., 495, 2018
5WOP
  • Download 5wop
  • View 5wop
Molmil generated image of 5wop
HIGH RESOLUTION STRUCTURE OF MUTANT CA09-PB2CAP
Descriptor:Polymerase PB2, GLYCEROL
Authors:Constantinides, A.E., Gumpper, R.H., Severin, C., Luo, M.
Deposit date:2017-08-02
Release date:2017-12-20
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:High-resolution structure of the Influenza A virus PB2cap binding domain illuminates the changes induced by ligand binding.
Acta Crystallogr F Struct Biol Commun, 74, 2018
5W1Y
  • Download 5w1y
  • View 5w1y
Molmil generated image of 5w1y
SETD8 IN COMPLEX WITH A COVALENT INHIBITOR
Descriptor:N-lysine methyltransferase KMT5A, 2-(4-methylpiperazin-1-yl)-3-(phenylsulfanyl)naphthalene-1,4-dione, UNKNOWN ATOM OR ION
Authors:Tempel, W., Yu, W., Li, Y., Blum, G., Luo, M., Pittella-Silva, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2017-06-05
Release date:2017-06-21
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:SETD8 in complex with a covalent inhibitor
to be published
5UR2
  • Download 5ur2
  • View 5ur2
Molmil generated image of 5ur2
CRYSTAL STRUCTURE OF PROLINE UTILIZATION A (PUTA) FROM BDELLOVIBRIO BACTERIOVORUS INACTIVATED BY N-PROPARGYLGLYCINE
Descriptor:Bifunctional protein PutA, N-propargylglycine-modified flavin adenine dinucleotide
Authors:Tanner, J.J.
Deposit date:2017-02-09
Release date:2017-08-02
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Biophysical investigation of type A PutAs reveals a conserved core oligomeric structure.
FEBS J., 284, 2017
5U07
  • Download 5u07
  • View 5u07
Molmil generated image of 5u07
CRISPR RNA-GUIDED SURVEILLANCE COMPLEX
Descriptor:CRISPR-associated protein, Cse3 family, Cse2, ...
Authors:Xiao, Y., Luo, M., Hayes, R.P., Kim, J., Ng, S., Ding, F., Liao, M., Ke, A.
Deposit date:2016-11-23
Release date:2017-08-09
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System.
Cell, 170, 2017
5U0A
  • Download 5u0a
  • View 5u0a
Molmil generated image of 5u0a
CRISPR RNA-GUIDED SURVEILLANCE COMPLEX
Descriptor:CRISPR-associated protein, Cse3 family, Cse1 family, ...
Authors:Xiao, Y., Luo, M., Hayes, R.P., Kim, J., Ng, S., Ding, F., Liao, M., Ke, A.
Deposit date:2016-11-23
Release date:2017-08-09
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System.
Cell, 170, 2017
5TH7
  • Download 5th7
  • View 5th7
Molmil generated image of 5th7
COMPLEX OF SETD8 WITH MS453
Descriptor:N-lysine methyltransferase KMT5A, N-(3-{[6,7-dimethoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl]amino}propyl)propanamide, UNKNOWN ATOM OR ION, ...
Authors:Yu, W., Tempel, W., Babault, N., Ma, A., Butler, K.V., Jin, J., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2016-09-29
Release date:2016-11-09
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
J. Med. Chem., 59, 2016
5T5G
  • Download 5t5g
  • View 5t5g
Molmil generated image of 5t5g
HUMAN SETD8 IN COMPLEX WITH MS2177
Descriptor:N-lysine methyltransferase KMT5A, UNKNOWN ATOM OR ION, 7-(2-aminoethoxy)-6-methoxy-2-(pyrrolidin-1-yl)-N-[5-(pyrrolidin-1-yl)pentyl]quinazolin-4-amine
Authors:Yu, W., Tempel, W., Babault, N., Ma, A., Butler, K.V., Jin, J., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2016-08-30
Release date:2016-09-28
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
J. Med. Chem., 59, 2016
5KF6
  • Download 5kf6
  • View 5kf6
Molmil generated image of 5kf6
STRUCTURE OF PROLINE UTILIZATION A FROM SINORHIZOBIUM MELILOTI COMPLEXED WITH L-TETRAHYDROFUROIC ACID AND NAD+ IN SPACE GROUP P21
Descriptor:Bifunctional protein PutA, FLAVIN-ADENINE DINUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Tanner, J.J.
Deposit date:2016-06-12
Release date:2016-10-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of Proline Utilization A (PutA) Reveal the Fold and Functions of the Aldehyde Dehydrogenase Superfamily Domain of Unknown Function.
J.Biol.Chem., 291, 2016
5KF7
  • Download 5kf7
  • View 5kf7
Molmil generated image of 5kf7
STRUCTURE OF PROLINE UTILIZATION A FROM SINORHIZOBIUM MELILOTI COMPLEXED WITH L-TETRAHYDROFUROIC ACID AND NAD+ IN SPACE GROUP P3121
Descriptor:Bifunctional protein PutA, FLAVIN-ADENINE DINUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Tanner, J.J.
Deposit date:2016-06-12
Release date:2016-10-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of Proline Utilization A (PutA) Reveal the Fold and Functions of the Aldehyde Dehydrogenase Superfamily Domain of Unknown Function.
J.Biol.Chem., 291, 2016
5IHW
  • Download 5ihw
  • View 5ihw
Molmil generated image of 5ihw
THE CRYSTAL STRUCTURE OF SDRE FROM STAPHYLOCOCCUS AUREUS
Descriptor:Serine-aspartate repeat-containing protein E
Authors:Zhang, S., Wei, J., Wu, S., Zhang, X., Luo, M., Wang, D.
Deposit date:2016-02-29
Release date:2017-03-22
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:The crystal structure of SdrE from staphylococcus aureus
To Be Published
5HZM
  • Download 5hzm
  • View 5hzm
Molmil generated image of 5hzm
HUMAN HMT1 HNRNP METHYLTRANSFERASE-LIKE PROTEIN 6 (S. CEREVISIAE)
Descriptor:Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN ATOM OR ION
Authors:DONG, A., ZENG, H., WALKER, J.R., Seitova, A., Hutchinson, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., MIN, J., WU, H., Structural Genomics Consortium (SGC)
Deposit date:2016-02-02
Release date:2016-02-17
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural basis of arginine asymmetrical dimethylation by PRMT6.
Biochem. J., 473, 2016