Author results

3R21
  • Download 3r21
  • View 3r21
Molmil generated image of 3r21
DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF PYRAZOLOPYRIDINE-SULFONAMIDES AS POTENT MULTIPLE-MITOTIC KINASE (MMK) INHIBITORS (PART I)
Descriptor:Serine/threonine-protein kinase 6, N-(2-aminoethyl)-N-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamide, MAGNESIUM ION
Authors:Zhang, L., Fan, J., Chong, J.-H., Cesena, A., Tam, B., Gilson, C., Boykin, C., Wang, D., Marcotte, D., Le Brazidec, J.-Y., Aivazian, D., Piao, J., Lundgren, K., Hong, K., Vu, K., Nguyen, K.
Deposit date:2011-03-11
Release date:2011-08-10
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Bioorg.Med.Chem.Lett., 21, 2011
3R22
  • Download 3r22
  • View 3r22
Molmil generated image of 3r22
DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF PYRAZOLOPYRIDINE-SULFONAMIDES AS POTENT MULTIPLE-MITOTIC KINASE (MMK) INHIBITORS (PART I)
Descriptor:Serine/threonine-protein kinase 6, N-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamide
Authors:Zhang, L., Fan, J., Chong, J.-H., Cesana, A., Tam, B., Gilson, C., Boykin, C., Wang, D., Marcotte, D., Le Brazidec, J.-Y., Aivazian, D., Piao, J., Lundgren, K., Hong, K., Vu, K., Nguyen, K.
Deposit date:2011-03-11
Release date:2011-08-10
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Bioorg.Med.Chem.Lett., 21, 2011
1IA8
  • Download 1ia8
  • View 1ia8
Molmil generated image of 1ia8
THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINT KINASE CHK1
Descriptor:CHK1 CHECKPOINT KINASE, SULFATE ION
Authors:Chen, P., Luo, C., Deng, Y., Ryan, K., Register, J., Margosiak, S., Tempczyk-Russell, A., Nguyen, B., Myers, P., Lundgren, K., Chen Kan, C.-C., O'Connor, P.M.
Deposit date:2001-03-22
Release date:2001-04-18
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation.
Cell(Cambridge,Mass.), 100, 2000
3NMQ
  • Download 3nmq
  • View 3nmq
Molmil generated image of 3nmq
HSP90B N-TERMINAL DOMAIN IN COMPLEX WITH EC44, A PYRROLO-PYRIMIDINE METHOXYPYRIDINE INHIBITOR
Descriptor:Heat shock protein HSP 90-beta, 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2-ol
Authors:Arndt, J.W., Yun, T.J., Harning, E.K., Giza, K., Rabah, D., Li, P., Luchetti, D., Shi, J., Manning, A., Kehry, M.R.
Deposit date:2010-06-22
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity.
J.Immunol., 186, 2011
3QDD
  • Download 3qdd
  • View 3qdd
Molmil generated image of 3qdd
HSP90A N-TERMINAL DOMAIN IN COMPLEX WITH BIIB021
Descriptor:Heat shock protein HSP 90-alpha, 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine
Authors:Arndt, J.W., Biamonte, M.A.
Deposit date:2011-01-18
Release date:2012-07-18
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:EC144 Is a Potent Inhibitor of the Heat Shock Protein 90.
J.Med.Chem., 55, 2012