5VGZ | | CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE | | Descriptor: | 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, 26S proteasome regulatory subunit 8, ... | | Authors: | Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y. | | Deposit date: | 2017-04-12 | | Release date: | 2017-08-23 | | Last modified: | 2018-08-22 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
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5VHF | | CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE | | Descriptor: | 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ... | | Authors: | Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y. | | Deposit date: | 2017-04-13 | | Release date: | 2017-08-23 | | Last modified: | 2018-08-22 | | Method: | ELECTRON MICROSCOPY (5.7 Å) | | Cite: | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
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5VHH | | CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE | | Descriptor: | 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, 26S proteasome regulatory subunit 8, ... | | Authors: | Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y. | | Deposit date: | 2017-04-13 | | Release date: | 2017-08-23 | | Last modified: | 2018-08-22 | | Method: | ELECTRON MICROSCOPY (6.1 Å) | | Cite: | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
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5VHI | | CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE | | Descriptor: | 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, 26S proteasome regulatory subunit 8, ... | | Authors: | Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y. | | Deposit date: | 2017-04-13 | | Release date: | 2017-08-23 | | Last modified: | 2018-08-22 | | Method: | ELECTRON MICROSCOPY (6.8 Å) | | Cite: | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
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5VHJ | | CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE | | Descriptor: | 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ... | | Authors: | Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y. | | Deposit date: | 2017-04-13 | | Release date: | 2017-08-23 | | Last modified: | 2018-08-22 | | Method: | ELECTRON MICROSCOPY (8.5 Å) | | Cite: | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
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5VHM | | CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE | | Descriptor: | 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ... | | Authors: | Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y. | | Deposit date: | 2017-04-13 | | Release date: | 2017-08-23 | | Last modified: | 2018-09-12 | | Method: | ELECTRON MICROSCOPY (8.3 Å) | | Cite: | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
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5VHN | | CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE | | Descriptor: | 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ... | | Authors: | Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y. | | Deposit date: | 2017-04-13 | | Release date: | 2017-08-23 | | Last modified: | 2018-08-22 | | Method: | ELECTRON MICROSCOPY (7.3 Å) | | Cite: | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
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5VHO | | CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE | | Descriptor: | 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ... | | Authors: | Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y. | | Deposit date: | 2017-04-13 | | Release date: | 2017-08-23 | | Last modified: | 2018-08-22 | | Method: | ELECTRON MICROSCOPY (8.3 Å) | | Cite: | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
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5VHP | | CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE | | Descriptor: | 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ... | | Authors: | Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y. | | Deposit date: | 2017-04-13 | | Release date: | 2017-08-23 | | Last modified: | 2018-08-22 | | Method: | ELECTRON MICROSCOPY (7.9 Å) | | Cite: | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
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5VHQ | | CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE | | Descriptor: | 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ... | | Authors: | Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y. | | Deposit date: | 2017-04-13 | | Release date: | 2017-08-23 | | Last modified: | 2018-08-22 | | Method: | ELECTRON MICROSCOPY (8.9 Å) | | Cite: | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
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5VHR | | CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE | | Descriptor: | 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ... | | Authors: | Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y. | | Deposit date: | 2017-04-13 | | Release date: | 2017-08-23 | | Last modified: | 2018-08-22 | | Method: | ELECTRON MICROSCOPY (7.7 Å) | | Cite: | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
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5VHS | | CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE | | Descriptor: | 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, 26S proteasome regulatory subunit 8, ... | | Authors: | Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y. | | Deposit date: | 2017-04-13 | | Release date: | 2017-08-23 | | Last modified: | 2018-08-22 | | Method: | ELECTRON MICROSCOPY (8.8 Å) | | Cite: | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
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5WZX | | STRUCTURAL BASIS FOR A PENTACYCLIC OLEANANE-TYPE TRITERPENOID AS A LIGAND OF FXR | | Descriptor: | Bile acid receptor, SRC2-3 peptide from Nuclear receptor coactivator 2, (4aR,6aR,6aS,6bS,8aS,9R,12aR,14bR)-2,2,6a,6b,9,12a-hexamethyl-10-oxidanylidene-1,3,4,5,6,6a,7,8,8a,9,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid, ... | | Authors: | Lu, Y., Li, Y. | | Deposit date: | 2017-01-19 | | Release date: | 2018-01-03 | | Last modified: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity
Mol. Pharmacol., 93, 2018
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5Y1J | | CRYSTAL STRUCTURE OF HUMAN FXR IN COMPLEX WITH A FUNCTIONAL DRUG LIGAND | | Descriptor: | Bile acid receptor, Peptide from Nuclear receptor coactivator 2, 2-[[2-fluoranyl-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic acid | | Authors: | Lu, Y., Li, Y. | | Deposit date: | 2017-07-20 | | Release date: | 2018-10-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of human FXR in complex with a functional drug liagnd
To Be Published
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5Y44 | | A NOVEL MODERATOR XD4 FOR BILE ACID RECEPTOR | | Descriptor: | Bile acid receptor, Peptide from Nuclear receptor coactivator 1, [(1R,2R,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl] 4-azanyl-3-methyl-benzoate, ... | | Authors: | Lu, Y., Li, Y. | | Deposit date: | 2017-08-01 | | Release date: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | A novel moderator XD4 for bile acid receptor
To Be Published
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5Y49 | | A MODERATOR XD22 BINDING TO BILE ACID RECEPTOR | | Descriptor: | Bile acid receptor, Peptide from Nuclear receptor coactivator 2, [(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl] 4-azanylbenzoate | | Authors: | Lu, Y., Li, Y. | | Deposit date: | 2017-08-02 | | Release date: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | A moderator XD22 binding to bile acid receptor
To Be Published
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3K3P | |
5XQ5 | |
5IAW | | NOVEL NATURAL FXR MODULATOR WITH A UNIQUE BINDING MODE | | Descriptor: | Bile acid receptor, Peptide from Nuclear receptor coactivator 2, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 4-hydroxybenzoate | | Authors: | Lu, Y., Li, Y. | | Deposit date: | 2016-02-22 | | Release date: | 2017-03-08 | | Last modified: | 2017-05-03 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly
Chembiochem, 18, 2017
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5ICK | | A UNIQUE BINDING MODEL OF FXR LBD WITH FEROLINE | | Descriptor: | Bile acid receptor, Nuclear receptor coactivator 2, (1S,2S,3Z,5S,8Z)-5-hydroxy-5,9-dimethyl-2-(propan-2-yl)cyclodeca-3,8-dien-1-yl 4-hydroxybenzoate | | Authors: | Lu, Y., Li, Y. | | Deposit date: | 2016-02-23 | | Release date: | 2017-03-08 | | Last modified: | 2017-08-30 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly
Chembiochem, 18, 2017
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5Z12 | | A STRUCTURE OF FXR/RXR | | Descriptor: | Bile acid receptor, Retinoic acid receptor RXR-alpha, Peptide from Nuclear receptor coactivator 2, ... | | Authors: | Lu, Y., Li, Y. | | Deposit date: | 2017-12-23 | | Release date: | 2018-07-04 | | Last modified: | 2018-08-22 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR
J. Biol. Chem., 293, 2018
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4FQ5 | | CRYSTAL STRUCTURE OF THE MALEATE ISOMERASE ISO(C200A) FROM PSEUDOMONAS PUTIDA S16 WITH MALEATE | | Descriptor: | Maleate cis-trans isomerase, MALEIC ACID | | Authors: | Lu, Y., Chen, D., Zhang, Z., Li, Q., Wu, G., Xu, P. | | Deposit date: | 2012-06-25 | | Release date: | 2013-07-24 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside.
Mol.Microbiol., 87, 2013
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4FQ7 | | CRYSTAL STRUCTURE OF THE MALEATE ISOMERASE ISO FROM PSEUDOMONAS PUTIDA S16 | | Descriptor: | Maleate cis-trans isomerase | | Authors: | Lu, Y., Chen, D., Zhang, Z., Li, Q., Wu, G., Xu, P. | | Deposit date: | 2012-06-25 | | Release date: | 2013-07-24 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside.
Mol.Microbiol., 87, 2013
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2FDP | | CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH AN AMINO-ETHYLENE INHIBITOR | | Descriptor: | Beta-secretase 1, N1-((2S,3S,5R)-3-AMINO-6-(4-FLUOROPHENYLAMINO)-5-METHYL-6-OXO-1-PHENYLHEXAN-2-YL)-N3,N3-DIPROPYLISOPHTHALAMIDE | | Authors: | Yang, W., Lu, W., Lu, Y., Zhong, M., Sun, J., Thomas, A.E., Wilkinson, J.M., Fucini, R.V., Lam, M., Randal, M., Shi, X.P., Jacobs, J.W., McDowell, R.S., Gordon, E.M., Ballinger, M.D. | | Deposit date: | 2005-12-14 | | Release date: | 2006-01-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
J.Med.Chem., 49, 2006
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5VFO | | NUCLEOTIDE-DRIVEN TRIPLE-STATE REMODELING OF THE AAA-ATPASE CHANNEL IN THE ACTIVATED HUMAN 26S PROTEASOME | | Descriptor: | Proteasome subunit alpha type-6, Proteasome subunit alpha type-2, Proteasome subunit alpha type-4, ... | | Authors: | Zhu, Y., Wang, W.L., Yu, D., Ouyang, Q., Lu, Y., Mao, Y. | | Deposit date: | 2017-04-08 | | Release date: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome.
Nat Commun, 9, 2018
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