Author results

6NEY
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CRYSTAL STRUCTURE OF TCBDF5, A BROMODOMAIN CONTAINING PROTEIN FROM TRYPANOSOMA CRUZI
Descriptor:Uncharacterized protein
Authors:Loppnau, P., Dong, A., Tempel, W., Lin, Y.H., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Hui, R., Vedadi, M., Harding, R.J., Structural Genomics Consortium (SGC)
Deposit date:2018-12-18
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Crystal structure of TcBDF5, a bromodomain containing protein from Trypanosoma cruzi
To Be Published
5E26
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CRYSTAL STRUCTURE OF HUMAN PANK2: THE CATALYTIC CORE DOMAIN IN COMPLEX WITH PANTOTHENATE AND ADENOSINE DIPHOSPHATE
Descriptor:Pantothenate kinase 2, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:DONG, A., LOPPNAU, P., RAVICHANDRAN, M., CHENG, C., TEMPEL, W., SEITOVA, A., HUTCHINSON, A., HONG, B.S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., Structural Genomics Consortium (SGC)
Deposit date:2015-09-30
Release date:2015-10-21
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate
to be published
6CVZ
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CRYSTAL STRUCTURE OF THE WD40-REPEAT OF RFWD3
Descriptor:E3 ubiquitin-protein ligase RFWD3, MAGNESIUM ION
Authors:DONG, A., LOPPNAU, P., SEITOVA, A., HUTCHINSON, A., TEMPEL, W., WEI, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2018-03-29
Release date:2018-06-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the WD40-repeat of RFWD3
to be published
2J2C
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II (NT5C2, CN-II)
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, SULFATE ION, ...
Authors:Wallden, K., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Hogbom, M., Karlberg, T., Kotenyova, T., Loppnau, P., Magnusdottir, A., Nilsson-Ehle, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2006-08-16
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
2JC9
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH ADENOSINE
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, MAGNESIUM ION, ...
Authors:Wallden, K., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg, S.L., Hogbom, M., Karlberg, T., Kotenyova, T., Magnusdottir, A., Nilsson-Ehle, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Thorsell, A.G., Van Den Berg, S., Loppnau, P., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2006-12-21
Release date:2007-01-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
2JCM
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH BERYLLIUM TRIFLUORIDE
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, UNKNOWN ATOM OR ION, MAGNESIUM ION, ...
Authors:Wallden, K., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Hogbom, M., Karlberg, T., Kotenyova, T., Magnusdottir, A., Nilsson-Ehle, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Thorsell, A.G., Van Den Berg, S., Loppnau, P., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2006-12-27
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
4PY6
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CRYSTAL STRUCTURE OF BROMODOMAIN OF PFA0510W FROM PLASMODIUM FALCIPARUM
Descriptor:Bromodomain protein, putative, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, ...
Authors:Fonseca, M., Tallant, C., Hutchinson, A., Savitsky, P., Krojer, T., Filippakopoulos, P., Loppnau, P., Brennan, P.E., von Delft, F., Dong, A., Josling, G.A., Duffy, M.F., Arrowsmith, C.H., Bountra, C., Hui, R., Knapp, S., Wernimont, A.K., Structural Genomics Consortium (SGC)
Deposit date:2014-03-26
Release date:2014-04-30
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of bromodomain of PFA0510w from Plasmodium Falciparum
To be Published
2REO
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CRYSTAL STRUCTURE OF HUMAN SULFOTRANSFERASE 1C3 (SULT1C3) IN COMPLEX WITH PAP
Descriptor:Putative sulfotransferase 1C3, ADENOSINE-3'-5'-DIPHOSPHATE
Authors:Tempel, W., Pan, P., Dong, A., Loppnau, P., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2007-09-26
Release date:2007-10-09
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.651 Å)
Cite:Crystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAP.
To be Published
4FLA
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CRYSTAL STRUCTURE OF HUMAN RPRD1B, CARBOXY-TERMINAL DOMAIN
Descriptor:Regulation of nuclear pre-mRNA domain-containing protein 1B, UNKNOWN ATOM OR ION
Authors:Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Guo, X., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
Deposit date:2012-06-14
Release date:2012-08-22
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
4FLB
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CID OF HUMAN RPRD2
Descriptor:Regulation of nuclear pre-mRNA domain-containing protein 2, SULFATE ION, PRASEODYMIUM ION, ...
Authors:Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Guo, X., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
Deposit date:2012-06-14
Release date:2012-08-15
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
4JXT
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CID OF HUMAN RPRD1A IN COMPLEX WITH A PHOSPHORYLATED PEPTIDE FROM RPB1-CTD
Descriptor:Regulation of nuclear pre-mRNA domain-containing protein 1A, DNA-directed RNA polymerase II subunit RPB1, UNKNOWN ATOM OR ION
Authors:Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Guo, X., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
Deposit date:2013-03-28
Release date:2013-11-13
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
4Q94
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HUMAN RPRD1B CID IN COMPLEX WITH A RPB1-CTD DERIVED SER2 PHOSPHORYLATED PEPTIDE
Descriptor:Regulation of nuclear pre-mRNA domain-containing protein 1B, rpb1-ctd, SULFATE ION, ...
Authors:Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
Deposit date:2014-04-29
Release date:2014-06-18
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
4Q96
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CID OF HUMAN RPRD1B IN COMPLEX WITH AN UNMODIFIED CTD PEPTIDE
Descriptor:Regulation of nuclear pre-mRNA domain-containing protein 1B, RPB1-CTD, UNKNOWN ATOM OR ION, ...
Authors:Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Guo, X., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
Deposit date:2014-04-29
Release date:2014-06-04
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
3TLX
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CRYSTAL STRUCTURE OF PF10_0086, ADENYLATE KINASE FROM PLASMODIUM FALCIPARUM
Descriptor:Adenylate kinase 2, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE, ...
Authors:Wernimont, A.K., Loppnau, P., Crombet, L., Weadge, J., Perieteanu, A., Edwards, A.M., Arrowsmith, C.H., Park, H., Bountra, C., Hui, R., Amani, M., Structural Genomics Consortium (SGC)
Deposit date:2011-08-30
Release date:2011-10-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal Structure of PF10_0086, adenylate kinase from plasmodium falciparum
TO BE PUBLISHED
4YY8
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CRYSTAL STRUCTURE ANALYSIS OF KELCH PROTEIN FROM PLASMODIUM FALCIPARUM
Descriptor:Kelch protein, UNKNOWN ATOM OR ION, GLYCEROL
Authors:Jiang, D.Q., Tempel, W., Loppnau, P., Graslund, S., He, H., Ravichandran, M., Seitova, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., El Bakkouri, M., Senisterra, G., Osman, K.T., Lovato, D.V., Hui, R., Hutchinson, A., Lin, Y.H., Structural Genomics Consortium (SGC)
Deposit date:2015-03-23
Release date:2015-04-01
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Crystal Structure Analysis of Kelch protein from Plasmodium falciparum.
to be published
4ZGC
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CRYSTAL STRUCTURE ANALYSIS OF KELCH PROTEIN (WITH DISULFIDE BOND) FROM PLASMODIUM FALCIPARUM
Descriptor:Kelch protein, UNKNOWN ATOM OR ION
Authors:Jiang, D.Q., Tempel, W., Loppnau, P., Graslund, S., He, H., Ravichandran, M., Seitova, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., El Bakkouri, M., Senisterra, G., Osman, K.T., Lovato, D.V., Hui, R., Hutchinson, A., Lin, Y.H., Structural Genomics Consortium (SGC)
Deposit date:2015-04-22
Release date:2015-06-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of kelch protein with disulfide bond from Plasmodium falciparum.
to be published
1T2A
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CRYSTAL STRUCTURE OF HUMAN GDP-D-MANNOSE 4,6-DEHYDRATASE
Descriptor:GDP-mannose 4,6 dehydratase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GUANOSINE-5'-DIPHOSPHATE
Authors:Walker, J.R., Vedadi, M., Sharma, S., Houston, S., Wasney, G., Loppnau, P., Sundstrom, M., Arrowsmith, C., Edwards, A., Oppermann, U.
Deposit date:2004-04-20
Release date:2004-05-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Crystal Structure and Biophysical Characterization of Human GDP-D-mannose 4,6-dehydratase
To be Published
1Y6Z
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MIDDLE DOMAIN OF PLASMODIUM FALCIPARUM PUTATIVE HEAT SHOCK PROTEIN PF14_0417
Descriptor:heat shock protein, putative
Authors:Lunin, V.V., Botchkareva, E., Loppnau, P., Amani, M., Bray, J., Vedadi, M., Edwards, A., Arrowsmith, C., Sundstrom, M., Bochkarev, A., Hui, R., Plotnikova, O., Structural Genomics Consortium (SGC)
Deposit date:2004-12-07
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
1Z4R
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HUMAN GCN5 ACETYLTRANSFERASE
Descriptor:General control of amino acid synthesis protein 5-like 2, ACETYL COENZYME *A
Authors:Dong, A., Bernstein, G., Schuetz, A., Antoshenko, T., Wu, H., Loppnau, P., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Plotnikov, A., Structural Genomics Consortium (SGC)
Deposit date:2005-03-16
Release date:2005-03-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A
Proteins, 68, 2007
1ZD1
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HUMAN SULFORTRANSFERASE SULT4A1
Descriptor:Sulfotransferase 4A1, GLYCEROL
Authors:Dong, A., Dombrovski, L., Loppnau, P., Edwards, A.M., Arrowsmith, C.H., Sundstrom, M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-04-13
Release date:2005-04-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural and chemical profiling of the human cytosolic sulfotransferases.
Plos Biol., 5, 2007
1ZQ9
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CRYSTAL STRUCTURE OF HUMAN DIMETHYLADENOSINE TRANSFERASE
Descriptor:Probable dimethyladenosine transferase, S-ADENOSYLMETHIONINE
Authors:Dong, A., Wu, H., Zeng, H., Loppnau, P., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Plotnikov, A., Structural Genomics Consortium (SGC)
Deposit date:2005-05-18
Release date:2005-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human Dimethyladenosine transferase with SAM
TO BE PUBLISHED
1ZRH
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CRYSTAL STRUCTURE OF HUMAN HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 1 IN COMPLEX WITH PAP
Descriptor:Heparan sulfate glucosamine 3-O-sulfotransferase 1, ADENOSINE-3'-5'-DIPHOSPHATE
Authors:Dong, A., Dombrovski, L., Loppnau, P., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-05-19
Release date:2005-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP
To be Published
2A14
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CRYSTAL STRUCTURE OF HUMAN INDOLETHYLAMINE N-METHYLTRANSFERASE WITH SAH
Descriptor:indolethylamine N-methyltransferase, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Dong, A., Wu, H., Zeng, H., Loppnau, P., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-06-17
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Human Indolethylamine N-methyltransferase in complex with SAH.
To be Published
2AD1
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HUMAN SULFOTRANSFERASE SULT1C2
Descriptor:Sulfotransferase 1C2
Authors:Dong, A., Dombrovski, L., Loppnau, P., Edwards, A.M., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-07-19
Release date:2005-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and chemical profiling of the human cytosolic sulfotransferases.
Plos Biol., 5, 2007
2AVD
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CRYSTAL STRUCTURE OF HUMAN CATECHOL-O-METHYLTRANSFERASE DOMAIN CONTAINING 1
Descriptor:Catechol-O-methyltransferase, S-ADENOSYLMETHIONINE
Authors:Min, J.R., Wu, H., Zeng, H., Loppnau, P., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-08-29
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Human Catechol-O-methyltransferase domain containing 1 in complex with S-adenosyl-L-methionine
To be Published