2M60
| Enterocin 7B | Descriptor: | Enterocin JSB | Authors: | Lohans, C.T, Towle, K.M, Miskolzie, M, McKay, R.T, van Belkum, M.J, McMullen, L.M, Vederas, J.C. | Deposit date: | 2013-03-18 | Release date: | 2013-06-12 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Solution Structures of the Linear Leaderless Bacteriocins Enterocin 7A and 7B Resemble Carnocyclin A, a Circular Antimicrobial Peptide Biochemistry, 52, 2013
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2M5Z
| Enterocin 7A | Descriptor: | Enterocin JSA | Authors: | Lohans, C.T, Towle, K.M, Miskolzie, M, McKay, R.T, van Belkum, M.J, McMullen, L.M, Vederas, J.C. | Deposit date: | 2013-03-16 | Release date: | 2013-06-12 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Solution Structures of the Linear Leaderless Bacteriocins Enterocin 7A and 7B Resemble Carnocyclin A, a Circular Antimicrobial Peptide Biochemistry, 52, 2013
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2LJT
| C9L,C14L-LeuA | Descriptor: | Bacteriocin leucocin-A | Authors: | Sit, C.S, Lohans, C.T, van Belkum, M.J, Campbell, C.D, Miskolzie, M, Vederas, J.C. | Deposit date: | 2011-09-23 | Release date: | 2012-01-11 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Substitution of a Conserved Disulfide in the Type IIa Bacteriocin, Leucocin A, with L-Leucine and L-Serine Residues: Effects on Activity and Three-Dimensional Structure. Chembiochem, 13, 2012
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5UJQ
| NMR Solution Structure of the Two-component Bacteriocin CbnXY | Descriptor: | Bacteriocin | Authors: | Acedo, J.Z, Towle, K.M, Lohans, C.T, McKay, R.T, Miskolzie, M, Doerksen, T, Vederas, J.C, Martin-Visscher, L.A. | Deposit date: | 2017-01-18 | Release date: | 2017-11-29 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Identification and three-dimensional structure of carnobacteriocin XY, a class IIb bacteriocin produced by Carnobacteria. FEBS Lett., 591, 2017
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5UJR
| NMR Solution Structure of the Two-component Bacteriocin CbnXY | Descriptor: | Bacteriocin | Authors: | Acedo, J.Z, Towle, K.M, Lohans, C.T, McKay, R.T, Miskolzie, M, Doerksen, T, Vederas, J.C, Martin-Visscher, L.A. | Deposit date: | 2017-01-18 | Release date: | 2017-11-29 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Identification and three-dimensional structure of carnobacteriocin XY, a class IIb bacteriocin produced by Carnobacteria. FEBS Lett., 591, 2017
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2LJQ
| (C9S, C14S)-leucocin A | Descriptor: | Bacteriocin leucocin-A | Authors: | Sit, C.S, Lohans, C.T, van Belkum, M.J, Campbell, C.D, Miskolzie, M, Vederas, J.C. | Deposit date: | 2011-09-22 | Release date: | 2012-01-18 | Method: | SOLUTION NMR | Cite: | Substitution of a Conserved Disulfide in the Type IIa Bacteriocin, Leucocin A, with L-Leucine and L-Serine Residues: Effects on Activity and Three-Dimensional Structure. Chembiochem, 13, 2012
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2N4K
| Solution Structure of Enterocin HF, an Antilisterial Bacteriocin Produced by Enterococcus faecium M3K31 | Descriptor: | Enterocin-HF | Authors: | Arbulu, S, Lohans, C.T, van Belkum, M.J, Cintas, L.M, Herranz, C, Vederas, J.C, Hernandez, P.E. | Deposit date: | 2015-06-21 | Release date: | 2015-12-02 | Last modified: | 2016-01-06 | Method: | SOLUTION NMR | Cite: | Solution Structure of Enterocin HF, an Antilisterial Bacteriocin Produced by Enterococcus faecium M3K31. J.Agric.Food Chem., 63, 2015
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2MWR
| Solution Structure of Acidocin B, a Circular Bacteriocin from Lactobacillus acidophilus M46 | Descriptor: | Acidocin B | Authors: | Vederas, J.C, Acedo, J.Z, van Belkum, M.J, Lohans, C.T. | Deposit date: | 2014-11-19 | Release date: | 2015-03-04 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Solution Structure of Acidocin B, a Circular Bacteriocin Produced by Lactobacillus acidophilus M46. Appl.Environ.Microbiol., 81, 2015
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2N8O
| NMR Solution Structure of Aureocin A53 | Descriptor: | Bacteriocin aureocin A53 | Authors: | Acedo, J.Z, van Belkum, M.J, Lohans, C.T, Towle, K.M, Miskolzie, M, Vederas, J.C. | Deposit date: | 2015-10-22 | Release date: | 2016-02-17 | Method: | SOLUTION NMR | Cite: | Nuclear Magnetic Resonance Solution Structures of Lacticin Q and Aureocin A53 Reveal a Structural Motif Conserved among Leaderless Bacteriocins with Broad-Spectrum Activity. Biochemistry, 55, 2016
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2N8P
| Solution Structure of Lacticin Q | Descriptor: | Lacticin Q | Authors: | Acedo, J.Z, van Belkum, M.J, Lohans, C.T, Towle, K.M, Miskolzie, M, Vederas, J.C. | Deposit date: | 2015-10-22 | Release date: | 2016-02-17 | Method: | SOLUTION NMR | Cite: | Nuclear Magnetic Resonance Solution Structures of Lacticin Q and Aureocin A53 Reveal a Structural Motif Conserved among Leaderless Bacteriocins with Broad-Spectrum Activity. Biochemistry, 55, 2016
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5KGY
| Phenol-soluble modulin Alpha 3 | Descriptor: | Phenol-soluble modulin alpha 3 peptide | Authors: | Towle, K.M, Lohans, C.T, Acedo, J.Z, Van Belkum, M.J, Miskolzie, M, Vederas, J.C. | Deposit date: | 2016-06-13 | Release date: | 2016-08-31 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Solution Structures of Phenol-Soluble Modulins alpha 1, alpha 3, and beta 2, Virulence Factors from Staphylococcus aureus. Biochemistry, 55, 2016
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5KHB
| Structure of Phenol-soluble modulin Alpha1 | Descriptor: | PSM Alpha1 | Authors: | Towle, K.M, Lohans, C.T, Acedo, J.Z, Miskolzie, M, van Belkum, M.J, Vederas, J.C. | Deposit date: | 2016-06-14 | Release date: | 2016-08-31 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Solution Structures of Phenol-Soluble Modulins alpha 1, alpha 3, and beta 2, Virulence Factors from Staphylococcus aureus. Biochemistry, 55, 2016
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5KGZ
| Phenol-soluble modulin Beta2 | Descriptor: | Modulin Beta2 | Authors: | Towle, K.M, Lohans, C.T, Acedo, J.Z, Van Belkum, M.J, Miskolzie, M, Vederas, J.C. | Deposit date: | 2016-06-13 | Release date: | 2016-08-31 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Solution Structures of Phenol-Soluble Modulins alpha 1, alpha 3, and beta 2, Virulence Factors from Staphylococcus aureus. Biochemistry, 55, 2016
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5MMY
| Crystal structure of OXA10 with HEPES | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase OXA-10, ... | Authors: | Brem, J. | Deposit date: | 2016-12-12 | Release date: | 2017-07-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | (13)C-Carbamylation as a mechanistic probe for the inhibition of class D beta-lactamases by avibactam and halide ions. Org. Biomol. Chem., 15, 2017
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5MOX
| OXA-10 Avibactam complex with bound CO2 | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase OXA-10, CARBON DIOXIDE, ... | Authors: | Brem, J. | Deposit date: | 2016-12-14 | Release date: | 2017-07-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | (13)C-Carbamylation as a mechanistic probe for the inhibition of class D beta-lactamases by avibactam and halide ions. Org. Biomol. Chem., 15, 2017
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5MOZ
| OXA-10 Avibactam complex with bound Iodide | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase OXA-10, CHLORIDE ION, ... | Authors: | Brem, J. | Deposit date: | 2016-12-15 | Release date: | 2017-07-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | (13)C-Carbamylation as a mechanistic probe for the inhibition of class D beta-lactamases by avibactam and halide ions. Org. Biomol. Chem., 15, 2017
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5MNU
| OXA-10 Avibactam complex with bound bromide | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, BROMIDE ION, Beta-lactamase OXA-10, ... | Authors: | Brem, J, McDonough, M, Clifton, I. | Deposit date: | 2016-12-13 | Release date: | 2017-07-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | (13)C-Carbamylation as a mechanistic probe for the inhibition of class D beta-lactamases by avibactam and halide ions. Org. Biomol. Chem., 15, 2017
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6RJ7
| Crystal structure of the 19F labelled OXA-48 | Descriptor: | Beta-lactamase, CALCIUM ION, CHLORIDE ION | Authors: | Brem, J, Lohans, C, Schofield, C. | Deposit date: | 2019-04-26 | Release date: | 2019-07-31 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.73002231 Å) | Cite: | 19F NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D beta-Lactamase Carbamylation and Inhibition. Chemistry, 25, 2019
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6RRM
| Crystal structure of LdtMt2 from Mycobacterium tuberculosis bound to Ebselen | Descriptor: | 1,2-ETHANEDIOL, AMMONIUM ION, GLYCEROL, ... | Authors: | Brem, J, Lohans, C, Schofield, C. | Deposit date: | 2019-05-20 | Release date: | 2019-08-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2with cysteine-reactive inhibitors including ebselen. Chem.Commun.(Camb.), 55, 2019
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6RLG
| Crystal structure of LdtMt2 from Mycobacterium tuberculosis | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, L,D-transpeptidase 2, ... | Authors: | Brem, J, Lohans, C, Schofield, C. | Deposit date: | 2019-05-02 | Release date: | 2019-08-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.51000178 Å) | Cite: | Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2with cysteine-reactive inhibitors including ebselen. Chem.Commun.(Camb.), 55, 2019
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5OP6
| Factor Inhibiting HIF (FIH) in complex with zinc and GSK128863 | Descriptor: | 2-[[1,3-dicyclohexyl-4-oxidanyl-2,6-bis(oxidanylidene)pyrimidin-5-yl]carbonylamino]ethanoic acid, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ... | Authors: | Leissing, T.M, Schofield, C.J, Clifton, I.J, Thinnes, C.C, Lu, X. | Deposit date: | 2017-08-09 | Release date: | 2017-10-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem Sci, 8, 2017
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5OPC
| Factor Inhibiting HIF (FIH) in complex with zinc and Vadadustat | Descriptor: | GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ... | Authors: | Leissing, T.M, Schofield, C.J, Clifton, I.J, Lu, X, Zhang, D. | Deposit date: | 2017-08-09 | Release date: | 2017-10-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem Sci, 8, 2017
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5OX6
| HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Vadadustat | Descriptor: | Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Chowdhury, R, Zhang, D, Schofield, C.J. | Deposit date: | 2017-09-06 | Release date: | 2017-10-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem Sci, 8, 2017
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5OP8
| Factor Inhibiting HIF (FIH) in complex with zinc and Molidustat | Descriptor: | 2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(1,2,3-triazol-1-yl)-1~{H}-pyrazol-3-one, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ... | Authors: | Leissing, T.M, Schofield, C.J, Clifton, I.J, Lu, X. | Deposit date: | 2017-08-09 | Release date: | 2017-10-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem Sci, 8, 2017
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5OX5
| HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with CCT6, a GSK1278863-related compound | Descriptor: | (6-hydroxy-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl)glycine, BICARBONATE ION, Egl nine homolog 1, ... | Authors: | Chowdhury, R, Thinnes, C.C, Schofield, C.J. | Deposit date: | 2017-09-06 | Release date: | 2017-10-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.251 Å) | Cite: | Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem Sci, 8, 2017
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