Author results

5FID
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CRYSTAL STRUCTURE OF THE PROTEIN ELICITOR MOHRIP2 FROM MAGNAPORTHE ORYZAE
Descriptor:Elicitor protein Hrip2
Authors:Liu, M., Duan, L., Qiu, D., Liu, X.
Deposit date:2015-12-23
Release date:2016-12-07
Method:X-RAY DIFFRACTION (1.809 Å)
Cite:Crystal Structure Analysis and the Identification of Distinctive Functional Regions of the Protein Elicitor Mohrip2
Front Plant Sci, 7, 2016
3W0F
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CRYSTAL STRUCTURE OF MOUSE ENDONUCLEASE VIII-LIKE 3 (MNEIL3)
Descriptor:Endonuclease 8-like 3, ZINC ION, IODIDE ION
Authors:Liu, M., Imamura, K., Averill, A.M., Wallace, S.S., Doublie, S.
Deposit date:2012-10-30
Release date:2013-01-16
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Characterization of a Mouse Ortholog of Human NEIL3 with a Marked Preference for Single-Stranded DNA
Structure, 21, 2013
3GKY
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THE STRUCTURAL BASIS OF AN ER STRESS-ASSOCIATED BOTTLENECK IN A PROTEIN FOLDING LANDSCAPE
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Liu, M., Wan, Z.L., Chu, Y.C., Alddin, H., Klaproth, B., Weiss, M.A.
Deposit date:2009-03-11
Release date:2009-03-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY.
J.Biol.Chem., 284, 2009
5H7V
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STRUCTURE OF FULL-LENGTH EXTRACELLULAR DOMAIN OF HAI-1 AT PH 4.6
Descriptor:Kunitz-type protease inhibitor 1
Authors:Liu, M., Huang, M.
Deposit date:2016-11-21
Release date:2017-03-29
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (3.82 Å)
Cite:The crystal structure of a multidomain protease inhibitor (HAI-1) reveals the mechanism of its auto-inhibition
J. Biol. Chem., 292, 2017
4H86
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CRYSTAL STRUCTURE OF AHP1 FROM SACCHAROMYCES CEREVISIAE IN REDUCED FORM
Descriptor:Peroxiredoxin type-2
Authors:Liu, M., Wang, F., Qiu, R., Wu, T., Gu, S., Tang, R., Ji, C.
Deposit date:2012-09-21
Release date:2012-10-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:Crystal structure of Ahp1 from Saccharomyces cerevisiae in reduced form
To be Published
2LMC
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STRUCTURE OF T7 TRANSCRIPTION FACTOR GP2-E. COLI RNAP JAW DOMAIN COMPLEX
Descriptor:Bacterial RNA polymerase inhibitor, DNA-directed RNA polymerase subunit beta
Authors:Liu, M.
Deposit date:2011-11-29
Release date:2012-03-14
Last modified:2012-10-03
Method:SOLUTION NMR
Cite:Structural and Mechanistic Basis for the Inhibition of Escherichia coli RNA Polymerase by T7 Gp2.
Mol.Cell, 47, 2012
3TG2
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CRYSTAL STRUCTURE OF THE ISC DOMAIN OF VIBB IN COMPLEX WITH ISOCHORISMATE
Descriptor:Vibriobactin-specific isochorismatase, (5S,6S)-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohexa-1,3-diene-1-carboxylic acid, TRIETHYLENE GLYCOL
Authors:Liu, S., Zhang, C., Niu, B., Li, N., Liu, X., Liu, M., Wei, T., Zhu, D., Huang, Y., Xu, S., Gu, L.
Deposit date:2011-08-17
Release date:2012-08-29
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (1.101 Å)
Cite:Structural insight into the ISC domain of VibB from Vibrio cholerae at atomic resolution: a snapshot just before the enzymatic reaction
Acta Crystallogr.,Sect.D, 68, 2012
3TB4
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CRYSTAL STRUCTURE OF THE ISC DOMAIN OF VIBB
Descriptor:Vibriobactin-specific isochorismatase, B-OCTYLGLUCOSIDE, TRIETHYLENE GLYCOL, ...
Authors:Liu, S., Zhang, C., Niu, B., Li, N., Liu, M., Wei, T., Zhu, D., Xu, S., Gu, L.
Deposit date:2011-08-05
Release date:2012-08-29
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural insight into the ISC domain of VibB from Vibrio cholerae at atomic resolution: a snapshot just before the enzymatic reaction
Acta Crystallogr.,Sect.D, 68, 2012
2LUH
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NMR STRUCTURE OF THE VTA1-VPS60 COMPLEX
Descriptor:Vacuolar protein sorting-associated protein VTA1, Vacuolar protein-sorting-associated protein 60
Authors:Yang, Z., Vild, C., Ju, J., Zhang, X., Liu, J., Shen, J., Zhao, B., Lan, W., Gong, F., Liu, M., Cao, C., Xu, Z.
Deposit date:2012-06-13
Release date:2012-11-07
Last modified:2013-01-09
Method:SOLUTION NMR
Cite:Structural Basis of Molecular Recognition between ESCRT-III-like Protein Vps60 and AAA-ATPase Regulator Vta1 in the Multivesicular Body Pathway.
J.Biol.Chem., 287, 2012
2WNM
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SOLUTION STRUCTURE OF GP2
Descriptor:GENE 2
Authors:Camara, B., Liu, M., Shadrinc, A., Liu, B., Simpson, P., Weinzierl, R., Severinovc, K., Cota, E., Matthews, S., Wigneshweraraj, S.R.
Deposit date:2009-07-13
Release date:2010-02-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:T7 Phage Protein Gp2 Inhibits the Escherichia Coli RNA Polymerase by Antagonizing Stable DNA Strand Separation Near the Transcription Start Site.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KH2
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CRYSTAL STRUCTURE OF THE P1 BACTERIOPHAGE DOC TOXIN (F68S) IN COMPLEX WITH THE PHD ANTITOXIN (L17M/V39A). NORTHEAST STRUCTURAL GENOMICS TARGETS ER385-ER386
Descriptor:Death on curing protein, Prevent host death protein, CHLORIDE ION, ...
Authors:Arbing, M.A., Kuzin, A.P., Su, M., Abashidze, M., Verdon, G., Liu, M., Xiao, R., Acton, T., Inouye, M., Montelione, G.T., Woychik, N.A., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2009-10-29
Release date:2010-08-18
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal Structures of Phd-Doc, HigA, and YeeU Establish Multiple Evolutionary Links between Microbial Growth-Regulating Toxin-Antitoxin Systems.
Structure, 18, 2010
4C4E
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STRUCTURE-BASED DESIGN OF ORALLY BIOAVAILABLE PYRROLOPYRIDINE INHIBITORS OF THE MITOTIC KINASE MPS1
Descriptor:DUAL SPECIFICITY PROTEIN KINASE TTK, N-(3,4-dimethoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine, PENTAETHYLENE GLYCOL, ...
Authors:Naud, S., Westwood, I.M., Faisal, A., Sheldrake, P., Bavetsias, V., Atrash, B., Liu, M., Hayes, A., Schmitt, J., Wood, A., Choi, V., Boxall, K., Mak, G., Gurden, M., Valenti, M., de Haven Brandon, A., Henley, A., Baker, R., McAndrew, C., Matijssen, B., Burke, R., Eccles, S.A., Raynaud, F.I., Linardopoulos, S., van Montfort, R., Blagg, J.
Deposit date:2013-09-05
Release date:2013-12-04
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3, 2-C]Pyridine Inhibitors of the Mitotic Kinase Monopolar Spindle 1 (Mps1).
J.Med.Chem., 56, 2013
4C4F
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STRUCTURE-BASED DESIGN OF ORALLY BIOAVAILABLE PYRROLOPYRIDINE INHIBITORS OF THE MITOTIC KINASE MPS1
Descriptor:DUAL SPECIFICITY PROTEIN KINASE TTK, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, N-(2-methoxyphenyl)-2-(1,3-oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine, ...
Authors:Naud, S., Westwood, I.M., Faisal, A., Sheldrake, P., Bavetsias, V., Atrash, B., Liu, M., Hayes, A., Schmitt, J., Wood, A., Choi, V., Boxall, K., Mak, G., Gurden, M., Valenti, M., de Haven Brandon, A., Henley, A., Baker, R., McAndrew, C., Matijssen, B., Burke, R., Eccles, S.A., Raynaud, F.I., Linardopoulos, S., van Montfort, R., Blagg, J.
Deposit date:2013-09-05
Release date:2013-12-04
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3, 2-C]Pyridine Inhibitors of the Mitotic Kinase Monopolar Spindle 1 (Mps1).
J.Med.Chem., 56, 2013
4C4G
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STRUCTURE-BASED DESIGN OF ORALLY BIOAVAILABLE PYRROLOPYRIDINE INHIBITORS OF THE MITOTIC KINASE MPS1
Descriptor:DUAL SPECIFICITY PROTEIN KINASE TTK, tert-butyl 6-((2-chloro-4-(dimethylcarbamoyl)phenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, ...
Authors:Naud, S., Westwood, I.M., Faisal, A., Sheldrake, P., Bavetsias, V., Atrash, B., Liu, M., Hayes, A., Schmitt, J., Wood, A., Choi, V., Boxall, K., Mak, G., Gurden, M., Valenti, M., de Haven Brandon, A., Henley, A., Baker, R., McAndrew, C., Matijssen, B., Burke, R., Eccles, S.A., Raynaud, F.I., Linardopoulos, S., van Montfort, R., Blagg, J.
Deposit date:2013-09-05
Release date:2013-12-04
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3, 2-C]Pyridine Inhibitors of the Mitotic Kinase Monopolar Spindle 1 (Mps1).
J.Med.Chem., 56, 2013
4C4H
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STRUCTURE-BASED DESIGN OF ORALLY BIOAVAILABLE PYRROLOPYRIDINE INHIBITORS OF THE MITOTIC KINASE MPS1
Descriptor:DUAL SPECIFICITY PROTEIN KINASE TTK, tert-butyl 6-((2-chloro-4-(dimethylcarbamoyl)phenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
Authors:Naud, S., Westwood, I.M., Faisal, A., Sheldrake, P., Bavetsias, V., Atrash, B., Liu, M., Hayes, A., Schmitt, J., Wood, A., Choi, V., Boxall, K., Mak, G., Gurden, M., Valenti, M., de Haven Brandon, A., Henley, A., Baker, R., McAndrew, C., Matijssen, B., Burke, R., Eccles, S.A., Raynaud, F.I., Linardopoulos, S., van Montfort, R., Blagg, J.
Deposit date:2013-09-05
Release date:2013-12-04
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3, 2-C]Pyridine Inhibitors of the Mitotic Kinase Monopolar Spindle 1 (Mps1).
J.Med.Chem., 56, 2013
4C4I
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STRUCTURE-BASED DESIGN OF ORALLY BIOAVAILABLE PYRROLOPYRIDINE INHIBITORS OF THE MITOTIC KINASE MPS1
Descriptor:DUAL SPECIFICITY PROTEIN KINASE TTK, tert-butyl 6-{[2-chloro-4-(dimethylcarbamoyl)phenyl]amino}-2-(1,3-oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
Authors:Naud, S., Westwood, I.M., Faisal, A., Sheldrake, P., Bavetsias, V., Atrash, B., Liu, M., Hayes, A., Schmitt, J., Wood, A., Choi, V., Boxall, K., Mak, G., Gurden, M., Valenti, M., de Haven Brandon, A., Henley, A., Baker, R., McAndrew, C., Matijssen, B., Burke, R., Eccles, S.A., Raynaud, F.I., Linardopoulos, S., van Montfort, R., Blagg, J.
Deposit date:2013-09-05
Release date:2013-12-04
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3, 2-C]Pyridine Inhibitors of the Mitotic Kinase Monopolar Spindle 1 (Mps1).
J.Med.Chem., 56, 2013
4C4J
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STRUCTURE-BASED DESIGN OF ORALLY BIOAVAILABLE PYRROLOPYRIDINE INHIBITORS OF THE MITOTIC KINASE MPS1
Descriptor:DUAL SPECIFICITY PROTEIN KINASE TTK, tert-butyl 6-{[2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl]amino}-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate
Authors:Naud, S., Westwood, I.M., Faisal, A., Sheldrake, P., Bavetsias, V., Atrash, B., Liu, M., Hayes, A., Schmitt, J., Wood, A., Choi, V., Boxall, K., Mak, G., Gurden, M., Valenti, M., de Haven Brandon, A., Henley, A., Baker, R., McAndrew, C., Matijssen, B., Burke, R., Eccles, S.A., Raynaud, F.I., Linardopoulos, S., van Montfort, R., Blagg, J.
Deposit date:2013-09-05
Release date:2013-12-04
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3, 2-C]Pyridine Inhibitors of the Mitotic Kinase Monopolar Spindle 1 (Mps1).
J.Med.Chem., 56, 2013
5H64
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CRYO-EM STRUCTURE OF MTORC1
Descriptor:Serine/threonine-protein kinase mTOR, Regulatory-associated protein of mTOR, Target of rapamycin complex subunit LST8
Authors:Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M., Wong, C.C.L., Wang, J., Xu, Y., Wang, H.
Deposit date:2016-11-10
Release date:2017-01-25
Last modified:2017-12-06
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:4.4 angstrom Resolution Cryo-EM structure of human mTOR Complex 1
Protein Cell, 7, 2016
3JSD
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2009-09-10
Release date:2010-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3KLU
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CRYSTAL STRUCTURE OF THE PROTEIN YQBN. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SR445.
Descriptor:Uncharacterized protein yqbN, MANGANESE (II) ION
Authors:Kuzin, A.P., Su, M., Seetharaman, J., Wang, D., Fang, Y., Cunningham, K., Ma, L.-C., Xiao, R., Liu, M., Baran, M.C., Acton, T.B., Rost, B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2009-11-09
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the protein yqbn. northeast structural genomics consortium target sr445.
To be Published
3ROV
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2011-04-26
Release date:2012-05-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
4XSK
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STRUCTURE OF PAITRAP, AN UPA MUTANT
Descriptor:Urokinase-type plasminogen activator, SULFATE ION, TRIETHYLENE GLYCOL, ...
Authors:Gong, L., Proulle, V., Hong, Z., Lin, Z., Liu, M., Yuan, C., Lin, L., Furie, B., Flaumenhaft, R., Andreasen, P., Furie, B., Huang, M.
Deposit date:2015-01-22
Release date:2016-02-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of PAItrap, an uPA mutant
To Be Published
5AQF
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, ADENOSINE, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQG
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, (2R,3R,4S,5R)-2-(3-AMINO-5-METHYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-1(5H)-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
5AQH
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FRAGMENT-BASED SCREENING OF HSP70 SHEDS LIGHT ON THE FUNCTIONAL ROLE OF ATP-BINDING SITE RESIDUES
Descriptor:HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, 5-methyl-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine, ...
Authors:Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., Liu, M., Richards, M., McAndrew, C., Yahya, N., Dobson, S.E., Jones, K., Workman, P., Collins, I., van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016