1Q1M | | A HIGHLY EFFICIENT APPROACH TO A SELECTIVE AND CELL ACTIVE PTP1B INHIBITORS | | Descriptor: | Protein-tyrosine phosphatase, non-receptor type 1, 5-{2-FLUORO-5-[3-(3-HYDROXY-2-METHOXYCARBONYL-PHENOXY)-PROPENYL]-PHENYL}-ISOXAZOLE-3-CARBOXYLIC ACID | | Authors: | Liu, G., Xin, Z., Pei, Z., Hajduk, P.J., Abad-Zapatero, C., Hutchins, C.W., Zhao, H., Lubben, T.H., Ballaron, S.J., Haasch, D.L., Kaszubska, W., Rondinone, C.M., Trevillyan, J.M., Jirousek, M.R. | | Deposit date: | 2003-07-22 | | Release date: | 2003-09-16 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.
J.Med.Chem., 46, 2003
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2JWY | | SOLUTION NMR STRUCTURE OF UNCHARACTERIZED LIPOPROTEIN YAJI FROM ESCHERICHIA COLI. NORTHEAST STRUCTURAL GENOMICS TARGET ER540 | | Descriptor: | Uncharacterized lipoprotein yajI | | Authors: | Liu, G., Xiao, R., Chen, C., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-10-31 | | Release date: | 2007-11-20 | | Last modified: | 2020-02-19 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of uncharacterized lipoprotein yajI from Escherichia coli.
To be Published
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5HLG | | STRUCTURE OF REDUCED ABFR BOUND TO DNA | | Descriptor: | DNA (5'-D(*TP*AP*AP*CP*TP*CP*AP*AP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*TP*TP*GP*AP*GP*T)-3'), MarR family transcriptional regulator | | Authors: | Liu, G., Liu, X., Gan, J., Yang, C.G. | | Deposit date: | 2016-01-15 | | Release date: | 2017-01-25 | | Last modified: | 2017-04-05 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.
J. Am. Chem. Soc., 139, 2017
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5HLH | | CRYSTAL STRUCTURE OF THE OVEROXIDIZED ABFR BOUND TO DNA | | Descriptor: | DNA (5'-D(*TP*AP*AP*CP*TP*CP*AP*AP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*TP*TP*GP*AP*GP*T)-3'), MarR family transcriptional regulator | | Authors: | Liu, G., Liu, X., Gan, J., Yang, C.-G. | | Deposit date: | 2016-01-15 | | Release date: | 2017-01-25 | | Last modified: | 2017-04-05 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.
J. Am. Chem. Soc., 139, 2017
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5HLI | | STRUCTURE OF DISULFIDE FORMED ABFR | | Descriptor: | MarR family transcriptional regulator, COPPER (II) ION, CHLORIDE ION | | Authors: | Liu, G., Liu, X., Gan, J., Yang, C.-G. | | Deposit date: | 2016-01-15 | | Release date: | 2017-01-25 | | Last modified: | 2017-04-05 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.
J. Am. Chem. Soc., 139, 2017
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1ONY | | OXALYL-ARYL-AMINO BENZOIC ACID INHIBITORS OF PTP1B, COMPOUND 17 | | Descriptor: | Protein-tyrosine phosphatase, non-receptor type 1, 2-{[2-(2-CARBAMOYL-VINYL)-4-(2-METHANESULFONYLAMINO-2-PENTYLCARBAMOYL-ETHYL)-PHENYL]-OXALYL-AMINO}-BENZOIC ACID | | Authors: | Liu, G., Szczepankiewicz, B.G., Pei, Z., Janowich, D.A., Xin, Z., Hadjuk, P.J., Abad-Zapatero, C., Liang, H., Hutchins, C.W., Fesik, S.W., Ballaron, S.J., Stashko, M.A., Lubben, T., Mika, A.K., Zinker, B.A., Trevillyan, J.M., Jirousek, M.R. | | Deposit date: | 2003-03-02 | | Release date: | 2003-05-20 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic
Acids as Inhibitors of Protein Tyrosine Phosphatase 1B
J.Med.Chem., 46, 2003
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1ONZ | | OXALYL-ARYL-AMINO BENZOIC ACID INHIBITORS OF PTP1B, COMPOUND 8B | | Descriptor: | Protein-tyrosine phosphatase, non-receptor type 1, 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID | | Authors: | Liu, G., Szczepankiewicz, B.G., Pei, Z., Janowich, D.A., Xin, Z., Hadjuk, P.J., Abad-Zapatero, C., Liang, H., Hutchins, C.W., Fesik, S.W., Ballaron, S.J., Stashko, M.A., Lubben, T., Mika, A.K., Zinker, B.A., Trevillyan, J.M., Jirousek, M.R. | | Deposit date: | 2003-03-02 | | Release date: | 2003-05-20 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic
Acids as Inhibitors of Protein Tyrosine Phosphatase 1B
J.Med.Chem., 46, 2003
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2JXT | | SOLUTION STRUCTURE OF 50S RIBOSOMAL PROTEIN LX FROM METHANOBACTERIUM THERMOAUTOTROPHICUM. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR80 | | Descriptor: | 50S ribosomal protein LX | | Authors: | Liu, G., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-11-29 | | Release date: | 2007-12-11 | | Last modified: | 2020-02-19 | | Method: | SOLUTION NMR | | Cite: | Solution structure of 50S ribosomal protein LX from Methanobacterium thermoautotrophicum.
To be Published
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2KCP | | SOLUTION STRUCTURE OF 30S RIBOSOMAL PROTEIN S8E; FROM METHANOTHERMOBACTER THERMAUTOTROPHICUS, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR71D | | Descriptor: | 30S ribosomal protein S8e | | Authors: | Liu, G., Rossi, P., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-12-24 | | Release date: | 2009-07-14 | | Last modified: | 2020-02-19 | | Method: | SOLUTION NMR | | Cite: | SOLUTION STRUCTURE OF 30S RIBOSOMAL PROTEIN S8E FROM Methanothermobacter thermautotrophicus, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET
To be Published
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2KCV | | SOLUTION NMR STRUCTURE OF TETRATRICOPEPTIDE REPEAT DOMAIN PROTEIN SRU_0103 FROM SALINIBACTER RUBER, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET SRR115C | | Descriptor: | Tetratricopeptide repeat domain protein | | Authors: | Liu, G., Rossi, P., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-12-29 | | Release date: | 2009-01-20 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution nmr structure of tetratricopeptide repeat domain protein sru_0103 from salinibacter ruber, northeast structural genomics consortium (nesg) target srr115c
To be Published
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2KCY | | SOLUTION STRUCTURE OF RIBOSOMAL PROTEIN S8E FROM METHANOTHERMOBACTER THERMAUTOTROPHICUS, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR71D | | Descriptor: | 30S ribosomal protein S8e | | Authors: | Liu, G., Rossi, P., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B.C., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-12-30 | | Release date: | 2009-01-20 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | SOLUTION STRUCTURE OF RIBOSOMAL PROTEIN S8E FROM Methanothermobacter thermautotrophicus, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR71D
To be Published
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2KK0 | | SOLUTION STRUCTURE OF DEAD RINGER-LIKE PROTEIN 1 (AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A) FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET HR4394C | | Descriptor: | AT-rich interactive domain-containing protein 3A | | Authors: | Liu, G., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2009-06-14 | | Release date: | 2009-07-14 | | Last modified: | 2020-02-26 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of the ARID domain of human AT-rich interactive domain-containing protein 3A: a human cancer protein interaction network target.
Proteins, 78, 2010
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2KK1 | | SOLUTION STRUCTURE OF C-TERMINAL DOMAIN OF TYROSINE-PROTEIN KINASE ABL2 FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET HR5537A | | Descriptor: | Tyrosine-protein kinase ABL2 | | Authors: | Liu, G., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2009-06-14 | | Release date: | 2009-08-11 | | Last modified: | 2020-02-26 | | Method: | SOLUTION NMR | | Cite: | NMR structure of F-actin-binding domain of Arg/Abl2 from Homo sapiens.
Proteins, 78, 2010
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2HFI | | SOLUTION NMR STRUCTURE OF PROTEIN YPPE FROM BACILLUS SUBTILIS. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SR213 | | Descriptor: | Hypothetical protein yppE | | Authors: | Liu, G., Singarapu, K.K., Parish, D., Eletsky, A., Xu, D., Sukumaran, D., Ho, C.K., Fang, Y., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2006-06-23 | | Release date: | 2006-07-25 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of hypothetical protein yppE: Northeast Structural Genomics Consortium Target SR213
TO BE PUBLISHED
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2HG7 | | SOLUTION NMR STRUCTURE OF PHAGE-LIKE ELEMENT PBSX PROTEIN XKDW, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SR355 | | Descriptor: | Phage-like element PBSX protein xkdW | | Authors: | Liu, G., Parish, D., Xu, D., Atreya, H., Sukumaran, D., Ho, C.K., Jiang, M., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M., Swapna, G.V., Acton, T.B., Rost, B., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2006-06-26 | | Release date: | 2006-08-22 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of Phage-like element PBSX protein xkdW, Northeast Structural Genomics Consortium Target SR355
TO BE PUBLISHED
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2HI6 | | SOLUTION NMR STRUCTURE OF UPF0107 PROTEIN AF_0055, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET GR101 | | Descriptor: | UPF0107 protein AF0055 | | Authors: | Liu, G., Atreya, H., Xu, D., Sukumaran, D.K., Chen, C.X., Janjua, H., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2006-06-29 | | Release date: | 2006-08-29 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of UPF0107 protein AF_0055, Northeast Structural Genomics Consortium Target GR101 (CASP Target)
To be Published
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2KCL | | SOLUTION NMR STRUCTURE OF TETRATRICOPEPTIDE REPEAT DOMAIN PROTEIN SRU_0103 FROM SALINIBACTER RUBER, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET SRR115C | | Descriptor: | Tetratricopeptide repeat domain protein | | Authors: | Liu, G., Rossi, P., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-12-22 | | Release date: | 2009-01-06 | | Last modified: | 2020-02-19 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of tetratricopeptide repeat domain protein SrU_0103 from Salinibacter ruber, Northeast Structural Genomics Consortium (NESG) Target SrR115C
To be Published
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2K07 | | SOLUTION NMR STRUCTURE OF HUMAN E2-LIKE UBIQUITIN-FOLD MODIFIER CONJUGATING ENZYME 1 (UFC1). NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR41 | | Descriptor: | Ufm1-conjugating enzyme 1 | | Authors: | Liu, G., Eletsky, A., Atreya, H.S., Aramini, J.M., Xiao, R., Acton, T., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-01-25 | | Release date: | 2008-02-19 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway.
J.STRUCT.FUNCT.GENOM., 10, 2009
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2MBL | | SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED TOP7 FOLD PROTEIN TOP7M13, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR33 | | Descriptor: | Top7 Fold Protein Top7m13 | | Authors: | Liu, G., Zanghellini, A.L., Chan, K., Xiao, R., Janjua, H., Kogan, S., Maglaqui, M., Ciccosanti, C., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2013-08-02 | | Release date: | 2013-11-13 | | Method: | SOLUTION NMR | | Cite: | Solution NMR Structure of De novo designed Top7 Fold Protein Top7m13, Northeast Structural Genomics Consortium (NESG) Target OR33
To be Published
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2MBM | | SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED TOP7 FOLD PROTEIN TOP7M13, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR33 | | Descriptor: | Top7 Fold Protein Top7m13 | | Authors: | Liu, G., Zanghellini, A.L., Chan, K., Xiao, R., Janjua, H., Kogan, S., Maglaqui, M., Ciccosanti, C., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2013-08-02 | | Release date: | 2013-11-13 | | Method: | SOLUTION NMR | | Cite: | Solution NMR Structure of De novo designed Top7 Fold Protein Top7m13, Northeast Structural Genomics Consortium (NESG) Target OR33
To be Published
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2MTL | | SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED FR55, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR109 | | Descriptor: | De novo designed protein FR55 OR109 | | Authors: | Liu, G., Koga, N., Koga, R., Xiao, R., Hamilton, K., Ciccosanti, C., Sahdev, S., Kohan, E., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2014-08-19 | | Release date: | 2014-10-29 | | Method: | SOLUTION NMR | | Cite: | Solution NMR Structure of De novo designed FR55, Northeast Structural Genomics Consortium (NESG) Target OR109
To be Published
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2N2T | | SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED PROTEIN (FDA_60), NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR303 | | Descriptor: | OR303 | | Authors: | Liu, G., Lin, Y., Koga, N., Koga, R., Xiao, R., Janjua, H., Hamilton, K., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2015-05-14 | | Release date: | 2015-09-16 | | Method: | SOLUTION NMR | | Cite: | Solution NMR Structure of DE NOVO DESIGNED PROTEIN (FDA_60), Northeast Structural Genomics Consortium (NESG) Target OR303
To be Published
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2N2U | | SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED FERREDOXIN FOLD PROTEIN SFR3, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR358 | | Descriptor: | OR358 | | Authors: | Liu, G., Lin, Y., Koga, N., Koga, R., Xiao, R., Janjua, H., Hamilton, K., Pederson, K., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2015-05-14 | | Release date: | 2015-09-16 | | Method: | SOLUTION NMR | | Cite: | Solution NMR Structure of DE NOVO DESIGNED Ferredoxin Fold PROTEIN sfr3, Northeast Structural Genomics Consortium (NESG) Target OR358
To be Published
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2N3Z | | SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED PROTEIN, ROSSMANN2X2 FOLD, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR446 | | Descriptor: | OR446 | | Authors: | Liu, G., Lin, Y., Koga, N., Koga, R., Xiao, R., Janjua, H., Pederson, K., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2015-06-15 | | Release date: | 2015-09-16 | | Method: | SOLUTION NMR | | Cite: | Solution NMR Structure of DE NOVO DESIGNED PROTEIN, Rossmann2x2 Fold, Northeast Structural Genomics Consortium (NESG) Target OR446
To be Published
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2N41 | | SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED PROTEIN TOP7NNSTYCC, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR34 | | Descriptor: | OR34 | | Authors: | Liu, G., Chan, K., Basanta, B., Xiao, R., Janjua, H., Kogan, S., Maglaqui, M., Ciccosanti, C., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2015-06-16 | | Release date: | 2016-03-02 | | Method: | SOLUTION NMR | | Cite: | Solution NMR Structure of DE NOVO DESIGNED PROTEIN Top7NNSTYCC, Northeast Structural Genomics Consortium (NESG) Target OR34
To be Published
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