Author results

1Q1M
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A HIGHLY EFFICIENT APPROACH TO A SELECTIVE AND CELL ACTIVE PTP1B INHIBITORS
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, 5-{2-FLUORO-5-[3-(3-HYDROXY-2-METHOXYCARBONYL-PHENOXY)-PROPENYL]-PHENYL}-ISOXAZOLE-3-CARBOXYLIC ACID
Authors:Liu, G., Xin, Z., Pei, Z., Hajduk, P.J., Abad-Zapatero, C., Hutchins, C.W., Zhao, H., Lubben, T.H., Ballaron, S.J., Haasch, D.L., Kaszubska, W., Rondinone, C.M., Trevillyan, J.M., Jirousek, M.R.
Deposit date:2003-07-22
Release date:2003-09-16
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.
J.Med.Chem., 46, 2003
2JWY
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SOLUTION NMR STRUCTURE OF UNCHARACTERIZED LIPOPROTEIN YAJI FROM ESCHERICHIA COLI. NORTHEAST STRUCTURAL GENOMICS TARGET ER540
Descriptor:Uncharacterized lipoprotein yajI
Authors:Liu, G., Xiao, R., Chen, C., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-10-31
Release date:2007-11-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR structure of uncharacterized lipoprotein yajI from Escherichia coli.
To be Published
5HLG
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STRUCTURE OF REDUCED ABFR BOUND TO DNA
Descriptor:DNA (5'-D(*TP*AP*AP*CP*TP*CP*AP*AP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*TP*TP*GP*AP*GP*T)-3'), MarR family transcriptional regulator
Authors:Liu, G., Liu, X., Gan, J., Yang, C.G.
Deposit date:2016-01-15
Release date:2017-01-25
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.
J. Am. Chem. Soc., 139, 2017
5HLH
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CRYSTAL STRUCTURE OF THE OVEROXIDIZED ABFR BOUND TO DNA
Descriptor:DNA (5'-D(*TP*AP*AP*CP*TP*CP*AP*AP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*TP*TP*GP*AP*GP*T)-3'), MarR family transcriptional regulator
Authors:Liu, G., Liu, X., Gan, J., Yang, C.-G.
Deposit date:2016-01-15
Release date:2017-01-25
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.
J. Am. Chem. Soc., 139, 2017
5HLI
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STRUCTURE OF DISULFIDE FORMED ABFR
Descriptor:MarR family transcriptional regulator, COPPER (II) ION, CHLORIDE ION
Authors:Liu, G., Liu, X., Gan, J., Yang, C.-G.
Deposit date:2016-01-15
Release date:2017-01-25
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.
J. Am. Chem. Soc., 139, 2017
1ONY
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OXALYL-ARYL-AMINO BENZOIC ACID INHIBITORS OF PTP1B, COMPOUND 17
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, 2-{[2-(2-CARBAMOYL-VINYL)-4-(2-METHANESULFONYLAMINO-2-PENTYLCARBAMOYL-ETHYL)-PHENYL]-OXALYL-AMINO}-BENZOIC ACID
Authors:Liu, G., Szczepankiewicz, B.G., Pei, Z., Janowich, D.A., Xin, Z., Hadjuk, P.J., Abad-Zapatero, C., Liang, H., Hutchins, C.W., Fesik, S.W., Ballaron, S.J., Stashko, M.A., Lubben, T., Mika, A.K., Zinker, B.A., Trevillyan, J.M., Jirousek, M.R.
Deposit date:2003-03-02
Release date:2003-05-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B
J.Med.Chem., 46, 2003
1ONZ
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OXALYL-ARYL-AMINO BENZOIC ACID INHIBITORS OF PTP1B, COMPOUND 8B
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID
Authors:Liu, G., Szczepankiewicz, B.G., Pei, Z., Janowich, D.A., Xin, Z., Hadjuk, P.J., Abad-Zapatero, C., Liang, H., Hutchins, C.W., Fesik, S.W., Ballaron, S.J., Stashko, M.A., Lubben, T., Mika, A.K., Zinker, B.A., Trevillyan, J.M., Jirousek, M.R.
Deposit date:2003-03-02
Release date:2003-05-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B
J.Med.Chem., 46, 2003
2HFI
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SOLUTION NMR STRUCTURE OF PROTEIN YPPE FROM BACILLUS SUBTILIS. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SR213
Descriptor:Hypothetical protein yppE
Authors:Liu, G., Singarapu, K.K., Parish, D., Eletsky, A., Xu, D., Sukumaran, D., Ho, C.K., Fang, Y., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-06-23
Release date:2006-07-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR structure of hypothetical protein yppE: Northeast Structural Genomics Consortium Target SR213
TO BE PUBLISHED
2HG7
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SOLUTION NMR STRUCTURE OF PHAGE-LIKE ELEMENT PBSX PROTEIN XKDW, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SR355
Descriptor:Phage-like element PBSX protein xkdW
Authors:Liu, G., Parish, D., Xu, D., Atreya, H., Sukumaran, D., Ho, C.K., Jiang, M., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M., Swapna, G.V., Acton, T.B., Rost, B., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-06-26
Release date:2006-08-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR structure of Phage-like element PBSX protein xkdW, Northeast Structural Genomics Consortium Target SR355
TO BE PUBLISHED
2HI6
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SOLUTION NMR STRUCTURE OF UPF0107 PROTEIN AF_0055, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET GR101
Descriptor:UPF0107 protein AF0055
Authors:Liu, G., Atreya, H., Xu, D., Sukumaran, D.K., Chen, C.X., Janjua, H., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-06-29
Release date:2006-08-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR structure of UPF0107 protein AF_0055, Northeast Structural Genomics Consortium Target GR101 (CASP Target)
To be Published
2JXT
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SOLUTION STRUCTURE OF 50S RIBOSOMAL PROTEIN LX FROM METHANOBACTERIUM THERMOAUTOTROPHICUM. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR80
Descriptor:50S ribosomal protein LX
Authors:Liu, G., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-11-29
Release date:2007-12-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of 50S ribosomal protein LX from Methanobacterium thermoautotrophicum.
To be Published
2KCL
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SOLUTION NMR STRUCTURE OF TETRATRICOPEPTIDE REPEAT DOMAIN PROTEIN SRU_0103 FROM SALINIBACTER RUBER, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET SRR115C
Descriptor:Tetratricopeptide repeat domain protein
Authors:Liu, G., Rossi, P., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-12-22
Release date:2009-01-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR structure of tetratricopeptide repeat domain protein SrU_0103 from Salinibacter ruber, Northeast Structural Genomics Consortium (NESG) Target SrR115C
To be Published
2KCP
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SOLUTION STRUCTURE OF 30S RIBOSOMAL PROTEIN S8E; FROM METHANOTHERMOBACTER THERMAUTOTROPHICUS, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR71D
Descriptor:30S ribosomal protein S8e
Authors:Liu, G., Rossi, P., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-12-24
Release date:2009-07-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:SOLUTION STRUCTURE OF 30S RIBOSOMAL PROTEIN S8E FROM Methanothermobacter thermautotrophicus, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET
To be Published
2KCV
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SOLUTION NMR STRUCTURE OF TETRATRICOPEPTIDE REPEAT DOMAIN PROTEIN SRU_0103 FROM SALINIBACTER RUBER, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET SRR115C
Descriptor:Tetratricopeptide repeat domain protein
Authors:Liu, G., Rossi, P., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-12-29
Release date:2009-01-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution nmr structure of tetratricopeptide repeat domain protein sru_0103 from salinibacter ruber, northeast structural genomics consortium (nesg) target srr115c
To be Published
2KCY
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SOLUTION STRUCTURE OF RIBOSOMAL PROTEIN S8E FROM METHANOTHERMOBACTER THERMAUTOTROPHICUS, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR71D
Descriptor:30S ribosomal protein S8e
Authors:Liu, G., Rossi, P., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B.C., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-12-30
Release date:2009-01-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:SOLUTION STRUCTURE OF RIBOSOMAL PROTEIN S8E FROM Methanothermobacter thermautotrophicus, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR71D
To be Published
2KK0
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SOLUTION STRUCTURE OF DEAD RINGER-LIKE PROTEIN 1 (AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A) FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET HR4394C
Descriptor:AT-rich interactive domain-containing protein 3A
Authors:Liu, G., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2009-06-14
Release date:2009-07-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR structure of the ARID domain of human AT-rich interactive domain-containing protein 3A: a human cancer protein interaction network target.
Proteins, 78, 2010
2KK1
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SOLUTION STRUCTURE OF C-TERMINAL DOMAIN OF TYROSINE-PROTEIN KINASE ABL2 FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET HR5537A
Descriptor:Tyrosine-protein kinase ABL2
Authors:Liu, G., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2009-06-14
Release date:2009-08-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of F-actin-binding domain of Arg/Abl2 from Homo sapiens.
Proteins, 78, 2010
2K07
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SOLUTION NMR STRUCTURE OF HUMAN E2-LIKE UBIQUITIN-FOLD MODIFIER CONJUGATING ENZYME 1 (UFC1). NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR41
Descriptor:Ufm1-conjugating enzyme 1
Authors:Liu, G., Eletsky, A., Atreya, H.S., Aramini, J.M., Xiao, R., Acton, T., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-01-25
Release date:2008-02-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway.
J.STRUCT.FUNCT.GENOM., 10, 2009
2MBL
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED TOP7 FOLD PROTEIN TOP7M13, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR33
Descriptor:Top7 Fold Protein Top7m13
Authors:Liu, G., Zanghellini, A.L., Chan, K., Xiao, R., Janjua, H., Kogan, S., Maglaqui, M., Ciccosanti, C., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-08-02
Release date:2013-11-13
Method:SOLUTION NMR
Cite:Solution NMR Structure of De novo designed Top7 Fold Protein Top7m13, Northeast Structural Genomics Consortium (NESG) Target OR33
To be Published
2MBM
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED TOP7 FOLD PROTEIN TOP7M13, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR33
Descriptor:Top7 Fold Protein Top7m13
Authors:Liu, G., Zanghellini, A.L., Chan, K., Xiao, R., Janjua, H., Kogan, S., Maglaqui, M., Ciccosanti, C., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-08-02
Release date:2013-11-13
Method:SOLUTION NMR
Cite:Solution NMR Structure of De novo designed Top7 Fold Protein Top7m13, Northeast Structural Genomics Consortium (NESG) Target OR33
To be Published
2MTL
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED FR55, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR109
Descriptor:De novo designed protein FR55 OR109
Authors:Liu, G., Koga, N., Koga, R., Xiao, R., Hamilton, K., Ciccosanti, C., Sahdev, S., Kohan, E., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2014-08-19
Release date:2014-10-29
Method:SOLUTION NMR
Cite:Solution NMR Structure of De novo designed FR55, Northeast Structural Genomics Consortium (NESG) Target OR109
To be Published
2N2T
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED PROTEIN (FDA_60), NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR303
Descriptor:OR303
Authors:Liu, G., Lin, Y., Koga, N., Koga, R., Xiao, R., Janjua, H., Hamilton, K., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2015-05-14
Release date:2015-09-16
Method:SOLUTION NMR
Cite:Solution NMR Structure of DE NOVO DESIGNED PROTEIN (FDA_60), Northeast Structural Genomics Consortium (NESG) Target OR303
To be Published
2N2U
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED FERREDOXIN FOLD PROTEIN SFR3, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR358
Descriptor:OR358
Authors:Liu, G., Lin, Y., Koga, N., Koga, R., Xiao, R., Janjua, H., Hamilton, K., Pederson, K., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2015-05-14
Release date:2015-09-16
Method:SOLUTION NMR
Cite:Solution NMR Structure of DE NOVO DESIGNED Ferredoxin Fold PROTEIN sfr3, Northeast Structural Genomics Consortium (NESG) Target OR358
To be Published
2N3Z
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED PROTEIN, ROSSMANN2X2 FOLD, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR446
Descriptor:OR446
Authors:Liu, G., Lin, Y., Koga, N., Koga, R., Xiao, R., Janjua, H., Pederson, K., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2015-06-15
Release date:2015-09-16
Method:SOLUTION NMR
Cite:Solution NMR Structure of DE NOVO DESIGNED PROTEIN, Rossmann2x2 Fold, Northeast Structural Genomics Consortium (NESG) Target OR446
To be Published
2N41
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED PROTEIN TOP7NNSTYCC, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR34
Descriptor:OR34
Authors:Liu, G., Chan, K., Basanta, B., Xiao, R., Janjua, H., Kogan, S., Maglaqui, M., Ciccosanti, C., Acton, T.B., Kornhaber, G., Everett, J.K., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2015-06-16
Release date:2016-03-02
Method:SOLUTION NMR
Cite:Solution NMR Structure of DE NOVO DESIGNED PROTEIN Top7NNSTYCC, Northeast Structural Genomics Consortium (NESG) Target OR34
To be Published