Author results

4LQI
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YEAST 20S PROTEASOME IN COMPLEX WITH VIBRALACTONE
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:List, A., Zeiler, E., Gallastegui, N., Rusch, M., Hedberg, C., Sieber, S.A., Groll, M.
Deposit date:2013-07-18
Release date:2013-12-25
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Omuralide and Vibralactone: Differences in the Proteasome-beta-Lactone-gamma-Lactam Binding Scaffold Alter Target Preferences.
Angew.Chem.Int.Ed.Engl., 53, 2014
3V5I
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THE CRYSTAL STRUCTURE OF THE MUTANT CLPP S98A (STAPHYLOCOCCUS AUREUS)
Descriptor:ATP-dependent Clp protease proteolytic subunit
Authors:List, A., Gersch, M., Groll, M., Sieber, S.
Deposit date:2011-12-16
Release date:2012-02-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein.
J.Biol.Chem., 287, 2012
4J70
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YEAST 20S PROTEASOME IN COMPLEX WITH THE BELACTOSIN DERIVATIVE 3E
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Kawamura, S., Unno, Y., List, A., Tanaka, M., Sasaki, T., Arisawa, M., Asai, A., Groll, M., Shuto, S.
Deposit date:2013-02-12
Release date:2013-04-17
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Potent Proteasome Inhibitors Derived from the Unnatural cis-Cyclopropane Isomer of Belactosin A: Synthesis, Biological Activity, and Mode of Action.
J.Med.Chem., 56, 2013
3T7V
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CRYSTAL STRUCTURE OF METHYLORNITHINE SYNTHASE (PYLB)
Descriptor:methylornithine synthase PylB, IRON/SULFUR CLUSTER, S-ADENOSYLMETHIONINE, ...
Authors:Quitterer, F., List, A., Eisenreich, W., Bacher, A., Groll, M.
Deposit date:2011-07-31
Release date:2011-11-30
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesis.
Angew.Chem.Int.Ed.Engl., 51, 2012
4FFL
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PYLC IN COMPLEX WITH L-LYSINE
Descriptor:PylC, LYSINE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Quitterer, F., List, A., Beck, P., Bacher, A., Groll, M.
Deposit date:2012-06-01
Release date:2012-09-19
Last modified:2013-06-12
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
J.Mol.Biol., 424, 2012
4FFM
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PYLC IN COMPLEX WITH L-LYSINE-NE-D-ORNITHINE (COCRYSTALLIZED WITH L-LYSINE-NE-D-ORNITHINE)
Descriptor:PylC, N~6~-D-ornithyl-L-lysine, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Quitterer, F., List, A., Beck, P., Bacher, A., Groll, M.
Deposit date:2012-06-01
Release date:2012-09-19
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
J.Mol.Biol., 424, 2012
4FFN
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PYLC IN COMPLEX WITH D-ORNITHINE AND AMPPNP
Descriptor:PylC, D-ORNITHINE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Quitterer, F., List, A., Beck, P., Bacher, A., Groll, M.
Deposit date:2012-06-01
Release date:2012-09-19
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
J.Mol.Biol., 424, 2012
4FFO
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PYLC IN COMPLEX WITH PHOSPHORYLATED D-ORNITHINE
Descriptor:PylC, (2R)-2,5-diaminopentanoyl dihydrogen phosphate, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Quitterer, F., List, A., Beck, P., Bacher, A., Groll, M.
Deposit date:2012-06-01
Release date:2012-09-19
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
J.Mol.Biol., 424, 2012
4FFP
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PYLC IN COMPLEX WITH L-LYSINE-NE-D-ORNITHINE (COCRYSTALLIZED WITH L-LYSINE AND D-ORNITHINE)
Descriptor:Putative uncharacterized protein, N~6~-D-ornithyl-L-lysine, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Quitterer, F., List, A., Beck, P., Bacher, A., Groll, M.
Deposit date:2012-06-01
Release date:2012-09-19
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
J.Mol.Biol., 424, 2012
4FFR
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SEMET-LABELED PYLC (REMOTE)
Descriptor:PylC, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Quitterer, F., List, A., Beck, P., Bacher, A., Groll, M.
Deposit date:2012-06-01
Release date:2012-09-19
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
J.Mol.Biol., 424, 2012
3V5E
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CRYSTAL STRUCTURE OF CLPP FROM STAPHYLOCOCCUS AUREUS IN THE ACTIVE, EXTENDED CONFORMATION
Descriptor:ATP-dependent Clp protease proteolytic subunit
Authors:Gersch, M., List, A., Groll, M., Sieber, S.
Deposit date:2011-12-16
Release date:2012-02-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein.
J.Biol.Chem., 287, 2012
4JCQ
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CLPP1 FROM LISTERIA MONOCYTOGENES
Descriptor:ATP-dependent Clp protease proteolytic subunit
Authors:Zeiler, E., List, A., Alte, F., Gersch, M., Wachtel, R., Groll, M., Sieber, S.
Deposit date:2013-02-22
Release date:2013-06-12
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JCR
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CLPP1 N165D MUTANT FROM LISTERIA MONOCYTOGENES
Descriptor:ATP-dependent Clp protease proteolytic subunit
Authors:Zeiler, E., List, A., Alte, F., Gersch, M., Wachtel, R., Groll, M., Sieber, S.
Deposit date:2013-02-22
Release date:2013-06-12
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JCT
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CLPP2 FROM LISTERIA MONOCYTOGENES
Descriptor:ATP-dependent Clp protease proteolytic subunit
Authors:Zeiler, E., List, A., Alte, F., Gersch, M., Wachtel, R., Groll, M., Sieber, S.
Deposit date:2013-02-22
Release date:2013-06-12
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
6CFD
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ADEP4 BOUND TO E. FAECIUM CLPP
Descriptor:ATP-dependent Clp protease proteolytic subunit, (4S)-2-METHYL-2,4-PENTANEDIOL, N-[(6aS,12S,15aS,17R,21R,23aS)-17,21-dimethyl-6,11,15,20,23-pentaoxooctadecahydro-2H,6H,11H,15H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13]oxatetraazacyclohexadecin-12-yl]-3,5-difluoro-Nalpha-[(2E)-hept-2-enoyl]-L-phenylalaninamide
Authors:Lee, R.E., Griffith, E.C.
Deposit date:2018-02-14
Release date:2018-05-16
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:In VivoandIn VitroEffects of a ClpP-Activating Antibiotic against Vancomycin-Resistant Enterococci.
Antimicrob. Agents Chemother., 62, 2018
5W18
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STAPHYLOCOCCUS AUREUS CLPP IN COMPLEX WITH (S)-N-((2R,6S,8AS,14AS,20S,23AS)-2,6-DIMETHYL-5,8,14,19,23-PENTAOXOOCTADECAHYDRO-1H,5H,14H,19H-PYRIDO[2,1-I]DIPYRROLO[2,1-C:2',1'-L][1]OXA[4,7,10,13]TETRAAZACYCLOHEXADECIN-20-YL)-3-PHENYL-2-(3-PHENYLUREIDO)PROPANAMIDE
Descriptor:ATP-dependent Clp protease proteolytic subunit, 9V7-PHE-SER-PRO-YCP-ALA-MP8
Authors:Lee, R.E., Griffith, E.C.
Deposit date:2017-06-02
Release date:2017-08-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Design and Synthesis of Urea Depsipeptide as ClpP Activators
To Be Published
5VZ2
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STRUCTURE OF CLPP FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH ACYLDEPSIPEPTIDE
Descriptor:ATP-dependent Clp protease proteolytic subunit, Acyldepsipeptide
Authors:Griffith, E.C., Lee, R.E.
Deposit date:2017-05-26
Release date:2017-06-21
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Design and Synthesis of Urea Depsipeptides as ClpP Activators
To Be Published