Author results

1DF7
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DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND METHOTREXATE
Descriptor:DIHYDROFOLATE REDUCTASE, SULFATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G.
Deposit date:1999-11-17
Release date:2000-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
1DG5
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DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND TRIMETHOPRIM
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETHOPRIM, ...
Authors:Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G.
Deposit date:1999-11-23
Release date:2000-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
1DG7
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DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210
Descriptor:DIHYDROFOLATE REDUCTASE, 1-[3-(4-BROMO-PHENOXY)-PROPOXY]-6,6-DIMETHYL-1.6-DIHYDRO-[1,3,5]TRIAZINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G.
Deposit date:1999-11-23
Release date:2000-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
1DG8
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DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL
Authors:Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G.
Deposit date:1999-11-23
Release date:2000-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
1A2V
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COPPER AMINE OXIDASE FROM HANSENULA POLYMORPHA
Descriptor:METHYLAMINE OXIDASE, COPPER (II) ION
Authors:Li, R., Mathews, F.S.
Deposit date:1998-01-12
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic study of yeast copper amine oxidase.
Acta Crystallogr.,Sect.D, 53, 1997
1P4X
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CRYSTAL STRUCTURE OF SARS PROTEIN FROM STAPHYLOCOCCUS AUREUS
Descriptor:staphylococcal accessory regulator A homologue
Authors:Li, R., Manna, A.C., Dai, S., Cheung, A.L., Zhang, G.
Deposit date:2003-04-24
Release date:2003-07-08
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the SarS protein from Staphylococcus aureus
J.BACTERIOL., 185, 2003
1QRD
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QUINONE REDUCTASE/FAD/CIBACRON BLUE/DUROQUINONE COMPLEX
Descriptor:QUINONE-REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, CIBACRON BLUE, ...
Authors:Li, R., Bianchet, M.A., Talalay, P., Amzel, L.M.
Deposit date:1995-07-28
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction.
Proc.Natl.Acad.Sci.USA, 92, 1995
4LTV
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CRYSTAL STRUCTURE OF EPI-ISOZIZAENE SYNTHASE FROM STREPTOMYCES COELICOLOR A3(2)
Descriptor:Epi-isozizaene synthase, SULFATE ION
Authors:Li, R., Chou, W., Himmelberger, J.A., Litwin, K., Harris, G., Cane, D.E., Christianson, D.W.
Deposit date:2013-07-24
Release date:2013-12-18
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.403 Å)
Cite:Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase.
Biochemistry, 53, 2014
4LTZ
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F95M EPI-ISOZIZAENE SYNTHASE: COMPLEX WITH MG, INORGANIC PYROPHOSPHATE AND BENZYL TRIETHYL AMMONIUM CATION
Descriptor:Epi-isozizaene synthase, GLYCEROL, MAGNESIUM ION, ...
Authors:Li, R., Chou, W., Himmelberger, J.A., Litwin, K., Harris, G., Cane, D.E., Christianson, D.W.
Deposit date:2013-07-24
Release date:2013-12-18
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.448 Å)
Cite:Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase.
Biochemistry, 53, 2014
4LUU
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V329A EPI-ISOZIZAENE SYNTHASE: COMPLEX WITH MG, INORGANIC PYROPHOSPHATE AND BENZYL TRIETHYL AMMONIUM CATION
Descriptor:Epi-isozizaene synthase, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
Authors:Li, R., Chou, W., Himmelberger, J.A., Litwin, K., Harris, G., Cane, D.E., Christianson, D.W.
Deposit date:2013-07-25
Release date:2013-12-18
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase.
Biochemistry, 53, 2014
4LXW
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L72V EPI-ISOZIZAENE SYNTHASE: COMPLEX WITH MG, INORGANIC PYROPHOSPHATE AND BENZYL TRIETHYL AMMONIUM CATION
Descriptor:Epi-isozizaene synthase, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
Authors:Li, R., Chou, W., Himmelberger, J.A., Litwin, K., Harris, G., Cane, D.E., Christianson, D.W.
Deposit date:2013-07-30
Release date:2013-12-18
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase.
Biochemistry, 53, 2014
4LZ0
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A236G EPI-ISOZIZAENE SYNTHASE: COMPLEX WITH MG, INORGANIC PYROPHOSPHATE AND BENZYL TRIETHYL AMMONIUM CATION
Descriptor:Epi-isozizaene synthase, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
Authors:Li, R., Chou, W., Himmelberger, J.A., Litwin, K., Harris, G., Cane, D.E., Christianson, D.W.
Deposit date:2013-07-31
Release date:2013-12-18
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.754 Å)
Cite:Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase.
Biochemistry, 53, 2014
4LZ3
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F95H EPI-ISOZIZAENE SYNTHASE: COMPLEX WITH MG, INORGANIC PYROPHOSPHATE AND BENZYL TRIETHYL AMMONIUM CATION
Descriptor:Epi-isozizaene synthase, GLYCEROL, MAGNESIUM ION, ...
Authors:Li, R., Chou, W., Himmelberger, J.A., Litwin, K., Harris, G., Cane, D.E., Christianson, D.W.
Deposit date:2013-07-31
Release date:2013-12-18
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase.
Biochemistry, 53, 2014
4LZC
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W325F EPI-ISOZIZAENE SYNTHASE: COMPLEX WITH MG, INORGANIC PYROPHOSPHATE
Descriptor:Epi-isozizaene synthase, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
Authors:Li, R., Chou, W., Himmelberger, J.A., Litwin, K., Harris, G., Cane, D.E., Christianson, D.W.
Deposit date:2013-07-31
Release date:2013-12-18
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.457 Å)
Cite:Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase.
Biochemistry, 53, 2014
6ITE
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CRYSTAL STRUCTURE OF GROUP A STREPTOCOCCAL SURFACE DEHYDROGENASE (SDH)
Descriptor:Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION
Authors:Yuan, C., Li, R., Huang, M.D.
Deposit date:2018-11-21
Release date:2019-09-25
Method:X-RAY DIFFRACTION (1.739 Å)
Cite:Structural determination of group A Streptococcal surface dehydrogenase and characterization of its interaction with urokinase-type plasminogen activator receptor.
Biochem.Biophys.Res.Commun., 510, 2019
5KZN
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METABOTROPIC GLUTAMATE RECEPTOR
Descriptor:Metabotropic glutamate receptor 2, N-ACETYL-D-GLUCOSAMINE, MAGNESIUM ION
Authors:Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.
Deposit date:2016-07-25
Release date:2016-12-28
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J. Med. Chem., 59, 2016
5KZQ
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METABOTROPIC GLUTAMATE RECEPTOR IN COMPLEX WITH ANTAGONIST (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-AZANYL-3-[[3,4-BIS(FLUORANYL)PHENYL]SULFANYLMETHYL]-4-OXIDANYL-BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID
Descriptor:Metabotropic glutamate receptor 2, (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, N-ACETYL-D-GLUCOSAMINE
Authors:Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.
Deposit date:2016-07-25
Release date:2016-12-28
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J. Med. Chem., 59, 2016
5Z65
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CRYSTAL STRUCTURE OF PORCINE AMINOPEPTIDASE N ECTODOMAIN IN FUNCTIONAL FORM
Descriptor:Aminopeptidase, N-ACETYL-D-GLUCOSAMINE, ZINC ION
Authors:Sun, Y.G., Li, R., Jiang, L.G., Qiao, S.L., Zhang, G.P.
Deposit date:2018-01-22
Release date:2019-01-02
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Characterization of the interaction between recombinant porcine aminopeptidase N and spike glycoprotein of porcine epidemic diarrhea virus.
Int. J. Biol. Macromol., 117, 2018
1EKM
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CRYSTAL STRUCTURE AT 2.5 A RESOLUTION OF ZINC-SUBSTITUTED COPPER AMINE OXIDASE OF HANSENULA POLYMORPHA EXPRESSED IN ESCHERICHIA COLI
Descriptor:COPPER AMINE OXIDASE, ZINC ION
Authors:Chen, Z., Schwartz, B., Williams, N.K., Li, R., Klinman, J.P., Mathews, F.S.
Deposit date:2000-03-09
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure at 2.5 A resolution of zinc-substituted copper amine oxidase of Hansenula polymorpha expressed in Escherichia coli.
Biochemistry, 39, 2000
1JV8
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NMR STRUCTURE OF BPTI MUTANT G37A
Descriptor:TRYPSIN INHIBITOR
Authors:Battiste, J.L., Li, R., Woodward, C.
Deposit date:2001-08-28
Release date:2001-09-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility
Biochemistry, 41, 2002
1JV9
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NMR STRUCTURE OF BPTI MUTANT G37A
Descriptor:TRYPSIN INHIBITOR
Authors:Battiste, J.L., Li, R., Woodward, C.
Deposit date:2001-08-28
Release date:2001-09-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility
Biochemistry, 41, 2002
1BOZ
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STRUCTURE-BASED DESIGN AND SYNTHESIS OF LIPOPHILIC 2,4-DIAMINO-6-SUBSTITUTED QUINAZOLINES AND THEIR EVALUATION AS INHIBITORS OF DIHYDROFOLATE REDUCTASE AND POTENTIAL ANTITUMOR AGENTS
Descriptor:PROTEIN (DIHYDROFOLATE REDUCTASE), NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N6-(2,5-DIMETHOXY-BENZYL)-N6-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE
Authors:Gangjee, A., Vidwans, A.P., Vasudevan, A., Queener, S.F., Kisliuk, R.L., Cody, V., Li, R., Galitsky, N., Luft, J.R., Pangborn, W.
Deposit date:1998-08-06
Release date:1998-08-12
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
J.Med.Chem., 41, 1998
1EUJ
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A NOVEL ANTI-TUMOR CYTOKINE CONTAINS A RNA-BINDING MOTIF PRESENT IN AMINOACYL-TRNA SYNTHETASES
Descriptor:ENDOTHELIAL MONOCYTE ACTIVATING POLYPEPTIDE 2
Authors:Kim, Y., Shin, J., Li, R., Cheong, C., Kim, S.
Deposit date:2000-04-17
Release date:2000-09-06
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases.
J.Biol.Chem., 275, 2000
1M1U
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AN ISOLEUCINE-BASED ALLOSTERIC SWITCH CONTROLS AFFINITY AND SHAPE SHIFTING IN INTEGRIN CD11B A-DOMAIN
Descriptor:Integrin alpha-M, CALCIUM ION
Authors:Xiong, J.-P., Li, R., Essafi, M., Stehle, T., Arnaout, M.A.
Deposit date:2002-06-20
Release date:2002-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain.
J.Biol.Chem., 275, 2000
3GO6
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CRYSTAL STRUCTURE OF M. TUBERCULOSIS RIBOKINASE (RV2436) IN COMPLEX WITH RIBOSE AND AMP-PNP
Descriptor:RIBOKINASE RBSK, RIBOSE, MAGNESIUM ION, ...
Authors:Masters, E.I., Sun, Y., Wang, Y., Parker, W.B., Li, R.
Deposit date:2009-03-18
Release date:2010-03-31
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal structure and biochemical characterization of M.tuberculosis ribokinase (Rv2436)
To be Published