Author results

6IFE
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A GLYCOSIDE HYDROLASE FAMILY 43 BETA-XYLOSIDASE
Descriptor:Beta-xylosidase, GLYCEROL
Authors:Li, N., Liu, Y., Zhang, R., Zhou, J.P., Huang, Z.X.
Deposit date:2018-09-20
Release date:2019-03-13
Method:X-RAY DIFFRACTION (1.804 Å)
Cite:A Glycoside Hydrolase Family 43 beta-Xylosidase
To Be Published
5WFY
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CRYSTAL STRUCTURE OF DNA-BINDING DOMAIN OF THE BACTERIOPHAGE T4 LIGASE
Descriptor:DNA ligase, GLYCEROL
Authors:Shi, K., Aihara, H.
Deposit date:2017-07-13
Release date:2018-09-26
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:T4 DNA ligase structure reveals a prototypical ATP-dependent ligase with a unique mode of sliding clamp interaction.
Nucleic Acids Res., 46, 2018
6DRT
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CRYSTAL STRUCTURE OF THE PROCESSIVITY CLAMP GP45 COMPLEXED WITH RECOGNITION PEPTIDE OF LIGASE FROM BACTERIOPHAGE T4
Descriptor:DNA polymerase clamp, GP45 recognition loop, 1,2-ETHANEDIOL
Authors:Shi, K., Aihara, H.
Deposit date:2018-06-13
Release date:2018-09-26
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.117 Å)
Cite:T4 DNA ligase structure reveals a prototypical ATP-dependent ligase with a unique mode of sliding clamp interaction.
Nucleic Acids Res., 46, 2018
6DT1
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CRYSTAL STRUCTURE OF THE LIGASE FROM BACTERIOPHAGE T4 COMPLEXED WITH DNA INTERMEDIATE
Descriptor:DNA ligase, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*(DOC))-3'), DNA (5'-D((AMP)*GP*TP*CP*GP*GP*AP*CP*TP*GP*AP*)-3'), ...
Authors:Shi, K., Aihara, H.
Deposit date:2018-06-14
Release date:2018-09-19
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:T4 DNA ligase structure reveals a prototypical ATP-dependent ligase with a unique mode of sliding clamp interaction.
Nucleic Acids Res., 46, 2018
5ZR1
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SACCHAROMYCES CEREVISIAE ORIGIN RECOGNITION COMPLEX BOUND TO A 72-BP ORIGIN DNA CONTAINING ACS AND B1 ELEMENT
Descriptor:Origin recognition complex subunit 1, Origin recognition complex subunit 2, Origin recognition complex subunit 3, ...
Authors:Li, N., Lam, W.H., Zhai, Y., Cheng, J., Cheng, E., Zhao, Y., Gao, N., Tye, B.K.
Deposit date:2018-04-21
Release date:2018-07-11
Last modified:2018-07-25
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of the origin recognition complex bound to DNA replication origin.
Nature, 559, 2018
5ZQZ
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STRUCTURE OF HUMAN MITOCHONDRIAL TRIFUNCTIONAL PROTEIN, TETRAMER
Descriptor:Trifunctional enzyme subunit alpha, mitochondrial, Trifunctional enzyme subunit beta
Authors:Liang, K., Li, N., Dai, J., Wang, X., Liu, P., Chen, X., Wang, C., Gao, N., Xiao, J.
Deposit date:2018-04-20
Release date:2018-06-20
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-EM structure of human mitochondrial trifunctional protein
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5ZRV
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STRUCTURE OF HUMAN MITOCHONDRIAL TRIFUNCTIONAL PROTEIN, OCTAMER
Descriptor:Trifunctional enzyme subunit alpha, mitochondrial, Trifunctional enzyme subunit beta
Authors:Liang, K., Li, N., Dai, J., Wang, X., Liu, P., Chen, X., Wang, C., Gao, N., Xiao, J.
Deposit date:2018-04-25
Release date:2018-06-20
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Cryo-EM structure of human mitochondrial trifunctional protein
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5YRP
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CRYSTAL STRUCTURE OF THE EAL DOMAIN OF MYCOBACTERIUM SMEGMATIS DCPA
Descriptor:Sensory box/response regulator, MAGNESIUM ION
Authors:Chen, H.J., li, N., Luo, Y., Jiang, Y.L., Zhou, C.Z., Chen, Y., Li, Q.
Deposit date:2017-11-09
Release date:2018-05-09
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:The GDP-switched GAF domain of DcpA modulates the concerted synthesis/hydrolysis of c-di-GMP inMycobacterium smegmatis.
Biochem. J., 475, 2018
5XLO
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ANTI-CRISPR PROTEINS ACRF1/2 BOUND TO CSY SURVEILLANCE COMPLEX WITH A 32NT SPACER CRRNA BACKBONE REGION
Descriptor:CRISPR-associated protein Csy3, crRNA with 32nt spacer sequence, Uncharacterized protein AcrF1
Authors:Peng, R., Shi, Y., Gao, G.F.
Deposit date:2017-05-11
Release date:2018-01-10
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures.
Cell Res., 27, 2017
5XLP
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ANTI-CRISPR PROTEINS ACRF1/2 BOUND TO CSY SURVEILLANCE COMPLEX WITH A 20NT SPACER CRRNA BACKBONE REGION
Descriptor:CRISPR-associated protein Csy3, crRNA with 20nt spacer sequence, Uncharacterized protein AcrF1
Authors:Peng, R., Shi, Y., Gao, G.F.
Deposit date:2017-05-11
Release date:2018-01-10
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures.
Cell Res., 27, 2017
5XTS
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CRYSTAL STRUCTURE OF THE CYSR-CTLD3 FRAGMENT OF HUMAN MR AT BASIC/NEUTRAL PH
Descriptor:Macrophage mannose receptor 1, CALCIUM ION
Authors:He, Y., Hu, Z.
Deposit date:2017-06-20
Release date:2017-12-27
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights into the pH-Dependent Conformational Change and Collagen Recognition of the Human Mannose Receptor
Structure, 26, 2018
5XTW
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CRYSTAL STRUCTURE OF THE CYSR-CTLD2 FRAGMENT OF HUMAN MR AT ACIDIC PH
Descriptor:Macrophage mannose receptor 1, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION
Authors:He, Y., Hu, Z.
Deposit date:2017-06-21
Release date:2017-12-27
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Insights into the pH-Dependent Conformational Change and Collagen Recognition of the Human Mannose Receptor
Structure, 26, 2018
5YDZ
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STRUCTURE OF ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO AMPHIPOL: STATE 1
Descriptor:mammalian endo-lysosomal TRPML1 channel
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-12-27
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5YE1
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STRUCTURE OF ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO AMPHIPOL: STATE 2
Descriptor:Mucolipin-1
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-12-27
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5YE2
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MAMMALIAN ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO AMPHIPOL
Descriptor:mammalian endo-lysosomal TRPML1 channel
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-12-27
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5WTT
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STRUCTURE OF THE 093G9 FAB IN COMPLEX WITH THE EPITOPE PEPTIDE
Descriptor:Heavy chain of 093G9 Fab, Light chain of 093G9 Fab, Epitope peptide of Cyr61
Authors:Zhong, C., Hu, K., Shen, J., Ding, J.
Deposit date:2016-12-14
Release date:2017-12-20
Last modified:2019-01-02
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis for the recognition of CCN1 by monoclonal antibody 093G9.
J. Mol. Recognit., 30, 2017
5TOB
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SELECTIVITY SWITCH BETWEEN FAK AND PYK2: MACROCYCLIZATION OF FAK INHIBITORS IMPROVES PYK2 POTENCY
Descriptor:Protein-tyrosine kinase 2-beta, N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide
Authors:Newby, Z.E.
Deposit date:2016-10-17
Release date:2017-11-29
Method:X-RAY DIFFRACTION (2.117 Å)
Cite:Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency.
Bioorg. Med. Chem. Lett., 26, 2016
5YE5
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STRUCTURE OF ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO NANODISC
Descriptor:mammalian endo-lysosomal TRPML1 channel, N-ACETYL-D-GLUCOSAMINE
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-11-15
Last modified:2017-11-22
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5Y0W
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THE STRUCTURE OF RVFV GN HEAD DOMAIN
Descriptor:NSmGnGc
Authors:Wu, Y., Gao, F., Qi, J.X., Chai, Y., Gao, G.F.
Deposit date:2017-07-19
Release date:2017-09-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5Y0Y
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RVFV GN-AU
Descriptor:NSmGnGc, GOLD ION
Authors:Wu, Y., Gao, F., Qi, J.X., Chai, Y., Gao, G.F.
Deposit date:2017-07-19
Release date:2017-09-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.398 Å)
Cite:Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5Y10
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SFTSV GN HEAD DOMAIN
Descriptor:Membrane glycoprotein polyprotein, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE
Authors:Wu, Y., Gao, F., Qi, J.X., Chai, Y., Gao, G.F.
Deposit date:2017-07-19
Release date:2017-09-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5Y11
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SFTSV GN WITH NEUTRALIZING ANTIBODY MAB4-5
Descriptor:MAb 4-5 heavy chain, MAb 4-5 light chain, Membrane glycoprotein polyprotein, ...
Authors:Wu, Y., Gao, F., Qi, J.X., Chai, Y., Gao, G.F.
Deposit date:2017-07-19
Release date:2017-09-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5H65
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CRYSTAL STRUCTURE OF HUMAN POT1 AND TPP1
Descriptor:Protection of telomeres protein 1, Adrenocortical dysplasia protein homolog, ZINC ION
Authors:Chen, C., Wu, J., Lei, M.
Deposit date:2016-11-10
Release date:2017-05-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.
Nat Commun, 8, 2017
5XF8
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CRYO-EM STRUCTURE OF THE CDT1-MCM2-7 COMPLEX IN AMPPNP STATE
Descriptor:DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
Authors:Zhai, Y., Cheng, E., Wu, H., Li, N., Yung, P.Y., Gao, N., Tye, B.K.
Deposit date:2017-04-09
Release date:2017-05-03
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer
Nat. Struct. Mol. Biol., 24, 2017
5WVI
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THE RESTING STATE OF YEAST PROTEASOME
Descriptor:26S protease regulatory subunit 4 homolog, 26S protease regulatory subunit 6B homolog, Proteasome subunit beta type-2, ...
Authors:Ding, Z., Cong, Y.
Deposit date:2016-12-25
Release date:2017-03-22
Last modified:2017-06-14
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx
Cell Res., 27, 2017