Author results

6KZ8
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CRYSTAL STRUCTURE OF PLANT PHOSPHOLIPASE D ALPHA COMLEX WITH PHOSPHATIDIC ACID
Descriptor:Phospholipase D alpha 1, 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHATE, CALCIUM ION
Authors:Li, J.X., Yu, F., Zhang, P.
Deposit date:2019-09-23
Release date:2019-11-13
Method:X-RAY DIFFRACTION (2.291 Å)
Cite:Crystal structure of plant PLD alpha 1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D.
Cell Res., 2019
6O3E
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MOUSE AE-CATENIN 82-883
Descriptor:Catenin alpha-1
Authors:Pokutta, S., Weis, W.I.
Deposit date:2019-02-26
Release date:2019-11-13
Method:X-RAY DIFFRACTION (4.001 Å)
Cite:Binding partner- and force-promoted changes in alpha E-catenin conformation probed by native cysteine labeling.
Sci Rep, 9, 2019
6J04
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CRYSTAL STRUCTURE OF FULL LENGTH HUMAN LC3B DELTA G120 MUTANT (2_125)
Descriptor:Microtubule-associated proteins 1A/1B light chain 3B, SULFATE ION
Authors:Ding, Y., Lu, B.X., Wang, Z.Y.
Deposit date:2018-12-21
Release date:2019-11-06
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds
Nature, 575, 2019
6KZ9
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CRYSTAL STRUCTURE OF PLANT PHOSPHOLIPASE D ALPHA
Descriptor:Phospholipase D alpha 1, CALCIUM ION
Authors:Li, J.X., Yu, F., Zhang, P.
Deposit date:2019-09-23
Release date:2019-10-30
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Crystal structure of plant PLD alpha 1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D.
Cell Res., 2019
6IM6
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CRYSTAL STRUCTURE OF PDE4D COMPLEXED WITH A NOVEL INHIBITOR
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, X.L., Su, H.X., Xu, Y.C.
Deposit date:2018-10-22
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
6IMB
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CRYSTAL STRUCTURE OF PDE4D COMPLEXED WITH A NOVEL INHIBITOR
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, X., Su, H., Xu, Y.
Deposit date:2018-10-22
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.549 Å)
Cite:Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
6IMD
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CRYSTAL STRUCTURE OF PDE4D COMPLEXED WITH A NOVEL INHIBITOR
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, X., Su, H., Xu, Y.
Deposit date:2018-10-22
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.499 Å)
Cite:Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
6IMI
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CRYSTAL STRUCTURE OF PDE4D COMPLEXED WITH A NOVEL INHIBITOR
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ZINC ION, ...
Authors:Zhang, X., Su, H., Xu, Y.
Deposit date:2018-10-23
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
6IMO
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CRYSTAL STRUCTURE OF PDE4D COMPLEXED WITH A NOVEL INHIBITOR
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, X.L., Su, H.X., Xu, Y.C.
Deposit date:2018-10-23
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
6IMR
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CRYSTAL STRUCTURE OF PDE4D COMPLEXED WITH A NOVEL INHIBITOR
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, X.L., Su, H.X., Xu, Y.C.
Deposit date:2018-10-23
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.503 Å)
Cite:Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
6IMT
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CRYSTAL STRUCTURE OF PDE4D COMPLEXED WITH A NOVEL INHIBITOR
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, X.L., Su, H.X., Xu, Y.C.
Deposit date:2018-10-23
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.483 Å)
Cite:Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
6IND
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CRYSTAL STRUCTURE OF PDE4D COMPLEXED WITH A NOVEL INHIBITOR
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, (1S)-6,7-dimethoxy-1-[2-(6-methyl-1H-indol-3-yl)ethyl]-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, MAGNESIUM ION, ...
Authors:Zhang, X.L., Su, H.X., Xu, Y.C.
Deposit date:2018-10-24
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.872 Å)
Cite:Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
6INK
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CRYSTAL STRUCTURE OF PDE4D COMPLEXED WITH A NOVEL INHIBITOR
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, X.L., Su, H.X., Xu, Y.C.
Deposit date:2018-10-25
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
6INM
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CRYSTAL STRUCTURE OF PDE4D COMPLEXED WITH A NOVEL INHIBITOR
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, X.L., Su, H.X., Xu, Y.C.
Deposit date:2018-10-26
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
6IS8
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CRYSTAL STRUCTURE OF ZMMOC1 D115N MUTANT IN COMPLEX WITH HOLLIDAY JUNCTION
Descriptor:Monokaryotic chloroplast 1, DNA (33-MER), MAGNESIUM ION, ...
Authors:Lin, Z., Lin, H., Zhang, D., Yuan, C.
Deposit date:2018-11-15
Release date:2019-10-23
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural basis of sequence-specific Holliday junction cleavage by MOC1.
Nat.Chem.Biol., 2019
6IS9
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CRYSTAL STRUCTURE OF ZMMOC1
Descriptor:Monokaryotic chloroplast 1
Authors:Lin, Z., Lin, H., Zhang, D., Yuan, C.
Deposit date:2018-11-15
Release date:2019-10-23
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural basis of sequence-specific Holliday junction cleavage by MOC1.
Nat.Chem.Biol., 2019
6JRF
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CRYSTAL STRUCTURE OF ZMMOC1-HOLLIDAY JUNCTION COMPLEX IN THE PRESENCE OF CALCIUM
Descriptor:Monokaryotic chloroplast 1, DNA (33-MER), CALCIUM ION, ...
Authors:Lin, Z., Lin, H., Zhang, D., Yuan, C.
Deposit date:2019-04-03
Release date:2019-10-23
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Structural basis of sequence-specific Holliday junction cleavage by MOC1.
Nat.Chem.Biol., 2019
6JRG
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CRYSTAL STRUCTURE OF ZMMOC1 H253A MUTANT IN COMPLEX WITH HOLLIDAY JUNCTION
Descriptor:Monokaryotic chloroplast 1, DNA (33-MER), DNA (32-MER), ...
Authors:Lin, Z., Lin, H., Zhang, D., Yuan, C.
Deposit date:2019-04-03
Release date:2019-10-23
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:Structural basis of sequence-specific Holliday junction cleavage by MOC1.
Nat.Chem.Biol., 2019
6KKR
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HUMAN KCC1 STRUCTURE DETERMINED IN KCL AND DETERGENT GDN
Descriptor:Solute carrier family 12 member 4, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Liu, S., Chang, S., Ye, S., Bai, X., Guo, J.
Deposit date:2019-07-27
Release date:2019-10-23
Last modified:2019-11-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM structures of the human cation-chloride cotransporter KCC1.
Science, 366, 2019
6KKT
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HUMAN KCC1 STRUCTURE DETERMINED IN KCL AND LIPID NANODISC
Descriptor:Solute carrier family 12 member 4, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Liu, S., Chang, S., Ye, S., Bai, X., Guo, J.
Deposit date:2019-07-27
Release date:2019-10-23
Last modified:2019-11-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM structures of the human cation-chloride cotransporter KCC1.
Science, 366, 2019
6KKU
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HUMAN KCC1 STRUCTURE DETERMINED IN NACL AND GDN
Descriptor:Solute carrier family 12 member 4, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Liu, S., Chang, S., Ye, S., Bai, X., Guo, J.
Deposit date:2019-07-27
Release date:2019-10-23
Last modified:2019-11-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structures of the human cation-chloride cotransporter KCC1.
Science, 366, 2019
6MS7
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PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A NOVEL SELECTIVE PPAR-GAMMA MODULATOR VSP-77
Descriptor:Peroxisome proliferator-activated receptor gamma, PGC1 LXXLL motif, {[(1S)-1-(4-chlorophenyl)octyl]oxy}acetic acid
Authors:Yi, W., Jiang, H., Zhou, X.E., Shi, J., Zhao, G., Zhang, X., Sun, Y., Suino-Powell, K., Li, J., Li, J., Melcher, K., Xu, H.E.
Deposit date:2018-10-16
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Identification and Structural Insight of a Safe and Effective PPAR-gamma Modulator for Anti-Diabetic Drug Discovery
To Be Published
6PYH
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CRYO-EM STRUCTURE OF FULL-LENGTH IGF1R-IGF1 COMPLEX. ONLY THE EXTRACELLULAR REGION OF THE COMPLEX IS RESOLVED.
Descriptor:Insulin-like growth factor 1 receptor, Insulin-like growth factor I
Authors:Li, J., Choi, E., Yu, H.T., Bai, X.C.
Deposit date:2019-07-29
Release date:2019-10-23
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural basis of the activation of type 1 insulin-like growth factor receptor.
Nat Commun, 10, 2019
6IHH
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CRYSTAL STRUCTURE OF RASADH F12 FROM RALSTONIA.SP IN COMPLEX WITH NADPH AND A6O
Descriptor:Alclohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R,3S)-2-ethyl-2-[(2E)-2-(6-methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)ethyl]-3-oxidanyl-cyclopentan-1-one
Authors:Zhang, H.L., Chen, X., Liu, W.D., Wu, Q.Q., Zhu, D.M.
Deposit date:2018-09-30
Release date:2019-10-02
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase.
Nat Catal, 2, 2019
6IHI
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CRYSTAL STRUCTURE OF RASADH 3B3/I91V FROM RALSTONIA.SP IN COMPLEX WITH NADPH AND A6O
Descriptor:Alclohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R,3S)-2-ethyl-2-[(2E)-2-(6-methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)ethyl]-3-oxidanyl-cyclopentan-1-one
Authors:Zhang, H.L., Chen, X., Liu, W.D., Wu, Q.Q., Zhu, D.M.
Deposit date:2018-09-30
Release date:2019-10-02
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase.
Nat Catal, 2, 2019