Author results

1ULH
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A SHORT PEPTIDE INSERTION CRUCIAL FOR ANGIOSTATIC ACTIVITY OF HUMAN TRYPTOPHANYL-TRNA SYNTHETASE
Descriptor:Tryptophanyl-tRNA synthetase
Authors:Kise, Y., Sengoku, T., Ishii, R., Yokoyama, S., Park, S.G., Lee, S.W., Kim, S., Nureki, O., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-09-12
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase
Nat.Struct.Mol.Biol., 11, 2004
6AAE
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CRYSTAL STRUCTURE OF CHLORAMPHENICOL-METABOLIZAING ENZYME ESTDL136
Descriptor:Esterase, PENTAETHYLENE GLYCOL, DI(HYDROXYETHYL)ETHER
Authors:Kim, S.H., Kang, P.A., Han, K.T., Lee, S.W., Rhee, S.K.
Deposit date:2018-07-18
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.641 Å)
Cite:Crystal structure of chloramphenicol-metabolizing enzyme EstDL136 from a metagenome.
PLoS ONE, 14, 2019
6IEY
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CRYSTAL STRUCTURE OF CHLORAMPHENICOL-METABOLIZAING ENZYME ESTDL136-CHLORAMPHENICOL COMPLEX
Descriptor:Esterase, CHLORAMPHENICOL
Authors:Kim, S.H., Kang, P.A., Han, K.T., Lee, S.W., Rhee, S.K.
Deposit date:2018-09-18
Release date:2019-02-06
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Crystal structure of chloramphenicol-metabolizing enzyme EstDL136 from a metagenome.
PLoS ONE, 14, 2019
5GPG
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CO-CRYSTAL STRUCTURE OF THE FK506 BINDING DOMAIN OF HUMAN FKBP25, RAPAMYCIN AND THE FRB DOMAIN OF HUMAN MTOR
Descriptor:Peptidyl-prolyl cis-trans isomerase FKBP3, Serine/threonine-protein kinase mTOR, RAPAMYCIN IMMUNOSUPPRESSANT DRUG
Authors:Lee, H.B., Lee, S.Y., Rhee, H.W., Lee, C.W.
Deposit date:2016-08-02
Release date:2016-10-12
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells
Acs Cent.Sci., 2, 2016
6A6K
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CRYSTAL STRUCTURE OF ESTROGEN-RELATED RECEPTOR-3 (ERR-GAMMA) LIGAND BINDING DOMAIN WITH DN201000
Descriptor:Estrogen-related receptor gamma, 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol
Authors:Yoon, H., Kim, J., Chin, J., Cho, S.J., Song, J.
Deposit date:2018-06-28
Release date:2019-04-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-gamma Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.
J. Med. Chem., 62, 2019
5YSO
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CRYSTAL STRUCTURE OF ESTROGEN RELATED RECEPTOR-3 (ERR-GAMMA) LIGAND BINDING DOMAIN WITH DN200434
Descriptor:Estrogen-related receptor gamma, 4-[5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol
Authors:Cho, S.J., Chin, J.W., Yoon, H.S., Jeon, Y.H., Bae, J.H., Song, J.Y.
Deposit date:2017-11-14
Release date:2018-12-26
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:A novel orally active inverse agonist of estrogen-related receptor gamma (ERR gamma ), DN200434, a booster of NIS in anaplastic thyroid cancer.
Clin. Cancer Res., 2019
2OIB
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CRYSTAL STRUCTURE OF IRAK4 KINASE DOMAIN APO FORM
Descriptor:Interleukin-1 receptor-associated kinase 4
Authors:Kuglstatter, A., Villasenor, A.G., Browner, M.F.
Deposit date:2007-01-10
Release date:2007-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations.
J.Immunol., 178, 2007
2OIC
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CRYSTAL STRUCTURE OF IRAK4 KINASE DOMAIN COMPLEXED WITH STAUROSPORINE
Descriptor:Interleukin-1 receptor-associated kinase 4, STAUROSPORINE
Authors:Kuglstatter, A., Villasenor, A.G., Browner, M.F.
Deposit date:2007-01-10
Release date:2007-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations.
J.Immunol., 178, 2007
2OID
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CRYSTAL STRUCTURE OF IRAK4 KINASE DOMAIN COMPLEXED WITH AMPPNP
Descriptor:Interleukin-1 receptor-associated kinase 4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Kuglstatter, A., Villasenor, A.G., Browner, M.F.
Deposit date:2007-01-10
Release date:2007-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations.
J.Immunol., 178, 2007
3PIX
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 2-ISOPROPYL-7-(4-METHYL-PIPERAZIN-1-YL)-4-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-2H-PHTHALAZIN-1-ONE
Descriptor:Tyrosine-protein kinase BTK, 7-(4-methylpiperazin-1-yl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-(propan-2-yl)phthalazin-1(2H)-one
Authors:Kuglstatter, A., Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
3PIY
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH R406
Descriptor:Tyrosine-protein kinase BTK, 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Authors:Kuglstatter, A., Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
3PIZ
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH (5-AMINO-1-O-TOLYL-1H-PYRAZOL-4-YL)-[3-(1-METHANESULFONYL-PIPERIDIN-4-YL)-PHENYL]-METHANONE
Descriptor:Tyrosine-protein kinase BTK, [5-amino-1-(2-methylphenyl)-1H-pyrazol-4-yl]{3-[1-(methylsulfonyl)piperidin-4-yl]phenyl}methanone
Authors:Kuglstatter, A., Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
3PJ1
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 3-(2,6-DICHLORO-PHENYL)-7-[4-(2-DIETHYLAMINO-ETHOXY)-PHENYLAMINO]-1-METHYL-3,4-DIHYDRO-1H-PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE
Descriptor:Tyrosine-protein kinase BTK, 3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
Authors:Kuglstatter, A., Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
3PJ2
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 2-[4-(2-DIETHYLAMINO-ETHOXY)-PHENYLAMINO]-6-(4-FLUORO-PHENOXY)-8-METHYL-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE
Descriptor:Tyrosine-protein kinase BTK, 2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-6-(4-fluorophenoxy)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Authors:Kuglstatter, A., Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
3PJ3
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 2-METHYL-5-[(E)-(3-PHENYL-ACRYLOYL)AMINO]-N-(2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-BENZAMIDE
Descriptor:Tyrosine-protein kinase BTK, 2-methyl-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-5-{[(2E)-3-phenylprop-2-enoyl]amino}benzamide
Authors:Kuglstatter, A., Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
4CKR
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CRYSTAL STRUCTURE OF THE HUMAN DDR1 KINASE DOMAIN IN COMPLEX WITH DDR1-IN-1
Descriptor:EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1, 4-[(4-ethylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(2-oxo-2,3-dihydro-1h-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide, 1,2-ETHANEDIOL
Authors:Canning, P., Elkins, J.M., Goubin, S., Mahajan, P., Krojer, T., Newman, J.A., Dixon-Clarke, S., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2014-01-07
Release date:2014-01-15
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of a Potent and Selective Ddr1 Receptor Tyrosine Kinase Inhibitor.
Acs Chem.Biol., 8, 2013
5V4U
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SOLUTION STRUCTURE OF VKK38 BOUND TO PLASMINOGEN KRINGLE 2
Descriptor:M protein
Authors:Yuan, Y., Castellino, F.
Deposit date:2017-03-10
Release date:2017-07-26
Last modified:2017-09-20
Method:SOLUTION NMR
Cite:Conformationally organized lysine isosteres in Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen.
J. Biol. Chem., 292, 2017
6BZJ
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SOLUTION STRUCTURE OF AGL55
Descriptor:M protein
Authors:Qiu, C., Yuan, Y., Castellino, F.J.
Deposit date:2017-12-24
Release date:2019-01-16
Last modified:2019-02-20
Method:SOLUTION NMR
Cite:The C-Domain Repeats in Plasminogen-binding Group A Streptococcal M-Protein are Essential Determinants for its Dimerization
To Be Published
6BZL
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SOLUTION STRUCTURE OF VEK75
Descriptor:M protein
Authors:Qiu, C., Yuan, Y., Castellino, F.J.
Deposit date:2017-12-24
Release date:2019-01-16
Last modified:2019-02-20
Method:SOLUTION NMR
Cite:The C-Domain Repeats in Plasminogen-binding Group A Streptococcal M-Protein are Essential Determinants for its Dimerization
To Be Published