2A0L | | CRYSTAL STRUCTURE OF KVAP-33H1 FV COMPLEX | | Descriptor: | Voltage-gated potassium channel, 33H1 Fv fragment, POTASSIUM ION | | Authors: | Lee, S.Y., Lee, A., Chen, J., Mackinnon, R. | | Deposit date: | 2005-06-16 | | Release date: | 2005-11-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.9 Å) | | Cite: | Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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3PSA | | CLASSIFICATION OF A HAEMOPHILUS INFLUENZAE ABC TRANSPORTER HI1470/71 THROUGH ITS COGNATE MOLYBDATE PERIPLASMIC BINDING PROTEIN MOLA (MOLA BOUND TO TUNGSTATE) | | Descriptor: | protein HI_1472, TUNGSTATE(VI)ION | | Authors: | Tirado-Lee, L., Lee, A., Rees, D.C., Pinkett, H.W. | | Deposit date: | 2010-12-01 | | Release date: | 2011-11-30 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Classification of a Haemophilus influenzae ABC Transporter HI1470/71 through Its Cognate Molybdate Periplasmic Binding Protein, MolA.
Structure, 19, 2011
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3PSH | | CLASSIFICATION OF A HAEMOPHILUS INFLUENZAE ABC TRANSPORTER HI1470/71 THROUGH ITS COGNATE MOLYBDATE PERIPLASMIC BINDING PROTEIN MOLA (MOLA BOUND TO MOLYBDATE) | | Descriptor: | protein HI_1472, MOLYBDATE ION | | Authors: | Tirado-Lee, L., Lee, A., Rees, D.C., Pinkett, H.W. | | Deposit date: | 2010-12-01 | | Release date: | 2011-11-30 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Classification of a Haemophilus influenzae ABC Transporter HI1470/71 through Its Cognate Molybdate Periplasmic Binding Protein, MolA.
Structure, 19, 2011
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1LNQ | | CRYSTAL STRUCTURE OF MTHK AT 3.3 A | | Descriptor: | POTASSIUM CHANNEL RELATED PROTEIN, CALCIUM ION | | Authors: | Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B.T., Mackinnon, R. | | Deposit date: | 2002-05-03 | | Release date: | 2002-06-19 | | Last modified: | 2014-11-12 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | CRYSTAL STRUCTURE AND MECHANISM OF A CALCIUM-GATED POTASSIUM CHANNEL
Nature, 417, 2002
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4JTA | | CRYSTAL STRUCTURE OF KV1.2-2.1 PADDLE CHIMERA CHANNEL IN COMPLEX WITH CHARYBDOTOXIN | | Descriptor: | Voltage-gated potassium channel subunit beta-2, Potassium voltage-gated channel subfamily A member 2, Potassium voltage-gated channel subfamily B member 1, ... | | Authors: | MacKinnon, R., Banerjee, A., Lee, A., Campbell, E. | | Deposit date: | 2013-03-23 | | Release date: | 2013-06-12 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
Elife, 2, 2013
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4JTC | | CRYSTAL STRUCTURE OF KV1.2-2.1 PADDLE CHIMERA CHANNEL IN COMPLEX WITH CHARYBDOTOXIN IN CS+ | | Descriptor: | Voltage-gated potassium channel subunit beta-2, Potassium voltage-gated channel subfamily A member 2, Potassium voltage-gated channel subfamily B member 1, ... | | Authors: | Banerjee, A., Lee, A., Campbell, E., MacKinnon, R. | | Deposit date: | 2013-03-23 | | Release date: | 2013-06-12 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
Elife, 2, 2013
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4JTD | | CRYSTAL STRUCTURE OF KV1.2-2.1 PADDLE CHIMERA CHANNEL IN COMPLEX WITH LYS27MET MUTANT OF CHARYBDOTOXIN | | Descriptor: | Voltage-gated potassium channel subunit beta-2, Potassium voltage-gated channel subfamily A member 2, Potassium voltage-gated channel subfamily B member 1, ... | | Authors: | Banerjee, A., Lee, A., Campbell, E., MacKinnon, R. | | Deposit date: | 2013-03-23 | | Release date: | 2013-06-12 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
Elife, 2, 2013
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1BE9 | | THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 IN COMPLEX WITH A C-TERMINAL PEPTIDE DERIVED FROM CRIPT. | | Descriptor: | PSD-95, CRIPT | | Authors: | Doyle, D.A., Lee, A., Lewis, J., Kim, E., Sheng, M., Mackinnon, R. | | Deposit date: | 1998-05-20 | | Release date: | 1998-10-21 | | Last modified: | 2018-03-07 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
Cell(Cambridge,Mass.), 85, 1996
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1BFE | | THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 | | Descriptor: | PSD-95 | | Authors: | Doyle, D.A., Lee, A., Lewis, J., Kim, E., Sheng, M., Mackinnon, R. | | Deposit date: | 1998-05-20 | | Release date: | 1998-10-21 | | Last modified: | 2018-03-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
Cell(Cambridge,Mass.), 85, 1996
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1BYW | |
1ORQ | | X-RAY STRUCTURE OF A VOLTAGE-DEPENDENT POTASSIUM CHANNEL IN COMPLEX WITH AN FAB | | Descriptor: | 6E1 Fab light chain, 6E1 Fab heavy chain, potassium channel, ... | | Authors: | Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B.T., MacKinnon, R. | | Deposit date: | 2003-03-14 | | Release date: | 2003-05-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | X-ray structure of a voltage-dependent K+ channel
Nature, 423, 2003
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1ORS | | X-RAY STRUCTURE OF THE KVAP POTASSIUM CHANNEL VOLTAGE SENSOR IN COMPLEX WITH AN FAB | | Descriptor: | 33H1 Fab light chain, 33H1 Fab heavy chain, potassium channel | | Authors: | Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B.T., MacKinnon, R. | | Deposit date: | 2003-03-14 | | Release date: | 2003-05-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | X-ray structure of a voltage-dependent K+ channel
Nature, 423, 2003
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3LNM | | F233W MUTANT OF THE KV2.1 PADDLE-KV1.2 CHIMERA CHANNEL | | Descriptor: | Voltage-gated potassium channel subunit beta-2, F233W mutant of the Kv2.1 paddle-Kv1.2 chimera, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Tao, X., Lee, A., Limapichat, W., Dougherty, D.A., MacKinnon, R. | | Deposit date: | 2010-02-02 | | Release date: | 2010-04-14 | | Last modified: | 2017-08-02 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | A gating charge transfer center in voltage sensors.
Science, 328, 2010
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6NJV | | C-TERMINAL REGION OF THE XANTHOMONAS CAMPESTRIS PV. CAMPESTRIS OLD PROTEIN PHASED WITH IODINE | | Descriptor: | Xcc_CTR_I, IODIDE ION, MAGNESIUM ION | | Authors: | Schiltz, C.J., Lee, A., Partlow, E.A., Hosford, C.J., Chappie, J.S. | | Deposit date: | 2019-01-04 | | Release date: | 2019-08-07 | | Last modified: | 2019-10-09 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural characterization of Class 2 OLD family nucleases supports a two-metal catalysis mechanism for cleavage.
Nucleic Acids Res., 47, 2019
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6NJW | | C-TERMINAL REGION OF THE XANTHOMONAS CAMPESTRIS PV. CAMPESTRIS OLD PROTEIN PHASED WITH PLATINUM | | Descriptor: | Xcc_ctr_pt, PLATINUM (II) ION, IODIDE ION, ... | | Authors: | Schiltz, C.J., Lee, A., Partlow, E.A., Hosford, C.J., Chappie, J.S. | | Deposit date: | 2019-01-04 | | Release date: | 2019-08-07 | | Last modified: | 2019-10-09 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Structural characterization of Class 2 OLD family nucleases supports a two-metal catalysis mechanism for cleavage.
Nucleic Acids Res., 47, 2019
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6NJX | | C-TERMINAL REGION OF THE XANTHOMONAS CAMPESTRIS PV. CAMPESTRIS OLD PROTEIN PHASED WITH MERCURY | | Descriptor: | Xcc_ctr_Hg, MERCURY (II) ION, IODIDE ION | | Authors: | Schiltz, C.J., Lee, A., Partlow, E.A., Hosford, C.J., Chappie, J.S. | | Deposit date: | 2019-01-04 | | Release date: | 2019-08-07 | | Last modified: | 2019-10-09 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural characterization of Class 2 OLD family nucleases supports a two-metal catalysis mechanism for cleavage.
Nucleic Acids Res., 47, 2019
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6NK8 | | C-TERMINAL REGION OF THE BURKHOLDERIA PSEUDOMALLEI OLD PROTEIN | | Descriptor: | Class 2 OLD family nuclease, MAGNESIUM ION | | Authors: | Schiltz, C.J., Lee, A., Partlow, E.A., Hosford, C.J., Chappie, J.S. | | Deposit date: | 2019-01-05 | | Release date: | 2019-08-07 | | Last modified: | 2019-10-09 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Structural characterization of Class 2 OLD family nucleases supports a two-metal catalysis mechanism for cleavage.
Nucleic Acids Res., 47, 2019
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2RVC | | SOLUTION STRUCTURE OF ZALPHA DOMAIN OF GOLDFISH ZBP-CONTAINING PROTEIN KINASE | | Descriptor: | Interferon-inducible and double-stranded-dependent eIF-2kinase | | Authors: | Lee, A., Park, C., Park, J., Kwon, M., Choi, Y., Kim, K., Choi, B., Lee, J. | | Deposit date: | 2015-07-08 | | Release date: | 2016-02-03 | | Last modified: | 2017-06-07 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the Z-DNA binding domain of PKR-like protein kinase from Carassius auratus and quantitative analyses of the intermediate complex during B-Z transition.
Nucleic Acids Res., 44, 2016
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6ICI | | CRYSTAL STRUCTURE OF HUMAN MICAL3 | | Descriptor: | [F-actin]-monooxygenase MICAL3, FLAVIN-ADENINE DINUCLEOTIDE | | Authors: | Hwang, K.Y., Kim, J.S. | | Deposit date: | 2018-09-06 | | Release date: | 2020-03-04 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural and kinetic insights into flavin-containing monooxygenase and calponin-homology domains in human MICAL3.
Iucrj, 7, 2020
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5UIQ | | CRYSTAL STRUCTURE OF IRAK4 IN COMPLEX WITH COMPOUND 9 | | Descriptor: | Interleukin-1 receptor-associated kinase 4, 2-[(propan-2-yl)oxy]benzamide | | Authors: | Han, S., Chang, J.S. | | Deposit date: | 2017-01-14 | | Release date: | 2017-05-24 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J. Med. Chem., 60, 2017
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5UIR | | CRYSTAL STRUCTURE OF IRAK4 IN COMPLEX WITH COMPOUND 11 | | Descriptor: | Interleukin-1 receptor-associated kinase 4, 5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide | | Authors: | Han, S., Chang, J.S. | | Deposit date: | 2017-01-14 | | Release date: | 2017-05-24 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J. Med. Chem., 60, 2017
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5UIS | | CRYSTAL STRUCTURE OF IRAK4 IN COMPLEX WITH COMPOUND 12 | | Descriptor: | Interleukin-1 receptor-associated kinase 4, 4-{[(3R)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | | Authors: | Han, S., Chang, J.S. | | Deposit date: | 2017-01-14 | | Release date: | 2017-05-24 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J. Med. Chem., 60, 2017
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5UIT | | CRYSTAL STRUCTURE OF IRAK4 IN COMPLEX WITH COMPOUND 14 | | Descriptor: | Interleukin-1 receptor-associated kinase 4, 1-{[(2S)-5-oxopyrrolidin-2-yl]methoxy}-7-[(propan-2-yl)oxy]isoquinoline-6-carboxamide | | Authors: | Han, S., Chang, J.S. | | Deposit date: | 2017-01-14 | | Release date: | 2017-05-24 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J. Med. Chem., 60, 2017
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5UIU | | CRYSTAL STRUCTURE OF IRAK4 IN COMPLEX WITH COMPOUND 30 | | Descriptor: | Interleukin-1 receptor-associated kinase 4, 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide | | Authors: | Han, S., Chang, J.S. | | Deposit date: | 2017-01-14 | | Release date: | 2017-05-24 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J. Med. Chem., 60, 2017
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3DHW | | CRYSTAL STRUCTURE OF METHIONINE IMPORTER METNI | | Descriptor: | D-methionine transport system permease protein metI, Methionine import ATP-binding protein metN | | Authors: | Rees, D.C., Kaiser, J.T., Kadaba, N.S., Johnson, E., Lee, A.T. | | Deposit date: | 2008-06-18 | | Release date: | 2008-08-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | The high-affinity E. coli methionine ABC transporter: structure and allosteric regulation.
Science, 321, 2008
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