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2A0L
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CRYSTAL STRUCTURE OF KVAP-33H1 FV COMPLEX
Descriptor:Voltage-gated potassium channel, 33H1 Fv fragment, POTASSIUM ION
Authors:Lee, S.Y., Lee, A., Chen, J., Mackinnon, R.
Deposit date:2005-06-16
Release date:2005-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane.
Proc.Natl.Acad.Sci.Usa, 102, 2005
3PSA
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CLASSIFICATION OF A HAEMOPHILUS INFLUENZAE ABC TRANSPORTER HI1470/71 THROUGH ITS COGNATE MOLYBDATE PERIPLASMIC BINDING PROTEIN MOLA (MOLA BOUND TO TUNGSTATE)
Descriptor:protein HI_1472, TUNGSTATE(VI)ION
Authors:Tirado-Lee, L., Lee, A., Rees, D.C., Pinkett, H.W.
Deposit date:2010-12-01
Release date:2011-11-30
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Classification of a Haemophilus influenzae ABC Transporter HI1470/71 through Its Cognate Molybdate Periplasmic Binding Protein, MolA.
Structure, 19, 2011
3PSH
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CLASSIFICATION OF A HAEMOPHILUS INFLUENZAE ABC TRANSPORTER HI1470/71 THROUGH ITS COGNATE MOLYBDATE PERIPLASMIC BINDING PROTEIN MOLA (MOLA BOUND TO MOLYBDATE)
Descriptor:protein HI_1472, MOLYBDATE ION
Authors:Tirado-Lee, L., Lee, A., Rees, D.C., Pinkett, H.W.
Deposit date:2010-12-01
Release date:2011-11-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Classification of a Haemophilus influenzae ABC Transporter HI1470/71 through Its Cognate Molybdate Periplasmic Binding Protein, MolA.
Structure, 19, 2011
1LNQ
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CRYSTAL STRUCTURE OF MTHK AT 3.3 A
Descriptor:POTASSIUM CHANNEL RELATED PROTEIN, CALCIUM ION
Authors:Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B.T., Mackinnon, R.
Deposit date:2002-05-03
Release date:2002-06-19
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:CRYSTAL STRUCTURE AND MECHANISM OF A CALCIUM-GATED POTASSIUM CHANNEL
Nature, 417, 2002
4JTA
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CRYSTAL STRUCTURE OF KV1.2-2.1 PADDLE CHIMERA CHANNEL IN COMPLEX WITH CHARYBDOTOXIN
Descriptor:Voltage-gated potassium channel subunit beta-2, Potassium voltage-gated channel subfamily A member 2, Potassium voltage-gated channel subfamily B member 1, ...
Authors:MacKinnon, R., Banerjee, A., Lee, A., Campbell, E.
Deposit date:2013-03-23
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
Elife, 2, 2013
4JTC
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CRYSTAL STRUCTURE OF KV1.2-2.1 PADDLE CHIMERA CHANNEL IN COMPLEX WITH CHARYBDOTOXIN IN CS+
Descriptor:Voltage-gated potassium channel subunit beta-2, Potassium voltage-gated channel subfamily A member 2, Potassium voltage-gated channel subfamily B member 1, ...
Authors:Banerjee, A., Lee, A., Campbell, E., MacKinnon, R.
Deposit date:2013-03-23
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
Elife, 2, 2013
4JTD
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CRYSTAL STRUCTURE OF KV1.2-2.1 PADDLE CHIMERA CHANNEL IN COMPLEX WITH LYS27MET MUTANT OF CHARYBDOTOXIN
Descriptor:Voltage-gated potassium channel subunit beta-2, Potassium voltage-gated channel subfamily A member 2, Potassium voltage-gated channel subfamily B member 1, ...
Authors:Banerjee, A., Lee, A., Campbell, E., MacKinnon, R.
Deposit date:2013-03-23
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
Elife, 2, 2013
1BE9
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THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 IN COMPLEX WITH A C-TERMINAL PEPTIDE DERIVED FROM CRIPT.
Descriptor:PSD-95, CRIPT
Authors:Doyle, D.A., Lee, A., Lewis, J., Kim, E., Sheng, M., Mackinnon, R.
Deposit date:1998-05-20
Release date:1998-10-21
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
Cell(Cambridge,Mass.), 85, 1996
1BFE
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THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95
Descriptor:PSD-95
Authors:Doyle, D.A., Lee, A., Lewis, J., Kim, E., Sheng, M., Mackinnon, R.
Deposit date:1998-05-20
Release date:1998-10-21
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
Cell(Cambridge,Mass.), 85, 1996
1BYW
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STRUCTURE OF THE N-TERMINAL DOMAIN OF THE HUMAN-ERG POTASSIUM CHANNEL
Descriptor:PROTEIN (HUMAN ERG POTASSIUM CHANNEL)
Authors:Cabral, J.H.M., Lee, A., Mackinnon, R.
Deposit date:1998-10-15
Release date:1998-12-16
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure and Functional Analysis of the Herg Potassium Channel N-Terminus: A Eukaryotic Pas Domain
Cell(Cambridge,Mass.), 95, 1998
1ORQ
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X-RAY STRUCTURE OF A VOLTAGE-DEPENDENT POTASSIUM CHANNEL IN COMPLEX WITH AN FAB
Descriptor:6E1 Fab light chain, 6E1 Fab heavy chain, potassium channel, ...
Authors:Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B.T., MacKinnon, R.
Deposit date:2003-03-14
Release date:2003-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:X-ray structure of a voltage-dependent K+ channel
Nature, 423, 2003
1ORS
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X-RAY STRUCTURE OF THE KVAP POTASSIUM CHANNEL VOLTAGE SENSOR IN COMPLEX WITH AN FAB
Descriptor:33H1 Fab light chain, 33H1 Fab heavy chain, potassium channel
Authors:Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B.T., MacKinnon, R.
Deposit date:2003-03-14
Release date:2003-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structure of a voltage-dependent K+ channel
Nature, 423, 2003
3LNM
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F233W MUTANT OF THE KV2.1 PADDLE-KV1.2 CHIMERA CHANNEL
Descriptor:Voltage-gated potassium channel subunit beta-2, F233W mutant of the Kv2.1 paddle-Kv1.2 chimera, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Tao, X., Lee, A., Limapichat, W., Dougherty, D.A., MacKinnon, R.
Deposit date:2010-02-02
Release date:2010-04-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A gating charge transfer center in voltage sensors.
Science, 328, 2010
2RVC
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SOLUTION STRUCTURE OF ZALPHA DOMAIN OF GOLDFISH ZBP-CONTAINING PROTEIN KINASE
Descriptor:Interferon-inducible and double-stranded-dependent eIF-2kinase
Authors:Lee, A., Park, C., Park, J., Kwon, M., Choi, Y., Kim, K., Choi, B., Lee, J.
Deposit date:2015-07-08
Release date:2016-02-03
Last modified:2017-06-07
Method:SOLUTION NMR
Cite:Solution structure of the Z-DNA binding domain of PKR-like protein kinase from Carassius auratus and quantitative analyses of the intermediate complex during B-Z transition.
Nucleic Acids Res., 44, 2016
5UIQ
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CRYSTAL STRUCTURE OF IRAK4 IN COMPLEX WITH COMPOUND 9
Descriptor:Interleukin-1 receptor-associated kinase 4, 2-[(propan-2-yl)oxy]benzamide
Authors:Han, S., Chang, J.S.
Deposit date:2017-01-14
Release date:2017-05-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J. Med. Chem., 60, 2017
5UIR
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CRYSTAL STRUCTURE OF IRAK4 IN COMPLEX WITH COMPOUND 11
Descriptor:Interleukin-1 receptor-associated kinase 4, 5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide
Authors:Han, S., Chang, J.S.
Deposit date:2017-01-14
Release date:2017-05-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J. Med. Chem., 60, 2017
5UIS
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CRYSTAL STRUCTURE OF IRAK4 IN COMPLEX WITH COMPOUND 12
Descriptor:Interleukin-1 receptor-associated kinase 4, 4-{[(3R)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide
Authors:Han, S., Chang, J.S.
Deposit date:2017-01-14
Release date:2017-05-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J. Med. Chem., 60, 2017
5UIT
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CRYSTAL STRUCTURE OF IRAK4 IN COMPLEX WITH COMPOUND 14
Descriptor:Interleukin-1 receptor-associated kinase 4, 1-{[(2S)-5-oxopyrrolidin-2-yl]methoxy}-7-[(propan-2-yl)oxy]isoquinoline-6-carboxamide
Authors:Han, S., Chang, J.S.
Deposit date:2017-01-14
Release date:2017-05-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J. Med. Chem., 60, 2017
5UIU
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CRYSTAL STRUCTURE OF IRAK4 IN COMPLEX WITH COMPOUND 30
Descriptor:Interleukin-1 receptor-associated kinase 4, 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide
Authors:Han, S., Chang, J.S.
Deposit date:2017-01-14
Release date:2017-05-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J. Med. Chem., 60, 2017
3DHW
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CRYSTAL STRUCTURE OF METHIONINE IMPORTER METNI
Descriptor:D-methionine transport system permease protein metI, Methionine import ATP-binding protein metN
Authors:Rees, D.C., Kaiser, J.T., Kadaba, N.S., Johnson, E., Lee, A.T.
Deposit date:2008-06-18
Release date:2008-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:The high-affinity E. coli methionine ABC transporter: structure and allosteric regulation.
Science, 321, 2008
3DHX
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CRYSTAL STRUCTURE OF ISOLATED C2 DOMAIN OF THE METHIONINE UPTAKE TRANSPORTER
Descriptor:Methionine import ATP-binding protein metN, IODIDE ION
Authors:Johnson, E., Kaiser, J.T., Lee, A.T., Rees, D.C.
Deposit date:2008-06-18
Release date:2008-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The high-affinity E. coli methionine ABC transporter: structure and allosteric regulation.
Science, 321, 2008
5C0N
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DEVELOPMENT OF A MONOCLONAL ANTIBODY TARGETING SECRETED AP2 TO TREAT DIABETES AND FATTY LIVER DISEASE
Descriptor:Fatty acid-binding protein, adipocyte, Fab CA33 Heavy chain, ...
Authors:Doyle, C.
Deposit date:2015-06-12
Release date:2015-06-24
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.
Sci Transl Med, 7, 2015
5D8J
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DEVELOPMENT OF A THERAPEUTIC MONOCLONAL ANTIBODY TARGETING SECRETED AP2 TO TREAT TYPE 2 DIABETES.
Descriptor:Fatty acid-binding protein, adipocyte, HA3 Fab Heavy Chain, ...
Authors:Doyle, C., Birrane, G.
Deposit date:2015-08-17
Release date:2016-01-13
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (3 Å)
Cite:Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.
Sci Transl Med, 7, 2015
2DF6
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CRYSTAL STRUCTURE OF THE SH3 DOMAIN OF BETAPIX IN COMPLEX WITH A HIGH AFFINITY PEPTIDE FROM PAK2
Descriptor:Rho guanine nucleotide exchange factor 7, 18-mer from PAK2
Authors:Hoelz, A.
Deposit date:2006-02-25
Release date:2006-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal Structure of the SH3 Domain of betaPIX in Complex with a High Affinity Peptide from PAK2
J.Mol.Biol., 358, 2006
2G6F
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CRYSTAL STRUCTURE OF THE SH3 DOMAIN OF BETAPIX IN COMPLEX WITH A HIGH AFFINITY PEPTIDE FROM PAK2
Descriptor:Rho guanine nucleotide exchange factor 7, COBALT HEXAMMINE(III)
Authors:Hoelz, A.
Deposit date:2006-02-24
Release date:2006-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.92 Å)
Cite:Crystal Structure of the SH3 Domain of betaPIX in Complex with a High Affinity Peptide from PAK2
J.Mol.Biol., 358, 2006
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