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dHP1 Chromodomain Y24W variant bound to histone H3 peptide containing trimethyllysine
Descriptor:	Heterochromatin protein 1, histone H3 peptide containing trimethyllysine, H3K9me3
Authors:	Brustad, E.M, Krone, M.W, Albanese, K.I, Waters, M.L.
Deposit date:	2018-09-17
Release date:	2019-09-25
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.497 Å)
Cite:	Thermodynamic consequences of Tyr to Trp mutations in the cation-pi-mediated binding of trimethyllysine by the HP1 chromodomain Chem Sci, 11, 2020

MAGE-A3 MHD crystal soaked with KL861
Descriptor:	(furan-2-yl)[4-({(5P)-5-(1H-indazol-4-yl)-2-[3-(morpholin-4-yl)propoxy]phenyl}methyl)piperazin-1-yl]methanone, Melanoma-associated antigen 3
Authors:	Butrin, A, Krone, M.W, Li, K, Bond, M.J, Linhares, B.M, Crews, C.
Deposit date:	2024-04-10
Release date:	2024-09-18
Method:	X-RAY DIFFRACTION (2.24 Å)
Cite:	Development of Ligands and Degraders Targeting MAGE-A3. J.Am.Chem.Soc., 2024

Chromodomain HP1 with a p-nitro-L-phenylalanine mutation at position 24 bound to histone H3 peptide containing trimethyl lysine
Descriptor:	Heterochromatin protein 1, trimethyl lysine histone H3 tail peptide
Authors:	Brustad, E.M, Baril, S.A, Waters, M.L.
Deposit date:	2017-08-27
Release date:	2017-12-06
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.285 Å)
Cite:	Investigation of Trimethyllysine Binding by the HP1 Chromodomain via Unnatural Amino Acid Mutagenesis. J. Am. Chem. Soc., 139, 2017

Chromodomain HP1 with Y24F mutation bound to histone H3 peptide containing trimethyl lysine
Descriptor:	Heterochromatin protein 1, trimethyl lysine histone H3 tail peptide
Authors:	Brustad, E.M, Baril, S.A, Waters, M.L.
Deposit date:	2017-08-27
Release date:	2017-12-06
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.518 Å)
Cite:	Investigation of Trimethyllysine Binding by the HP1 Chromodomain via Unnatural Amino Acid Mutagenesis. J. Am. Chem. Soc., 139, 2017