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3CS0
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BU of 3cs0 by Molmil
Crystal structure of DegP24
Descriptor: Periplasmic serine endoprotease DegP, pentapeptide
Authors:Krojer, T, Sawa, J, Schaefer, E, Saibil, H.R, Ehrmann, M, Clausen, T.
Deposit date:2008-04-08
Release date:2008-05-27
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for the regulated protease and chaperone function of DegP
Nature, 453, 2008
9QOB
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BU of 9qob by Molmil
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound 4
Descriptor: (5-phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl)methanol, 1,2-ETHANEDIOL, Bromodomain-containing protein 4
Authors:Krojer, T, Martinez-Cartro, M, Picaud, S, Filippakopoulos, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Barril, X, von Delft, F.
Deposit date:2025-03-25
Release date:2025-05-14
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound 2
To Be Published
9QNV
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BU of 9qnv by Molmil
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound 2
Descriptor: 1,2-ETHANEDIOL, 3-methyl-5-phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazole, Bromodomain-containing protein 4, ...
Authors:Krojer, T, Martinez-Cartro, M, Picaud, S, Filippakopoulos, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Barril, X, von Delft, F, Structural Genomics Consortium (SGC)
Deposit date:2025-03-25
Release date:2025-05-14
Method:X-RAY DIFFRACTION (1.226 Å)
Cite:CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound 2
To Be Published
1KY9
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BU of 1ky9 by Molmil
Crystal Structure of DegP (HtrA)
Descriptor: PROTEASE DO
Authors:Krojer, T, Garrido-Franco, M, Huber, R, Ehrmann, M, Clausen, T.
Deposit date:2002-02-04
Release date:2002-04-03
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine.
Nature, 416, 2002
4D6Q
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BU of 4d6q by Molmil
crystal structure of human JMJD2D in complex with 2,4-PDCA
Descriptor: 1,2-ETHANEDIOL, LYSINE-SPECIFIC DEMETHYLASE 4D, NICKEL (II) ION, ...
Authors:Krojer, T, Vollmar, M, Bradley, A, Crawley, L, Szykowska, A, Burgess-Brown, N, Gileadi, C, Johansson, C, Oppermann, U, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F.
Deposit date:2014-11-14
Release date:2014-12-24
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.292 Å)
Cite:Crystal Structure of Human Jmjd2D in Complex with 2,4-Pdca
To be Published
7BBP
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BU of 7bbp by Molmil
Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with H4K5acK8ac
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Histone H4, ...
Authors:Krojer, T, Talon, R, Fairhead, M, Szykowska, A, Burgess-Brown, N.A, Brennan, P.E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Structural Genomics Consortium (SGC)
Deposit date:2020-12-18
Release date:2021-03-03
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with H4K5acK8ac
To Be Published
4D6R
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BU of 4d6r by Molmil
crystal structure of human JMJD2D in complex with N-OXALYLGLYCINE and bound o-toluenesulfonamide
Descriptor: 1,2-ETHANEDIOL, LYSINE-SPECIFIC DEMETHYLASE 4D, N-OXALYLGLYCINE, ...
Authors:Krojer, T, Vollmar, M, Bradley, A, Crawley, L, Szykowska, A, Burgess-Brown, N, Gileadi, C, Johansson, C, Oppermann, U, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F.
Deposit date:2014-11-14
Release date:2014-12-24
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.398 Å)
Cite:Crystal Structure of Human Jmjd2D in Complex with N-Oxalylglycine and Bound O-Toluenesulfonamide
To be Published
7BBO
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BU of 7bbo by Molmil
Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in space group P212121
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, PH-interacting protein
Authors:Krojer, T, Talon, R, Fairhead, M, Szykowska, A, Burgess-Brown, N.A, Brennan, P.E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Structural Genomics Consortium (SGC)
Deposit date:2020-12-18
Release date:2021-03-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in space group P21212
To Be Published
9FWH
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BU of 9fwh by Molmil
Crystal Structure of SARS-CoV-2 NSP10-ExoN in complex with VT00019
Descriptor: (4R)-4-phenyl-1,2-thiazolidine 1,1-dioxide, Guanine-N7 methyltransferase nsp14, Non-structural protein 10, ...
Authors:Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W.
Deposit date:2024-06-30
Release date:2025-07-09
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure of SARS-CoV-2 NSP10-ExoN in complex with VT00019
To Be Published
9FWO
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BU of 9fwo by Molmil
Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00216
Descriptor: 1-methylpyrrole-2-carboxamide, Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, ...
Authors:Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W.
Deposit date:2024-06-30
Release date:2025-07-09
Method:X-RAY DIFFRACTION (2.179 Å)
Cite:Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00216
To Be Published
9FWQ
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BU of 9fwq by Molmil
Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00218
Descriptor: 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine, Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, ...
Authors:Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W.
Deposit date:2024-06-30
Release date:2025-07-09
Method:X-RAY DIFFRACTION (2.322 Å)
Cite:Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00218
To Be Published
9FWN
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BU of 9fwn by Molmil
Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00219
Descriptor: 1-methyl-1-(phenylmethyl)urea, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ...
Authors:Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W.
Deposit date:2024-06-30
Release date:2025-07-09
Method:X-RAY DIFFRACTION (1.866 Å)
Cite:Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00219
To Be Published
9FWR
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BU of 9fwr by Molmil
Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00249
Descriptor: (4R)-4-phenyl-1,3-oxazolidin-2-one, Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, ...
Authors:Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W.
Deposit date:2024-06-30
Release date:2025-07-09
Method:X-RAY DIFFRACTION (2.294 Å)
Cite:Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00249
To Be Published
9FWI
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BU of 9fwi by Molmil
Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00025
Descriptor: (3-oxidanylazetidin-1-yl)-phenyl-methanone, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ...
Authors:Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W.
Deposit date:2024-06-30
Release date:2025-07-09
Method:X-RAY DIFFRACTION (1.533 Å)
Cite:Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00025
To Be Published
9FWL
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BU of 9fwl by Molmil
Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00025
Descriptor: 3-phenylthiophene-2-carboxamide, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ...
Authors:Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W.
Deposit date:2024-06-30
Release date:2025-07-09
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00025
To Be Published
9FWM
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BU of 9fwm by Molmil
Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00180
Descriptor: 1H-indole-3-carboxamide, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ...
Authors:Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W.
Deposit date:2024-06-30
Release date:2025-07-09
Method:X-RAY DIFFRACTION (1.574 Å)
Cite:Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00180
To Be Published
9FWP
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BU of 9fwp by Molmil
Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00198
Descriptor: Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, N-methylbenzamide, ...
Authors:Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W.
Deposit date:2024-06-30
Release date:2025-07-09
Method:X-RAY DIFFRACTION (2.381 Å)
Cite:Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00198
To Be Published
9FWU
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BU of 9fwu by Molmil
Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00421
Descriptor: DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, N,N-dimethyl-3-oxidanyl-benzamide, ...
Authors:Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W.
Deposit date:2024-06-30
Release date:2025-07-09
Method:X-RAY DIFFRACTION (1.425 Å)
Cite:Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00421
To Be Published
9FWJ
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BU of 9fwj by Molmil
Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00079
Descriptor: 2-methoxybenzamide, Guanine-N7 methyltransferase nsp14, MAGNESIUM ION, ...
Authors:Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W.
Deposit date:2024-06-30
Release date:2025-07-09
Method:X-RAY DIFFRACTION (2.424 Å)
Cite:Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00079
To Be Published
9FWS
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BU of 9fws by Molmil
Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00258
Descriptor: 7-METHOXY-1H-INDAZOLE, DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, ...
Authors:Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W.
Deposit date:2024-06-30
Release date:2025-07-09
Method:X-RAY DIFFRACTION (1.433 Å)
Cite:Crystal Structure of SARS-CoV-2 NSP10-NSP14 (ExoN) in complex with VT00258
To Be Published
9FWT
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BU of 9fwt by Molmil
Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00259
Descriptor: DIMETHYL SULFOXIDE, Guanine-N7 methyltransferase nsp14, Non-structural protein 10, ...
Authors:Krojer, T, Kozielski, F, Sele, C, Nyblom, M, Fisher, S.Z, Knecht, W.
Deposit date:2024-06-30
Release date:2025-07-09
Method:X-RAY DIFFRACTION (1.639 Å)
Cite:Ensemble model of ligand-free SARS-CoV-2 NSP10-NSP14 (ExoN) and in complex with partially bound VT00259
To Be Published
6SE4
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BU of 6se4 by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with (+)-JD1, an Organometallic BET Bromodomain Inhibitor
Descriptor: (+)-JD1, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ...
Authors:Krojer, T, Hassell-Hart, S, Picaud, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Filippakopoulos, P, Spencer, J, von Delft, F, Structural Genomics Consortium (SGC)
Deposit date:2019-07-29
Release date:2019-08-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Crystal Structure of the first bromodomain of human BRD4 in complex with (+)-JD1, an Organometallic BET Bromodomain Inhibitor
To Be Published
5MQ4
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BU of 5mq4 by Molmil
Crystal Structure of the leucine zipper of human PRKCBP1
Descriptor: Protein kinase C-binding protein 1, SULFATE ION, ZINC ION
Authors:Krojer, T, Savitsky, P, Picaud, S, Newman, J, Tallant, C, Heroven, C, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Filippakopoulos, P.
Deposit date:2016-12-20
Release date:2017-01-25
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of the leucine zipper of human PRKCBP1
To Be Published
4DIP
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BU of 4dip by Molmil
Crystal structure of human Peptidyl-prolyl cis-trans isomerase FKBP14
Descriptor: PHOSPHATE ION, Peptidyl-prolyl cis-trans isomerase FKBP14, SODIUM ION
Authors:Krojer, T, Kiyani, W, Goubin, S, Muniz, J.R.C, Filippakopoulos, P, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Oppermann, U, Zschocke, J, Yue, W.W, Structural Genomics Consortium (SGC)
Deposit date:2012-01-31
Release date:2012-02-22
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal structure of human Peptidyl-prolyl cis-trans isomerase FKBP14
To be Published
3MH5
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BU of 3mh5 by Molmil
HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular cues
Descriptor: DIISOPROPYL PHOSPHONATE, Protease do
Authors:Krojer, T, Sawa, J, Huber, R, Clausen, T.
Deposit date:2010-04-07
Release date:2010-06-30
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues
Nat.Struct.Mol.Biol., 17, 2010

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