Author results

5JEA
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STRUCTURE OF A CYTOPLASMIC 11-SUBUNIT RNA EXOSOME COMPLEX INCLUDING SKI7, BOUND TO RNA
Descriptor:Exosome complex component RRP45, Exosome complex component SKI6, Exosome complex component RRP43, ...
Authors:Kowalinski, E., Ebert, J., Stegmann, E., Conti, E.
Deposit date:2016-04-18
Release date:2016-07-13
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex.
Mol.Cell, 63, 2016
4ZKD
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CRYSTAL STRUCTURE OF THE S. CEREVISIAE SKI7 GTPASE-LIKE DOMAIN, BOUND TO GDP AND INORGANIC PHOSPHATE.
Descriptor:Superkiller protein 7, PHOSPHATE ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Kowalinski, E., Conti, E.
Deposit date:2015-04-30
Release date:2015-06-17
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (2.181 Å)
Cite:Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases.
Structure, 23, 2015
4ZKE
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CRYSTAL STRUCTURE OF THE S. CEREVISIAE SKI7 GTPASE-LIKE DOMAIN, BOUND TO GTP.
Descriptor:Superkiller protein 7, MAGNESIUM ION, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Kowalinski, E., Conti, E.
Deposit date:2015-04-30
Release date:2015-06-17
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases.
Structure, 23, 2015
2Q8K
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THE CRYSTAL STRUCTURE OF EBP1
Descriptor:Proliferation-associated protein 2G4, SULFATE ION, GLYCEROL
Authors:Kowalinski, E., Bange, G., Wild, K., Sinning, I.
Deposit date:2007-06-11
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions.
Febs Lett., 581, 2007
4A2P
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STRUCTURE OF DUCK RIG-I HELICASE DOMAIN
Descriptor:RETINOIC ACID INDUCIBLE PROTEIN I
Authors:Kowalinski, E., Lunardi, T., McCarthy, A.A., Cusack, S.
Deposit date:2011-09-28
Release date:2011-10-19
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for the Activation of Innate Immune Pattern Recognition Receptor Rig-I by Viral RNA.
Cell(Cambridge,Mass.), 147, 2011
4A2Q
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STRUCTURE OF DUCK RIG-I TANDEM CARDS AND HELICASE DOMAIN
Descriptor:RETINOIC ACID INDUCIBLE PROTEIN I
Authors:Kowalinski, E., Lunardi, T., McCarthy, A.A., Cusack, S.
Deposit date:2011-09-28
Release date:2011-10-19
Last modified:2012-02-08
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural Basis for the Activation of Innate Immune Pattern Recognition Receptor Rig-I by Viral RNA.
Cell(Cambridge,Mass.), 147, 2011
4A2V
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STRUCTURE OF DUCK RIG-I C-TERMINAL DOMAIN (CTD)
Descriptor:RETINOIC ACID INDUCIBLE PROTEIN I, ZINC ION, GLYCEROL
Authors:Kowalinski, E., Lunardi, T., McCarthy, A.A., Cusack, S.
Deposit date:2011-09-29
Release date:2011-10-19
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structural Basis for the Activation of Innate Immune Pattern Recognition Receptor Rig-I by Viral RNA.
Cell(Cambridge,Mass.), 147, 2011
4A2W
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STRUCTURE OF FULL-LENGTH DUCK RIG-I
Descriptor:RETINOIC ACID INDUCIBLE PROTEIN I
Authors:Kowalinski, E., Lunardi, T., McCarthy, A.A., Cusack, S.
Deposit date:2011-09-29
Release date:2011-10-19
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural Basis for the Activation of Innate Immune Pattern Recognition Receptor Rig-I by Viral RNA.
Cell(Cambridge,Mass.), 147, 2011
4A2X
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STRUCTURE OF DUCK RIG-I C-TERMINAL DOMAIN (CTD) WITH 14-MER DSRNA
Descriptor:RETINOIC ACID INDUCIBLE PROTEIN I, 5'-R(*GP*GP*GP*AP*GP*AP*AP*CP*AP*AP*CP*GP*CP*GP)-3', 5'-R(*CP*GP*CP*GP*UP*UP*GP*UP*UP*CP*UP*CP*CP*CP)-3', ...
Authors:Kowalinski, E., Lunardi, T., McCarthy, A.A., Cusack, S.
Deposit date:2011-09-29
Release date:2011-10-19
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA.
Cell, 147, 2011
4A36
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STRUCTURE OF DUCK RIG-I HELICASE DOMAIN BOUND TO 19-MER DSRNA AND ATP TRANSITION STATE ANALOGUE
Descriptor:RETINOIC ACID INDUCIBLE PROTEIN I, 5'-R(*GP*CP*AP*UP*GP*CP*GP*AP*CP*CP*UP*CP*UP*GP *UP*UP*UP*GP*A)-3', 5'-R(*UP*CP*AP*AP*AP*CP*AP*GP*AP*GP*GP*UP*CP*GP *CP*AP*UP*GP*C)-3', ...
Authors:Kowalinski, E., Lunardi, T., McCarthy, A.A., Cusack, S.
Deposit date:2011-09-30
Release date:2011-10-19
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural Basis for the Activation of Innate Immune Pattern Recognition Receptor Rig-I by Viral RNA.
Cell(Cambridge,Mass.), 147, 2011
4AVG
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INFLUENZA STRAIN PH1N1 2009 POLYMERASE SUBUNIT PA ENDONUCLEASE IN COMPLEX WITH DIKETO COMPOUND 2
Descriptor:POLYMERASE PA, (Z)-4-[4-[(4-chlorophenyl)methyl]-1-(cyclohexylmethyl)piperidin-4-yl]-2-oxidanyl-4-oxidanylidene-but-2-enoic acid, MANGANESE (II) ION
Authors:Kowalinski, E., Zubieta, C., Wolkerstorfer, A., Szolar, O.H., Ruigrok, R.W., Cusack, S.
Deposit date:2012-05-25
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
4AVL
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INFLUENZA STRAIN PH1N1 2009 POLYMERASE SUBUNIT PA ENDONUCLEASE IN COMPLEX WITH DTMP
Descriptor:POLYMERASE PA, MANGANESE (II) ION, THYMIDINE-5'-PHOSPHATE
Authors:Kowalinski, E., Zubieta, C., Wolkerstorfer, A., Szolar, O.H.J., Ruigrok, R.W.H., Cusack, S.
Deposit date:2012-05-28
Release date:2012-08-22
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
4AVQ
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INFLUENZA STRAIN PH1N1 2009 POLYMERASE SUBUNIT PA ENDONUCLEASE
Descriptor:POLYMERASE PA, MANGANESE (II) ION, MAGNESIUM ION
Authors:Kowalinski, E., Zubieta, C., Wolkerstorfer, A., Szolar, O.H., Ruigrok, R.W., Cusack, S.
Deposit date:2012-05-29
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
4AWF
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INFLUENZA STRAIN PH1N1 2009 POLYMERASE SUBUNIT PA ENDONUCLEASE IN COMPLEX WITH 2 4-DIOXO-4-PHENYLBUTANOIC ACID DPBA
Descriptor:POLYMERASE PA, MANGANESE (II) ION, 2-4-DIOXO-4-PHENYLBUTANOIC ACID
Authors:Kowalinski, E., Zubieta, C., Wolkerstorfer, A., Szolar, O.H., Ruigrok, R.W., Cusack, S.
Deposit date:2012-06-03
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
4AWG
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INFLUENZA STRAIN PH1N1 2009 POLYMERASE SUBUNIT PA ENDONUCLEASE IN COMPLEX WITH DIKETO COMPOUND 3
Descriptor:POLYMERASE PA, SULFATE ION, (2Z)-4-[(3S)-1-benzyl-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid, ...
Authors:Kowalinski, E., Zubieta, C., Wolkerstorfer, A., Szolar, O.H., Ruigrok, R.W., Cusack, S.
Deposit date:2012-06-03
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
4AWH
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INFLUENZA STRAIN PH1N1 2009 POLYMERASE SUBUNIT PA ENDONUCLEASE IN COMPLEX WITH RUMP
Descriptor:POLYMERASE PA, MANGANESE (II) ION, URIDINE-5'-MONOPHOSPHATE
Authors:Kowalinski, E., Zubieta, C., Wolkerstorfer, A., Szolar, O.H., Ruigrok, R.W., Cusack, S.
Deposit date:2012-06-03
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
4AWK
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INFLUENZA STRAIN PH1N1 2009 POLYMERASE SUBUNIT PA ENDONUCLEASE IN COMPLEX WITH DIKETO COMPOUND 1
Descriptor:POLYMERASE PA, (2Z)-4-[(3S)-1-(benzylsulfonyl)-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid, MANGANESE (II) ION
Authors:Kowalinski, E., Zubieta, C., Wolkerstorfer, A., Szolar, O.H., Ruigrok, R.W., Cusack, S.
Deposit date:2012-06-04
Release date:2012-08-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
4AWM
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INFLUENZA STRAIN PH1N1 2009 POLYMERASE SUBUNIT PA ENDONUCLEASE IN COMPLEX WITH (-)-EPIGALLOCATECHIN GALLATE FROM GREEN TEA
Descriptor:POLYMERASE PA, MANGANESE (II) ION, (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
Authors:Kowalinski, E., Zubieta, C., Wolkerstorfer, A., Szolar, O.H., Ruigrok, R.W., Cusack, S.
Deposit date:2012-06-04
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
2VVP
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS RIBOSE-5-PHOSPHATE ISOMERASE B IN COMPLEX WITH ITS SUBSTRATES RIBOSE 5-PHOSPHATE AND RIBULOSE 5-PHOSPHATE
Descriptor:RIBOSE-5-PHOSPHATE ISOMERASE B, 5-O-phosphono-D-ribose, RIBULOSE-5-PHOSPHATE
Authors:Kowalinski, E., Roos, A.K., Mariano, S., Salmon, L., Mowbray, S.L.
Deposit date:2008-06-10
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:D-Ribose-5-Phosphate Isomerase B from Escherichia Coli is Also a Functional D-Allose-6-Phosphate Isomerase, While the Mycobacterium Tuberculosis Enzyme is not.
J.Mol.Biol., 382, 2008
2VVQ
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS RIBOSE-5-PHOSPHATE ISOMERASE B IN COMPLEX WITH THE INHIBITOR 5-DEOXY-5-PHOSPHO-D- RIBONATE
Descriptor:RIBOSE-5-PHOSPHATE ISOMERASE B, 5-O-phosphono-D-ribonic acid, SULFATE ION
Authors:Kowalinski, E., Roos, A.K., Mariano, S., Salmon, L., Mowbray, S.L.
Deposit date:2008-06-10
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:D-Ribose-5-Phosphate Isomerase B from Escherichia Coli is Also a Functional D-Allose-6-Phosphate Isomerase, While the Mycobacterium Tuberculosis Enzyme is not.
J.Mol.Biol., 382, 2008
5MC6
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CRYO-EM STRUCTURE OF A NATIVE RIBOSOME-SKI2-SKI3-SKI8 COMPLEX FROM S. CEREVISIAE
Descriptor:18S ribosomal RNA, 40S ribosomal protein S3, 40S ribosomal protein S5, ...
Authors:Schmidt, C., Kowalinski, E., Shanmuganathan, V., Defenouillere, Q., Braunger, K., Heuer, A., Pech, M., Namane, A., Berninghausen, O., Fromont-Racine, M., Jacquier, A., Conti, E., Becker, T., Beckmann, R.
Deposit date:2016-11-09
Release date:2017-01-18
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
Science, 354, 2016
2VVO
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS RIBOSE-5-PHOSPHATE ISOMERASE B IN COMPLEX WITH ALPHA D-ALLOSE 6-PHOSPHATE
Descriptor:RIBOSE-5-PHOSPHATE ISOMERASE B, 6-O-phosphono-alpha-D-allopyranose
Authors:Roos, A.K., Mariano, S., Kowalinski, E., Salmon, L., Mowbray, S.L.
Deposit date:2008-06-10
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:D-Ribose-5-Phosphate Isomerase B from Escherichia Coli is Also a Functional D-Allose-6-Phosphate Isomerase, While the Mycobacterium Tuberculosis Enzyme is not.
J.Mol.Biol., 382, 2008
6FLM
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CRYSTAL STRUCTURE OF THE HUMAN TRIM25 PRYSPRY DOMAIN
Descriptor:E3 ubiquitin/ISG15 ligase TRIM25, SULFATE ION, CHLORIDE ION
Authors:Cusack, S., Kowalinski, E.
Deposit date:2018-01-26
Release date:2018-05-23
Method:X-RAY DIFFRACTION (2.009 Å)
Cite:Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Nat Commun, 9, 2018
2VVR
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CRYSTAL STRUCTURE OF THE H99N MUTANT OF RIBOSE-5-PHOSPHATE ISOMERASE B FROM E. COLI SOAKED WITH RIBOSE 5-PHOSPHATE
Descriptor:RIBOSE-5-PHOSPHATE ISOMERASE B
Authors:Roos, A.K., Mowbray, S.L.
Deposit date:2008-06-11
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:D-Ribose-5-Phosphate Isomerase B from Escherichia Coli is Also a Functional D-Allose-6-Phosphate Isomerase, While the Mycobacterium Tuberculosis Enzyme is not.
J.Mol.Biol., 382, 2008
5NT1
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COMPLEX OF INFLUENZA A NS1 EFFECTOR DOMAIN WITH TRIM25 COILED COIL
Descriptor:E3 ubiquitin/ISG15 ligase TRIM25, Non-structural protein 1
Authors:Koliopoulos, M.G., Rittinger, K.
Deposit date:2017-04-27
Release date:2018-05-16
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Nat Commun, 9, 2018
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