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5JEA
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BU of 5jea by Molmil
Structure of a cytoplasmic 11-subunit RNA exosome complex including Ski7, bound to RNA
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Exosome complex component CSL4, Exosome complex component MTR3, ...
Authors:Kowalinski, E, Ebert, J, Stegmann, E, Conti, E.
Deposit date:2016-04-18
Release date:2016-07-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex.
Mol.Cell, 63, 2016
2Q8K
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BU of 2q8k by Molmil
The crystal structure of Ebp1
Descriptor: GLYCEROL, Proliferation-associated protein 2G4, SULFATE ION
Authors:Kowalinski, E, Bange, G, Wild, K, Sinning, I.
Deposit date:2007-06-11
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions.
Febs Lett., 581, 2007
4ZKE
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BU of 4zke by Molmil
Crystal structure of the S. cerevisiae Ski7 GTPase-like domain, bound to GTP.
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SODIUM ION, ...
Authors:Kowalinski, E, Conti, E.
Deposit date:2015-04-30
Release date:2015-06-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases.
Structure, 23, 2015
4ZKD
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BU of 4zkd by Molmil
Crystal structure of the S. cerevisiae Ski7 GTPase-like domain, bound to GDP and inorganic phosphate.
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Kowalinski, E, Conti, E.
Deposit date:2015-04-30
Release date:2015-06-17
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (2.181 Å)
Cite:Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases.
Structure, 23, 2015
4A2Q
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BU of 4a2q by Molmil
Structure of duck RIG-I tandem CARDs and helicase domain
Descriptor: RETINOIC ACID INDUCIBLE PROTEIN I
Authors:Kowalinski, E, Lunardi, T, McCarthy, A.A, Cusack, S.
Deposit date:2011-09-28
Release date:2011-10-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural Basis for the Activation of Innate Immune Pattern Recognition Receptor Rig-I by Viral RNA.
Cell(Cambridge,Mass.), 147, 2011
4A2P
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BU of 4a2p by Molmil
Structure of duck RIG-I helicase domain
Descriptor: RETINOIC ACID INDUCIBLE PROTEIN I
Authors:Kowalinski, E, Lunardi, T, McCarthy, A.A, Cusack, S.
Deposit date:2011-09-28
Release date:2011-10-19
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for the Activation of Innate Immune Pattern Recognition Receptor Rig-I by Viral RNA.
Cell(Cambridge,Mass.), 147, 2011
4A2V
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BU of 4a2v by Molmil
Structure of duck RIG-I C-terminal domain (CTD)
Descriptor: GLYCEROL, RETINOIC ACID INDUCIBLE PROTEIN I, ZINC ION
Authors:Kowalinski, E, Lunardi, T, McCarthy, A.A, Cusack, S.
Deposit date:2011-09-29
Release date:2011-10-19
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structural Basis for the Activation of Innate Immune Pattern Recognition Receptor Rig-I by Viral RNA.
Cell(Cambridge,Mass.), 147, 2011
4A2W
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BU of 4a2w by Molmil
Structure of full-length duck RIG-I
Descriptor: RETINOIC ACID INDUCIBLE PROTEIN I
Authors:Kowalinski, E, Lunardi, T, McCarthy, A.A, Cusack, S.
Deposit date:2011-09-29
Release date:2011-10-19
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural Basis for the Activation of Innate Immune Pattern Recognition Receptor Rig-I by Viral RNA.
Cell(Cambridge,Mass.), 147, 2011
4A2X
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BU of 4a2x by Molmil
Structure of duck RIG-I C-terminal domain (CTD) with 14-mer dSRNA
Descriptor: 5'-R(*CP*GP*CP*GP*UP*UP*GP*UP*UP*CP*UP*CP*CP*CP)-3', 5'-R(*GP*GP*GP*AP*GP*AP*AP*CP*AP*AP*CP*GP*CP*GP)-3', RETINOIC ACID INDUCIBLE PROTEIN I, ...
Authors:Kowalinski, E, Lunardi, T, McCarthy, A.A, Cusack, S.
Deposit date:2011-09-29
Release date:2011-10-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA.
Cell, 147, 2011
4A36
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BU of 4a36 by Molmil
Structure of duck RIG-I helicase domain bound to 19-mer dsRNA and ATP transition state analogue
Descriptor: 5'-R(*GP*CP*AP*UP*GP*CP*GP*AP*CP*CP*UP*CP*UP*GP *UP*UP*UP*GP*A)-3', 5'-R(*UP*CP*AP*AP*AP*CP*AP*GP*AP*GP*GP*UP*CP*GP *CP*AP*UP*GP*C)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Kowalinski, E, Lunardi, T, McCarthy, A.A, Cusack, S.
Deposit date:2011-09-30
Release date:2011-10-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural Basis for the Activation of Innate Immune Pattern Recognition Receptor Rig-I by Viral RNA.
Cell(Cambridge,Mass.), 147, 2011
4AVL
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BU of 4avl by Molmil
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with dTMP
Descriptor: MANGANESE (II) ION, POLYMERASE PA, THYMIDINE-5'-PHOSPHATE
Authors:Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H.J, Ruigrok, R.W.H, Cusack, S.
Deposit date:2012-05-28
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
4AVG
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BU of 4avg by Molmil
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 2
Descriptor: (Z)-4-[4-[(4-chlorophenyl)methyl]-1-(cyclohexylmethyl)piperidin-4-yl]-2-oxidanyl-4-oxidanylidene-but-2-enoic acid, MANGANESE (II) ION, POLYMERASE PA
Authors:Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S.
Deposit date:2012-05-25
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
4AVQ
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BU of 4avq by Molmil
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease
Descriptor: MAGNESIUM ION, MANGANESE (II) ION, POLYMERASE PA
Authors:Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S.
Deposit date:2012-05-29
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
4AWK
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BU of 4awk by Molmil
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1
Descriptor: (2Z)-4-[(3S)-1-(benzylsulfonyl)-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid, MANGANESE (II) ION, POLYMERASE PA
Authors:Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S.
Deposit date:2012-06-04
Release date:2012-08-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
4AWH
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BU of 4awh by Molmil
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with rUMP
Descriptor: MANGANESE (II) ION, POLYMERASE PA, URIDINE-5'-MONOPHOSPHATE
Authors:Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S.
Deposit date:2012-06-03
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
4AWG
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BU of 4awg by Molmil
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 3
Descriptor: (2Z)-4-[(3S)-1-benzyl-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid, MANGANESE (II) ION, POLYMERASE PA, ...
Authors:Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S.
Deposit date:2012-06-03
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
4AWM
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BU of 4awm by Molmil
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with (-)-epigallocatechin gallate from green tea
Descriptor: (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, MANGANESE (II) ION, POLYMERASE PA
Authors:Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S.
Deposit date:2012-06-04
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
4AWF
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BU of 4awf by Molmil
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with 2 4-dioxo-4-phenylbutanoic acid DPBA
Descriptor: 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MANGANESE (II) ION, POLYMERASE PA
Authors:Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S.
Deposit date:2012-06-03
Release date:2012-08-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
Plos Pathog., 8, 2012
2VVQ
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BU of 2vvq by Molmil
Crystal structure of Mycobacterium tuberculosis ribose-5-phosphate isomerase B in complex with the inhibitor 5-deoxy-5-phospho-D- ribonate
Descriptor: 5-O-phosphono-D-ribonic acid, RIBOSE-5-PHOSPHATE ISOMERASE B, SULFATE ION
Authors:Kowalinski, E, Roos, A.K, Mariano, S, Salmon, L, Mowbray, S.L.
Deposit date:2008-06-10
Release date:2008-07-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:D-Ribose-5-Phosphate Isomerase B from Escherichia Coli is Also a Functional D-Allose-6-Phosphate Isomerase, While the Mycobacterium Tuberculosis Enzyme is not.
J.Mol.Biol., 382, 2008
2VVP
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BU of 2vvp by Molmil
Crystal structure of Mycobacterium tuberculosis ribose-5-phosphate isomerase B in complex with its substrates ribose 5-phosphate and ribulose 5-phosphate
Descriptor: 5-O-phosphono-D-ribose, RIBOSE-5-PHOSPHATE ISOMERASE B, RIBULOSE-5-PHOSPHATE
Authors:Kowalinski, E, Roos, A.K, Mariano, S, Salmon, L, Mowbray, S.L.
Deposit date:2008-06-10
Release date:2008-07-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:D-Ribose-5-Phosphate Isomerase B from Escherichia Coli is Also a Functional D-Allose-6-Phosphate Isomerase, While the Mycobacterium Tuberculosis Enzyme is not.
J.Mol.Biol., 382, 2008
5MC6
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BU of 5mc6 by Molmil
Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Schmidt, C, Kowalinski, E, Shanmuganathan, V, Defenouillere, Q, Braunger, K, Heuer, A, Pech, M, Namane, A, Berninghausen, O, Fromont-Racine, M, Jacquier, A, Conti, E, Becker, T, Beckmann, R.
Deposit date:2016-11-09
Release date:2017-01-18
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
Science, 354, 2016
8AW3
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BU of 8aw3 by Molmil
Cryo-EM structure of the Tb ADAT2/3 deaminase in complex with tRNA
Descriptor: Deaminase, putative, RNA (75-MER), ...
Authors:Dolce, L.G, Tengo, L, Weis, F, Kowalinski, E.
Deposit date:2022-08-29
Release date:2022-11-16
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for sequence-independent substrate selection by eukaryotic wobble base tRNA deaminase ADAT2/3.
Nat Commun, 13, 2022
8CDP
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BU of 8cdp by Molmil
Cryo-EM structure of the RESC1-RESC2 complex
Descriptor: Guide_RNA_associated_protein_-_putative, Mitochondrial guide RNA binding complex subunit 2
Authors:Dolce, L.G, Weis, F, Kowalinski, E.
Deposit date:2023-01-31
Release date:2023-03-29
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for guide RNA selection by the RESC1-RESC2 complex.
Nucleic Acids Res., 51, 2023
8QCB
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BU of 8qcb by Molmil
CryoEM structure of a S. Cerevisiae Ski2387 complex in the open state
Descriptor: Antiviral helicase SKI2, Antiviral protein SKI8, Superkiller protein 3, ...
Authors:Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E.
Deposit date:2023-08-25
Release date:2023-11-08
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly.
Mol.Cell, 83, 2023
8QCA
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BU of 8qca by Molmil
CryoEM structure of a S. Cerevisiae Ski2387 complex in the closed state bound to RNA
Descriptor: Antiviral helicase SKI2, Antiviral protein SKI8, RNA (5'-R(P*UP*UP*UP*U)-3'), ...
Authors:Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E.
Deposit date:2023-08-25
Release date:2023-11-15
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly.
Mol.Cell, 83, 2023

 

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