Author results

6P6F
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BG505 SOSIP-I53-50NP
Descriptor:I53-50A.1NT1, I53-50B.4PT1
Authors:Berndsen, Z.T., Ward, A.B.
Deposit date:2019-06-03
Release date:2019-06-19
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle.
Nat Commun, 10, 2019
6MSR
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CRYSTAL STRUCTURE OF PRO-2.5
Descriptor:pRO-2.5
Authors:Bick, M.J., Boyken, S.E., Baker, D.
Deposit date:2018-10-17
Release date:2019-05-08
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:De novo design of tunable, pH-driven conformational changes.
Science, 364, 2019
6MSQ
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CRYSTAL STRUCTURE OF PRO-2.3
Descriptor:pRO-2.3
Authors:Boyken, S.E., Bick, M.J., Baker, D.
Deposit date:2018-10-17
Release date:2019-05-08
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:De novo design of tunable, pH-driven conformational changes.
Science, 364, 2019
5KP9
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STRUCTURE OF NANOPARTICLE RELEASED FROM ENVELOPED PROTEIN NANOPARTICLE
Descriptor:EPN-01*
Authors:Votteler, J., Ogohara, C., Yi, S., Hsia, Y., Natterman, U., Belnap, D.M., King, N.P., Sundquist, W.I.
Deposit date:2016-07-02
Release date:2016-12-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Designed proteins induce the formation of nanocage-containing extracellular vesicles.
Nature, 540, 2016
5IM6
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CRYSTAL STRUCTURE OF DESIGNED TWO-COMPONENT SELF-ASSEMBLING ICOSAHEDRAL CAGE I32-28
Descriptor:Designed self-assembling icosahedral cage I32-28 trimeric subunit, Designed self-assembling icosahedral cage I32-28 dimeric subunit
Authors:Liu, Y.A., Cascio, D., Sawaya, M.R., Bale, J.B., Collazo, M.J., Thomas, C., Sheffler, W., King, N.P., Baker, D., Yeates, T.O.
Deposit date:2016-03-05
Release date:2016-07-27
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (5.588 Å)
Cite:Accurate design of megadalton-scale two-component icosahedral protein complexes.
Science, 353, 2016
5IM5
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CRYSTAL STRUCTURE OF DESIGNED TWO-COMPONENT SELF-ASSEMBLING ICOSAHEDRAL CAGE I53-40
Descriptor:Designed Riboflavin synthase, Designed Keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase
Authors:Liu, Y.A., Cascio, D., Sawaya, M.R., Bale, J.B., Collazo, M.J., Thomas, C., Sheffler, W., King, N.P., Baker, D., Yeates, T.O.
Deposit date:2016-03-05
Release date:2016-07-27
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (3.699 Å)
Cite:Accurate design of megadalton-scale two-component icosahedral protein complexes.
Science, 353, 2016
5IM4
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CRYSTAL STRUCTURE OF DESIGNED TWO-COMPONENT SELF-ASSEMBLING ICOSAHEDRAL CAGE I52-32
Descriptor:6,7-dimethyl-8-ribityllumazine synthase, Phosphotransferase system, mannose/fructose-specific component IIA
Authors:Liu, Y.A., Cascio, D., Sawaya, M.R., Bale, J.B., Collazo, M.J., Thomas, C., Sheffler, W., King, N.P., Baker, D., Yeates, T.O.
Deposit date:2016-03-05
Release date:2016-07-27
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Accurate design of megadalton-scale two-component icosahedral protein complexes.
Science, 353, 2016
4ZK7
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CRYSTAL STRUCTURE OF RESCUED TWO-COMPONENT SELF-ASSEMBLING TETRAHEDRAL CAGE T33-31
Descriptor:Chorismate mutase, Divalent-cation tolerance protein CutA
Authors:Liu, Y., Cascio, D., Sawaya, M.R., Bale, J., Collazo, M.J., Park, R., King, N., Baker, D., Yeates, T.
Deposit date:2015-04-30
Release date:2015-07-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression.
Protein Sci., 24, 2015
4NWR
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COMPUTATIONALLY DESIGNED TWO-COMPONENT SELF-ASSEMBLING TETRAHEDRAL CAGE T33-28
Descriptor:integron gene cassette protein, Macrophage migration inhibitory factor-like protein
Authors:McNamara, D.E., King, N.P., Bale, J.B., Sheffler, W., Baker, D., Yeates, T.O.
Deposit date:2013-12-06
Release date:2014-05-28
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Accurate design of co-assembling multi-component protein nanomaterials.
Nature, 510, 2014
4NWQ
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COMPUTATIONALLY DESIGNED TWO-COMPONENT SELF-ASSEMBLING TETRAHEDRAL CAGE, T33-21, CRYSTALLIZED IN SPACE GROUP F4132
Descriptor:Putative uncharacterized protein PH0671, Uncharacterized protein, SULFATE ION
Authors:McNamara, D.E., King, N.P., Bale, J.B., Sheffler, W., Baker, D., Yeates, T.O.
Deposit date:2013-12-06
Release date:2014-05-28
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Accurate design of co-assembling multi-component protein nanomaterials.
Nature, 510, 2014
4NWP
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COMPUTATIONALLY DESIGNED TWO-COMPONENT SELF-ASSEMBLING TETRAHEDRAL CAGE, T33-21, CRYSTALLIZED IN SPACE GROUP R32
Descriptor:Putative uncharacterized protein, Uncharacterized protein, SULFATE ION, ...
Authors:McNamara, D.E., King, N.P., Bale, J.B., Sheffler, W., Baker, D., Yeates, T.O.
Deposit date:2013-12-06
Release date:2014-05-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Accurate design of co-assembling multi-component protein nanomaterials.
Nature, 510, 2014
4NWO
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COMPUTATIONALLY DESIGNED TWO-COMPONENT SELF-ASSEMBLING TETRAHEDRAL CAGE T33-15
Descriptor:Molybdenum cofactor biosynthesis protein MogA, Chorismate mutase AroH, CALCIUM ION
Authors:McNamara, D.E., King, N.P., Bale, J.B., Sheffler, W., Baker, D., Yeates, T.O.
Deposit date:2013-12-06
Release date:2014-05-28
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Accurate design of co-assembling multi-component protein nanomaterials.
Nature, 510, 2014
4NWN
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COMPUTATIONALLY DESIGNED TWO-COMPONENT SELF-ASSEMBLING TETRAHEDRAL CAGE T32-28
Descriptor:Uncharacterized protein, Propanediol utilization: polyhedral bodies pduT
Authors:McNamara, D.E., King, N.P., Bale, J.B., Sheffler, W., Baker, D., Yeates, T.O.
Deposit date:2013-12-06
Release date:2014-05-28
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Accurate design of co-assembling multi-component protein nanomaterials.
Nature, 510, 2014
4GXZ
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CRYSTAL STRUCTURE OF A PERIPLASMIC THIOREDOXIN-LIKE PROTEIN FROM SALMONELLA ENTERICA SEROVAR TYPHIMURIUM
Descriptor:Suppression of copper sensitivity protein
Authors:Shepherd, M., Heras, B., King, G.J., Argente, M.P., Achard, M.E.S., King, N.P., McEwan, A.G., Schembri, M.A.
Deposit date:2012-09-04
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural and functional characterization of ScsC, a periplasmic thioredoxin-like protein from Salmonella enterica serovar Typhimurium
Antioxid Redox Signal, 19, 2013
4EGG
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COMPUTATIONALLY DESIGNED SELF-ASSEMBLING TETRAHEDRON PROTEIN, T310
Descriptor:Putative acetyltransferase SACOL2570, GLYCEROL
Authors:Sawaya, M.R., King, N.P., Sheffler, W., Baker, D., Yeates, T.O.
Deposit date:2012-03-30
Release date:2012-05-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Computational design of self-assembling protein nanomaterials with atomic level accuracy.
Science, 336, 2012
4DDF
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COMPUTATIONALLY DESIGNED SELF-ASSEMBLING OCTAHEDRAL CAGE PROTEIN, O333, CRYSTALLIZED IN SPACE GROUP P4
Descriptor:Propanediol utilization polyhedral body protein PduT, SULFATE ION, CHLORIDE ION
Authors:Sawaya, M.R., King, N.P., Sheffler, W., Baker, D., Yeates, T.O.
Deposit date:2012-01-18
Release date:2012-06-06
Last modified:2012-06-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Computational design of self-assembling protein nanomaterials with atomic level accuracy.
Science, 336, 2012
4DCL
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COMPUTATIONALLY DESIGNED SELF-ASSEMBLING TETRAHEDRON PROTEIN, T308, CRYSTALLIZED IN SPACE GROUP F23
Descriptor:Putative acetyltransferase SACOL2570
Authors:Sawaya, M.R., King, N.P., Sheffler, W., Baker, D., Yeates, T.O.
Deposit date:2012-01-17
Release date:2012-06-06
Last modified:2012-06-13
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Computational design of self-assembling protein nanomaterials with atomic level accuracy.
Science, 336, 2012
3VCD
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COMPUTATIONALLY DESIGNED SELF-ASSEMBLING OCTAHEDRAL CAGE PROTEIN, O333, CRYSTALLIZED IN SPACE GROUP R32
Descriptor:Propanediol utilization polyhedral body protein PduT, SULFATE ION, CHLORIDE ION
Authors:Sawaya, M.R., King, N.P., Sheffler, W., Baker, D., Yeates, T.O.
Deposit date:2012-01-03
Release date:2012-06-06
Last modified:2012-06-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Computational design of self-assembling protein nanomaterials with atomic level accuracy.
Science, 336, 2012
3MLI
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2OUF-DS, A DISULFIDE-LINKED DIMER OF HELICOBACTER PYLORI PROTEIN HP0242
Descriptor:Putative uncharacterized protein, CALCIUM ION
Authors:King, N.P., Sawaya, M.R., Jacobitz, A.W., Yeates, T.O.
Deposit date:2010-04-16
Release date:2010-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure and folding of a designed knotted protein.
Proc.Natl.Acad.Sci.USA, 107, 2010
3MLG
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2OUF-2X, A DESIGNED KNOTTED PROTEIN
Descriptor:2X chimera of Helicobacter pylori protein HP0242
Authors:King, N.P., Sawaya, M.R., Jacobitz, A.W., Yeates, T.O.
Deposit date:2010-04-16
Release date:2010-05-12
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structure and folding of a designed knotted protein.
Proc.Natl.Acad.Sci.USA, 107, 2010
2VH6
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STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH BIARYL P4 MOTIFS
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, ACTIVATED FACTOR XA LIGHT CHAIN, 2-(5-chlorothiophen-2-yl)-N-{(3S)-1-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-2-oxopyrrolidin-3-yl}ethanesulfonamide
Authors:Young, R.J., Borthwick, A.D., Brown, D., Burns-Kurtis, C.L., Campbell, M., Chan, C., Charbaut, M., Chung, C.W., Convery, M.A., Kelly, H.A., King, N.P., Kleanthous, S., Mason, A.M., Pateman, A.J., Patikis, A.N., Pinto, I.L., Pollard, D.R., Senger, S., Shah, G.P., Toomey, J.R., Watson, N.S., Weston, H.E.
Deposit date:2007-11-19
Release date:2008-12-16
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and Property Based Design of Factor Xa Inhibitors: Pyrrolidin-2-Ones with Biaryl P4 Motifs.
Bioorg.Med.Chem.Lett., 18, 2008
2VH0
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STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS:BIARYL PYRROLIDIN-2-ONES INCORPORATING BASIC HETEROCYCLIC MOTIFS
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, ACTIVATED FACTOR XA LIGHT CHAIN, CALCIUM ION, ...
Authors:Young, R.J., Borthwick, A.D., Brown, D., Burns-Kurtis, C.L., Campbell, M., Chan, C., Charbaut, M., Convery, M.A., Diallo, H., Hortense, E., Irving, W.R., Kelly, H.A., King, N.P., Kleanthous, S., Mason, A.M., Pateman, A.J., Patikis, A., Pinto, I.L., Pollard, D.R., Senger, S., Shah, G.P., Toomey, J.R., Watson, N.S., Weston, H.E., Zhou, P.
Deposit date:2007-11-16
Release date:2008-11-25
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs.
Bioorg. Med. Chem. Lett., 18, 2008
2RIH
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CBS DOMAIN PROTEIN PAE2072 FROM PYROBACULUM AEROPHILUM
Descriptor:Conserved protein with 2 CBS domains, SULFATE ION, ACETIC ACID
Authors:Lee, T.M., King, N.P., Sawaya, M.R., Cascio, D., Yeates, T.O.
Deposit date:2007-10-10
Release date:2008-06-17
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures and Functional Implications of an AMP-Binding Cystathionine beta-Synthase Domain Protein from a Hyperthermophilic Archaeon
J.Mol.Biol., 380, 2008
2RIF
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CBS DOMAIN PROTEIN PAE2072 FROM PYROBACULUM AEROPHILUM COMPLEXED WITH AMP
Descriptor:Conserved protein with 2 CBS domains, CESIUM ION, ADENOSINE MONOPHOSPHATE
Authors:Lee, T.M., King, N.P., Sawaya, M.R., Cascio, D., Yeates, T.O.
Deposit date:2007-10-10
Release date:2008-06-17
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structures and Functional Implications of an AMP-Binding Cystathionine beta-Synthase Domain Protein from a Hyperthermophilic Archaeon.
J.Mol.Biol., 380, 2008
2CJI
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CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, CALCIUM ION, ...
Authors:Watson, N.S., Campbell, M., Chan, C., Convery, M.A., Hamblin, J.N., Kelly, H.A., King, N.P., Mason, A.M., Mitchell, C., Patel, V.K., Senger, S., Shah, G.P., Weston, H.E., Whitworth, C., Young, R.J.
Deposit date:2006-04-03
Release date:2006-05-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design and Synthesis of Orally Active Pyrrolidin-2-One-Based Factor Xa Inhibitors
Bioorg.Med.Chem.Lett., 16, 2006