Author results

1JEZ
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THE STRUCTURE OF XYLOSE REDUCTASE, A DIMERIC ALDO-KETO REDUCTASE FROM CANDIDA TENUIS
Descriptor:XYLOSE REDUCTASE
Authors:Kavanagh, K.L., Klimacek, M., Nidetzky, B., Wilson, D.K.
Deposit date:2001-06-19
Release date:2002-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of apo and holo forms of xylose reductase, a dimeric aldo-keto reductase from Candida tenuis.
Biochemistry, 41, 2002
1K8C
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CRYSTAL STRUCTURE OF DIMERIC XYLOSE REDUCTASE IN COMPLEX WITH NADP(H)
Descriptor:xylose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Kavanagh, K.L., Klimacek, M., Nidetzky, B., Wilson, D.K.
Deposit date:2001-10-23
Release date:2002-07-05
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of apo and holo forms of xylose reductase, a dimeric aldo-keto reductase from Candida tenuis.
Biochemistry, 41, 2002
1LJ8
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CRYSTAL STRUCTURE OF MANNITOL DEHYDROGENASE IN COMPLEX WITH NAD
Descriptor:mannitol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kavanagh, K.L., Klimacek, M., Nidetzky, B., Wilson, D.K.
Deposit date:2002-04-19
Release date:2002-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of Pseudomonas fluorescens mannitol 2-dehydrogenase binary and ternary complexes. Specificity and catalytic mechanism
J.Biol.Chem., 277, 2002
1M2W
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PSEUDOMONAS FLUORESCENS MANNITOL 2-DEHYDROGENASE TERNARY COMPLEX WITH NAD AND D-MANNITOL
Descriptor:mannitol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, D-MANNITOL
Authors:Kavanagh, K.L., Klimacek, M., Nidetzky, B., Wilson, D.K.
Deposit date:2002-06-25
Release date:2002-11-15
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Pseudomonas fluorescens Mannitol 2-Dehydrogenase Binary and Ternary Complexes. Specificity and Catalytic Mechanism
J.Biol.Chem., 277, 2002
1MI3
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1.8 ANGSTROM STRUCTURE OF XYLOSE REDUCTASE FROM CANDIDA TENUIS IN COMPLEX WITH NAD
Descriptor:xylose reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kavanagh, K.L., Klimacek, M., Nidetzky, B., Wilson, D.K.
Deposit date:2002-08-21
Release date:2003-08-05
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of xylose reductase bound to NAD+ and the basis for single and dual co-substrate specificity in family 2 aldo-keto reductases
Biochem.J., 373, 2003
1PZE
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T.GONDII LDH1 APO FORM
Descriptor:lactate dehydrogenase
Authors:Kavanagh, K.L., Elling, R.A., Wilson, D.K.
Deposit date:2003-07-10
Release date:2004-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use.
Biochemistry, 43, 2004
1PZF
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T.GONDII LDH1 TERNARY COMPLEX WITH APAD+ AND OXALATE
Descriptor:lactate dehydrogenase, OXALATE ION, 3-ACETYLPYRIDINE ADENINE DINUCLEOTIDE
Authors:Kavanagh, K.L., Elling, R.A., Wilson, D.K.
Deposit date:2003-07-10
Release date:2004-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use.
Biochemistry, 43, 2004
1PZG
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T.GONDII LDH1 COMPLEXED WITH APAD AND SULFATE AT 1.6 ANGSTROMS
Descriptor:lactate dehydrogenase, SULFATE ION, 3-ACETYLPYRIDINE ADENINE DINUCLEOTIDE
Authors:Kavanagh, K.L., Elling, R.A., Wilson, D.K.
Deposit date:2003-07-10
Release date:2004-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use.
Biochemistry, 43, 2004
1PZH
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T.GONDII LDH1 TERNARY COMPLEX WITH NAD AND OXALATE
Descriptor:lactate dehydrogenase, OXALATE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kavanagh, K.L., Elling, R.A., Wilson, D.K.
Deposit date:2003-07-10
Release date:2004-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use.
Biochemistry, 43, 2004
1SOV
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TOXOPLASMA GONDII BRADYZOITE-SPECIFIC LDH (LDH2) APO FORM
Descriptor:L-lactate dehydrogenase
Authors:Kavanagh, K.L., Wilson, D.K.
Deposit date:2004-03-15
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of apo and ternary forms of Toxoplasma gondii LDH2
To be Published
1SOW
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T. GONDII BRADYZOITE-SPECIFIC LDH (LDH2) IN COMPLEX WITH NAD AND OXALATE
Descriptor:L-lactate dehydrogenase, OXALATE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kavanagh, K.L., Wilson, D.K.
Deposit date:2004-03-15
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of apo and ternary forms of Toxoplasma gondii LDH2
To be Published
1YQ7
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HUMAN FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH RISEDRONATE
Descriptor:Farnesyl pyrophosphate synthetase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Kavanagh, K.L., Guo, K., Von delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-02-01
Release date:2005-02-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Human farnesyl diphosphate complexed with clinical inhibitor risedronate
To be Published
1YV5
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HUMAN FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH MG AND RISEDRONATE
Descriptor:Farnesyl pyrophosphate synthetase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Kavanagh, K.L., Guo, K., Von Delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-02-15
Release date:2005-03-01
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
1ZW5
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X-RAY STRUCTURE OF FARNESYL DIPHOSPHATE SYNTHASE PROTEIN
Descriptor:farnesyl diphosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Kavanagh, K.L., Guo, K., Wu, X., von Delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-06-03
Release date:2005-06-28
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2F8A
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CRYSTAL STRUCTURE OF THE SELENOCYSTEINE TO GLYCINE MUTANT OF HUMAN GLUTATHIONE PEROXIDASE 1
Descriptor:Glutathione peroxidase 1, MALONIC ACID
Authors:Kavanagh, K.L., Johansson, C., Smee, C., Gileadi, O., von Delft, F., Weigelt, J., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-12-02
Release date:2005-12-13
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1
To be Published
2I3Y
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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE PEROXIDASE 5
Descriptor:Epididymal secretory glutathione peroxidase, 1,2-ETHANEDIOL
Authors:Kavanagh, K.L., Johansson, C., Rojkova, A., Umeano, C., Bunkoczi, G., Gileadi, O., von Delft, F., Weigelt, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-08-21
Release date:2006-09-12
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human glutathione peroxidase 5
To be published
2I9P
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CRYSTAL STRUCTURE OF HUMAN HYDROXYISOBUTYRATE DEHYDROGENASE COMPLEXED WITH NAD+
Descriptor:3-hydroxyisobutyrate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kavanagh, K.L., Papagrigoriou, E., Salah, E., Lukacik, P., Smee, C., Burgess, N., von Delft, F., Weigelt, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-09-06
Release date:2006-09-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+
To be Published
2O23
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THE STRUCTURE OF WILD-TYPE HUMAN HADH2 (17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 10) BOUND TO NAD+ AT 1.2 A
Descriptor:HADH2 protein, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL
Authors:Kavanagh, K.L., Shafqat, N., Scholer, K., Debreczeni, J., Zschocke, J., von Delft, F., Weigelt, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-11-29
Release date:2006-12-12
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The structure of wild-type human HADH2 (17beta-hydroxysteroid dehydrogenase type 10) bound to NAD+ at 1.2 A
To be Published
2P31
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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE PEROXIDASE 7
Descriptor:Glutathione peroxidase 7, CHLORIDE ION
Authors:Kavanagh, K.L., Johansson, C., Papagrigoriou, E., Kochan, G., Umeano, C., Gileadi, O., von Delft, F., Weigelt, J., Arrowsmith, C.H., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-03-08
Release date:2007-03-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human glutathione peroxidase 7
To be Published
2Q80
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CRYSTAL STRUCTURE OF HUMAN GERANYLGERANYL PYROPHOSPHATE SYNTHASE BOUND TO GGPP
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, GERANYLGERANYL DIPHOSPHATE
Authors:Kavanagh, K.L., Dunford, J.E., Bunkoczi, G., Smee, C., von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-06-08
Release date:2007-06-19
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding
J.Biol.Chem., 281, 2006
2QIS
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CRYSTAL STRUCTURE OF HUMAN FARNESYL PYROPHOSPHATE SYNTHASE T210S MUTANT BOUND TO RISEDRONATE
Descriptor:Farnesyl pyrophosphate synthetase, MAGNESIUM ION, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID
Authors:Kavanagh, K.L., Dunford, J.E., Hozjan, V., Evdokimov, A., Gileadi, O., von Delft, F., Weigelt, J., Arrowsmith, C.H., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-07-05
Release date:2007-07-24
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human farnesyl pyrophosphate synthase T210S mutant bound to risedronate.
To be Published
3COS
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CRYSTAL STRUCTURE OF HUMAN CLASS II ALCOHOL DEHYDROGENASE (ADH4) IN COMPLEX WITH NAD AND ZN
Descriptor:Alcohol dehydrogenase 4, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Kavanagh, K.L., Shafqat, N., Yue, W., von Delft, F., Bishop, S., Roos, A., Murray, J., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-03-29
Release date:2008-04-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human class II alcohol dehydrogenase (ADH4) in complex with NAD and Zn.
To be Published
3CYN
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THE STRUCTURE OF HUMAN GPX8
Descriptor:Probable glutathione peroxidase 8, SULFATE ION, GLYCEROL
Authors:Kavanagh, K.L., Johansson, C., Yue, W.W., Kochan, G., Pike, A.C.W., Murray, J., Roos, A.K., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Wikstrom, M., Edwards, A.M., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-04-25
Release date:2008-08-12
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of human GPX8
To be Published
3DLX
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CRYSTAL STRUCTURE OF HUMAN 3-OXOACID COA TRANSFERASE 1
Descriptor:Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, GLYCEROL
Authors:Kavanagh, K.L., Shafqat, N., Yue, W.W., Picaud, S., Murray, J.W., Maclean, E.M., von Delft, F., Roos, A.K., Arrowsmith, C.H., Wikstrom, M., Edwards, A.M., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-06-30
Release date:2008-08-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of human 3-oxoacid CoA transferase 1.
To be Published
3E04
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CRYSTAL STRUCTURE OF HUMAN FUMARATE HYDRATASE
Descriptor:Fumarate hydratase, 1,2-ETHANEDIOL
Authors:Kavanagh, K.L., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-07-30
Release date:2008-08-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human fumarate hydratase
TO BE PUBLISHED