Author results

1XHX
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PHI29 DNA POLYMERASE, ORTHORHOMBIC CRYSTAL FORM
Descriptor:DNA polymerase, MAGNESIUM ION, SULFATE ION
Authors:Kamtekar, S., Berman, A.J., Wang, J., Lazaro, J.M., de Vega, M., Blanco, L., Salas, M., Steitz, T.A.
Deposit date:2004-09-21
Release date:2004-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Insights into Strand Displacement and Processivity from the Crystal Structure of the Protein-Primed DNA Polymerase of Bacteriophage phi29
Mol.Cell, 16, 2004
1XHZ
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PHI29 DNA POLYMERASE, ORTHORHOMBIC CRYSTAL FORM, SSDNA COMPLEX
Descriptor:5'-D(*TP*TP*TP*TP*T)-3', DNA polymerase
Authors:Kamtekar, S., Berman, A.J., Wang, J., Lazaro, J.M., de Vega, M., Blanco, L., Salas, M., Steitz, T.A.
Deposit date:2004-09-21
Release date:2004-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Insights into Strand Displacement and Processivity from the Crystal Structure of the Protein-Primed DNA Polymerase of Bacteriophage phi29
Mol.Cell, 16, 2004
1NJ1
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CRYSTAL STRUCTURE OF PROLYL-TRNA SYNTHETASE FROM METHANOTHERMOBACTER THERMAUTOTROPHICUS BOUND TO CYSTEINE SULFAMOYL ADENYLATE
Descriptor:Proline-tRNA Synthetase, ZINC ION, MAGNESIUM ION, ...
Authors:Kamtekar, S., Kennedy, W.D., Wang, J., Stathopoulos, C., Soll, D., Steitz, T.A.
Deposit date:2002-12-30
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases
Proc.Natl.Acad.Sci.USA, 100, 2003
1NJ2
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CRYSTAL STRUCTURE OF PROLYL-TRNA SYNTHETASE FROM METHANOTHERMOBACTER THERMAUTOTROPHICUS
Descriptor:Proline-tRNA Synthetase, ZINC ION, MAGNESIUM ION
Authors:Kamtekar, S., Kennedy, W.D., Wang, J., Stathopoulos, C., Soll, D., Steitz, T.A.
Deposit date:2002-12-30
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases
Proc.Natl.Acad.Sci.USA, 100, 2003
1NJ5
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CRYSTAL STRUCTURE OF PROLYL-TRNA SYNTHETASE FROM METHANOTHERMOBACTER THERMAUTOTROPHICUS BOUND TO PROLINE SULFAMOYL ADENYLATE
Descriptor:Proline-tRNA Synthetase, ZINC ION, MAGNESIUM ION, ...
Authors:Kamtekar, S., Kennedy, W.D., Wang, J., Stathopoulos, C., Soll, D., Steitz, T.A.
Deposit date:2002-12-30
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases
Proc.Natl.Acad.Sci.USA, 100, 2003
1NJ6
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CRYSTAL STRUCTURE OF PROLYL-TRNA SYNTHETASE FROM METHANOTHERMOBACTER THERMAUTOTROPHICUS BOUND TO ALANINE SULFAMOYL ADENYLATE
Descriptor:Proline-tRNA Synthetase, ZINC ION, MAGNESIUM ION, ...
Authors:Kamtekar, S., Kennedy, W.D., Wang, J., Stathopoulos, C., Soll, D., Steitz, T.A.
Deposit date:2002-12-30
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases
Proc.Natl.Acad.Sci.USA, 100, 2003
1NJ8
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CRYSTAL STRUCTURE OF PROLYL-TRNA SYNTHETASE FROM METHANOCALDOCOCCUS JANASCHII
Descriptor:Proline-tRNA Synthetase
Authors:Kamtekar, S., Kennedy, W.D., Wang, J., Stathopoulos, C., Soll, D., Steitz, T.A.
Deposit date:2002-12-30
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases
Proc.Natl.Acad.Sci.USA, 100, 2003
2EX3
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BACTERIOPHAGE PHI29 DNA POLYMERASE BOUND TO TERMINAL PROTEIN
Descriptor:DNA polymerase, DNA terminal protein, LEAD (II) ION
Authors:Kamtekar, S., Berman, A.J., Wang, J., de Vega, M., Blanco, L., Salas, M., Steitz, T.A.
Deposit date:2005-11-07
Release date:2006-03-14
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition
Embo J., 25, 2006
2GM4
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AN ACTIVATED, TETRAMERIC GAMMA-DELTA RESOLVASE: HIN CHIMAERA BOUND TO CLEAVED DNA
Descriptor:5'-D(*CP*AP*GP*TP*GP*TP*CP*CP*GP*AP*TP*AP*AP*TP*TP*TP*AP*TP*AP*AP*A)-3', 5'-D(*TP*TP*AP*TP*CP*GP*GP*AP*CP*AP*CP*TP*G)-3', Transposon gamma-delta resolvase
Authors:Kamtekar, S., Ho, R.S., Li, W., Steitz, T.A.
Deposit date:2006-04-05
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2GM5
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AN ACTIVATED, TRUNCATED GAMMA-DELTA RESOLVASE TETRAMER
Descriptor:Transposon gamma-delta resolvase
Authors:Kamtekar, S., Ho, R.S., Li, W., Steitz, T.A.
Deposit date:2006-04-05
Release date:2006-06-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2XR9
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CRYSTAL STRUCTURE OF AUTOTAXIN (ENPP2)
Descriptor:ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Kamtekar, S., Hausmann, J., Day, J.E., Christodoulou, E., Perrakis, A.
Deposit date:2010-09-13
Release date:2011-01-19
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis of substrate discrimination and integrin binding by autotaxin.
Nat. Struct. Mol. Biol., 18, 2011
1XI1
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PHI29 DNA POLYMERASE SSDNA COMPLEX, MONOCLINIC CRYSTAL FORM
Descriptor:5'-D(P*TP*TP*TP*TP*T)-3', DNA polymerase, MAGNESIUM ION
Authors:Kamtekar, S., Berman, A.J., Wang, J., Lazaro, J.M., de Vega, M., Blanco, L., Salas, M., Steitz, T.A.
Deposit date:2004-09-21
Release date:2004-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Correction of X-ray intensities from single crystals containing lattice-translocation defects
Acta Crystallogr.,Sect.D, 61, 2005
2ODR
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METHANOCOCCUS MARIPALUDIS PHOSPHOSERYL-TRNA SYNTHETASE
Descriptor:phosphoseryl-tRNA synthetase
Authors:Steitz, T.A., Kamtekar, S.
Deposit date:2006-12-26
Release date:2007-02-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.228 Å)
Cite:Toward understanding phosphoseryl-tRNACys formation: the crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3KJF
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CASPASE 3 BOUND TO A COVALENT INHIBITOR
Descriptor:Caspase-3, (3S)-3-({[(5S,10aS)-2-{(2S)-4-carboxy-2-[(phenylacetyl)amino]butyl}-1,3-dioxo-2,3,5,7,8,9,10,10a-octahydro-1H-[1,2,4]triazolo[1,2-a]cinnolin-5-yl]carbonyl}amino)-4-oxopentanoic acid
Authors:Kamtekar, S., Watt, W., Finzel, B.C., Harris, M.S., Blinn, J., Wang, Z., Tomasselli, A.G.
Deposit date:2009-11-03
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
3KJN
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CASPASE 8 BOUND TO A COVALENT INHIBITOR
Descriptor:Caspase-8, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, (3S)-3-({[(5S)-2-{2-[(1H-benzimidazol-5-ylcarbonyl)amino]ethyl}-7-(cyclohexylmethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid
Authors:Kamtekar, S., Watt, W., Finzel, B.C., Harris, M.S., Blinn, J., Wang, Z., Tomasselli, A.G.
Deposit date:2009-11-03
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
3KJQ
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CASPASE 8 WITH COVALENT INHIBITOR
Descriptor:Caspase-8, (3S)-3-({[(5S,8R)-2-(3-carboxypropyl)-8-(2-{[(4-chlorophenyl)acetyl]amino}ethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid
Authors:Kamtekar, S., Watt, W., Finzel, B.C., Harris, M.S., Blinn, J., Wang, Z., Tomasselli, A.G.
Deposit date:2009-11-03
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
3LCD
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INHIBITOR BOUND TO A DFG-IN STRUCTURE OF THE KINASE DOMAIN OF CSF-1R
Descriptor:Macrophage colony-stimulating factor 1 receptor, SULFATE ION, N~3~-(2,6-dichlorobenzyl)-5-(4-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}phenyl)pyrazine-2,3-diamine
Authors:Kamtekar, S., Day, J.E., Reitz, B.A., Mathis, K.J., Meyers, M.J.
Deposit date:2010-01-10
Release date:2010-03-02
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode
Bioorg.Med.Chem.Lett., 20, 2010
3LCO
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INHIBITOR BOUND TO A DFG-OUT STRUCTURE OF THE KINASE DOMAIN OF CSF-1R
Descriptor:Macrophage colony-stimulating factor 1 receptor, 3-({4-methoxy-5-[(4-methoxybenzyl)oxy]pyridin-2-yl}methoxy)-5-(1-methyl-1H-pyrazol-4-yl)pyrazin-2-amine
Authors:Kamtekar, S., Day, J.E., Reitz, B.A., Mathis, K.J., Meyers, M.J.
Deposit date:2010-01-11
Release date:2010-09-15
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.
Bioorg.Med.Chem.Lett., 20, 2010
1HQY
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NUCLEOTIDE-DEPENDENT CONFORMATIONAL CHANGES IN A PROTEASE-ASSOCIATED ATPASE HSLU
Descriptor:HEAT SHOCK LOCUS HSLV, HEAT SHOCK LOCUS HSLU, ADENOSINE-5'-DIPHOSPHATE
Authors:Wang, J., Song, J.J., Seong, I.S., Franklin, M.C., Kamtekar, S., Eom, S.H., Chung, C.H.
Deposit date:2000-12-20
Release date:2001-11-14
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU.
Structure, 9, 2001
1HT1
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NUCLEOTIDE-DEPENDENT CONFORMATIONAL CHANGES IN A PROTEASE-ASSOCIATED ATPASE HSLU
Descriptor:HEAT SHOCK LOCUS HSLV, HEAT SHOCK LOCUS HSLU, ADENOSINE-5'-DIPHOSPHATE
Authors:Wang, J., Song, J.J., Seong, I.S., Franklin, M.C., Kamtekar, S., Eom, S.H., Chung, C.H.
Deposit date:2000-12-27
Release date:2001-11-14
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU.
Structure, 9, 2001
1HT2
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NUCLEOTIDE-DEPENDENT CONFORMATIONAL CHANGES IN A PROTEASE-ASSOCIATED ATPASE HSLU
Descriptor:HEAT SHOCK LOCUS HSLV, HEAT SHOCK LOCUS HSLU, ADENOSINE-5'-DIPHOSPHATE
Authors:Wang, J., Song, J.J., Seong, I.S., Franklin, M.C., Kamtekar, S., Eom, S.H., Chung, C.H.
Deposit date:2000-12-27
Release date:2001-11-14
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU.
Structure, 9, 2001
2WAP
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3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH THE DRUG-LIKE UREA INHIBITOR PF-3845
Descriptor:FATTY-ACID AMIDE HYDROLASE 1, 4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid, CHLORIDE ION, ...
Authors:Mileni, M., Kamtekar, S., Stevens, R.C.
Deposit date:2009-02-11
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery and Characterization of a Highly Selective Faah Inhibitor that Reduces Inflammatory Pain.
Chem.Biol., 16, 2009
1G4A
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CRYSTAL STRUCTURES OF THE HSLVU PEPTIDASE-ATPASE COMPLEX REVEAL AN ATP-DEPENDENT PROTEOLYSIS MECHANISM
Descriptor:ATP-DEPENDENT HSL PROTEASE ATP-BINDING SUBUNIT HSLU, ATP-DEPENDENT PROTEASE HSLV, 2'-DEOXYADENOSINE-5'-DIPHOSPHATE
Authors:Wang, J., Song, J.J., Franklin, M.C., Kamtekar, S., Im, Y.J., Rho, S.H., Seong, I.S., Lee, C.S., Chung, C.H., Eom, S.H.
Deposit date:2000-10-26
Release date:2001-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanism.
Structure, 9, 2001
1G4B
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CRYSTAL STRUCTURES OF THE HSLVU PEPTIDASE-ATPASE COMPLEX REVEAL AN ATP-DEPENDENT PROTEOLYSIS MECHANISM
Descriptor:ATP-DEPENDENT HSL PROTEASE ATP-BINDING SUBUNIT HSLU, ATP-DEPENDENT PROTEASE HSLV
Authors:Wang, J., Song, J.J., Franklin, M.C., Kamtekar, S., Im, Y.J., Rho, S.H., Seong, I.S., Lee, C.S., Chung, C.H., Eom, S.H.
Deposit date:2000-10-26
Release date:2001-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (7 Å)
Cite:Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanism.
Structure, 9, 2001
1ZR2
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STRUCTURE OF A SYNAPTIC GAMMA-DELTA RESOLVASE TETRAMER COVALENTLY LINKED TO TWO CLEAVED DNAS
Descriptor:TCAGTGTCCGATAATTTAT, AAA, TTATCGGACACTG, ...
Authors:Li, W., Kamtekar, S., Xiong, Y., Sarkis, G.J., Grindley, N.D., Steitz, T.A.
Deposit date:2005-05-18
Release date:2005-08-30
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structure of a synaptic gamma delta resolvase tetramer covalently linked to two cleaved DNAs.
Science, 309, 2005
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