Author results

5XJD
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TEAD IN COMPLEX WITH FRAGMENT
Descriptor:Transcriptional enhancer factor TEF-3, (2S)-2-phenyl-2-pyrrol-1-yl-ethanoic acid
Authors:Kaan, H.Y.K., Sim, A.Y.L., Tan, S.K.J., Verma, C., Song, H.
Deposit date:2017-05-01
Release date:2018-01-24
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches.
PLoS ONE, 12, 2017
2WOG
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INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Hackney, D.D., Kozielski, F.
Deposit date:2009-07-23
Release date:2010-08-04
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:An Allosteric Transition Trapped in an Intermediate State of a New Kinesin-Inhibitor Complex.
Biochem.J., 425, 2010
2X2R
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((4-CHLOROPHENYL)DIPHENYLMETHYLTHIO)PROPANOIC ACID
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, (2R)-2-AMINO-3-[(2R)-2-METHYL-1,1-DIPHENYL-BUTYL]SULFANYL-PROPANOIC ACID, ...
Authors:Kaan, H.Y.K., Weiss, J., Menger, D., Ulaganathan, V., Laggner, C., Popowycz, F., Joseph, B., Kozielski, F.
Deposit date:2010-01-15
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
J.Med.Chem., 54, 2011
2X7C
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (S)-ENASTRON
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
2X7D
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (S)-DIMETHYLENASTRON
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
2X7E
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-FLUORASTROL
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
2XAE
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((S)-2-METHYL-1,1-DIPHENYLBUTYLTHIO)PROPANOIC ACID
Descriptor:KINESIN-LIKE PROTEIN KIF11, (2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC ACID, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Weiss, J., Menger, D., Ulaganathan, V., Tkocz, K., Laggner, C., Popowycz, F., Joseph, B., Kozielski, F.
Deposit date:2010-03-31
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
J.Med.Chem., 54, 2011
2Y5W
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CRYSTAL STRUCTURE OF DROSOPHILA MELANOGASTER KINESIN-1 MOTOR DOMAIN DIMER
Descriptor:KINESIN HEAVY CHAIN, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Kaan, H.Y.K., Hackney, D.D., Kozielski, F.
Deposit date:2011-01-18
Release date:2011-08-24
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition.
Science, 333, 2011
2Y65
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CRYSTAL STRUCTURE OF DROSOPHILA MELANOGASTER KINESIN-1 MOTOR DOMAIN DIMER-TAIL COMPLEX
Descriptor:KINESIN HEAVY CHAIN, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Kaan, H.Y.K., Hackney, D.D., Kozielski, F.
Deposit date:2011-01-19
Release date:2011-08-24
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition.
Science, 333, 2011
4A5Y
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INTERMEDIATE STATE OF HUMAN KINESIN EG5 IN COMPLEX WITH ISPINESIB
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:Kaan, H.Y.K., Kozielski, F.
Deposit date:2011-10-29
Release date:2012-11-07
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:"Snapshots" of Ispinesib-Induced Conformational Changes in the Mitotic Kinesin Eg5.
J.Biol.Chem., 288, 2013
5GN0
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STRUCTURE OF TAZ-TEAD COMPLEX
Descriptor:Transcriptional enhancer factor TEF-3, WW domain-containing transcription regulator protein 1, CITRIC ACID, ...
Authors:Kaan, H.Y.K., Song, H.
Deposit date:2016-07-18
Release date:2017-05-31
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex
Sci Rep, 7, 2017
4A50
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH 2-AMINO-5-(3-METHYLPHENYL)-5,5-DIPHENYLPENTANOIC ACID
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Kozielski, F.
Deposit date:2011-10-24
Release date:2012-10-31
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity.
J.Med.Chem., 55, 2012
4A51
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH 1-(3-(((2-AMINOETHYL)THIO)DIPHENYLMETHYL)PHENYL)ETHANONE HYDROCHLORIDE
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Kozielski, F.
Deposit date:2011-10-24
Release date:2012-10-31
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity.
J.Med.Chem., 55, 2012
4BBG
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH 3-(((2-AMINOETHYL)SULFANYL)(3-ETHYLPHENYL) PHENYLMETHYL)PHENOL
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Kozielski, F.
Deposit date:2012-09-22
Release date:2013-05-15
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Optimized S-Trityl-L-Cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models.
J.Med.Chem., 56, 2013
3DYT
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CRYSTAL STRUCTURE OF SNX9PX-BAR (230-595), C2221
Descriptor:Sorting nexin-9, SULFATE ION
Authors:Wang, Q., Kaan, H.Y.K., Sondermann, H.
Deposit date:2008-07-28
Release date:2008-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structure and plasticity of endophilin and sorting nexin 9.
Structure, 16, 2008
3DYU
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CRYSTAL STRUCTURE OF SNX9PX-BAR (230-595), H32
Descriptor:Sorting nexin-9
Authors:Wang, Q., Kaan, H.Y.K., Sondermann, H.
Deposit date:2008-07-28
Release date:2008-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Structure and plasticity of endophilin and sorting nexin 9.
Structure, 16, 2008