Author results

5EFX
  • Download 5efx
  • View 5efx
Molmil generated image of 5efx
CRYSTAL STRUCTURE OF RHO GTPASE REGULATOR
Descriptor:Rho guanine nucleotide exchange factor 2
Authors:Jiang, Y., Ouyang, S., Liu, Z.J.
Deposit date:2015-10-26
Release date:2016-06-29
Method:X-RAY DIFFRACTION (2.451 Å)
Cite:Crystal structure of hGEF-H1 PH domain provides insight into incapability in phosphoinositide binding
Biochem.Biophys.Res.Commun., 471, 2016
1LNQ
  • Download 1lnq
  • View 1lnq
Molmil generated image of 1lnq
CRYSTAL STRUCTURE OF MTHK AT 3.3 A
Descriptor:POTASSIUM CHANNEL RELATED PROTEIN, CALCIUM ION
Authors:Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B.T., Mackinnon, R.
Deposit date:2002-05-03
Release date:2002-06-19
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:CRYSTAL STRUCTURE AND MECHANISM OF A CALCIUM-GATED POTASSIUM CHANNEL
Nature, 417, 2002
4LMM
  • Download 4lmm
  • View 4lmm
Molmil generated image of 4lmm
CRYSTAL STRUCTURE OF NHERF1 PDZ1 DOMAIN COMPLEXED WITH THE CXCR2 C-TERMINAL TAIL IN P21 SPACE GROUP
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF1, ACETIC ACID, CHLORIDE ION
Authors:Jiang, Y., Lu, G., Wu, Y., Brunzelle, J., Sirinupong, N., Li, C., Yang, Z.
Deposit date:2013-07-10
Release date:2014-01-15
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:New Conformational State of NHERF1-CXCR2 Signaling Complex Captured by Crystal Lattice Trapping.
Plos One, 8, 2013
4MPA
  • Download 4mpa
  • View 4mpa
Molmil generated image of 4mpa
CRYSTAL STRUCTURE OF NHERF1-CXCR2 SIGNALING COMPLEX IN P21 SPACE GROUP
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF1, C-X-C chemokine receptor type 2 chimera, ACETIC ACID, ...
Authors:Jiang, Y., Lu, G., Wu, Y., Brunzelle, J., Sirinupong, N., Li, C., Yang, Z.
Deposit date:2013-09-12
Release date:2014-01-15
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.097 Å)
Cite:New Conformational State of NHERF1-CXCR2 Signaling Complex Captured by Crystal Lattice Trapping.
Plos One, 8, 2013
4PQW
  • Download 4pqw
  • View 4pqw
Molmil generated image of 4pqw
CRYSTAL STRUCTURE OF PHOSPHOLIPASE C BETA 3 IN COMPLEX WITH PDZ1 OF NHERF1
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF1, CHLORIDE ION, NICKEL (II) ION
Authors:Jiang, Y., Wang, S., Holcomb, J., Trescott, L., Guan, X., Hou, Y., Brunzelle, J., Sirinupong, N., Li, C., Yang, Z.
Deposit date:2014-03-04
Release date:2014-04-02
Last modified:2014-04-23
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Crystallographic analysis of NHERF1-PLC beta 3 interaction provides structural basis for CXCR2 signaling in pancreatic cancer.
Biochem.Biophys.Res.Commun., 446, 2014
2L5F
  • Download 2l5f
  • View 2l5f
Molmil generated image of 2l5f
SOLUTION STRUCTURE OF THE TANDEM WW DOMAINS FROM HYPA/FBP11
Descriptor:Pre-mRNA-processing factor 40 homolog A
Authors:Jiang, Y., Hu, H.
Deposit date:2010-11-01
Release date:2011-05-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Interaction with polyglutamine expanded huntingtin alters cellular distribution and RNA processing of huntingtin yeast two-hybrid protein A (HYPA)
To be Published
5H1Y
  • Download 5h1y
  • View 5h1y
Molmil generated image of 5h1y
CRYSTAL STRUCTURE OF THE DDX41 DEAD DOMAIN IN COMPLEX WITH SO42- AND MG2+
Descriptor:Probable ATP-dependent RNA helicase DDX41, SULFATE ION, MAGNESIUM ION
Authors:Jiang, Y., Ouyang, S., Liu, Z.J.
Deposit date:2016-10-13
Release date:2017-01-18
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural and functional analyses of human DDX41 DEAD domain
Protein Cell, 8, 2017
5XJ1
  • Download 5xj1
  • View 5xj1
Molmil generated image of 5xj1
CRYSTAL STRUCTURE OF SPRLMCD
Descriptor:Uncharacterized RNA methyltransferase SP_1029, GLYCEROL, HEXAETHYLENE GLYCOL, ...
Authors:Jiang, Y., Gong, Q.
Deposit date:2017-04-28
Release date:2017-11-01
Method:X-RAY DIFFRACTION (1.753 Å)
Cite:Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD
PLoS ONE, 12, 2017
5XJ2
  • Download 5xj2
  • View 5xj2
Molmil generated image of 5xj2
STRUCTURE OF SPRLMCD WITH U747 RNA
Descriptor:Uncharacterized RNA methyltransferase SP_1029, RNA (5'-R(*GP*GP*CP*AP*CP*GP*UP*GP*CP*U)-3'), ZINC ION, ...
Authors:Jiang, Y., Gong, Q.
Deposit date:2017-04-28
Release date:2017-11-01
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD
PLoS ONE, 12, 2017
1ID1
  • Download 1id1
  • View 1id1
Molmil generated image of 1id1
CRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNEL
Descriptor:PUTATIVE POTASSIUM CHANNEL PROTEIN
Authors:Jiang, Y., Pico, A., Cadene, M., Chait, B.T., MacKinnon, R.
Deposit date:2001-04-02
Release date:2001-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel.
Neuron, 29, 2001
1ORQ
  • Download 1orq
  • View 1orq
Molmil generated image of 1orq
X-RAY STRUCTURE OF A VOLTAGE-DEPENDENT POTASSIUM CHANNEL IN COMPLEX WITH AN FAB
Descriptor:6E1 Fab light chain, 6E1 Fab heavy chain, potassium channel, ...
Authors:Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B.T., MacKinnon, R.
Deposit date:2003-03-14
Release date:2003-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:X-ray structure of a voltage-dependent K+ channel
Nature, 423, 2003
1ORS
  • Download 1ors
  • View 1ors
Molmil generated image of 1ors
X-RAY STRUCTURE OF THE KVAP POTASSIUM CHANNEL VOLTAGE SENSOR IN COMPLEX WITH AN FAB
Descriptor:33H1 Fab light chain, 33H1 Fab heavy chain, potassium channel
Authors:Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B.T., MacKinnon, R.
Deposit date:2003-03-14
Release date:2003-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structure of a voltage-dependent K+ channel
Nature, 423, 2003
1TFE
  • Download 1tfe
  • View 1tfe
Molmil generated image of 1tfe
DIMERIZATION DOMAIN OF EF-TS FROM T. THERMOPHILUS
Descriptor:ELONGATION FACTOR TS
Authors:Jiang, Y., Nock, S., Nesper, M., Sprinzl, M., Sigler, P.B.
Deposit date:1996-04-16
Release date:1996-11-08
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and importance of the dimerization domain in elongation factor Ts from Thermus thermophilus.
Biochemistry, 35, 1996
2LJ0
  • Download 2lj0
  • View 2lj0
Molmil generated image of 2lj0
THE THIRD SH3 DOMAIN OF R85FL
Descriptor:Sorbin and SH3 domain-containing protein 1
Authors:Jiang, Y., Hu, H.
Deposit date:2011-09-02
Release date:2012-09-05
Method:SOLUTION NMR
Cite:Structure Basis for the Recognition of Ataxin-7 PRR with R85FL SH3 Domain
To be Published
2LJ1
  • Download 2lj1
  • View 2lj1
Molmil generated image of 2lj1
THE THIRD SH3 DOMAIN OF R85FL WITH ATAXIN-7 PRR
Descriptor:Sorbin and SH3 domain-containing protein 1
Authors:Jiang, Y., Hu, H.
Deposit date:2011-09-02
Release date:2012-09-05
Method:SOLUTION NMR
Cite:Structure Basis for the Recognition of Ataxin-7 PRR with R85FL SH3 Domain
To be Published
3QWV
  • Download 3qwv
  • View 3qwv
Molmil generated image of 3qwv
CRYSTAL STRUCTURE OF HISTONE LYSINE METHYLTRANSFERASE SMYD2 IN COMPLEX WITH THE COFACTOR PRODUCT ADOHCY
Descriptor:SET and MYND domain-containing protein 2, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION
Authors:Jiang, Y., Sirinupong, N., Brunzelle, J., Yang, Z.
Deposit date:2011-02-28
Release date:2011-07-06
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystal structures of histone and p53 methyltransferase SmyD2 reveal a conformational flexibility of the autoinhibitory C-terminal domain.
Plos One, 6, 2011
3QWW
  • Download 3qww
  • View 3qww
Molmil generated image of 3qww
CRYSTAL STRUCTURE OF HISTONE LYSINE METHYLTRANSFERASE SMYD2 IN COMPLEX WITH THE METHYLTRANSFERASE INHIBITOR SINEFUNGIN
Descriptor:SET and MYND domain-containing protein 2, SINEFUNGIN, ZINC ION
Authors:Jiang, Y., Sirinupong, N., Brunzelle, J., Yang, Z.
Deposit date:2011-02-28
Release date:2011-07-06
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of histone and p53 methyltransferase SmyD2 reveal a conformational flexibility of the autoinhibitory C-terminal domain.
Plos One, 6, 2011
4O6F
  • Download 4o6f
  • View 4o6f
Molmil generated image of 4o6f
STRUCTURAL BASIS OF ESTROGEN RECEPTOR ALPHA METHYLATION MEDIATED BY HISTONE METHYLTRANSFERASE SMYD2
Descriptor:N-lysine methyltransferase SMYD2, Estrogen receptor, ZINC ION, ...
Authors:Jiang, Y., Trescott, L., Holcomb, J., Brunzelle, J., Sirinupong, N., Shi, X., Yang, Z.
Deposit date:2013-12-20
Release date:2014-03-26
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.822 Å)
Cite:Structural Insights into Estrogen Receptor alpha Methylation by Histone Methyltransferase SMYD2, a Cellular Event Implicated in Estrogen Signaling Regulation.
J.Mol.Biol., 426, 2014
5X72
  • Download 5x72
  • View 5x72
Molmil generated image of 5x72
THE CRYSTAL STRUCTURE PDE DELTA IN COMPLEX WITH (RAC)-P9
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, (2R)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one, (2S)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one
Authors:Jiang, Y., Zhuang, C., Chen, L., Wang, R., Wang, F., Sheng, C.
Deposit date:2017-02-23
Release date:2017-10-04
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors
J. Med. Chem., 60, 2017
5X73
  • Download 5x73
  • View 5x73
Molmil generated image of 5x73
THE CRYSTAL STRUCTURE PDE DELTA IN COMPLEX WITH R-P9
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, (2R)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one
Authors:Jiang, Y., Zhuang, C., Chen, L., Wang, R., Wang, F., Sheng, C.
Deposit date:2017-02-23
Release date:2017-10-04
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors
J. Med. Chem., 60, 2017
5X74
  • Download 5x74
  • View 5x74
Molmil generated image of 5x74
THE CRYSTAL STRUCTURE PDE DELTA IN COMPLEX WITH COMPOUND (R, R)-1G
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, (2R)-2-(2-fluorophenyl)-3-[2-[4-[(2R)-2-(2-fluorophenyl)-4-oxidanylidene-1,2-dihydroquinazolin-3-yl]piperidin-1-yl]ethyl]-1,2-dihydroquinazolin-4-one
Authors:Jiang, Y., Zhuang, C., Chen, L., Wang, R., Wang, F., Sheng, C.
Deposit date:2017-02-23
Release date:2017-10-04
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors
J. Med. Chem., 60, 2017
6PPT
  • Download 6ppt
  • View 6ppt
Molmil generated image of 6ppt
STRUCTURAL BASIS FOR CLIENT RECOGNITION AND ACTIVITY OF HSP40 CHAPERONES
Descriptor:Alkaline phosphatase,Chaperone protein DnaJ 2 fusion
Authors:Jiang, Y., Rossi, P., Kalodimos, C.G.
Deposit date:2019-07-08
Release date:2019-09-18
Last modified:2019-10-23
Method:SOLUTION NMR
Cite:Structural basis for client recognition and activity of Hsp40 chaperones.
Science, 365, 2019
6PQ2
  • Download 6pq2
  • View 6pq2
Molmil generated image of 6pq2
STRUCTURAL BASIS FOR CLIENT RECOGNITION AND ACTIVITY OF HSP40 CHAPERONES
Descriptor:Alkaline phosphatase,Chaperone DnaJ domain-containing protein fusion
Authors:Jiang, Y., Rossi, P., Kalodimos, C.G.
Deposit date:2019-07-08
Release date:2019-09-18
Last modified:2019-10-23
Method:SOLUTION NMR
Cite:Structural basis for client recognition and activity of Hsp40 chaperones.
Science, 365, 2019
6PQE
  • Download 6pqe
  • View 6pqe
Molmil generated image of 6pqe
STRUCTURAL BASIS FOR CLIENT RECOGNITION AND ACTIVITY OF HSP40 CHAPERONES
Descriptor:Alkaline phosphatase,Chaperone protein DnaJ 2 fusion
Authors:Jiang, Y., Rossi, P., Kalodimos, C.G.
Deposit date:2019-07-09
Release date:2019-09-18
Last modified:2019-10-23
Method:SOLUTION NMR
Cite:Structural basis for client recognition and activity of Hsp40 chaperones.
Science, 365, 2019
6PQM
  • Download 6pqm
  • View 6pqm
Molmil generated image of 6pqm
STRUCTURAL BASIS FOR CLIENT RECOGNITION AND ACTIVITY OF HSP40 CHAPERONES
Descriptor:Alkaline phosphatase,Chaperone protein DnaJ 2 fusion
Authors:Jiang, Y., Rossi, P., Kalodimos, C.G.
Deposit date:2019-07-09
Release date:2019-09-18
Last modified:2019-10-23
Method:SOLUTION NMR
Cite:Structural basis for client recognition and activity of Hsp40 chaperones.
Science, 365, 2019