Author results

1GXC
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FHA DOMAIN FROM HUMAN CHK2 KINASE IN COMPLEX WITH A SYNTHETIC PHOSPHOPEPTIDE
Descriptor:SERINE/THREONINE-PROTEIN KINASE CHK2, SYNTHETIC PHOSPHOPEPTIDE
Authors:Li, J., Williams, B.L., Haire, L.F., Goldberg, M., Wilker, E., Durocher, D., Yaffe, M.B., Jackson, S.P., Smerdon, S.J.
Deposit date:2002-04-02
Release date:2002-06-13
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Functional Versatility of the Fha Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2
Mol.Cell, 9, 2002
1IK9
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CRYSTAL STRUCTURE OF A XRCC4-DNA LIGASE IV COMPLEX
Descriptor:DNA REPAIR PROTEIN XRCC4, DNA LIGASE IV
Authors:Sibanda, B.L., Critchlow, S.E., Begun, J., Pei, X.Y., Jackson, S.P., Blundell, T.L., Pellegrini, L.
Deposit date:2001-05-03
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of an Xrcc4-DNA ligase IV complex.
Nat.Struct.Biol., 8, 2001
1Z56
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CO-CRYSTAL STRUCTURE OF LIF1P-LIG4P
Descriptor:Ligase interacting factor 1, DNA ligase IV
Authors:Dore, A.S., Furnham, N., Davies, O.R., Sibanda, B.L., Chirgadze, D.Y., Jackson, S.P., Pellegrini, L., Blundell, T.L.
Deposit date:2005-03-17
Release date:2006-01-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.92 Å)
Cite:Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.
DNA REPAIR, 5, 2006
2AZM
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CRYSTAL STRUCTURE OF THE MDC1 BRCT REPEAT IN COMPLEX WITH THE HISTONE TAIL OF GAMMA-H2AX
Descriptor:Mediator of DNA damage checkpoint protein 1, GAMMA-H2AX HISTONE
Authors:Clapperton, J.A., Stucki, M., Mohammad, D., Yaffe, M.B., Jackson, S.P., Smerdon, S.J.
Deposit date:2005-09-12
Release date:2006-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
Cell(Cambridge,Mass.), 123, 2005
3I0M
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STRUCTURE OF THE S. POMBE NBS1 FHA/BRCT-REPEAT DOMAIN
Descriptor:DNA repair and telomere maintenance protein nbs1, GLYCEROL
Authors:Clapperton, J.A., Lloyd, J., Chapman, J.R., Jackson, S.P., Smerdon, S.J.
Deposit date:2009-06-25
Release date:2009-10-13
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage
Cell(Cambridge,Mass.), 139, 2009
3I0N
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STRUCTURE OF THE S. POMBE NBS1 FHA/BRCT-REPEAT DOMAIN
Descriptor:DNA repair and telomere maintenance protein nbs1, GLYCEROL
Authors:Clapperton, J.A., Lloyd, J., Chapman, J.R., Jackson, S.P., Smerdon, S.J.
Deposit date:2009-06-25
Release date:2009-10-13
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage
Cell(Cambridge,Mass.), 139, 2009
1D3U
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TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/BRE+TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI
Descriptor:DNA 24-MER: BRE+TATA-BOX, DNA 23-MER: BRE+TATA-BOX, TATA-BINDING PROTEIN, ...
Authors:Littlefield, O., Korkhin, Y., Sigler, P.B.
Deposit date:1999-10-01
Release date:1999-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structural basis for the oriented assembly of a TBP/TFB/promoter complex.
Proc.Natl.Acad.Sci.USA, 96, 1999
1G6G
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X-RAY STRUCTURE OF THE N-TERMINAL FHA DOMAIN FROM S. CEREVISIAE RAD53P IN COMPLEX WITH A PHOSPHOTHREONINE PEPTIDE AT 1.6 A RESOLUTION
Descriptor:PROTEIN KINASE RAD53, SER-LEU-GLU-VAL-TPO-GLU-ALA-ASPALA-THR-PHE-ALA-LYS
Authors:Durocher, D., Taylor, I.A.
Deposit date:2000-11-06
Release date:2000-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.
Mol.Cell, 6, 2000
1M2G
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SIR2 HOMOLOGUE-ADP RIBOSE COMPLEX
Descriptor:Silent Information Regulator 2, ZINC ION, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Chang, J., Cho, Y.
Deposit date:2002-06-24
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for the NAD-dependent deacetylase mechanism of Sir2
J.BIOL.CHEM., 277, 2002
1M2H
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SIR2 HOMOLOGUE S24A MUTANT-ADP RIBOSE COMPLEX
Descriptor:Silent Information Regulator 2, ZINC ION, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Chang, J., Cho, Y.
Deposit date:2002-06-24
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the NAD-dependent deacetylase mechanism of Sir2
J.BIOL.CHEM., 277, 2002
1M2J
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SIR2 HOMOLOGUE H80N MUTANT-ADP RIBOSE COMPLEX
Descriptor:Silent Information Regulator 2, ZINC ION, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Chang, J., Cho, Y.
Deposit date:2002-06-24
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for the NAD-dependent deacetylase mechanism of Sir2
J.BIOL.CHEM., 277, 2002
1M2K
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SIR2 HOMOLOGUE F159A MUTANT-ADP RIBOSE COMPLEX
Descriptor:Silent Information Regulator 2, ZINC ION, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Chang, J., Cho, Y.
Deposit date:2002-06-24
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structural basis for the NAD-dependent deacetylase mechanism of Sir2
J.BIOL.CHEM., 277, 2002
1M2N
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SIR2 HOMOLOGUES (D102G/F159A/R170A) MUTANT-2'-O-ACETYL ADP RIBOSE COMPLEX
Descriptor:Silent Information Regulator 2, ZINC ION, 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Chang, J., Cho, Y.
Deposit date:2002-06-24
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the NAD-dependent deacetylase mechanism of Sir2
J.BIOL.CHEM., 277, 2003
1PCZ
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STRUCTURE OF TATA-BINDING PROTEIN
Descriptor:TATA-BINDING PROTEIN
Authors:Dedecker, B.S., Sigler, P.B.
Deposit date:1996-10-04
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of a hyperthermophilic archaeal TATA-box binding protein.
J.Mol.Biol., 264, 1996
2N5N
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STRUCTURE OF AN N-TERMINAL DOMAIN OF CHD4
Descriptor:Chromodomain-helicase-DNA-binding protein 4
Authors:Silva, A.P.G., Mackay, J.P.
Deposit date:2015-07-22
Release date:2015-11-18
Last modified:2016-01-27
Method:SOLUTION NMR
Cite:The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose).
J.Biol.Chem., 291, 2016
2QM4
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CRYSTAL STRUCTURE OF HUMAN XLF/CERNUNNOS, A NON-HOMOLOGOUS END-JOINING FACTOR
Descriptor:Non-homologous end-joining factor 1
Authors:Li, Y., Chirgadze, D.Y., Sibanda, B.L., Bolanos-Garcia, V.M., Davies, O.R., Blundell, T.L.
Deposit date:2007-07-14
Release date:2007-12-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ.
Embo J., 27, 2008
3WTD
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STRUCTURE OF PAXX
Descriptor:Uncharacterized protein C9orf142
Authors:Ochi, T., Blundell, T.L.
Deposit date:2014-04-09
Release date:2015-01-21
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair
Science, 347, 2015
3WTF
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STRUCTURE OF PAXX
Descriptor:Uncharacterized protein C9orf142
Authors:Ochi, T., Blundell, T.L.
Deposit date:2014-04-09
Release date:2015-01-21
Method:X-RAY DIFFRACTION (3.451 Å)
Cite:PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair
Science, 347, 2015
4D2H
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CRYSTAL STRUCTURE OF THE TETRAMERISATION DOMAIN OF HUMAN CTIP
Descriptor:RBBP8, SULFATE ION
Authors:Davies, O.R., Sun, M., Pellegrini, L.
Deposit date:2014-05-09
Release date:2015-01-14
Last modified:2015-02-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ctip Tetramer Assembly is Required for DNA-End Resection and Repair.
Nat.Struct.Mol.Biol., 22, 2015
4FBK
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CRYSTAL STRUCTURE OF A COVALENTLY FUSED NBS1-MRE11 COMPLEX WITH ONE MANGANESE ION PER ACTIVE SITE
Descriptor:DNA repair and telomere maintenance protein nbs1,DNA repair protein rad32 CHIMERIC PROTEIN, SULFATE ION, MANGANESE (II) ION
Authors:Schiller, C.B., Lammens, K., Hopfner, K.P.
Deposit date:2012-05-23
Release date:2012-06-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.379 Å)
Cite:Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Nat.Struct.Mol.Biol., 19, 2012
4FBQ
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CRYSTAL STRUCTURE OF A COVALENTLY FUSED NBS1-MRE11 COMPLEX WITH TWO MANGANESE IONS PER ACTIVE SITE
Descriptor:DNA repair and telomere maintenance protein nbs1,DNA repair protein rad32 CHIMERIC PROTEIN, MANGANESE (II) ION
Authors:Schiller, C.B., Lammens, K., Hopfner, K.P.
Deposit date:2012-05-23
Release date:2012-06-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Nat.Struct.Mol.Biol., 19, 2012
4FBW
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CRYSTAL STRUCTURE OF AN UNFUSED MRE11-NBS1 COMPLEX WITH TWO MANGANESE IONS PER ACTIVE SITE
Descriptor:DNA repair protein rad32, DNA repair and telomere maintenance protein nbs1, MANGANESE (II) ION
Authors:Schiller, C.B., Lammens, K., Hopfner, K.P.
Deposit date:2012-05-23
Release date:2012-06-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Nat.Struct.Mol.Biol., 19, 2012
4FCX
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S.POMBE MRE11 APOENZYM
Descriptor:DNA repair protein rad32, MANGANESE (II) ION
Authors:Schiller, C.B., Lammens, K., Hopfner, K.P.
Deposit date:2012-05-25
Release date:2012-06-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Nat.Struct.Mol.Biol., 19, 2012
1H0X
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STRUCTURE OF ALBA: AN ARCHAEAL CHROMATIN PROTEIN MODULATED BY ACETYLATION
Descriptor:DNA BINDING PROTEIN SSO10B
Authors:Wardleworth, B.N., Russell, R.J.M., Bell, S.D., Taylor, G.L., White, M.F.
Deposit date:2002-07-01
Release date:2002-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Alba: An Archaeal Chromatin Protein Modulated by Acetylation
Embo J., 21, 2002
1H0Y
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STRUCTURE OF ALBA: AN ARCHAEAL CHROMATIN PROTEIN MODULATED BY ACETYLATION
Descriptor:DNA BINDING PROTEIN SSO10B, SULFATE ION
Authors:Wardleworth, B.N., Russell, R.J.M., Bell, S.D., Taylor, G.L., White, M.F.
Deposit date:2002-07-01
Release date:2002-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Alba: An Archaeal Chromatin Protein Modulated by Acetylation
Embo J., 21, 2002