Author results

2GEJ
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CRYSTAL STRUCTURE OF PHOSPHATIDYLINOSITOL MANNOSYLTRANSFERASE (PIMA) FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH GDP-MAN
Descriptor:PHOSPHATIDYLINOSITOL MANNOSYLTRANSFERASE (PimA), GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE
Authors:Guerin, M.E., Buschiazzo, A., Kordulakova, J., Jackson, M., Alzari, P.M.
Deposit date:2006-03-20
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria.
J.Biol.Chem., 282, 2007
2GEK
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CRYSTAL STRUCTURE OF PHOSPHATIDYLINOSITOL MANNOSYLTRANSFERASE (PIMA) FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH GDP
Descriptor:PHOSPHATIDYLINOSITOL MANNOSYLTRANSFERASE (PimA), GUANOSINE-5'-DIPHOSPHATE
Authors:Guerin, M.E., Buschiazzo, A., Kordulakova, J., Jackson, M., Alzari, P.M.
Deposit date:2006-03-20
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria.
J.Biol.Chem., 282, 2007
4A21
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE BOUND TO SULFATE
Descriptor:FRUCTOSE-BISPHOSPHATE ALDOLASE, SULFATE ION, SODIUM ION
Authors:Coincon, M., De la Paz Santangelo, M., Gest, P.M., Guerin, M.E., Pham, H., Ryan, G., Puckett, S.E., Spencer, J.S., Gonzalez-Juarrero, M., Daher, R., Lenaerts, A.J., Schnappinger, D., Therisod, M., Ehrt, S., Jackson, M., Sygusch, J.
Deposit date:2011-09-21
Release date:2011-10-05
Last modified:2011-11-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Glycolytic and Non-Glycolytic Functions of the Fructose-1,6-Bisphosphate Aldolase of Mycobacterium Tuberculosis, an Essential Enzyme Produced by Replicating and Non-Replicating Bacilli
J.Biol.Chem., 286, 2011
4A22
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE BOUND TO N-(4-HYDROXYBUTYL)- GLYCOLOHYDROXAMIC ACID BIS- PHOSPHATE
Descriptor:FRUCTOSE-BISPHOSPHATE ALDOLASE, 4-{hydroxy[(phosphonooxy)acetyl]amino}butyl dihydrogen phosphate, SODIUM ION, ...
Authors:Coincon, M., De la Paz Santangelo, M., Gest, P.M., Guerin, M.E., Pham, H., Ryan, G., Puckett, S.E., Spencer, J.S., Gonzalez-Juarrero, M., Daher, R., Lenaerts, A.J., Schnappinger, D., Therisod, M., Ehrt, S., Jackson, M., Sygusch, J.
Deposit date:2011-09-21
Release date:2011-10-12
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
J. Biol. Chem., 286, 2011
4DDZ
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE (GpgS), GLYCEROL
Authors:Albesa-Jove, D., Urresti, S., Gest, P.M., van der Woerd, M., Jackson, M., Guerin, M.E.
Deposit date:2012-01-19
Release date:2012-06-06
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria.
J.Biol.Chem., 287, 2012
4MQL
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CRYSTAL STRUCTURE OF ANTIGEN 85C-C209S MUTANT
Descriptor:Diacylglycerol acyltransferase/mycolyltransferase Ag85C, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Favrot, L., Grzegorzewicz, A.E., Lajiness, D.H., Marvin, R.K., Boucau, J., Isailovic, D., Jackson, M., Ronning, D.R.
Deposit date:2013-09-16
Release date:2013-11-13
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen.
Nat Commun, 4, 2013
4MQM
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CRYSTAL STRUCTURE OF ANTIGEN 85C IN PRESENCE OF EBSELEN
Descriptor:Diacylglycerol acyltransferase/mycolyltransferase Ag85C
Authors:Favrot, L., Grzegorzewicz, A.E., Lajiness, D.H., Marvin, R.K., Boucau, J., Isailovic, D., Jackson, M., Ronning, D.R.
Deposit date:2013-09-16
Release date:2013-11-13
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (1.346 Å)
Cite:Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen.
Nat Commun, 4, 2013
3C4U
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STRUCTURE OF CLASS II FRUCTOSE-BIPHOSPHATE ALDOLASE FROM HELICOBACTER PYLORI
Descriptor:Fructose-bisphosphate aldolase, SODIUM ION, ZINC ION
Authors:Coincon, M., Sygusch, J.
Deposit date:2008-01-30
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Synthesis and Biochemical Evaluation of Selective Inhibitors of Class II Fructose Bisphosphate Aldolases: Towards New Synthetic Antibiotics.
Chemistry, 14, 2008
3C52
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CLASS II FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE FROM HELICOBACTER PYLORI IN COMPLEX WITH PHOSPHOGLYCOLOHYDROXAMIC ACID, A COMPETITIVE INHIBITOR
Descriptor:Fructose-bisphosphate aldolase, ZINC ION, CALCIUM ION, ...
Authors:Coincon, M., Sygusch, J.
Deposit date:2008-01-30
Release date:2008-08-26
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Synthesis and Biochemical Evaluation of Selective Inhibitors of Class II Fructose Bisphosphate Aldolases: Towards New Synthetic Antibiotics.
Chemistry, 14, 2008
3C56
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CLASS II FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE FROM HELICOBACTER PYLORI IN COMPLEX WITH N-(3-HYDROXYPROPYL)-GLYCOLOHYDROXAMIC ACID BISPHOSPHATE, A COMPETITIVE INHIBITOR
Descriptor:Fructose-bisphosphate aldolase, ZINC ION, 3-{hydroxy[(phosphonooxy)acetyl]amino}propyl dihydrogen phosphate
Authors:Coincon, M., Sygusch, J., Potvin-Dulude, P.
Deposit date:2008-01-30
Release date:2008-08-26
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Synthesis and Biochemical Evaluation of Selective Inhibitors of Class II Fructose Bisphosphate Aldolases: Towards New Synthetic Antibiotics.
Chemistry, 14, 2008
3N9R
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CLASS II FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE FROM HELICOBACTER PYLORI IN COMPLEX WITH N-(4-HYDROXYBUTYL)-PHOSPHOGLYCOLOHYDROXAMIC ACID, A COMPETITIVE INHIBITOR
Descriptor:Fructose-bisphosphate aldolase, ZINC ION, SODIUM ION, ...
Authors:Coincon, M., Sygusch, S.
Deposit date:2010-05-31
Release date:2010-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Rational Design, Synthesis, and Evaluation of New Selective Inhibitors of Microbial Class II (Zinc Dependent) Fructose Bis-phosphate Aldolases.
J.Med.Chem., 53, 2010
3N9S
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CLASS II FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE FROM HELICOBACTER PYLORI IN COMPLEX WITH N-(4-HYDROXYBUTYL)- GLYCOLOHYDROXAMIC ACID BIS-PHOSPHATE, A COMPETITIVE INHIBITOR
Descriptor:Fructose-bisphosphate aldolase, 4-{hydroxy[(phosphonooxy)acetyl]amino}butyl dihydrogen phosphate, ZINC ION, ...
Authors:Coincon, M., Sygusch, S.
Deposit date:2010-05-31
Release date:2010-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Rational Design, Synthesis, and Evaluation of New Selective Inhibitors of Microbial Class II (Zinc Dependent) Fructose Bis-phosphate Aldolases.
J.Med.Chem., 53, 2010
2BYO
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LIPOPROTEIN LPPX (RV2945C)
Descriptor:LIPOPROTEIN LPPX, ZINC ION, ACETATE ION, ...
Authors:Sulzenbacher, G., Canaan, S., Roig-Zamboni, V., Maurin, D., Gicquel, B., Bourne, Y.
Deposit date:2005-08-03
Release date:2006-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Lppx is a Lipoprotein Required for the Translocation of Phthiocerol Dimycocerosates to the Surface of Mycobacterium Tuberculosis.
Embo J., 25, 2006
2FUM
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CATALYTIC DOMAIN OF PROTEIN KINASE PKNB FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MITOXANTRONE
Descriptor:Probable serine/threonine-protein kinase pknB, 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE
Authors:Wehenkel, A., Alzari, P.M.
Deposit date:2006-01-27
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria
Febs Lett., 580, 2006
4DE7
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MG2+ AND URIDINE-DIPHOSPHATE (UDP)
Descriptor:GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE (GpgS), URIDINE-5'-DIPHOSPHATE, GLYCEROL
Authors:Albesa-Jove, D., Urresti, S., van der Woerd, M., Guerin, M.E.
Deposit date:2012-01-20
Release date:2012-06-06
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria.
J.Biol.Chem., 287, 2012
4DEC
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MN2+, URIDINE-DIPHOSPHATE (UDP) AND PHOSPHOGLYCERIC ACID (PGA)
Descriptor:GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE (GpgS), URIDINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Albesa-Jove, D., Urresti, S., van der Woerd, M., Guerin, M.E.
Deposit date:2012-01-20
Release date:2012-06-06
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria.
J.Biol.Chem., 287, 2012
4LV4
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A NONCOMPETITIVE INHIBITOR FOR M. TUBERCULOSIS'S CLASS IIA FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE
Descriptor:Fructose-bisphosphate aldolase, ZINC ION, 8-hydroxyquinoline-2-carboxylic acid, ...
Authors:Capodagli, G.C., Pegan, S.D.
Deposit date:2013-07-25
Release date:2014-01-08
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:A Noncompetitive Inhibitor for Mycobacterium tuberculosis's Class IIa Fructose 1,6-Bisphosphate Aldolase.
Biochemistry, 53, 2014
5F2T
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CRYSTAL STRUCTURE OF MEMBRANE ASSOCIATED PATA FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH PALMITATE - C 2 SPACE GROUP
Descriptor:Phosphatidylinositol mannoside acyltransferase, PALMITIC ACID, MAGNESIUM ION
Authors:Albesa-Jove, D., Svetlikova, Z., Carreras-Gonzalez, A., Tersa, M., Sancho-Vaello, E., Cifuente, J.O., Mikusova, K., Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
5F2Z
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CRYSTAL STRUCTURE OF MEMBRANE ASSOCIATED PATA FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH PALMITATE - P21 SPACE GROUP
Descriptor:Phosphatidylinositol mannoside acyltransferase, PALMITIC ACID
Authors:Albesa-Jove, D., Svetlikova, Z., Carreras-Gonzalez, A., Tersa, M., Sancho-Vaello, E., Cifuente, J.O., Mikusova, K., Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
5F31
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CRYSTAL STRUCTURE OF MEMBRANE ASSOCIATED PATA FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH PALMITATE - P 42 21 2 SPACE GROUP
Descriptor:Phosphatidylinositol mannoside acyltransferase, PALMITIC ACID, ETHANOL, ...
Authors:Albesa-Jove, D., Svetlikova, Z., Carreras-Gonzalez, A., Tersa, M., Sancho-Vaello, E., Cifuente, J.O., Mikusova, K., Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
5F34
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CRYSTAL STRUCTURE OF MEMBRANE ASSOCIATED PATA FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH S-HEXADECYL COENZYME A - P21 SPACE GROUP
Descriptor:Phosphatidylinositol mannoside acyltransferase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{S})-4-[[3-(2-hexadecylsulfanylethylamino)-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate
Authors:Albesa-Jove, D., Svetlikova, Z., Carreras-Gonzalez, A., Tersa, M., Sancho-Vaello, E., Cifuente, J.O., Mikusova, K., Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (3.281 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
5JQQ
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS - APO FORM
Descriptor:Glucosyl-3-phosphoglycerate synthase, GLYCEROL
Authors:Albesa-Jove, D., Urresti, S., Gest, P.M., van der Woerd, M., Jackson, M., Guerin, M.E.
Deposit date:2016-05-05
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of glucosyl-3-phosphoglycerate synthase from Mycobacterium tuberculosis - apo form
To Be Published
5WM9
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CRYSTAL STRUCTURE OF TETR FAMILY REGULATOR RV0078 FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Rv0078, SULFATE ION
Authors:Hsu, H.C., Li, H.
Deposit date:2017-07-28
Release date:2018-07-04
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.850003 Å)
Cite:Cytokinin Signaling in Mycobacterium tuberculosis.
MBio, 9, 2018
6C31
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CRYSTAL STRUCTURE OF TETR FAMILY PROTEIN RV0078 IN COMPLEX WITH DNA
Descriptor:TetR family transcriptional regulator, DNA (5'-D(P*AP*CP*AP*AP*GP*CP*AP*GP*AP*CP*TP*GP*CP*CP*GP*GP*TP*AP*AP*C)-3'), DNA (5'-D(*GP*TP*TP*AP*CP*CP*GP*GP*CP*AP*GP*TP*CP*TP*GP*CP*TP*TP*GP*TP*AP*AP*A)-3')
Authors:Hsu, H.C., Li, H.
Deposit date:2018-01-09
Release date:2018-07-04
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Cytokinin Signaling in Mycobacterium tuberculosis.
MBio, 9, 2018