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6YVQ

Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in apo form

Summary for 6YVQ
Entry DOI10.2210/pdb6yvq/pdb
DescriptorPhosphoribosylaminoimidazole-succinocarboxamide synthase, SULFATE ION, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordssaicar synthetase, phosphoribosylaminoimidazole-succinocarboxamide synthase, purc, purine biosynthesis, ligase
Biological sourceMycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)
Total number of polymer chains1
Total formula weight34278.51
Authors
Thomas, S.E.,Charoensutthivarakul, S.,Coyne, A.G.,Abell, C.,Blundell, T.L. (deposition date: 2020-04-28, release date: 2021-05-12, Last modification date: 2024-01-24)
Primary citationCharoensutthivarakul, S.,Thomas, S.E.,Curran, A.,Brown, K.P.,Belardinelli, J.M.,Whitehouse, A.J.,Acebron-Garcia-de-Eulate, M.,Sangan, J.,Gramani, S.G.,Jackson, M.,Mendes, V.,Floto, R.A.,Blundell, T.L.,Coyne, A.G.,Abell, C.
Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
Acs Infect Dis., 8:296-309, 2022
Cited by
PubMed: 35037462
DOI: 10.1021/acsinfecdis.1c00432
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.48 Å)
Structure validation

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