6YY8

Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor

Summary for 6YY8

Entry DOI	10.2210/pdb6yy8/pdb
Descriptor	Phosphoribosylaminoimidazole-succinocarboxamide synthase, 1,2-ETHANEDIOL, 4-azanyl-6-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]pyrimidine-5-carbonitrile, ... (5 entities in total)
Functional Keywords	saicar synthetase, phosphoribosylaminoimidazole-succinocarboxamide synthase, purc, purine biosynthesis, ligase
Biological source	Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)
Total number of polymer chains	1
Total formula weight	34515.77
Authors	Thomas, S.E.,Charoensutthivarakul, S.,Coyne, A.G.,Abell, C.,Blundell, T.L. (deposition date: 2020-05-04, release date: 2021-05-12, Last modification date: 2024-01-24)
Primary citation	Charoensutthivarakul, S.,Thomas, S.E.,Curran, A.,Brown, K.P.,Belardinelli, J.M.,Whitehouse, A.J.,Acebron-Garcia-de-Eulate, M.,Sangan, J.,Gramani, S.G.,Jackson, M.,Mendes, V.,Floto, R.A.,Blundell, T.L.,Coyne, A.G.,Abell, C. Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach. Acs Infect Dis., 8:296-309, 2022 Cited by PubMed: 35037462 DOI: 10.1021/acsinfecdis.1c00432 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation