Author results

2DXL
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GLYCEROPHOSPHODIESTERASE FROM ENTEROBACTER AEROGENES
Descriptor:Phosphohydrolase, COBALT (II) ION
Authors:Jackson, C.J., Carr, P.D., Ollis, D.L.
Deposit date:2006-08-28
Release date:2007-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure and function of a novel glycerophosphodiesterase from Enterobacter aerogenes
J.Mol.Biol., 367, 2007
2DXN
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GLYCEROPHOSPHODIESTERASE FROM ENTEROBACTER AEROGENES
Descriptor:Phosphohydrolase, ZINC ION
Authors:Jackson, C.J., Carr, P.D., Ollis, D.L.
Deposit date:2006-08-28
Release date:2007-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:The structure and function of a novel glycerophosphodiesterase from Enterobacter aerogenes
J.Mol.Biol., 367, 2007
2ZO9
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MALONATE-BOUND STRUCTURE OF THE GLYCEROPHOSPHODIESTERASE FROM ENTEROBACTER AEROGENES (GPDQ) AND CHARACTERIZATION OF THE NATIVE FE2+ METAL ION PREFERENCE
Descriptor:Phosphohydrolase, FE (II) ION, MALONATE ION
Authors:Jackson, C.J., Carr, P.D., Ollis, D.L.
Deposit date:2008-05-07
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference.
Acta Crystallogr.,Sect.F, 64, 2008
4FNG
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THE ALPHA-ESTERASE-7 CARBOXYLESTERASE, E3, FROM THE BLOWFLY LUCILIA CUPRINA
Descriptor:E3 alpha-esterase-7 caboxylesterase
Authors:Jackson, C.J., Liu, J.-W., Carr, P.D., Younis, F., Pandey, G., Coppin, C., Meirelles, T., Ollis, D.L., Tawfik, D.S., Weik, M., Oakeshott, J.G.
Deposit date:2012-06-19
Release date:2013-06-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and function of an insect alpha-carboxylesterase ( alpha Esterase7) associated with insecticide resistance.
Proc.Natl.Acad.Sci.USA, 110, 2013
4FNM
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THE ALPHA-ESTERASE-7 CARBOXYLESTERASE, E3, FROM THE BLOWFLY LUCILIA CUPRINA
Descriptor:E3 alpha-esterase-7 carboxylesterase, DIETHYL HYDROGEN PHOSPHATE
Authors:Jackson, C.J., Liu, J.-W., Carr, P.D., Younis, F., Pandey, G., Coppin, C., Meirelles, T., Ollis, D.L., Tawfik, D.S., Weik, M., Oakeshott, J.G.
Deposit date:2012-06-20
Release date:2013-12-04
Method:X-RAY DIFFRACTION (1.804 Å)
Cite:Structure and function of an insect alpha-carboxylesterase ( alpha Esterase7) associated with insecticide resistance.
Proc.Natl.Acad.Sci.USA, 110, 2013
4L9X
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TRIAZINE HYDROLASE FROM ARTHOBACTER AURESCENS MODIFIED FOR MAXIMUM EXPRESSION IN E.COLI
Descriptor:Triazine hydrolase, ACETATE ION
Authors:Jackson, C.J., Coppin, C.W., Alexandrov, A., Wilding, M., Liu, J.-W., Ubels, J., Paks, M., Carr, P.D., Newman, J., Russell, R.J., Field, M., Weik, M., Oakeshott, J.G., Scott, C.
Deposit date:2013-06-18
Release date:2014-05-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Apoenzyme stabilization results in 300-fold increased soluble production of the Zn2+-dependent dechlorinase TrzN.
Appl.Environ.Microbiol., 2014
4LH8
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TRIAZINE HYDROLASE FROM ARTHOBACTER AURESCENS MODIFIED FOR MAXIMUM EXPRESSION IN E.COLI
Descriptor:Triazine hydrolase, ZINC ION
Authors:Jackson, C.J., Coppin, C.W., Alexandrov, A., Wilding, M., Liu, J.-W., Ubels, J., Paks, M., Carr, P.D., Newman, J., Russell, R.J., Field, M., Weik, M., Oakeshott, J.G., Scott, C.
Deposit date:2013-07-01
Release date:2014-05-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Apoenzyme stabilization results in 300-fold increased soluble production of the Zn2+-dependent dechlorinase TrzN.
Appl.Environ.Microbiol., 2014
5T0Y
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2A10 ANTIBODY FAB FRAGMENT
Descriptor:2A10 FAB fragment light chain, 2A10 FAB fragment heavy chain, SULFATE ION
Authors:Jackson, C.J., Fisher, C.
Deposit date:2016-08-17
Release date:2017-06-21
Method:X-RAY DIFFRACTION (3.011 Å)
Cite:Restricted antibody diversity and low affinity limit antibody responses to the Plasmodium circumsporozoite protein
To Be Published
2R1K
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OPDA FROM AGROBACTERIUM RADIOBACTER WITH BOUND DIETHYL PHOSPHATE FROM CRYSTAL SOAKING WITH THE COMPOUND- 1.9 A
Descriptor:Phosphotriesterase, FE (II) ION, COBALT (II) ION, ...
Authors:Ollis, D.L., Jackson, C.J., Foo, J.L., Kim, H.K., Carr, P.D., Liu, J.W., Salem, G.
Deposit date:2007-08-23
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase
J.Mol.Biol., 375, 2008
2R1L
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OPDA FROM AGROBACTERIUM RADIOBACTER WITH BOUND DIETHYL THIOPHOSPHATE FROM CRYSTAL SOAKING WITH THE COMPOUND- 1.95 A
Descriptor:Phosphotriesterase, FE (II) ION, COBALT (II) ION, ...
Authors:Ollis, D.L., Jackson, C.J., Foo, J.L., Kim, H.K., Carr, P.D., Liu, J.W., Salem, G.
Deposit date:2007-08-23
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase
J.Mol.Biol., 375, 2008
2R1M
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OPDA FROM AGROBACTERIUM RADIOBACTER WITH BOUND PRODUCT DIETHYL PHOSPHATE FROM CRYSTAL SOAKING WITH DIETHYL 4-METHOXYPHENYL PHOSPHATE (450H)- 2.5 A
Descriptor:Phosphotriesterase, FE (II) ION, COBALT (II) ION, ...
Authors:Ollis, D.L., Jackson, C.J., Foo, J.L., Kim, H.K., Carr, P.D., Liu, J.W., Salem, G.
Deposit date:2007-08-23
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase
J.Mol.Biol., 375, 2008
2R1N
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OPDA FROM AGROBACTERIUM RADIOBACTER WITH BOUND SLOW SUBSTRATE DIETHYL 4-METHOXYPHENYL PHOSPHATE (20H)- 1.7 A
Descriptor:Phosphotriesterase, FE (II) ION, COBALT (II) ION, ...
Authors:Ollis, D.L., Jackson, C.J., Foo, J.L., Kim, H.K., Carr, P.D., Liu, J.W., Salem, G.
Deposit date:2007-08-23
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase
J.Mol.Biol., 375, 2008
2R1P
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OPDA FROM AGROBACTERIUM RADIOBACTER WITH BOUND PRODUCT DIETHYL THIOPHOSPHATE FROM CO-CRYSTALLISATION WITH TETRAETHYL DITHIOPYROPHOSPHATE- 1.8 A
Descriptor:Phosphotriesterase, FE (II) ION, COBALT (II) ION, ...
Authors:Ollis, D.L., Jackson, C.J., Foo, J.L., Kim, H.K., Carr, P.D., Liu, J.W., Salem, G.
Deposit date:2007-08-23
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase
J.Mol.Biol., 375, 2008
2ZOA
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MALONATE-BOUND STRUCTURE OF THE GLYCEROPHOSPHODIESTERASE FROM ENTEROBACTER AEROGENES (GPDQ) COLLECTED AT 1.280 ANGSTROM
Descriptor:Phosphohydrolase, FE (II) ION, MALONATE ION
Authors:Ollis, D.L., Jackson, C.J., Carr, P.D.
Deposit date:2008-05-07
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference.
Acta Crystallogr.,Sect.F, 64, 2008
3A3W
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STRUCTURE OF OPDA MUTANT (G60A/A80V/S92A/R118Q/K185R/Q206P/D208G/I260T/G273S) WITH DIETHYL 4-METHOXYPHENYL PHOSPHATE BOUND IN THE ACTIVE SITE
Descriptor:Phosphotriesterase, COBALT (II) ION, DIETHYL 4-METHOXYPHENYL PHOSPHATE
Authors:Ollis, D.L., Tawfik, D.S., Schenk, G., Jackson, C.J., Foo, J.L., Tokuriki, N., Afriat, L., Carr, P.D., Kim, H.K.
Deposit date:2009-06-23
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase
Proc.Natl.Acad.Sci.USA, 2009
3A3X
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STRUCTURE OF OPDA MUTANT (G60A/A80V/R118Q/K185R/Q206P/D208G/I260T/G273S)
Descriptor:Phosphotriesterase, COBALT (II) ION
Authors:Ollis, D.L., Tawfik, D.S., Schenk, G., Jackson, C.J., Foo, J.L., Tokuriki, N., Afriat, L., Carr, P.D., Kim, H.K.
Deposit date:2009-06-23
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase
Proc.Natl.Acad.Sci.USA, 2009
3A4J
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ARPTE (K185R/D208G/N265D/T274N)
Descriptor:Phosphotriesterase, COBALT (II) ION, 1,2-ETHANEDIOL
Authors:Foo, J.L., Jackson, C.J., Carr, P.D., Ollis, D.L.
Deposit date:2009-07-07
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase
Proc.Natl.Acad.Sci.USA, 2009
3C86
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OPDA FROM AGROBACTERIUM RADIOBACTER WITH BOUND PRODUCT DIETHYL THIOPHOSPHATE FROM CRYSTAL SOAKING WITH TETRAETHYL DITHIOPYROPHOSPHATE- 1.8 A
Descriptor:Phosphotriesterase, FE (II) ION, COBALT (II) ION, ...
Authors:Ollis, D.L., Jackson, C.J., Foo, J.L., Kim, H.K., Carr, P.D., Liu, J.W., Salem, G.
Deposit date:2008-02-10
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase
J.Mol.Biol., 375, 2008
3F7E
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MSMEG_3380 F420 REDUCTASE
Descriptor:Pyridoxamine 5'-phosphate oxidase-related, FMN-binding
Authors:Jackson, C.J.
Deposit date:2008-11-08
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Identification and characterisation of two novel classes of F420-dependent reductases from Mycobacterium that degrade aflatoxin
To be Published
3H96
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MSMEG_3358 F420 REDUCTASE
Descriptor:F420-H2 Dependent Reductase A, 1,2-ETHANEDIOL
Authors:Jackson, C.J., French, N., Newman, J., Taylor, M.C., Russell, R.J., Oakeshott, J.G.
Deposit date:2009-04-30
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification and characterization of two families of F420 H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation.
Mol.Microbiol., 78, 2010
3WML
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STRUCTURE OF PHOSPHOTRIESTERASE MUTANT (S308L/Y309A) FROM AGROBACTERIUM RADIOBACTER
Descriptor:Phosphotriesterase, FE (II) ION, COBALT (II) ION, ...
Authors:Jackson, C.J., Carr, P.D., Sugrue, E.
Deposit date:2013-11-21
Release date:2014-09-24
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:A 5000-fold increase in the specificity of a bacterial phosphotriesterase for malathion through combinatorial active site mutagenesis
Plos One, 9, 2014
4GY0
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ROUND 18 ARYLESTERASE VARIANT OF PHOSPHOTRIESTERASE
Descriptor:arylesterase variant of phosphotriesterase, ZINC ION
Authors:Jackson, C.J., Tokuriki, N., Tawfik, D.S.
Deposit date:2012-09-05
Release date:2013-08-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme
Nat Commun, 3, 2012
4GY1
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ROUND 18 ARYLESTERASE VARIANT OF PHOSPHOTRIESTERASE WITH BOUND CACODYLATE
Descriptor:arylesterase variant of phosphotriesterase, ZINC ION, CACODYLATE ION
Authors:Jackson, C.J., Tokuriki, N., Tawfik, D.S.
Deposit date:2012-09-05
Release date:2013-08-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme
Nat Commun, 3, 2012
4NP7
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STRUCTURE OF PHOSPHOTRIESTERASE MUTANT (S308L/Y309A) FROM AGROBACTERIUM RADIOBACTER WITH DIETHYL THIOPHOSPHATE BOUND IN THE ACTIVE SITE
Descriptor:Phosphotriesterase, FE (II) ION, COBALT (II) ION, ...
Authors:Jackson, C.J., Carr, P.D., Sugrue, E.
Deposit date:2013-11-20
Release date:2014-09-24
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:A 5000-fold increase in the specificity of a bacterial phosphotriesterase for malathion through combinatorial active site mutagenesis
Plos One, 9, 2014
4PCN
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PHOSPHOTRIESTERASE VARIANT R22
Descriptor:Phosphotriesterase variant PTE-R22, (4S)-2-METHYL-2,4-PENTANEDIOL, ZINC ION
Authors:Jackson, C.J., Campbell, E., Kaltenbach, M., Tokuriki, N.
Deposit date:2014-04-16
Release date:2015-05-06
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:The role of protein dynamics in the evolution of new enzyme function.
Nat. Chem. Biol., 12, 2016