Author results

1AE5
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HUMAN HEPARIN BINDING PROTEIN
Descriptor:HEPARIN BINDING PROTEIN, N-ACETYL-D-GLUCOSAMINE
Authors:Iversen, L.F., Kastrup, J.S., Bjorn, S.E., Rasmussen, P.B., Wiberg, F.C., Flodgaard, H.J., Larsen, I.K.
Deposit date:1997-03-05
Release date:1998-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of HBP, a multifunctional protein with a serine proteinase fold.
Nat.Struct.Biol., 4, 1997
1C86
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Descriptor:PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B), 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Authors:Iversen, L.F., Andersen, H.S., Mortensen, S.B., Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
1C87
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Descriptor:PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B), 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Authors:Iversen, L.F., Andersen, H.S., Mortensen, S.B., Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
1C88
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID
Descriptor:PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B), 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID
Authors:Iversen, L.F., Andersen, H.S., Mortensen, S.B., Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
1L8G
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CRYSTAL STRUCTURE OF PTP1B COMPLEXED WITH 7-(1,1-DIOXO-1H-BENZO[D]ISOTHIAZOL-3-YLOXYMETHYL)-2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1, 7-(1,1-DIOXO-1H-BENZO[D]ISOTHIAZOL-3-YLOXYMETHYL)-2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Authors:Iversen, L.F., Andersen, H.S., Moller, K.B., Olsen, O.H., Peters, G.H., Branner, S., Mortensen, S.B., Hansen, T.K., Lau, J., Ge, Y., Holsworth, D.D., Newman, M.J., Moller, N.P.H.
Deposit date:2002-03-20
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases.
Biochemistry, 40, 2001
1L8K
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T CELL PROTEIN-TYROSINE PHOSPHATASE STRUCTURE
Descriptor:T-cell protein-tyrosine phosphatase
Authors:Iversen, L.F.
Deposit date:2002-03-21
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structure determination of T cell protein-tyrosine phosphatase.
J.Biol.Chem., 277, 2002
1GFY
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RESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITY OF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA
Descriptor:PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B), 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]THIOPYRAN-3-CARBOXYLIC ACID
Authors:Iversen, L.F.
Deposit date:2000-06-26
Release date:2000-07-04
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha.
J.Biol.Chem., 275, 2000
1FY1
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[R23S,F25E]HBP, A MUTANT OF HUMAN HEPARIN BINDING PROTEIN (CAP37)
Descriptor:HEPARIN-BINDING PROTEIN, N-ACETYL-D-GLUCOSAMINE, ETHANOL
Authors:Kastrup, J.S., Linde, V., Pedersen, A.K., Stoffer, B., Iversen, L.F., Larsen, I.K., Rasmussen, P.B., Flodgaard, H.J., Bjorn, S.E.
Deposit date:2000-09-28
Release date:2001-09-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Two mutants of human heparin binding protein (CAP37): toward the understanding of the nature of lipid A/LPS and BPTI binding.
Proteins, 42, 2001
1FY3
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[G175Q]HBP, A MUTANT OF HUMAN HEPARIN BINDING PROTEIN (CAP37)
Descriptor:HEPARIN-BINDING PROTEIN, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Kastrup, J.S., Linde, V., Pedersen, A.K., Stoffer, B., Iversen, L.F., Larsen, I.K., Rasmussen, P.B., Flodgaard, H.J., Bjorn, S.E.
Deposit date:2000-09-28
Release date:2001-09-28
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Two mutants of human heparin binding protein (CAP37): toward the understanding of the nature of lipid A/LPS and BPTI binding.
Proteins, 42, 2001
1A7S
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ATOMIC RESOLUTION STRUCTURE OF HBP
Descriptor:HEPARIN BINDING PROTEIN, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Karlsen, S., Iversen, L.F., Larsen, I.K., Flodgaard, H.J., Kastrup, J.S.
Deposit date:1998-03-17
Release date:1999-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Atomic resolution structure of human HBP/CAP37/azurocidin.
Acta Crystallogr.,Sect.D, 54, 1998
1SUG
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1.95 A STRUCTURE OF APO PROTEIN TYROSINE PHOSPHATASE 1B
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Pedersen, A.K., Peters, G.H., Moller, K.B., Iversen, L.F., Kastrup, J.S.
Deposit date:2004-03-26
Release date:2004-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Water-molecule network and active-site flexibility of apo protein tyrosine phosphatase 1B.
Acta Crystallogr.,Sect.D, 60, 2004
1C83
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID
Descriptor:PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B), 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID
Authors:Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.
Deposit date:2000-04-14
Release date:2000-05-03
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1C84
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID
Descriptor:PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B), 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXYLIC ACID
Authors:Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.
Deposit date:2000-04-14
Release date:2000-05-03
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1C85
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID
Descriptor:PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B), 2-(OXALYL-AMINO)-BENZOIC ACID
Authors:Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1ECV
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B, ACETATE ION, 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID
Authors:Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.H.
Deposit date:2000-01-26
Release date:2000-03-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1Z6P
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GLYCOGEN PHOSPHORYLASE AMP SITE INHIBITOR COMPLEX
Descriptor:Glycogen phosphorylase, muscle form, 4-{2-[(3-NITROBENZOYL)AMINO]PHENOXY}PHTHALIC ACID
Authors:Kristiansen, M., Andersen, B., Iversen, L.F., Westergaard, N.
Deposit date:2005-03-23
Release date:2005-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Identification, synthesis and chracterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site
J.Med.Chem., 47, 2004
1Z6Q
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GLYCOGEN PHOSPHORYLASE WITH INHIBITOR IN THE AMP SITE
Descriptor:Glycogen phosphorylase, muscle form, 4-{2,4-BIS[(3-NITROBENZOYL)AMINO]PHENOXY}PHTHALIC ACID
Authors:Kristiansen, M., Andersen, B., Iversen, L.F., Westergaard, N.
Deposit date:2005-03-23
Release date:2005-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Identification, synthesis and chracterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site
J.Med.Chem., 47, 2004
1WUY
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CRYSTALLOGRAPHIC STUDIES ON ACYL UREAS, A NEW CLASS OF INHIBITORS OF GLYCOGEN PHOSPHORYLASE. BROAD SPECIFICITY OF THE ALLOSTERIC SITE
Descriptor:Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G., Kosmopoulou, M.N., Chrysina, E.D., Leonidas, D.D., Klabunde, T., Wendt, K.U., Defossa, E.
Deposit date:2004-12-09
Release date:2005-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs
Protein Sci., 14, 2005
1WV0
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CRYSTALLOGRAPHIC STUDIES ON ACYL UREAS, A NEW CLASS OF INHIBITORS OF GLYCOGEN PHOSPHORYLASE. BROAD SPECIFICITY OF THE ALLOSTERIC SITE
Descriptor:Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G., Kosmopoulou, M.N., Chrysina, E.D., Leonidas, D.D., Klabunde, T., Wendt, K.U., Defossa, E.
Deposit date:2004-12-10
Release date:2005-12-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs
Protein Sci., 14, 2005
1WV1
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CRYSTALLOGRAPHIC STUDIES ON ACYL UREAS, A NEW CLASS OF INHIBITORS OF GLYCOGENPHOSPHORYLASE. BROAD SPECIFICITY OF THE ALLOSTERIC SITE
Descriptor:Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G., Kosmopoulou, M.N., Chrysina, E.D., Leonidas, D.D., Klabunde, T., Wendt, K.U., Defossa, E.
Deposit date:2004-12-10
Release date:2005-12-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs
Protein Sci., 14, 2005
6B90
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MULTICONFORMER MODEL OF APO WT PTP1B WITH GLYCEROL AT 100 K (ALTERNATIVE REFINEMENT OF PDB 1SUG SHOWING CONFORMATIONAL HETEROGENEITY)
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, GLYCEROL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2017-10-09
Release date:2018-06-20
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
Elife, 7, 2018