2QGH
| Crystal structure of diaminopimelate decarboxylase from Helicobacter pylori complexed with L-lysine | Descriptor: | Diaminopimelate decarboxylase, GLYCEROL, LYSINE, ... | Authors: | Hu, T, Wu, D, Jiang, H, Shen, X. | Deposit date: | 2007-06-28 | Release date: | 2008-05-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of diaminopimelate decarboxylase from Helicobacter pylori complexed with L-lysine TO BE PUBLISHED
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8WDA
| Cryo-EM structure of the substrate-bound DppABCD complex | Descriptor: | (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, PALMITIC ACID, Probable dipeptide-transport ATP-binding protein ABC transporter DppD, ... | Authors: | Hu, T, Zhang, B, Rao, Z. | Deposit date: | 2023-09-14 | Release date: | 2024-09-18 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Cryo-EM structure of the substrate-bound DppABCD complex To Be Published
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8XFC
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8WD9
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8WDB
| Cryo-EM structure of the ATP-bound DppABCD complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Probable dipeptide-transport ATP-binding protein ABC transporter DppD, ... | Authors: | Hu, T, Zhang, B, Rao, Z. | Deposit date: | 2023-09-14 | Release date: | 2024-09-18 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Cryo-EM structure of the ATP-bound DppABCD complex To Be Published
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4ZIA
| Crystal Structure of STAT3 N-terminal domain | Descriptor: | FORMIC ACID, MAGNESIUM ION, NICKEL (II) ION, ... | Authors: | Hu, T, Chopra, R. | Deposit date: | 2015-04-28 | Release date: | 2015-07-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity. Mol.Cell.Biol., 35, 2015
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3F9G
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3F9E
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3F9H
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3FXJ
| Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 3 mM of Mn2+ | Descriptor: | MANGANESE (II) ION, PHOSPHATE ION, Protein phosphatase 1A | Authors: | Hu, T, Wang, L, Wang, K, Jiang, H, Shen, X. | Deposit date: | 2009-01-21 | Release date: | 2010-01-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for the Mn2+-dependent activation of human PPM1A To be published
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3FXK
| Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 10 mM of Mn2+ | Descriptor: | MANGANESE (II) ION, PHOSPHATE ION, Protein phosphatase 1A | Authors: | Hu, T, Wang, L, Wang, K, Jiang, H, Shen, X. | Deposit date: | 2009-01-21 | Release date: | 2010-01-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for the Mn2+-dependent activation of human PPM1A To be published
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3FXL
| Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Citrate at 1 mM of Mn2+ | Descriptor: | CITRATE ANION, MANGANESE (II) ION, PHOSPHATE ION, ... | Authors: | Hu, T, Wang, L, Wang, K, Jiang, H, Shen, X. | Deposit date: | 2009-01-21 | Release date: | 2010-01-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the Mn2+-dependent activation of human PPM1A To be published
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3F9F
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3FXO
| Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 1 mM of Mn2+ | Descriptor: | MANGANESE (II) ION, PHOSPHATE ION, Protein phosphatase 1A | Authors: | Hu, T, Wang, L, Wang, K, Jiang, H, Shen, X. | Deposit date: | 2009-01-21 | Release date: | 2010-01-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for the Mn2+-dependent activation of human PPM1A To be published
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3FXM
| Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Citrate at 10 mM of Mn2+ | Descriptor: | CITRATE ANION, MANGANESE (II) ION, PHOSPHATE ION, ... | Authors: | Hu, T, Wang, L, Wang, K, Jiang, H, Shen, X. | Deposit date: | 2009-01-21 | Release date: | 2010-01-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for the Mn2+-dependent activation of human PPM1A To be published
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3C5Q
| Crystal structure of diaminopimelate decarboxylase (I148L mutant) from Helicobacter pylori complexed with L-lysine | Descriptor: | Diaminopimelate decarboxylase, GLYCEROL, LYSINE, ... | Authors: | Hu, T, Wu, D, Jiang, H, Shen, X. | Deposit date: | 2008-02-01 | Release date: | 2008-05-27 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of diaminopimelate decarboxylase from Helicobacter pylori To be Published
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5CZV
| Crystal structure of Notch3 NRR in complex with 20350 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fab 20350 heavy chain, ... | Authors: | Hu, T, Fryer, C, Chopra, R, Clark, K. | Deposit date: | 2015-08-01 | Release date: | 2016-06-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 2016
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5CZX
| Crystal structure of Notch3 NRR in complex with 20358 Fab | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 20358 Fab heavy chain, ... | Authors: | Hu, T, Fryer, C, Chopra, R, Clark, K. | Deposit date: | 2015-08-01 | Release date: | 2016-06-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 2016
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8WTW
| Cryo-EM structure of noradrenaline transporter in complex with a x-MrlA analogue | Descriptor: | CHLORIDE ION, MrlA, O-methyl-L-tyrosine, ... | Authors: | Zhao, Y, Hu, T, Yu, Z. | Deposit date: | 2023-10-19 | Release date: | 2024-08-07 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter. Nature, 632, 2024
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8WTU
| Cryo-EM structure of noradrenaline transporter in apo state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium-dependent noradrenaline transporter | Authors: | Zhao, Y, Hu, T, Yu, Z. | Deposit date: | 2023-10-19 | Release date: | 2024-08-07 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter. Nature, 632, 2024
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8WTX
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8WTY
| Cryo-EM structure of noradrenaline transporter in complex with ziprasidone | Descriptor: | 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloranyl-1,3-dihydroindol-2-one, Sodium-dependent noradrenaline transporter | Authors: | Zhao, Y, Hu, T, Yu, Z. | Deposit date: | 2023-10-19 | Release date: | 2024-08-07 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter. Nature, 632, 2024
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8WTV
| Cryo-EM structure of noradrenaline transporter in complex with noradrenaline | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Noradrenaline, ... | Authors: | Zhao, Y, Hu, T, Yu, Z. | Deposit date: | 2023-10-19 | Release date: | 2024-08-07 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter. Nature, 632, 2024
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7WNX
| Cryo-EM structure of Mycobacterium smegmatis MmpL3 complexed with ST004 in lipid nanodiscs | Descriptor: | N-[2-(2-adamantylamino)ethyl]-1-[2,4-bis(fluoranyl)phenyl]-5-(4-chlorophenyl)-4-methyl-pyrazole-3-carboxamide, Trehalose monomycolate exporter MmpL3 | Authors: | Zhang, B, Hu, T, Yang, X, Liu, F, Rao, Z. | Deposit date: | 2022-01-20 | Release date: | 2022-08-03 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3. Structure, 30, 2022
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2RJG
| Crystal structure of biosynthetic alaine racemase from Escherichia coli | Descriptor: | Alanine racemase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | Authors: | Wu, D, Hu, T, Zhang, L, Jiang, H, Shen, X. | Deposit date: | 2007-10-15 | Release date: | 2008-07-08 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis Protein Sci., 17, 2008
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