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3FC6
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BU of 3fc6 by Molmil
hRXRalpha & mLXRalpha with an indole Pharmacophore, SB786875
Descriptor: Nr1h3 protein, RETINOIC ACID, Retinoic acid receptor RXR-alpha, ...
Authors:Washburn, D.G, Hoang, T.H, Campobasso, N, Smallwood, A, Parks, D.J, Webb, C.L, Frank, K, Nord, M, Duraiswami, C, Evans, C, Jaye, M, Thompson, S.K.
Deposit date:2008-11-21
Release date:2009-02-10
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.063 Å)
Cite:Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.
Bioorg.Med.Chem.Lett., 19, 2009
6USQ
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BU of 6usq by Molmil
Telomerase Reverse Transcriptase binary complex with Y256A mutation, TERT:DNA
Descriptor: DNA (5'-D(*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*A)-3'), DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)-R(P*GP*AP*C)-D(P*C)-3'), MAGNESIUM ION, ...
Authors:Schaich, M.A, Freudenthal, B.D, Khoang, T.H.
Deposit date:2019-10-28
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.62 Å)
Cite:Mechanisms of nucleotide selection by telomerase.
Elife, 9, 2020
3KBA
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BU of 3kba by Molmil
Progesterone receptor bound to sulfonamide pyrrolidine partial agonist
Descriptor: 2-chloro-4-{(2-methylbenzyl)[(3S)-1-(methylsulfonyl)pyrrolidin-3-yl]amino}benzonitrile, Progesterone receptor, SULFATE ION
Authors:Kallander, L.S, Washburn, D.G, Williams, S.P, Madauss, K.P.
Deposit date:2009-10-20
Release date:2009-12-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Improving the developability profile of pyrrolidine progesterone receptor partial agonists.
Bioorg.Med.Chem.Lett., 20, 2010
3G8O
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BU of 3g8o by Molmil
Progesterone Receptor with bound Pyrrolidine 1
Descriptor: N~2~-[4-cyano-3-(trifluoromethyl)phenyl]-N,N-dimethyl-N~2~-(2,2,2-trifluoroethyl)-L-alaninamide, Progesterone receptor, SULFATE ION
Authors:Thompson, S.K, Washburn, D.G, Madauss, K.P, Williams, S.P, Stewart, E.L.
Deposit date:2009-02-12
Release date:2010-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.
Bioorg.Med.Chem.Lett., 19, 2009
3HQ5
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BU of 3hq5 by Molmil
Progesterone Receptor bound to an Alkylpyrrolidine ligand.
Descriptor: 2-chloro-4-{[(3S)-1-methylpyrrolidin-3-yl][2-(trifluoromethyl)benzyl]amino}benzonitrile, GLYCEROL, Progesterone receptor, ...
Authors:Madauss, K.P, Williams, S.P, Washburn, D.G.
Deposit date:2009-06-05
Release date:2010-03-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.
Bioorg.Med.Chem.Lett., 19, 2009
7T19
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BU of 7t19 by Molmil
Rev1 Ternary Complex with dGTP and Ca2+
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ...
Authors:Freudenthal, B.D, Weaver, T.M.
Deposit date:2021-12-01
Release date:2022-05-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1.
Nat Commun, 13, 2022
7T1B
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BU of 7t1b by Molmil
Rev1 Ternary Complex with rCTP and Ca2+
Descriptor: CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ...
Authors:Freudenthal, B.D, Weaver, T.M.
Deposit date:2021-12-01
Release date:2022-05-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1.
Nat Commun, 13, 2022
7T18
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BU of 7t18 by Molmil
Rev1 Ternary Complex with dTTP and Ca2+
Descriptor: CALCIUM ION, DNA (5'-D(*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*G)-3'), ...
Authors:Freudenthal, B.D, Weaver, T.M.
Deposit date:2021-12-01
Release date:2022-05-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1.
Nat Commun, 13, 2022
7T1A
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BU of 7t1a by Molmil
Rev1 Ternary Complex with dATP and Ca2+
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ...
Authors:Freudenthal, B.D, Weaver, T.M.
Deposit date:2021-12-01
Release date:2022-05-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1.
Nat Commun, 13, 2022
6USO
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BU of 6uso by Molmil
Telomerase Reverse Transcriptase prenucleotide binary complex, TERT:DNA
Descriptor: DNA (5'-D(*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*A)-3'), DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)-R(P*GP*AP*C)-D(P*C)-3'), MAGNESIUM ION, ...
Authors:Schaich, M.A, Freudenthal, B.D.
Deposit date:2019-10-28
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Mechanisms of nucleotide selection by telomerase.
Elife, 9, 2020
6USP
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BU of 6usp by Molmil
Telomerase Reverse Transcriptase product complex, TERT:DNA
Descriptor: DNA (5'-D(P*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*G)-3'), DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)-R(P*GP*AP*C)-D(P*C)-3'), MAGNESIUM ION, ...
Authors:Schaich, M.A, Freudenthal, B.D.
Deposit date:2019-10-28
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.56 Å)
Cite:Mechanisms of nucleotide selection by telomerase.
Elife, 9, 2020
6USR
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BU of 6usr by Molmil
Telomerase Reverse Transcriptase ternary complex, TERT:DNA:dGpCpp
Descriptor: DNA (5'-D(*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*A)-3'), DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)-R(P*GP*AP*C)-D(P*C)-3'), MAGNESIUM ION, ...
Authors:Schaich, M.A, Freudenthal, B.D.
Deposit date:2019-10-28
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Mechanisms of nucleotide selection by telomerase.
Elife, 9, 2020
7TR7
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BU of 7tr7 by Molmil
APE1 product complex with abasic ssDNA
Descriptor: DNA (5'-D(P*(3DR)P*CP*GP*AP*TP*GP*C)-3'), DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION
Authors:Freudenthal, B.D, Hoitsma, N.M.
Deposit date:2022-01-28
Release date:2023-04-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics.
Nucleic Acids Res., 51, 2023
6X76
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BU of 6x76 by Molmil
Rev1 L325G Mn2+-facilitated Product Complex with second dCTP bound
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*GP*C)-3'), ...
Authors:Weaver, T.M, Freudenthal, B.D.
Deposit date:2020-05-29
Release date:2020-09-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Visualizing Rev1 catalyze protein-template DNA synthesis.
Proc.Natl.Acad.Sci.USA, 117, 2020
6X72
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BU of 6x72 by Molmil
Rev1 Mg2+-facilitated Product Complex with two monophosphates
Descriptor: DNA (5'-D(*CP*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*GP*C*)-3'), DNA repair protein REV1, ...
Authors:Weaver, T.M, Freudenthal, B.D.
Deposit date:2020-05-29
Release date:2020-09-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Visualizing Rev1 catalyze protein-template DNA synthesis.
Proc.Natl.Acad.Sci.USA, 117, 2020
6X75
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BU of 6x75 by Molmil
Rev1 Mn2+-facilitated Product Complex with second dCTP bound
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*GP*C)-3'), ...
Authors:Weaver, T.M, Freudenthal, B.D.
Deposit date:2020-05-29
Release date:2020-09-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Visualizing Rev1 catalyze protein-template DNA synthesis.
Proc.Natl.Acad.Sci.USA, 117, 2020
6X6Z
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BU of 6x6z by Molmil
Rev1 Ternary Complex with dCTP and Ca2+
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ...
Authors:Weaver, T.M, Freudenthal, B.D.
Deposit date:2020-05-29
Release date:2020-09-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Visualizing Rev1 catalyze protein-template DNA synthesis.
Proc.Natl.Acad.Sci.USA, 117, 2020
6X73
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BU of 6x73 by Molmil
Rev1 Mg2+-facilitated Product Complex with one monophosphate
Descriptor: AMMONIUM ION, DNA (5'-D(*CP*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*GP*C)-3'), ...
Authors:Weaver, T.M, Freudenthal, B.D.
Deposit date:2020-05-29
Release date:2020-09-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Visualizing Rev1 catalyze protein-template DNA synthesis.
Proc.Natl.Acad.Sci.USA, 117, 2020
6X70
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BU of 6x70 by Molmil
Rev1-DNA Binary Complex
Descriptor: DNA (5'-D(*CP*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*G)-3'), DNA repair protein REV1, ...
Authors:Weaver, T.M, Freudenthal, B.D.
Deposit date:2020-05-29
Release date:2020-09-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Visualizing Rev1 catalyze protein-template DNA synthesis.
Proc.Natl.Acad.Sci.USA, 117, 2020
6X77
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BU of 6x77 by Molmil
Rev1 R518A Ternary Complex with dCTP and Ca2+
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ...
Authors:Weaver, T.M, Freudenthal, B.D.
Deposit date:2020-05-29
Release date:2020-09-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Visualizing Rev1 catalyze protein-template DNA synthesis.
Proc.Natl.Acad.Sci.USA, 117, 2020
6X74
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BU of 6x74 by Molmil
Rev1 Mg2+-facilitated Product Complex with no monophosphates
Descriptor: CHLORIDE ION, DNA (5'-D(*GP*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*GP*C*)-3'), DNA (5'-D(P*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ...
Authors:Weaver, T.M, Freudenthal, B.D.
Deposit date:2020-05-29
Release date:2020-09-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Visualizing Rev1 catalyze protein-template DNA synthesis.
Proc.Natl.Acad.Sci.USA, 117, 2020
6X71
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BU of 6x71 by Molmil
Rev1 Mg2+-facilitated Intermediate complex with reactant dCTP and product dCMP
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*GP*C*(MG))-3'), ...
Authors:Weaver, T.M, Freudenthal, B.D.
Deposit date:2020-05-29
Release date:2020-09-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Visualizing Rev1 catalyze protein-template DNA synthesis.
Proc.Natl.Acad.Sci.USA, 117, 2020

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