Author results

1R58
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CRYSTAL STRUCTURE OF METAP2 COMPLEXED WITH A357300
Descriptor:Methionine aminopeptidase 2, MANGANESE (II) ION, N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE
Authors:Sheppard, G.S., Wang, J., Kawai, M., BaMaung, N.Y., Craig, R.A., Ericken, S.A., Lynch, L., Patel, J., Yang, F., Searle, X.B., Lou, P., Park, C., Kim, K.H., Henkin, J., Lesniewski, R.
Deposit date:2003-10-09
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2.
Bioorg.Med.Chem.Lett., 14, 2004
1R5G
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CRYSTAL STRUCTURE OF METAP2 COMPLEXED WITH A311263
Descriptor:Methionine aminopeptidase 2, MANGANESE (II) ION, (2S,3R)-3-AMINO-2-HYDROXY-5-(ETHYLSULFANYL)PENTANOYL-((S)-(-)-(1-NAPHTHYL)ETHYL)AMIDE
Authors:Sheppard, G.S., Wang, J., Kawai, M., BaMaung, N.Y., Craig, R.A., Erickson, S.A., Lynch, L., Patel, J., Yang, F., Searle, X.B., Lou, P., Park, C., Kim, K.H., Henkin, J., Lesniewski, R.
Deposit date:2003-10-10
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2.
Bioorg.Med.Chem.Lett., 14, 2004
1R5H
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CRYSTAL STRUCTURE OF METAP2 COMPLEXED WITH A320282
Descriptor:Methionine aminopeptidase 2, MANGANESE (II) ION, N'-(2S,3R)-3-AMINO-4-CYCLOHEXYL-2-HYDROXY-BUTANO-N-(4-METHYLPHENYL)HYDRAZIDE
Authors:Sheppard, G.S., Wang, J., Kawai, M., BaMaung, N.Y., Craig, R.A., Erickson, S.A., Lynch, L., Patel, J., Yang, F., Searle, X.B., Lou, P., Park, C., Kim, K.H., Henkin, J., Lesniewski, R.
Deposit date:2003-10-10
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2.
Bioorg.Med.Chem.Lett., 14, 2004
1URK
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SOLUTION STRUCTURE OF THE AMINO TERMINAL FRAGMENT OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR
Descriptor:PLASMINOGEN ACTIVATOR, ALPHA-L-FUCOSE
Authors:Hansen, A.P., Petros, A.M., Meadows, R.P., Nettesheim, D.G., Mazar, A.P., Olejniczak, E.T., Xu, R.X., Pederson, T.M., Henkin, J., Fesik, S.W.
Deposit date:1994-01-10
Release date:1995-05-08
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator.
Biochemistry, 33, 1994
1YW7
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H-METAP2 COMPLEXED WITH A444148
Descriptor:Methionine aminopeptidase 2, MANGANESE (II) ION, 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID
Authors:Park, C.H.
Deposit date:2005-02-17
Release date:2006-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006
1YW8
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H-METAP2 COMPLEXED WITH A751277
Descriptor:Methionine aminopeptidase 2, MANGANESE (II) ION, 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID
Authors:Park, C.H.
Deposit date:2005-02-17
Release date:2006-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006
1YW9
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H-METAP2 COMPLEXED WITH A849519
Descriptor:Methionine aminopeptidase 2, MANGANESE (II) ION, 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID
Authors:Park, C.H.
Deposit date:2005-02-17
Release date:2006-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006
2GA2
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H-METAP2 COMPLEXED WITH A193400
Descriptor:Methionine aminopeptidase 2, MANGANESE (II) ION, 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID
Authors:Park, C.
Deposit date:2006-03-07
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties.
Bioorg.Med.Chem.Lett., 16, 2006
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