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3F7T
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BU of 3f7t by Molmil
Structure of active IspH shows a novel fold with a [3Fe-4S] cluster in the catalytic centre
Descriptor: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER, PHOSPHATE ION, ...
Authors:Graewert, T, Eppinger, J, Rohdich, F, Bacher, A, Eisenreich, W, Groll, M.
Deposit date:2008-11-10
Release date:2009-07-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction.
Angew.Chem.Int.Ed.Engl., 48, 2009
3KEF
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BU of 3kef by Molmil
Crystal structure of IspH:DMAPP-complex
Descriptor: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, DIMETHYLALLYL DIPHOSPHATE, FE3-S4 CLUSTER
Authors:Groll, M, Graewert, T, Span, I, Eisenreich, W, Bacher, A.
Deposit date:2009-10-26
Release date:2010-01-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Probing the reaction mechanism of IspH protein by x-ray structure analysis.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KEM
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BU of 3kem by Molmil
Crystal structure of IspH:IPP complex
Descriptor: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER
Authors:Groll, M, Graewert, T, Span, I, Eisenreich, W, Bacher, A.
Deposit date:2009-10-26
Release date:2010-01-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Probing the reaction mechanism of IspH protein by x-ray structure analysis.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KE9
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BU of 3ke9 by Molmil
Crystal structure of IspH:Intermediate-complex
Descriptor: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER
Authors:Groll, M, Graewert, T, Span, I, Eisenreich, W, Bacher, A.
Deposit date:2009-10-24
Release date:2010-01-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Probing the reaction mechanism of IspH protein by x-ray structure analysis.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KEL
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BU of 3kel by Molmil
Crystal Structure of IspH:PP complex
Descriptor: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER, PYROPHOSPHATE 2-
Authors:Groll, M, Graewert, T, Span, I, Eisenreich, W, Bacher, A.
Deposit date:2009-10-26
Release date:2010-01-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Probing the reaction mechanism of IspH protein by x-ray structure analysis.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KE8
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BU of 3ke8 by Molmil
Crystal structure of IspH:HMBPP-complex
Descriptor: 4-HYDROXY-3-METHYL BUTYL DIPHOSPHATE, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER
Authors:Groll, M, Graewert, T, Span, I, Eisenreich, W, Bacher, A.
Deposit date:2009-10-24
Release date:2010-01-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Probing the reaction mechanism of IspH protein by x-ray structure analysis.
Proc.Natl.Acad.Sci.USA, 107, 2010
4UQF
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BU of 4uqf by Molmil
CRYSTAL STRUCTURE OF LISTERIA MONOCYTOGENES GTP CYCLOHYDROLASE I
Descriptor: GTP cyclohydrolase 1
Authors:Schuessler, S, Perbandt, M, Fischer, M, Graewert, T.
Deposit date:2014-06-23
Release date:2015-07-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target.
Acta Crystallogr.,Sect.F, 75, 2019
3R0I
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BU of 3r0i by Molmil
IspC in complex with an N-methyl-substituted hydroxamic acid
Descriptor: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, MANGANESE (II) ION, {(1S)-1-(3,4-difluorophenyl)-4-[hydroxy(methyl)amino]-4-oxobutyl}phosphonic acid
Authors:Behrendt, C.T, Kunfermann, A, Illarionova, V, Matheeussen, A, Pein, M.K, Graewert, T, Bacher, A, Eisenreich, W, Illarionov, B, Fischer, M, Maes, L, Groll, M, Kurz, T.
Deposit date:2011-03-08
Release date:2011-09-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Reverse Fosmidomycin Derivatives against the Antimalarial Drug Target IspC (Dxr).
J.Med.Chem., 54, 2011
3NOY
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BU of 3noy by Molmil
Crystal structure of IspG (gcpE)
Descriptor: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, IRON/SULFUR CLUSTER
Authors:Groll, M, Graewert, T, Bacher, A.
Deposit date:2010-06-26
Release date:2010-11-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG.
J.Mol.Biol., 404, 2010
3SZL
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BU of 3szl by Molmil
IspH:Ligand Mutants - wt 70sec
Descriptor: (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER
Authors:Span, I, Graewert, T, Bacher, A, Eisenreich, W, Groll, M.
Deposit date:2011-07-19
Release date:2011-11-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis.
J.Mol.Biol., 416, 2012
3SZO
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BU of 3szo by Molmil
IspH:HMBPP complex after 3 minutes X-ray pre-exposure
Descriptor: (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER
Authors:Span, I, Graewert, T, Bacher, A, Eisenreich, W, Groll, M.
Deposit date:2011-07-19
Release date:2011-11-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis.
J.Mol.Biol., 416, 2012
3SZU
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BU of 3szu by Molmil
IspH:HMBPP complex structure of E126Q mutant
Descriptor: (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER
Authors:Span, I, Graewert, T, Bacher, A, Eisenreich, W, Groll, M.
Deposit date:2011-07-19
Release date:2011-11-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis.
J.Mol.Biol., 416, 2012
3T0G
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BU of 3t0g by Molmil
IspH:HMBPP (substrate) structure of the T167C mutant
Descriptor: (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER
Authors:Span, I, Graewert, T, Bacher, A, Eisenreich, W, Groll, M.
Deposit date:2011-07-20
Release date:2011-11-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis.
J.Mol.Biol., 416, 2012
3T0F
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BU of 3t0f by Molmil
IspH:HMBPP (substrate) structure of the E126D mutant
Descriptor: (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER
Authors:Span, I, Graewert, T, Bacher, A, Eisenreich, W, Groll, M.
Deposit date:2011-07-20
Release date:2011-11-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis.
J.Mol.Biol., 416, 2012

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