Author results

6MKK
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CRYSTALLOGRAPHIC SOLVENT MAPPING ANALYSIS OF DMSO/MG BOUND TO APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION, DIMETHYL SULFOXIDE, ...
Authors:Georgiadis, M.M., He, H., Chen, Q.
Deposit date:2018-09-25
Release date:2019-01-30
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (1.442 Å)
Cite:Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.
J. Med. Chem., 62, 2019
6MKM
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CRYSTALLOGRAPHIC SOLVENT MAPPING ANALYSIS OF DMSO/TRIS BOUND TO APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DIMETHYL SULFOXIDE, ...
Authors:Georgiadis, M.M., He, H., Chen, Q.
Deposit date:2018-09-25
Release date:2019-01-30
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (1.673 Å)
Cite:Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.
J. Med. Chem., 62, 2019
6MKO
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CRYSTALLOGRAPHIC SOLVENT MAPPING ANALYSIS OF GLYCEROL BOUND TO APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, GLYCEROL
Authors:Georgiadis, M.M., He, H., Chen, Q.
Deposit date:2018-09-25
Release date:2019-01-30
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.
J. Med. Chem., 62, 2019
6MK3
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CRYSTALLOGRAPHIC SOLVENT MAPPING ANALYSIS OF DMSO BOUND TO APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, DIMETHYL SULFOXIDE, 1,2-ETHANEDIOL
Authors:Georgiadis, M.M., He, H., Chen, Q.
Deposit date:2018-09-24
Release date:2019-01-30
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (1.478 Å)
Cite:Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.
J. Med. Chem., 62, 2019
6MIG
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CRYSTAL STRUCTURE OF HOST-GUEST COMPLEX WITH PB HACHIMOJI DNA
Descriptor:Gag-Pol polyprotein, DNA (5'-D(*CP*TP*TP*AP*TP*(1WA)P*(1WA)P*(DS))-3'), DNA (5'-D(P*(DB)P*(1W5)P*(1W5)P*AP*TP*AP*AP*G)-3')
Authors:Georgiadis, M.M.
Deposit date:2018-09-19
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Hachimoji DNA and RNA: A genetic system with eight building blocks.
Science, 363, 2019
6MIH
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CRYSTAL STRUCTURE OF HOST-GUEST COMPLEX WITH PC HACHIMOJI DNA
Descriptor:N-terminal fragment of MMLV reverse transcriptase, DNA (5'-D(*CP*TP*TP*AP*(1WA)P*CP*(DB)P*T)-3'), DNA (5'-D(P*AP*(DS)P*GP*(1W5)P*TP*AP*AP*G)-3')
Authors:Georgiadis, M.M.
Deposit date:2018-09-19
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Hachimoji DNA and RNA: A genetic system with eight building blocks.
Science, 363, 2019
6MIK
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CRYSTAL STRUCTURE OF HOST-GUEST COMPLEX WITH PP HACHIMOJI DNA
Descriptor:N-terminal fragment of MMLV reverse transcriptase, DNA (5'-D(*CP*TP*TP*AP*TP*(1WA)P*(1WA)P*(DS))-3'), DNA (5'-D(P*(DB)P*(1W5)P*(1W5)P*AP*TP*AP*AP*G)-3')
Authors:Georgiadis, M.M.
Deposit date:2018-09-19
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Hachimoji DNA and RNA: A genetic system with eight building blocks.
Science, 363, 2019
6B1Q
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HYDROGEN BONDING COMPLEMENTARY, NOT SIZE COMPLEMENTARITY IS KEY IN THE FORMATION OF THE DOUBLE HELIX
Descriptor:Reverse transcriptase, DNA (5'-D(*CP*TP*TP*AP*TP*(CJ1)P*(CJ1)P*(CJ1))-3'), DNA (5'-D(P*(1AP)P*(1AP)P*(1AP)P*AP*TP*AP*AP*G)-3')
Authors:Singh, I., Georgiadis, M.M.
Deposit date:2017-09-18
Release date:2018-09-19
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:"Skinny" and "Fat" DNA: Two New Double Helices.
J. Am. Chem. Soc., 140, 2018
6B1R
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HYDROGEN BONDING COMPLEMENTARY, NOT SIZE COMPLEMENTARITY IS KEY IN THE FORMATION OF THE DOUBLE HELIX
Descriptor:Reverse transcriptase, DNA (5'-D(*CP*TP*TP*AP*TP*(1WA)P*(1WA)P*(1WA))-3'), DNA (5'-D(P*(IGU)P*(IGU)P*(IGU)P*AP*TP*AP*AP*G)-3')
Authors:Singh, I., Georgiadis, M.M.
Deposit date:2017-09-18
Release date:2018-09-19
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:"Skinny" and "Fat" DNA: Two New Double Helices.
J. Am. Chem. Soc., 140, 2018
6B1S
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HYDROGEN BONDING COMPLEMENTARY, NOT SIZE COMPLEMENTARITY IS KEY IN THE FORMATION OF THE DOUBLE HELIX
Descriptor:Reverse transcriptase, DNA (5'-D(*CP*TP*TP*AP*TP*AP*(CGY)P*(CGY)P*TP*TP*TP*AP*TP*AP*AP*G)-3')
Authors:Singh, I., Georgiadis, M.M.
Deposit date:2017-09-18
Release date:2018-09-19
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:"Skinny" and "Fat" DNA: Two New Double Helices.
J. Am. Chem. Soc., 140, 2018
5W6K
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STRUCTURE OF MUTANT TAQ POLYMERASE INCORPORATING UNNATURAL BASE PAIRS Z:P
Descriptor:DNA polymerase I, thermostable, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ...
Authors:Singh, I., Georgiadis, M.M.
Deposit date:2017-06-16
Release date:2018-07-18
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.339 Å)
Cite:Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide.
Nucleic Acids Res., 46, 2018
5W6Q
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STRUCTURAL BASIS FOR RECOGNITION OF ARTIFICIAL DNA BY AN EVOLVED KLENTAQ VARIANT
Descriptor:DNA polymerase I, thermostable, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(1W5))-3'), ...
Authors:Singh, I., Georgiadis, M.M.
Deposit date:2017-06-16
Release date:2018-07-18
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide.
Nucleic Acids Res., 46, 2018
5VBS
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STRUCTURAL BASIS FOR A SIX LETTER ALPHABET INCLUDING GATCKX
Descriptor:reverse transcriptase catalytic fragment, DNA (5'-D(*CP*TP*TP*AP*TP*(DX)P*(DX)P*T)-3'), DNA (5'-D(P*AP*(93D)P*(93D)P*AP*TP*AP*AP*G)-3')
Authors:Singh, I., Georgiadis, M.M.
Deposit date:2017-03-30
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:Structure and Biophysics for a Six Letter DNA Alphabet that Includes Imidazo[1,2-a]-1,3,5-triazine-2(8H)-4(3H)-dione (X) and 2,4-Diaminopyrimidine (K).
ACS Synth Biol, 6, 2017
4XO0
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CRYSTAL STRUCTURE OF 5'-CTTATPPTAZZATAAG IN A HOST-GUEST COMPLEX
Descriptor:reverse transcriptase, DNA (5'-D(*CP*TP*TP*AP*TP*(1WA)P*(1WA)P*T)-3'), DNA (5'-D(P*AP*(1W5)P*(1W5)P*AP*TP*AP*AP*G)-3')
Authors:Georgiadis, M.M., Singh, I.
Deposit date:2015-01-16
Release date:2015-05-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for a six nucleotide genetic alphabet.
J. Am. Chem. Soc., 137, 2015
4XPC
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CRYSTAL STRUCTURE OF 5'- CTTATAAATTTATAAG IN A HOST-GUEST COMPLEX
Descriptor:reverse transcriptase, DNA (5'-D(*CP*TP*TP*AP*TP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*AP*TP*AP*AP*G)-3'), ...
Authors:Georgiadis, M.M., Singh, I.
Deposit date:2015-01-16
Release date:2015-05-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural basis for a six nucleotide genetic alphabet.
J. Am. Chem. Soc., 137, 2015
4XPE
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CRYSTAL STRUCTURE OF 5'-CTTATGGGCCCATAAG IN A HOST-GUEST COMPLEX
Descriptor:reverse transcriptase, DNA (5'-D(*CP*TP*TP*AP*TP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*AP*TP*AP*AP*G)-3'), ...
Authors:Georgiadis, M.M., Singh, I.
Deposit date:2015-01-16
Release date:2015-05-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural basis for a six nucleotide genetic alphabet.
J. Am. Chem. Soc., 137, 2015
4XNO
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CRYSTAL STRUCTURE OF 5'-CTTATPPPZZZATAAG
Descriptor:DNA (5'-D(*CP*TP*(BRU)P*AP*TP*(1WA)P*(1WA)P*(1WA)P*(1W5)P*(1W5)P*(1W5)P*AP*TP*AP*AP*G)-3')
Authors:Georgiadis, M.M., Singh, I.
Deposit date:2015-01-15
Release date:2015-05-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.985 Å)
Cite:Structural basis for a six nucleotide genetic alphabet.
J. Am. Chem. Soc., 137, 2015
4QHD
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CRYSTAL STRUCTURE OF APO HUMAN APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, 1,2-ETHANEDIOL
Authors:He, H., Chen, Q., Georgiadis, M.M.
Deposit date:2014-05-28
Release date:2014-11-12
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
4QHE
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CRYSTAL STRUCTURE OF MG2+ BOUND HUMAN APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION, 1,2-ETHANEDIOL
Authors:He, H., Chen, Q., Georgiadis, M.M.
Deposit date:2014-05-28
Release date:2014-11-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
4QH9
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CRYSTAL STRUCTURE OF MN2+ BOUND HUMAN APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, 1,2-ETHANEDIOL, MANGANESE (II) ION
Authors:Chen, Q., He, H., Georgiadis, M.M.
Deposit date:2014-05-27
Release date:2014-11-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.175 Å)
Cite:High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
4OTM
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN FROM YEAST GCN2
Descriptor:Serine/threonine-protein kinase GCN2
Authors:He, H., Georgiadis, M.M.
Deposit date:2014-02-13
Release date:2014-04-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and Mammals.
J.Biol.Chem., 289, 2014
4OTN
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CRYSTAL STRUCTURE OF THE C-TERMINAL REGULATORY DOMAIN OF MURINE GCN2
Descriptor:Eukaryotic translation initiation factor 2-alpha kinase 4, SULFATE ION, 1,2-ETHANEDIOL
Authors:He, H., Georgiadis, M.M.
Deposit date:2014-02-13
Release date:2014-04-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and Mammals.
J.Biol.Chem., 289, 2014
4MH8
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THE CRYSTAL STRUCTURE OF THE MONOMERIC REVERSE TRANSCRIPTASE FROM MOLONEY MURINE LEUKEMIA VIRUS
Descriptor:Reverse transcriptase/ribonuclease H p80
Authors:Das, D., Georgiadis, M.M.
Deposit date:2013-08-29
Release date:2013-10-16
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus.
Structure, 12, 2004
4M94
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D(ATCCGTTATAACGGAT) COMPLEXED WITH MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE CATALYTIC FRAGMENT
Descriptor:Gag-Pol polyprotein, 5' d(ATCCGttA) 3', 5' d(TAACGGAT) 3', ...
Authors:Singh, I.
Deposit date:2013-08-14
Release date:2014-03-12
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition.
Acta Crystallogr.,Sect.D, 70, 2014
4M95
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D(ATCCGTTATAACGGAT)COMPLEXED WITH MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE CATALYTIC FRAGMENT
Descriptor:Gag-Pol polyprotein, 5' d(ATCCGTTA) 3', 5' d(TAACGGAT) 3', ...
Authors:Singh, I.
Deposit date:2013-08-14
Release date:2014-03-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition.
Acta Crystallogr.,Sect.D, 70, 2014
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