Author results

2O0F
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DOCKING OF THE MODIFIED RF3 X-RAY STRUCTURE INTO CRYO-EM MAP OF E.COLI 70S RIBOSOME BOUND WITH RF3
Descriptor:Peptide chain release factor 3
Authors:Gao, H., Zhou, Z., Rawat, U., Huang, C., Bouakaz, L., Wang, C., Liu, Y., Zavialov, A., Gursky, R., Sanyal, S., Ehrenberg, M., Frank, J., Song, H.
Deposit date:2006-11-27
Release date:2007-07-24
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (15.5 Å)
Cite:RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors
Cell(Cambridge,Mass.), 129, 2007
3DG0
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COORDINATES OF 16S AND 23S RRNAS FITTED INTO THE CRYO-EM MAP OF EF-G-BOUND TRANSLOCATION COMPLEX
Descriptor:16S Ribosomal RNA from E. coli, 23S Ribosomal RNA from E. coli
Authors:Gao, H., LeBarron, J., Frank, J.
Deposit date:2008-06-12
Release date:2009-02-03
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY (10.8 Å)
Cite:Ribosomal Dynamics: Intrinsic Instability of a Moleculaar Machine
To be published, 2009
3DG2
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COORDINATES OF 16S AND 23S RRNAS FITTED INTO THE CRYO-EM MAP OF A PRETRANSLOCATION COMPLEX
Descriptor:16S Ribosomal RNA from E. coli, 23S Ribosomal RNA from E. coli
Authors:Gao, H., LeBarron, J., Frank, J.
Deposit date:2008-06-12
Release date:2009-02-03
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Ribosomal Dynamics: Intrinsic Instability of a Moleculaar Machine
To be published, 2009
3DG4
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COORDINATES OF 16S AND 23S RRNAS FITTED INTO THE CRYO-EM MAP OF RF1-BOUND TERMINATION COMPLEX
Descriptor:16S Ribosomal RNA from E. coli, 23S RibosomaL RNA from E. coli
Authors:Gao, H., LeBarron, J., Frank, J.
Deposit date:2008-06-12
Release date:2009-02-03
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY (12.8 Å)
Cite:Ribosomal Dynamics: Intrinsic Instability of a Moleculaar Machine
To be published, 2009
3DG5
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COORDINATES OF 16S AND 23S RRNAS FITTED INTO THE CRYO-EM MAP OF RF3-BOUND TERMINATION COMPLEX
Descriptor:16S Ribosomal RNA from E. coli, 23S Ribosomal RNA from E. coli
Authors:Gao, H., LeBarron, J., Frank, J.
Deposit date:2008-06-12
Release date:2009-02-03
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY (15.5 Å)
Cite:Ribosomal Dynamics: Intrinsic Instability of a Moleculaar Machine
To be published, 2009
4V47
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REAL SPACE REFINED COORDINATES OF THE 30S AND 50S SUBUNITS FITTED INTO THE LOW RESOLUTION CRYO-EM MAP OF THE EF-G.GTP STATE OF E. COLI 70S RIBOSOME
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Gao, H., Sengupta, J., Valle, M., Korostelev, A., Eswar, N., Stagg, S.M., Van Roey, P., Agrawal, R.K., Harvey, S.T., Sali, A., Chapman, M.S., Frank, J.
Deposit date:2003-05-06
Release date:2014-07-09
Last modified:2018-01-24
Method:ELECTRON MICROSCOPY (12.3 Å)
Cite:Study of the structural dynamics of the E. coli 70S ribosome using real space refinement
Cell(Cambridge,Mass.), 113, 2003
4V48
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REAL SPACE REFINED COORDINATES OF THE 30S AND 50S SUBUNITS FITTED INTO THE LOW RESOLUTION CRYO-EM MAP OF THE INITIATION-LIKE STATE OF E. COLI 70S RIBOSOME
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, tRNA-PHE, ...
Authors:Gao, H., Sengupta, J., Valle, M., Korostelev, A., Eswar, N., Stagg, S.M., Van Roey, P., Agrawal, R.K., Harvey, S.T., Sali, A., Chapman, M.S., Frank, J.
Deposit date:2003-05-06
Release date:2014-07-09
Last modified:2018-01-24
Method:ELECTRON MICROSCOPY (11.5 Å)
Cite:Study of the structural dynamics of the E. coli 70S ribosome using real space refinement
Cell(Cambridge,Mass.), 113, 2003
4HPZ
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CRYSTAL STRUCTURE OF A TALE PROTEIN REVEALS AN EXTENDED N-TERMINAL DNA BINDING REGION
Descriptor:dTale2, SULFATE ION
Authors:Chai, J., Han, Z., Gao, H.
Deposit date:2012-10-25
Release date:2012-12-05
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Crystal structure of a TALE protein reveals an extended N-terminal DNA binding region
Cell Res., 22, 2012
4A3N
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CRYSTAL STRUCTURE OF HMG-BOX OF HUMAN SOX17
Descriptor:TRANSCRIPTION FACTOR SOX-17, ZINC ION
Authors:Gao, N., Gao, H., Qian, H., Si, S., Xie, Y.
Deposit date:2011-10-01
Release date:2011-12-28
Last modified:2013-03-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of Human Transcription Factor Sry-Related Box 17 Binding to DNA.
Protein Pept.Lett., 20, 2013
5A7X
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NEGATIVE STAIN EM OF BG505 SOSIP.664 IN COMPLEX WITH SCD4, 17B, AND 8ANC195
Descriptor:HIV-1 YU2 GP120, T-CELL SURFACE GLYCOPROTEIN CD4, FAB OF BROADLY NEUTRALIZING ANTIBODY 17B, ...
Authors:Scharf, L., Wang, H., Gao, H., Chen, S., McDowall, A., Bjorkman, P.
Deposit date:2015-07-10
Release date:2015-08-05
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (17 Å)
Cite:Broadly Neutralizing Antibody 8Anc195 Recognizes Closed and Open States of HIV-1 Env.
Cell(Cambridge,Mass.), 162, 2015
5A8H
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CRYO-ET SUBTOMOGRAM AVERAGING OF BG505 SOSIP.664 IN COMPLEX WITH SCD4, 17B, AND 8ANC195
Descriptor:HIV-1 GP120, T-CELL SURFACE GLYCOPROTEIN CD4, FAB OF BROADLY NEUTRALIZING ANTIBODY 17B, ...
Authors:Scharf, L., Wang, H., Gao, H., Chen, S., McDowall, A., Bjorkman, P.
Deposit date:2015-07-15
Release date:2015-08-05
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (23 Å)
Cite:Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env.
Cell, 162, 2015
2FVO
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DOCKING OF THE MODIFIED RF1 X-RAY STRUCTURE INTO THE LOW RESOLUTION CRYO-EM MAP OF E.COLI 70S RIBOSOME BOUND WITH RF1
Descriptor:Peptide chain release factor 1
Authors:Rawat, U., Gao, H., Zavialov, A., Gursky, R., Ehrenberg, M., Frank, J.
Deposit date:2006-01-31
Release date:2006-04-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (12.8 Å)
Cite:Interactions of the Release Factor RF1 with the Ribosome as Revealed by Cryo-EM.
J.Mol.Biol., 357, 2006
2GOY
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CRYSTAL STRUCTURE OF ASSIMILATORY ADENOSINE 5'-PHOSPHOSULFATE REDUCTASE WITH BOUND APS
Descriptor:adenosine phosphosulfate reductase, IRON/SULFUR CLUSTER, ADENOSINE-5'-PHOSPHOSULFATE
Authors:Chartron, J., Carroll, K.S., Shiau, C., Gao, H., Leary, J.A., Bertozzi, C.R., Stout, C.D.
Deposit date:2006-04-14
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Substrate Recognition, Protein Dynamics, and Iron-Sulfur Cluster in Pseudomonas aeruginosa Adenosine 5'-Phosphosulfate Reductase.
J.Mol.Biol., 364, 2006
2W35
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STRUCTURES OF ENDONUCLEASE V WITH DNA REVEAL INITIATION OF DEAMINATED ADENINE REPAIR
Descriptor:ENDONUCLEASE V, 5'-D(*AP*TP*GP*CP*GP*AP*CP*IP*GP)-3', 5'-D(*AP*GP*CP*CP*GP*TP)-3', ...
Authors:Dalhus, B., Arvai, A.S., Rosnes, I., Olsen, O.E., Backe, P.H., Alseth, I., Gao, H., Cao, W., Tainer, J.A., Bjoras, M.
Deposit date:2008-11-06
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structures of Endonuclease V with DNA Reveal Initiation of Deaminated Adenine Repair.
Nat.Struct.Mol.Biol., 16, 2009
2W36
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STRUCTURES OF ENDONUCLEASE V WITH DNA REVEAL INITIATION OF DEAMINATED ADENINE REPAIR
Descriptor:ENDONUCLEASE V, 5'-D(*GP*CP*BRUP*AP*CP*IP*GP*AP*BRUP*CP*GP)-3', 5'-D(*CP*GP*AP*TP*CP*TP*GP*TP*AP*GP*CP)-3'
Authors:Dalhus, B., Arvai, A.S., Rosnes, I., Olsen, O.E., Backe, P.H., Alseth, I., Gao, H., Cao, W., Tainer, J.A., Bjoras, M.
Deposit date:2008-11-06
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of Endonuclease V with DNA Reveal Initiation of Deaminated Adenine Repair.
Nat.Struct.Mol.Biol., 16, 2009
3TL8
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THE AVRPTOB-BAK1 COMPLEX REVEALS TWO STRUCTURALLY SIMILAR KINASEINTERACTING DOMAINS IN A SINGLE TYPE III EFFECTOR
Descriptor:BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1, Effector protein HopAB2
Authors:Chai, J., Cheng, W., Gao, H.
Deposit date:2011-08-29
Release date:2012-01-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Analysis of Pseudomonas syringae AvrPtoB Bound to Host BAK1 Reveals Two Similar Kinase-Interacting Domains in a Type III Effector.
Cell Host Microbe, 10, 2011
2H5E
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CRYSTAL STRUCTURE OF E.COLI POLYPEPTIDE RELEASE FACTOR RF3
Descriptor:Peptide chain release factor RF-3, GUANOSINE-5'-DIPHOSPHATE
Authors:Song, H.W., Zhou, Z.H.
Deposit date:2006-05-26
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors
Cell(Cambridge,Mass.), 129, 2007
5HVU
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RHO-ASSOCIATED PROTEIN KINASE 1 (ROCK 1) IN COMPLEX WITH A PYRIDINE THIAZOLE PIPERIDINE INHIBITOR
Descriptor:Rho-associated protein kinase 1, 2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide
Authors:Jacobs, M.J.
Deposit date:2016-01-28
Release date:2017-02-08
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups.
Bioorg. Med. Chem. Lett., 2018
1ZN1
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COORDINATES OF RRF FITTED INTO CRYO-EM MAP OF THE 70S POST-TERMINATION COMPLEX
Descriptor:ribosomal 23S RNA, ribosomal 16S RNA, Ribosome recycling factor, ...
Authors:Gao, N., Zavialov, A.V., Li, W., Sengupta, J., Valle, M., Gursky, R.P., Ehrenberg, M., Frank, J.
Deposit date:2005-05-11
Release date:2005-06-14
Last modified:2018-01-31
Method:ELECTRON MICROSCOPY (14.1 Å)
Cite:Mechanism for the disassembly of the posttermination complex inferred from cryo-EM studies.
Mol.Cell, 18, 2005
4YVE
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ROCK 1 BOUND TO METHOXYPHENYL THIAZOLE INHIBITOR
Descriptor:Rho-associated protein kinase 1, 2-(3-methoxyphenyl)-N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide
Authors:Jacobs, M.D.
Deposit date:2015-03-19
Release date:2015-06-10
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.
J.Med.Chem., 58, 2015
6BNT
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CRYSTAL STRUCTURE OF AP2 MU1 ADAPTIN C-TERMINAL DOMAIN WITH IRS-1 PEPTIDE
Descriptor:AP-2 complex subunit mu, Insulin receptor substrate 1
Authors:Kikuchi, S., Choi, E., Yu, H.
Deposit date:2017-11-17
Release date:2018-11-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Targeting feedback regulation of insulin receptor endocytosis for diabetes treatment
To Be Published
2KLZ
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SOLUTION STRUCTURE OF THE TANDEM UIM DOMAIN OF ATAXIN-3 COMPLEXED WITH UBIQUITIN
Descriptor:Ataxin-3
Authors:Zhou, C., Song, A., Lin, D., Hu, H.
Deposit date:2009-07-12
Release date:2010-07-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the Tandem UIM Domain of Ataxin-3 Complexed with Ubiquitin
To be Published
5OVQ
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CRYSTAL STRUCTURE OF THE PEROXIREDOXIN (AHPC2) FROM THE HYPERTHERMOPHILIC BACTERIA AQUIFEX AEOLICUS VF
Descriptor:Peroxiredoxin, UNKNOWN LIGAND
Authors:Warkentin, E., Peng, G.
Deposit date:2017-08-29
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural properties of the peroxiredoxin AhpC2 from the hyperthermophilic eubacterium Aquifex aeolicus.
Biochim Biophys Acta Gen Subj, 1862, 2018
4FSF
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA PBP3 COMPLEXED WITH COMPOUND 14
Descriptor:Penicillin-binding protein 3, (4R,5S,8Z)-8-(2-amino-1,3-thiazol-4-yl)-1-[3-(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)-1,2-oxazol-5-yl]-5-formyl-11,11-dimethyl-1,7-dioxo-4-(sulfoamino)-10-oxa-2,6,9-triazadodec-8-en-12-oic acid
Authors:Han, S.
Deposit date:2012-06-27
Release date:2012-10-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.
Bioorg.Med.Chem.Lett., 22, 2012
4NCE
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INFLUENZA POLYMERASE BASIC PROTEIN 2 (PB2) BOUND TO 7-METHYL-GTP
Descriptor:Polymerase basic protein 2, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, 9,10-dioxo-9,10-dihydroanthracene-2,6-disulfonic acid
Authors:Jacobs, M.D.
Deposit date:2013-10-24
Release date:2014-07-30
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2.
J.Med.Chem., 57, 2014
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