6R66
| Crystal structure of transthyretin in complex with CHF5075, a flurbiprofen analogue | Descriptor: | 1-[4-[3,5-bis(chloranyl)phenyl]-3-fluoranyl-phenyl]cyclopropane-1-carboxylic acid, Transthyretin | Authors: | Loconte, V, Menozzi, I, Ferrari, A, Berni, R, Zanotti, G. | Deposit date: | 2019-03-26 | Release date: | 2019-09-11 | Last modified: | 2019-11-06 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. J.Struct.Biol., 208, 2019
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6R67
| Crystal structure of transthyretin in complex with CHF5075, a flurbiprofen analogue | Descriptor: | (2~{R})-2-[4-(3,5-dimethylphenyl)-3-fluoranyl-phenyl]propanoic acid, Transthyretin | Authors: | Loconte, V, Menozzi, I, Ferrari, A, Berni, R, Zanotti, G. | Deposit date: | 2019-03-26 | Release date: | 2019-09-11 | Last modified: | 2019-11-06 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. J.Struct.Biol., 208, 2019
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6R68
| Crystal structure of transthyretin in complex with CHF4795, a flurbiprofen analogue | Descriptor: | (2~{R})-2-[4-[3,5-bis(chloranyl)phenyl]-3-fluoranyl-phenyl]propanoic acid, Transthyretin | Authors: | Loconte, V, Menozzi, I, Ferrari, A, Berni, R, Zanotti, G. | Deposit date: | 2019-03-26 | Release date: | 2019-09-11 | Last modified: | 2019-11-06 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. J.Struct.Biol., 208, 2019
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6R6I
| Crystal structure of transthyretin mutant A25T in complex with CHF5074, a flurbiprofen analogue | Descriptor: | 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid, PHOSPHATE ION, Transthyretin | Authors: | Loconte, V, Menozzi, I, Ferrari, A, Berni, R, Zanotti, G. | Deposit date: | 2019-03-27 | Release date: | 2019-09-11 | Last modified: | 2019-11-06 | Method: | X-RAY DIFFRACTION (1.467 Å) | Cite: | Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. J.Struct.Biol., 208, 2019
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8AXW
| The structure of mouse AsterC (GramD1c) with Ezetimibe | Descriptor: | (3~{R},4~{S})-1-(4-fluorophenyl)-3-[(3~{S})-3-(4-fluorophenyl)-3-oxidanyl-propyl]-4-(4-hydroxyphenyl)azetidin-2-one, CHLORIDE ION, ETHANOL, ... | Authors: | Fairall, L, Xiao, X, Burger, L, Tontonoz, P, Schwabe, J.W.R. | Deposit date: | 2022-09-01 | Release date: | 2023-09-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake. Science, 382, 2023
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8C86
| Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 2 | Descriptor: | (2,4-dimethylphenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin | Authors: | Poonsiri, T, Benini, S, Loconte, V, Cianci, M. | Deposit date: | 2023-01-18 | Release date: | 2024-01-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | 3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity. Int J Mol Sci, 25, 2023
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8C85
| Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 1 | Descriptor: | (3,5-dimethylphenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin | Authors: | Poonsiri, T, Benini, S, Loconte, V, Cianci, M. | Deposit date: | 2023-01-18 | Release date: | 2024-01-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | 3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity. Int J Mol Sci, 25, 2023
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5OQ0
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6GQF
| The structure of mouse AsterA (GramD1a) with 25-hydroxy cholesterol | Descriptor: | 25-HYDROXYCHOLESTEROL, GLYCEROL, GRAM domain-containing protein 1A | Authors: | Fairall, L, Gurnett, J.E, Vashi, D, Sandhu, J, Tontonoz, P, Schwabe, J.W.R. | Deposit date: | 2018-06-07 | Release date: | 2018-09-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Cell, 175, 2018
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