6R6I

Crystal structure of transthyretin mutant A25T in complex with CHF5074, a flurbiprofen analogue

Summary for 6R6I

Entry DOI	10.2210/pdb6r6i/pdb
Descriptor	Transthyretin, 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	amyloidosis, tetramer, binding protein, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	32710.29
Authors	Loconte, V.,Menozzi, I.,Ferrari, A.,Berni, R.,Zanotti, G. (deposition date: 2019-03-27, release date: 2019-09-11, Last modification date: 2019-11-06)
Primary citation	Loconte, V.,Menozzi, I.,Ferrari, A.,Folli, C.,Imbimbo, B.P.,Zanotti, G.,Berni, R. Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. J.Struct.Biol., 208:165-173, 2019 Cited by PubMed: 31473362 DOI: 10.1016/j.jsb.2019.08.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.467 Å)

Structure validation