6R6I
Crystal structure of transthyretin mutant A25T in complex with CHF5074, a flurbiprofen analogue
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transthyretin | polymer | 147 | 15935.0 | 2 | UniProt (P02766) Pfam (PF00576) | Homo sapiens (Human) | ATTR,Prealbumin,TBPA |
| 2 | C, D (A, B) | 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid | non-polymer | 325.2 | 2 | Chemie (H50) | |||
| 3 | E, F (B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A, B: -19 - 127 (UniProt: P02766)
| PDB | External Database | Details |
|---|---|---|
| Thr 25 | Ala 45 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31870.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 840.3 | |
| All* | Total formula weight | 32710.3 |
