Author results

3EIN
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DELTA CLASS GST
Descriptor:Glutathione S-transferase 1-1, GLUTATHIONE
Authors:Feil, S.C.
Deposit date:2008-09-17
Release date:2009-09-01
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.126 Å)
Cite:Probing insect detoxification systems
To be Published
3LE0
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LECTIN DOMAIN OF LECTINOLYSIN COMPLEXED WITH GLYCEROL
Descriptor:Platelet aggregation factor Sm-hPAF, CALCIUM ION, NICKEL (II) ION, ...
Authors:Feil, S.C.
Deposit date:2010-01-13
Release date:2010-12-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity.
Structure, 20, 2012
3LEG
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LECTIN DOMAIN OF LECTINOLYSIN COMPLEXED WITH LEWIS Y ANTIGEN
Descriptor:Platelet aggregation factor Sm-hPAF, 6-deoxy-alpha-L-galactopyranosyl-(1->3)-[6-deoxy-alpha-L-galactopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->4)]-2-(acetylamino)-2-deoxy-beta-D-glucopyranose, NICKEL (II) ION, ...
Authors:Feil, S.C.
Deposit date:2010-01-14
Release date:2010-12-29
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity.
Structure, 20, 2012
3LEI
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LECTIN DOMAIN OF LECTINOLYSIN COMPLEXED WITH FUCOSE
Descriptor:Platelet aggregation factor Sm-hPAF, ALPHA-L-FUCOSE, CALCIUM ION, ...
Authors:Feil, S.C.
Deposit date:2010-01-14
Release date:2010-12-29
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity.
Structure, 20, 2012
3LEK
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LECTIN DOMAIN OF LECTINOLYSIN COMPLEXED WITH LEWIS B ANTIGEN
Descriptor:Platelet aggregation factor Sm-hPAF, 6-deoxy-alpha-L-galactopyranosyl-(1->4)-[6-deoxy-alpha-L-galactopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->3)]-2-(acetylamino)-2-deoxy-alpha-D-glucopyranose, CALCIUM ION, ...
Authors:Feil, S.C.
Deposit date:2010-01-15
Release date:2010-12-29
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity.
Structure, 20, 2012
4HSC
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CRYSTAL STRUCTURE OF A CHOLESTEROL DEPENDENT CYTOLYSIN
Descriptor:Streptolysin O
Authors:Feil, S.C., Parker, M.W.
Deposit date:2012-10-29
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of Streptococcus Pyogenes streptolysin O reveals a sprung out tryptophan-rich loop primed for membrane penetration
To be Published
3DLW
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ANTICHYMOTRYPSIN
Descriptor:Alpha-1-antichymotrypsin
Authors:Feil, S.C.
Deposit date:2008-06-29
Release date:2009-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Identification and characterization of a misfolded monomeric serpin formed at physiological temperature
J.Mol.Biol., 403, 2010
3VDD
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STRUCTURE OF HRV2 CAPSID COMPLEXED WITH ANTIVIRAL COMPOUND BTA798
Descriptor:Protein VP1, Protein VP2, Protein VP3, ...
Authors:Morton, C.J., Feil, S.C., Parker, M.W.
Deposit date:2012-01-05
Release date:2012-09-12
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus.
ACS Med Chem Lett, 3, 2012
4GWI
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HIS 62 MUTANT OF THE LECTIN BINDING DOMAIN OF LECTINOLYSIN COMPLEXED WITH LEWIS Y
Descriptor:Platelet aggregation factor Sm-hPAF, MAGNESIUM ION, GLYCEROL, ...
Authors:Feil, S.C.
Deposit date:2012-09-03
Release date:2012-11-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysin
Front Immunol, 3, 2012
4GWJ
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HIS 62 MUTANT OF THE LECTIN BINDING DOMAIN OF LECTINOLYSIN COMPLEXED WITH LEWIS B
Descriptor:Platelet aggregation factor Sm-hPAF, MAGNESIUM ION, CALCIUM ION, ...
Authors:Feil, S.C.
Deposit date:2012-09-03
Release date:2012-11-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysin
Front Immunol, 3, 2012
4OGB
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 2
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, (2R)-8-(3,4-dimethoxyphenyl)-6-methyl-2-(tetrahydro-2H-pyran-4-yl)-2H-chromen-4-ol, 1,2-ETHANEDIOL, ...
Authors:Feil, S.C., Parker, M.W.
Deposit date:2014-01-15
Release date:2015-01-21
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.032 Å)
Cite:The PDE inhibition profile of LY294002 and tetrahydropyranyl analogues reveals a chromone motif for the development of PDE inhibitors
To be Published
1KOA
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TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS
Descriptor:TWITCHIN
Authors:Kobe, B., Heierhorst, J., Feil, S.C., Parker, M.W., Benian, G.M., Weiss, K.R., Kemp, B.E.
Deposit date:1996-06-28
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Giant protein kinases: domain interactions and structural basis of autoregulation.
EMBO J., 15, 1996
1KOB
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TWITCHIN KINASE FRAGMENT (APLYSIA), AUTOREGULATED PROTEIN KINASE DOMAIN
Descriptor:TWITCHIN, VALINE
Authors:Kobe, B., Heierhorst, J., Feil, S.C., Parker, M.W., Benian, G.M., Weiss, K.R., Kemp, B.E.
Deposit date:1996-06-28
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Giant protein kinases: domain interactions and structural basis of autoregulation.
EMBO J., 15, 1996
1Z0M
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THE GLYCOGEN-BINDING DOMAIN OF THE AMP-ACTIVATED PROTEIN KINASE BETA1 SUBUNIT
Descriptor:5'-AMP-activated protein kinase, beta-1 subunit, BETA-CYCLODEXTRIN
Authors:Polekhina, G., Gupta, A., van Denderen, B.J., Feil, S.C., Kemp, B.E., Stapleton, D., Parker, M.W.
Deposit date:2005-03-02
Release date:2005-10-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structural Basis for Glycogen Recognition by AMP-Activated Protein Kinase.
Structure, 13, 2005
1Z0N
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THE GLYCOGEN-BINDING DOMAIN OF THE AMP-ACTIVATED PROTEIN KINASE
Descriptor:5'-AMP-activated protein kinase, beta-1 subunit, BETA-CYCLODEXTRIN
Authors:Polekhina, G., Gupta, A., van Denderen, B.J., Feil, S.C., Kemp, B.E., Stapleton, D., Parker, M.W.
Deposit date:2005-03-02
Release date:2005-10-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structural Basis for Glycogen Recognition by AMP-Activated Protein Kinase.
Structure, 13, 2005
1D5S
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CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER
Descriptor:P1-ARG ANTITRYPSIN
Authors:Dunstone, M.A., Dai, W., Whisstock, J.C., Rossjohn, J., Pike, R.N., Feil, S.C., Le Bonneic, B.F., Parker, M.W., Bottomley, S.P.
Deposit date:1999-10-11
Release date:2000-04-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Cleaved antitrypsin polymers at atomic resolution.
Protein Sci., 9, 2000
1MWP
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N-TERMINAL DOMAIN OF THE AMYLOID PRECURSOR PROTEIN
Descriptor:AMYLOID A4 PROTEIN
Authors:Rossjohn, J., Cappai, R., Feil, S.C., Henry, A., McKinstry, W.J., Galatis, D., Hesse, L., Multhaup, G., Beyreuther, K., Masters, C.L., Parker, M.W.
Deposit date:1999-03-09
Release date:2000-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.
Nat.Struct.Biol., 6, 1999
1PMT
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GLUTATHIONE TRANSFERASE FROM PROTEUS MIRABILIS
Descriptor:GLUTATHIONE TRANSFERASE, GLUTATHIONE
Authors:Rossjohn, J., Polekhina, G., Feil, S.C., Allocati, N., Masulli, M., Diilio, C., Parker, M.W.
Deposit date:1998-03-23
Release date:1999-04-20
Last modified:2011-12-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A mixed disulfide bond in bacterial glutathione transferase: functional and evolutionary implications.
Structure, 6, 1998
1Z52
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PROAEROLYSIN MUTANT W373L
Descriptor:Aerolysin
Authors:Parker, M.W., Feil, S.C., Tang, J.W.
Deposit date:2005-03-16
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal Structure of Proaerolysin at 2.3 A Resolution and Structural Analyses of Single-site Mutants as a Basis for Understanding Membrane Insertion of the Toxin
To be Published
2FHE
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FASCIOLA HEPATICA GLUTATHIONE S-TRANSFERASE ISOFORM 1 IN COMPLEX WITH GLUTATHIONE
Descriptor:GLUTATHIONE S-TRANSFERASE, GLUTATHIONE
Authors:Polekhina, G., Rossjohn, J., Feil, S.C., Parker, M.W.
Deposit date:1998-10-21
Release date:1998-10-28
Last modified:2011-12-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase.
J.Mol.Biol., 273, 1997
2PMT
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GLUTATHIONE TRANSFERASE FROM PROTEUS MIRABILIS
Descriptor:GLUTATHIONE TRANSFERASE, GLUTATHIONE
Authors:Rossjohn, J., Polekhina, G., Feil, S.C., Allocati, N., Masulli, M., Diilio, C., Parker, M.W.
Deposit date:1998-04-28
Release date:1999-04-27
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A mixed disulfide bond in bacterial glutathione transferase: functional and evolutionary implications.
Structure, 6, 1998
2QUG
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CRYSTAL STRUCTURE OF ALPHA-1-ANTITRYPSIN, CRYSTAL FORM A
Descriptor:Alpha-1-antitrypsin
Authors:Hansen, G., Morton, C.J., Pearce, M.C., Feil, S.C., Adams, J.J., Parker, M.W., Bottomley, S.P.
Deposit date:2007-08-05
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
3CWL
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CRYSTAL STRUCTURE OF ALPHA-1-ANTITRYPSIN, CRYSTAL FORM B
Descriptor:Alpha-1-antitrypsin, CHLORIDE ION
Authors:Morton, C.J., Hansen, G., Feil, S.C., Adams, J.J., Parker, M.W.
Deposit date:2008-04-22
Release date:2008-09-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
3CWM
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CRYSTAL STRUCTURE OF ALPHA-1-ANTITRYPSIN COMPLEXED WITH CITRATE
Descriptor:Alpha-1-antitrypsin, CITRIC ACID
Authors:Morton, C.J., Hansen, G., Feil, S.C., Adams, J.J., Parker, M.W.
Deposit date:2008-04-22
Release date:2008-09-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
4ZGH
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STRUCTURE OF SUGAR BINDING PROTEIN PNEUMOLYSIN
Descriptor:Pneumolysin, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Parker, M.W., Feil, S.C., Morton, C.
Deposit date:2015-04-23
Release date:2016-03-09
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation.
Sci Rep, 5, 2015
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