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2HDJ
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CRYSTAL STRUCTURE OF HUMAN TYPE 3 3ALPHA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP(H)
Descriptor:Aldo-keto reductase family 1 member C2, SULFATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Faucher, F., Pereira de Jesus-Tran, K., Cantin, L., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-06-20
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.
J.Mol.Biol., 364, 2006
2HE5
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CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE IN BINARY COMPLEX WITH NADP(H) IN AN OPEN CONFORMATION
Descriptor:Aldo-keto reductase family 1, member C21, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Faucher, F., Pereira de Jesus-Tran, K., Cantin, L., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-06-21
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.
J.Mol.Biol., 364, 2006
2HE8
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CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE IN ITS APO-FORM
Descriptor:Aldo-keto reductase family 1, member C21, ACETATE ION, ...
Authors:Faucher, F., Pereira de Jesus-Tran, K., Cantin, L., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-06-21
Release date:2006-12-05
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.
J.Mol.Biol., 364, 2006
2HEJ
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CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP(H) IN A CLOSED CONFORMATION
Descriptor:Aldo-keto reductase family 1, member C21, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Faucher, F., Pereira de Jesus-Tran, K., Cantin, L., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-06-21
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.
J.Mol.Biol., 364, 2006
2IPF
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CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP+ AND EPI-TESTOSTERONE
Descriptor:(3(17)alpha-hydroxysteroid dehydrogenase), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE, ...
Authors:Faucher, F., Cantin, L., Pereira de Jesus-Tran, K., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-10-12
Release date:2007-06-19
Last modified:2012-05-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding.
J.Mol.Biol., 369, 2007
2IPG
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CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE MUTANT K31A IN COMPLEX WITH NADP+ AND EPI-TESTOSTERONE
Descriptor:3(17)alpha-hydroxysteroid dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE, ...
Authors:Faucher, F., Cantin, L., Pereira de Jesus-Tran, K., Lemieux, M., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-10-12
Release date:2007-06-19
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding.
J.Mol.Biol., 369, 2007
2IPJ
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CRYSTAL STRUCTURE OF H3ALPHA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 MUTANT Y24A IN COMPLEX WITH NADP+ AND EPI-TESTOSTERONE
Descriptor:Aldo-keto reductase family 1 member C2, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Faucher, F., Cantin, L., Pereira de Jesus-Tran, K., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-10-12
Release date:2007-06-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding.
J.Mol.Biol., 369, 2007
3CAQ
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CRYSTAL STRUCTURE OF 5BETA-REDUCTASE (AKR1D1) IN COMPLEX WITH NADPH
Descriptor:3-oxo-5-beta-steroid 4-dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, BETA-MERCAPTOETHANOL, ...
Authors:Faucher, F., Cantin, L., Breton, R.
Deposit date:2008-02-20
Release date:2008-12-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of Human Delta4-3-Ketosteroid 5beta-Reductase (AKR1D1) Reveal the Presence of an Alternative Binding Site Responsible for Substrate Inhibition (dagger) (,) (double dagger).
Biochemistry, 47, 2008
3CAS
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CRYSTAL STRUCTURE OF 5BETA-REDUCTASE (AKR1D1) IN COMPLEX WITH NADP+ AND 4-ANDROSTENEDIONE
Descriptor:3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, BETA-MERCAPTOETHANOL, ...
Authors:Faucher, F., Cantin, L., Breton, R.
Deposit date:2008-02-20
Release date:2008-12-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Human Delta4-3-Ketosteroid 5beta-Reductase (AKR1D1) Reveal the Presence of an Alternative Binding Site Responsible for Substrate Inhibition (dagger) (,) (double dagger).
Biochemistry, 47, 2008
3CAV
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CRYSTAL STRUCTURE OF 5BETA-REDUCTASE (AKR1D1) IN COMPLEX WITH NADP+ AND 5BETA-PREGNAN-3,20-DIONE
Descriptor:3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5BETA)-PREGNANE-3,20-DIONE, ...
Authors:Faucher, F., Cantin, L., Breton, R.
Deposit date:2008-02-20
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism.
Biochemistry, 47, 2008
3F0Z
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CRYSTAL STRUCTURE OF CLOSTRIDIUM ACETOBUTYLICUM 8-OXOGUANINE GLYCOSYLASE/LYASE IN ITS APO-FORM
Descriptor:8-oxoguanine-DNA-glycosylase, GLYCEROL
Authors:Faucher, F., Doublie, S.
Deposit date:2008-10-27
Release date:2009-04-07
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural characterization of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase in its apo form and in complex with 8-oxodeoxyguanosine.
J.Mol.Biol., 387, 2009
3F10
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CRYSTAL STRUCTURE OF CLOSTRIDIUM ACETOBUTYLICUM 8-OXOGUANINE DNA GLYCOSYLASE IN COMPLEX WITH 8-OXOGUANOSINE
Descriptor:8-oxoguanine-DNA-glycosylase, 2'-DEOXY-8-OXOGUANOSINE, 1,2-ETHANEDIOL
Authors:Faucher, F., Doublie, S.
Deposit date:2008-10-27
Release date:2009-04-07
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural characterization of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase in its apo form and in complex with 8-oxodeoxyguanosine.
J.Mol.Biol., 387, 2009
3FHF
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CRYSTAL STRUCTURE OF METHANOCALDOCOCCUS JANNASCHII 8-OXOGUANINE DNA GLYCOSYLASE (MJOGG)
Descriptor:N-glycosylase/DNA lyase
Authors:Faucher, F., Doublie, S.
Deposit date:2008-12-09
Release date:2009-05-19
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.995 Å)
Cite:Crystal structures of two archaeal 8-oxoguanine DNA glycosylases provide structural insight into guanine/8-oxoguanine distinction.
Structure, 17, 2009
3FHG
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CRYSTAL STRUCTURE OF SULFOLOBUS SOLFATARICUS 8-OXOGUANINE DNA GLYCOSYLASE (SSOGG)
Descriptor:N-glycosylase/DNA lyase, GLYCEROL, SULFATE ION
Authors:Faucher, F., Doublie, S.
Deposit date:2008-12-09
Release date:2009-05-19
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of two archaeal 8-oxoguanine DNA glycosylases provide structural insight into guanine/8-oxoguanine distinction.
Structure, 17, 2009
3I0W
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CRYSTAL STRUCTURE OF CLOSTRIDIUM ACETOBUTYLICUM 8-OXOGUANINE GLYCOSYLASE/LYASE IN COMPLEX WITH DSDNA CONTAINING CYTOSINE OPPOSITE TO 8-OXOG
Descriptor:8-oxoguanine-DNA-glycosylase, 5'-D(*AP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*A)-3', ...
Authors:Faucher, F., Doublie, S.
Deposit date:2009-06-25
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural basis for the lack of opposite base specificity of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase.
Dna Repair, 8, 2009
3I0X
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CRYSTAL STRUCTURE OF CLOSTRIDIUM ACETOBUTYLICUM 8-OXOGUANINE GLYCOSYLASE/LYASE IN COMPLEX WITH DSDNA CONTAINING ADENINE OPPOSITE TO 8-OXOG
Descriptor:8-oxoguanine-DNA-glycosylase, 5'-D(*AP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*AP*TP*GP*GP*A)-3', ...
Authors:Faucher, F., Doublie, S.
Deposit date:2009-06-25
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the lack of opposite base specificity of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase.
Dna Repair, 8, 2009
3KNT
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CRYSTAL STRUCTURE OF METHANOCALDOCOCCUS JANNASCHII 8-OXOGUANINE GLYCOSYLASE/LYASE IN COMPLEX WITH 15MER DNA CONTAINING 8-OXOGUANINE
Descriptor:N-glycosylase/DNA lyase, 5'-D(*AP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*TP*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', ...
Authors:Faucher, F., Doublie, S.
Deposit date:2009-11-12
Release date:2010-02-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The C-terminal Lysine of Ogg2 DNA Glycosylases is a Major Molecular Determinant for Guanine/8-Oxoguanine Distinction.
J.Mol.Biol., 397, 2010
4GAC
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HIGH RESOLUTION STRUCTURE OF MOUSE ALDEHYDE REDUCTASE (AKR1A4) IN ITS APO-FORM
Descriptor:Alcohol dehydrogenase [NADP(+)], 1,2-ETHANEDIOL, CITRATE ANION
Authors:Faucher, F., Jia, Z.
Deposit date:2012-07-25
Release date:2012-11-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:High-resolution structure of AKR1a4 in the apo form and its interaction with ligands.
Acta Crystallogr.,Sect.F, 68, 2012
5BW0
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THE CRYSTAL STRUCTURE OF MINOR PSEUDOPILIN BINARY COMPLEX OF XCPV AND XCPW FROM THE TYPE 2 SECRETION SYSTEM OF PSEUDOMONAS AERUGINOSA
Descriptor:Type II secretion system protein J, Type II secretion system protein I, SULFATE ION
Authors:Zhang, Y., Faucher, F., Poole, K., Jia, Z.
Deposit date:2015-06-05
Release date:2016-07-20
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-guided disruption of the pseudopilus tip complex inhibits the Type II secretion in Pseudomonas aeruginosa.
PLoS Pathog., 14, 2018
2PNU
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CRYSTAL STRUCTURE OF HUMAN ANDROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH EM-5744
Descriptor:Androgen receptor, SULFATE ION, (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE, ...
Authors:Cantin, L., Faucher, F., Couture, J.F., Pereira de Jesus-Tran, K., Legrand, P., Ciobanu, C.L., Singh, S.M., Labrie, F., Breton, R.
Deposit date:2007-04-25
Release date:2007-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Characterization of the Human Androgen Receptor Ligand-binding Domain Complexed with EM5744, a Rationally Designed Steroidal Ligand Bearing a Bulky Chain Directed toward Helix 12.
J.Biol.Chem., 282, 2007
3P2U
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CRYSTAL STRUCTURE OF PHNP IN COMPLEX WITH ORTHOVANADATE
Descriptor:Protein phnP, VANADATE ION, MANGANESE (II) ION, ...
Authors:Podzelinska, K., Kim, Y.M., Zechel, D., Faucher, F., Jia, Z.
Deposit date:2010-10-04
Release date:2011-01-05
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal structure of PhnP in complex with orthovanadate
TO BE PUBLISHED
3ULT
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CRYSTAL STRUCTURE OF AN ICE-BINDING PROTEIN FROM THE PERENNIAL RYEGRASS, LOLIUM PERENNE
Descriptor:Ice recrystallization inhibition protein-like protein, 1,2-ETHANEDIOL, ETHANOL
Authors:Middleton, A.J., Faucher, F., Campbell, R.L., Davies, P.L.
Deposit date:2011-11-11
Release date:2012-02-15
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Antifreeze protein from freeze-tolerant grass has a beta-roll fold with an irregularly structured ice-binding site.
J.Mol.Biol., 416, 2012
4FL4
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SCAFFOLDIN CONFORMATION AND DYNAMICS REVEALED BY A TERNARY COMPLEX FROM THE CLOSTRIDIUM THERMOCELLUM CELLULOSOME
Descriptor:Glycoside hydrolase family 9, Scaffolding dockerin binding protein A, Cellulosome anchoring protein cohesin region, ...
Authors:Currie, M.A., Adams, J.J., Faucher, F., Bayer, E.A., Jia, Z., Smith, S.P., Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2012-06-14
Release date:2012-06-27
Last modified:2012-08-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Scaffoldin Conformation and Dynamics Revealed by a Ternary Complex from the Clostridium thermocellum Cellulosome.
J.Biol.Chem., 287, 2012
4IL1
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CRYSTAL STRUCTURE OF THE RAT CALCINEURIN
Descriptor:Calmodulin, Calcineurin subunit B type 1, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, ...
Authors:Ye, Q., Faucher, F., Jia, Z.
Deposit date:2012-12-28
Release date:2013-10-02
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of calcineurin activation by calmodulin.
Cell Signal, 25, 2013
5VTM
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THE CRYSTAL STRUCTURE OF MINOR PSEUDOPILIN TERNARY COMPLEX OF XCPVWX FROM THE TYPE 2 SECRETION SYSTEM OF PSEUDOMONAS AERUGINOSA
Descriptor:Type II secretion system protein J, Type II secretion system protein K, Type II secretion system protein I, ...
Authors:Zhang, Y., Jia, Z.
Deposit date:2017-05-17
Release date:2018-05-23
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (2.041 Å)
Cite:Structure-guided disruption of the pseudopilus tip complex inhibits the Type II secretion in Pseudomonas aeruginosa.
PLoS Pathog., 14, 2018