Author results

1KLM
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HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH BHAP U-90152
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, (1-(5-METHANSULPHONAMIDO-1H-INDOL-2-YL-CARBONYL)4-[METHYLAMINO)PYRIDINYL]PIPERAZINE
Authors:Ren, J., Esnouf, R.M., Stammers, D.K., Stuart, D.I.
Deposit date:1997-03-17
Release date:1998-03-18
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor.
Proc.Natl.Acad.Sci.USA, 94, 1997
1C0T
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN), (R)-(+)9B-(3-METHYL)PHENYL-2,3-DIHYDROTHIAZOLO[2,3-A]ISOINDOL-5(9BH)-ONE
Authors:Ren, J., Esnouf, R.M., Hopkins, A.L., Stuart, D.I., Stammers, D.K.
Deposit date:1999-07-19
Release date:2000-07-19
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies.
J.Med.Chem., 42, 1999
1C0U
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+50.0934
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN), (R)-(+) 5(9BH)-OXO-9B-PHENYL-2,3-DIHYDROTHIAZOLO[2,3-A]ISOINDOL-3-CARBOXYLIC ACID METHYL ESTER
Authors:Ren, J., Esnouf, R.M., Hopkins, A.L., Stuart, D.I., Stammers, D.K.
Deposit date:1999-07-19
Release date:2000-07-19
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies.
J.Med.Chem., 42, 1999
1DTQ
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94)
Descriptor:HIV-1 RT A-CHAIN, HIV-1 RT B-CHAIN, N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N'-[5-NITRILOMETHYL-PYRIDYL]-THIOUREA
Authors:Ren, J., Diprose, J., Warren, J., Esnouf, R.M., Bird, L.E., Ikemizu, S., Slater, M., Milton, J., Balzarini, J., Stuart, D.I., Stammers, D.K.
Deposit date:2000-01-13
Release date:2000-03-20
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.
J.Biol.Chem., 275, 2000
1DTT
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2 (PETT130A94)
Descriptor:HIV-1 RT A-CHAIN, HIV-1 RT B-CHAIN, N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N'-[5-CHLORO-PYRIDYL]-THIOUREA
Authors:Ren, J., Diprose, J., Warren, J., Esnouf, R.M., Bird, L.E., Ikemizu, S., Slater, M., Milton, J., Balzarini, J., Stuart, D.I., Stammers, D.K.
Deposit date:2000-01-13
Release date:2000-04-02
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.
J.Biol.Chem., 275, 2000
1EC4
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SOLUTION STRUCTURE OF A HEXITOL NUCLEIC ACID DUPLEX WITH FOUR CONSECUTIVE T:T BASE PAIRS
Descriptor:HEXITOL DODECANUCLEOTIDE
Authors:Lescrinier, E., Esnouf, R.M., Schraml, J., Busson, R., Herdewijn, P.
Deposit date:2000-01-25
Release date:2003-04-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a HNA-RNA hybrid
Chem.Biol., 7, 2000
1GP0
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HUMAN IGF2R DOMAIN 11
Descriptor:CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, SULFATE ION
Authors:Brown, J., Esnouf, R.M., Jones, M.A., Linnell, J., Harlos, K., Hassan, A.B., Jones, E.Y.
Deposit date:2001-10-29
Release date:2002-02-28
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of a Functional Igf2R Fragment Determined from the Anomalous Scattering of Sulfur
Embo J., 21, 2002
1GP3
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HUMAN IGF2R DOMAIN 11
Descriptor:CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
Authors:Brown, J., Esnouf, R.M., Jones, M.A., Linnell, J., Harlos, K., Hassan, A.B., Jones, E.Y.
Deposit date:2001-10-29
Release date:2002-02-28
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of a Functional Igf2R Fragment Determined from the Anomalous Scattering of Sulfur
Embo J., 21, 2002
1OLZ
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THE LIGAND-BINDING FACE OF THE SEMAPHORINS REVEALED BY THE HIGH RESOLUTION CRYSTAL STRUCTURE OF SEMA4D
Descriptor:SEMAPHORIN 4D
Authors:Love, C.A., Harlos, K., Mavaddat, N., Davis, S.J., Stuart, D.I., Jones, E.Y., Esnouf, R.M.
Deposit date:2003-08-19
Release date:2003-09-11
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Ligand-Binding Face of the Semaphorins Revealed by the High-Resolution Crystal Structure of Sema4D
Nat.Struct.Biol., 10, 2003
1YJD
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CRYSTAL STRUCTURE OF HUMAN CD28 IN COMPLEX WITH THE FAB FRAGMENT OF A MITOGENIC ANTIBODY (5.11A1)
Descriptor:Fab fragment of 5.11A1 antibody light chain, Fab fragment of 5.11A1 antibody heavy chain, T-cell-specific surface glycoprotein CD28, ...
Authors:Evans, E.J., Esnouf, R.M., Manso-Sancho, R., Gilbert, R.J.C., James, J.R., Sorensen, P., Stuart, D.I., Davis, S.J.
Deposit date:2005-01-14
Release date:2005-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a soluble CD28-Fab complex
Nat.Immunol., 6, 2005
2BNQ
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STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY OF T CELL VACCINES
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, SYNTHETIC PEPTIDE, ...
Authors:Chen, J.-L., Stewart-Jones, G., Bossi, G., Lissin, N.M., Wooldridge, L., Choi, E.M.L., Held, G., Dunbar, P.R., Esnouf, R.M., Sami, M., Boultier, J.M., Rizkallah, P.J., Renner, C., Sewell, A., van der Merwe, P.A., Jackobsen, B.K., Griffiths, G., Jones, E.Y., Cerundolo, V.
Deposit date:2005-03-31
Release date:2005-05-23
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201, 2005
2BNR
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STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY OF T CELL VACCINES
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, SYNTHETIC PEPTIDE, ...
Authors:Chen, J.-L., Stewart-Jones, G., Bossi, G., Lissin, N.M., Wooldridge, L., Choi, E.M.L., Held, G., Dunbar, P.R., Esnouf, R.M., Sami, M., Boultier, J.M., Rizkallah, P.J., Renner, C., Sewell, A., van der Merwe, P.A., Jackobsen, B.K., Griffiths, G., Jones, E.Y., Cerundolo, V.
Deposit date:2005-03-31
Release date:2005-05-23
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201, 2005
2BNU
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STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY OF T CELL VACCINES
Descriptor:T-CELL RECEPTOR ALPHA CHAIN C REGION, T-CELL RECEPTOR BETA CHAIN C REGION
Authors:Chen, J.-L., Stewart-Jones, G., Bossi, G., Lissin, N.M., Wooldridge, L., Choi, E.M.L., Held, G., Dunbar, P.R., Esnouf, R.M., Sami, M., Boultier, J.M., Rizkallah, P.J., Renner, C., Sewell, A., Van Der Merwe, P.A., Jackobsen, B.K., Griffiths, G., Jones, E.Y., Cerundolo, V.
Deposit date:2005-04-04
Release date:2005-05-24
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines.
J.Exp.Med., 201, 2005
2JCB
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THE CRYSTAL STRUCTURE OF 5-FORMYL-TETRAHYDROFOLATE CYCLOLIGASE FROM BACILLUS ANTHRACIS (BA4489)
Descriptor:5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE FAMILY PROTEIN, ADENOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, ...
Authors:Meier, C., Carter, L.G., Winter, G., Owens, R.J., Stuart, D.I., Esnouf, R.M., Oxford Protein Production Facility (OPPF), Structural Proteomics in Europe (SPINE)
Deposit date:2006-12-21
Release date:2007-02-20
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of 5-Formyltetrahydrofolate Cyclo-Ligase from Bacillus Anthracis (Ba4489).
Acta Crystallogr.,Sect.F, 63, 2007
2JJX
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THE CRYSTAL STRUCTURE OF UMP KINASE FROM BACILLUS ANTHRACIS (BA1797)
Descriptor:URIDYLATE KINASE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Meier, C., Carter, L.G., Mancini, E.J., Owens, R.J., Stuart, D.I., Esnouf, R.M., Oxford Protein Production Facility (OPPF), Structural Proteomics in Europe (SPINE)
Deposit date:2008-04-23
Release date:2008-07-29
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:The Crystal Structure of Ump Kinase from Bacillus Anthracis (Ba1797) Reveals an Allosteric Nucleotide-Binding Site.
J.Mol.Biol., 381, 2008
2UVD
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THE CRYSTAL STRUCTURE OF A 3-OXOACYL-(ACYL CARRIER PROTEIN) REDUCTASE FROM BACILLUS ANTHRACIS (BA3989)
Descriptor:3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE
Authors:Zaccai, N.R., Carter, L.G., Berrow, N.S., Sainsbury, S., Nettleship, J.E., Walter, T.S., Harlos, K., Owens, R.J., Wilson, K.S., Stuart, D.I., Esnouf, R.M., Oxford Protein Production Facility (OPPF), Structural Proteomics in Europe (SPINE)
Deposit date:2007-03-09
Release date:2007-04-17
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of a 3-Oxoacyl-(Acylcarrier Protein) Reductase (Ba3989) from Bacillus Anthracis at 2.4-A Resolution.
Proteins: Struct., Funct., Bioinf., 70, 2008
2VD8
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THE CRYSTAL STRUCTURE OF ALANINE RACEMASE FROM BACILLUS ANTHRACIS (BA0252)
Descriptor:ALANINE RACEMASE, PYRIDOXAL-5'-PHOSPHATE, MAGNESIUM ION, ...
Authors:Au, K., Ren, J., Walter, T.S., Harlos, K., Nettleship, J.E., Owens, R.J., Stuart, D.I., Esnouf, R.M., Oxford Protein Production Facility (OPPF), Structural Proteomics in Europe (SPINE)
Deposit date:2007-10-01
Release date:2008-05-20
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structures of an Alanine Racemase from Bacillus Anthracis (Ba0252) in the Presence and Absence of (R)-1-Aminoethylphosphonic Acid (L-Ala-P).
Acta Crystallogr.,Sect.F, 64, 2008
2VD9
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THE CRYSTAL STRUCTURE OF ALANINE RACEMASE FROM BACILLUS ANTHRACIS (BA0252) WITH BOUND L-ALA-P
Descriptor:ALANINE RACEMASE, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Au, K., Ren, J., Walter, T.S., Harlos, K., Nettleship, J.E., Owens, R.J., Stuart, D.I., Esnouf, R.M., Oxford Protein Production Facility (OPPF), Structural Proteomics in Europe (SPINE)
Deposit date:2007-10-01
Release date:2008-05-20
Last modified:2012-02-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of an Alanine Racemase from Bacillus Anthracis (Ba0252) in the Presence and Absence of (R)-1-Aminoethylphosphonic Acid (L-Ala-P).
Acta Crystallogr.,Sect.F, 64, 2008
2W8X
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STRUCTURE OF THE TICK ION-CHANNEL MODULATOR RA-KLP
Descriptor:ION-CHANNEL MODULATOR RAKLP, GLYCEROL, ACETATE ION, ...
Authors:Paesen, G.C., Siebold, C., Dallas, M., Peers, C., Harlos, K., Nuttall, P.A., Nunn, M.A., Stuart, D.I., Esnouf, R.M.
Deposit date:2009-01-20
Release date:2009-05-05
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:An Ion-Channel Modulator from the Saliva of the Brown Ear Tick Has a Highly Modified Kunitz/Bpti Structure.
J.Mol.Biol., 389, 2009
5AC9
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STRUCTURE-BASED ENERGETICS OF PROTEIN INTERFACES GUIDE FOOT-AND-MOUTH DISEASE VIRUS VACCINE DESIGN
Descriptor:VP1, VP3, VP2, ...
Authors:Kotecha, A., Seago, J., Scott, K., Burman, A., Loureiro, S., Ren, J., Porta, C., Ginn, H.M., Jackson, T., PerezMartin, E., Siebert, C.A., Paul, G., Huiskonen, J.T., Jones, I.M., Esnouf, R.M., Fry, E.E., Maree, F.F., Charleston, B., Stuart, D.I.
Deposit date:2015-08-14
Release date:2015-09-23
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure-Based Energetics of Protein Interfaces Guide Foot-and-Mouth Disease Vaccine Design
Nat.Struct.Mol.Biol., 22, 2015
5ACA
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STRUCTURE-BASED ENERGETICS OF PROTEIN INTERFACES GUIDE FOOT-AND-MOUTH DISEASE VIRUS VACCINE DESIGN
Descriptor:VP1, VP2, VP3, ...
Authors:Kotecha, A., Seago, J., Scott, K., Burman, A., Loureiro, S., Ren, J., Porta, C., Ginn, H.M., Jackson, T., Perez-Martin, E., Siebert, C.A., Paul, G., Huiskonen, J.T., Jones, I.M., Esnouf, R.M., Fry, E.E., Maree, F.F., Charleston, B., Stuart, D.I.
Deposit date:2015-08-14
Release date:2015-09-23
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure-Based Energetics of Protein Interfaces Guide Foot-and-Mouth Disease Vaccine Design
Nat.Struct.Mol.Biol., 22, 2015
5D8A
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CRYSTAL STRUCTURE OF RECOMBINANT FOOT-AND-MOUTH-DISEASE VIRUS A22-H2093F EMPTY CAPSID
Descriptor:VP1, VP2, VP3, ...
Authors:Kotecha, A., Seago, J., Scott, K., Burman, A., Loureiro, S., Ren, J., Porta, C., Ginn, H.M., Jackson, T., Perez-Martin, E., Siebert, C.A., Paul, G., Huiskonen, J.T., Jones, I.M., Esnouf, R.M., Fry, E.E., Maree, F.F., Charleston, B., Stuart, D.I.
Deposit date:2015-08-16
Release date:2015-09-23
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design.
Nat.Struct.Mol.Biol., 22, 2015
5DDJ
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CRYSTAL STRUCTURE OF RECOMBINANT FOOT-AND-MOUTH-DISEASE VIRUS O1M-S2093Y EMPTY CAPSID
Descriptor:Foot and mouth disease virus, VP1, VP2, ...
Authors:Kotecha, A., Seago, J., Scott, K., Burman, A., Loureiro, S., Ren, J., Porta, C., Ginn, H.M., Jackson, T., Perez-Martin, E., Siebert, C.A., Paul, G., Huiskonen, J.T., Jones, I.M., Esnouf, R.M., Fry, E.E., Maree, F.F., Charleston, B., Stuart, D.I.
Deposit date:2015-08-25
Release date:2015-09-23
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design.
Nat.Struct.Mol.Biol., 22, 2015
1EP4
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH S-1153
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, 5-(3,5-DICHLOROPHENYL)THIO-4-ISOPROPYL-1-(PYRIDIN-4-YL-METHYL)-1H-IMIDAZOL-2-YL-METHYL CARBAMATE
Authors:Ren, J., Nichols, C., Bird, L.E., Fujiwara, T., Suginoto, H., Stuart, D.I., Stammers, D.K.
Deposit date:2000-03-27
Release date:2000-09-27
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding.
J.Biol.Chem., 275, 2000
1FK9
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
Descriptor:HIV-1 RT, A-CHAIN, B-CHAIN, ...
Authors:Ren, J., Milton, J., Weaver, K.L., Short, S.A., Stuart, D.I., Stammers, D.K.
Deposit date:2000-08-09
Release date:2000-11-03
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
STRUCTURE FOLD.DES., 8, 2000
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