Author results

4B99
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CRYSTAL STRUCTURE OF MAPK7 (ERK5) WITH INHIBITOR
Descriptor:MITOGEN-ACTIVATED PROTEIN KINASE 7, 11-cyclopentyl-2-[[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl-phenyl]amino]-5-methyl-pyrimido[4,5-b][1,4]benzodiazepin-6-one
Authors:Elkins, J.M., Wang, J., Vollmar, M., Mahajan, P., Savitsky, P., Deng, X., Gray, N.S., Pike, A.C.W., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2012-09-03
Release date:2012-09-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-Ray Crystal Structure of Erk5 (Mapk7) in Complex with a Specific Inhibitor.
J.Med.Chem., 56, 2013
1GQ6
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PROCLAVAMINATE AMIDINO HYDROLASE FROM STREPTOMYCES CLAVULIGERUS
Descriptor:PROCLAVAMINATE AMIDINO HYDROLASE, MANGANESE (II) ION
Authors:Elkins, J.M., Clifton, I.J., Hernandez, H., Robinson, C.V., Schofield, C.J., Hewitson, K.S.
Deposit date:2001-11-20
Release date:2002-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Oligomeric Structure of Proclavaminic Acid Amidino Hydrolase: Evolution of a Hydrolytic Enzyme in Clavulanic Acid Biosynthesis
Biochem.J., 366, 2002
1GQ7
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PROCLAVAMINATE AMIDINO HYDROLASE FROM STREPTOMYCES CLAVULIGERUS
Descriptor:PROCLAVAMINATE AMIDINO HYDROLASE, MANGANESE (II) ION
Authors:Elkins, J.M., Clifton, I.J., Hernandez, H., Robinson, C.V., Schofield, C.J., Hewitson, K.S.
Deposit date:2001-11-20
Release date:2002-06-06
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.
Biochem. J., 366, 2002
1GQW
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TAURINE/ALPHA-KETOGLUTARATE DIOXYGENASE FROM ESCHERICHIA COLI
Descriptor:ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE, FE (II) ION, 2-AMINOETHANESULFONIC ACID, ...
Authors:Elkins, J.M., Ryle, M.J., Clifton, I.J., Dunning-Hotopp, J.C., Lloyd, J.S., Burzlaff, N.I., Baldwin, J.E., Hausinger, R.P., Roach, P.L.
Deposit date:2001-12-05
Release date:2002-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-Ray Crystal Structure of Escherichia Coli Taurine/Alpha-Ketoglutarate Dioxygenase Complexed to Ferrous Iron and Substrates
Biochemistry, 41, 2002
1GY9
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TAURINE/ALPHA-KETOGLUTARATE DIOXYGENASE FROM ESCHERICHIA COLI
Descriptor:ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE, FE (III) ION, 2-AMINOETHANESULFONIC ACID, ...
Authors:Elkins, J.M., Burzlaff, N.I., Ryle, M.J., Lloyd, J.S., Clifton, I.J., Baldwin, J.E., Hausinger, R.P., Roach, P.L.
Deposit date:2002-04-22
Release date:2002-04-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-Ray Crystal Structure of Escherichia Coli Taurine/Alpha-Ketoglutarate Dioxygenase Complexed to Ferrous Iron and Substrates.
Biochemistry, 41, 2002
1H2K
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH HIF-1 ALPHA FRAGMENT PEPTIDE
Descriptor:FACTOR INHIBITING HIF1, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, FE (II) ION, ...
Authors:Elkins, J.M., Hewitson, K.S., McNeill, L.A., Schlemminger, I., Seibel, J.F., Schofield, C.J.
Deposit date:2002-08-12
Release date:2002-11-28
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
1H2L
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH HIF-1 ALPHA FRAGMENT PEPTIDE
Descriptor:FACTOR INHIBITING HIF1, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, FE (II) ION, ...
Authors:Elkins, J.M., Hewitson, K.S., McNeill, L.A., Schlemminger, I., Seibel, J.F., Schofield, C.J.
Deposit date:2002-08-12
Release date:2002-11-28
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
1H2M
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH HIF-1 ALPHA FRAGMENT PEPTIDE
Descriptor:FACTOR INHIBITING HIF1, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, ZINC ION, ...
Authors:Elkins, J.M., Hewitson, K.S., McNeill, L.A., Schlemminger, I., Seibel, J.F., Schofield, C.J.
Deposit date:2002-08-12
Release date:2002-11-28
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
1H2N
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FACTOR INHIBITING HIF-1 ALPHA
Descriptor:HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, FE (II) ION, 2-OXOGLUTARIC ACID, ...
Authors:Elkins, J.M., Hewitson, K.S., McNeill, L.A., Schlemminger, I., Seibel, J.F., Schofield, C.J.
Deposit date:2002-08-12
Release date:2002-11-28
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
1ODM
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ANAEROBIC AC-VINYLGLYCINE FE COMPLEX)
Descriptor:ISOPENICILLIN N SYNTHASE, DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VINYLGLYCINE, SULFATE ION, ...
Authors:Elkins, J.M., Rutledge, P.J., Burzlaff, N.I., Clifton, I.J., Adlington, R.M., Roach, P.L., Baldwin, J.E.
Deposit date:2003-02-19
Release date:2003-06-19
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Crystallographic Studies on the Reaction of Isopenicillin N Synthase with an Unsaturated Substrate Analogue
Org.Biomol.Chem., 1, 2003
1ODN
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ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (OXYGEN-EXPOSED PRODUCT FROM ANAEROBIC AC-VINYLGLYCINE FE COMPLEX)
Descriptor:ISOPENICILLIN N SYNTHASE, 6-(5-AMINO-5-CARBOXY-PENTANOYLAMINO)-3-HYDROXYMETHYL-7-OXO-4-THIA-1-AZA-BICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, SULFATE ION, ...
Authors:Elkins, J.M., Rutledge, P.J., Burzlaff, N.I., Clifton, I.J., Adlington, R.M., Roach, P.L., Baldwin, J.E.
Deposit date:2003-02-19
Release date:2003-06-19
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystallographic Studies on the Reaction of Isopenicillin N Synthase with an Unsaturated Substrate Analogue
Org.Biomol.Chem., 1, 2003
1VZ6
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ORNITHINE ACETYLTRANSFERASE (ORF6 GENE PRODUCT - CLAVULANIC ACID BIOSYNTHESIS) FROM STREPTOMYCES CLAVULIGERUS
Descriptor:ORNITHINE ACETYL-TRANSFERASE, SULFATE ION
Authors:Elkins, J.M., Kershaw, N.J., Schofield, C.J.
Deposit date:2004-05-14
Release date:2004-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:X-Ray Crystal Structure of Ornithine Acetyltransferase from the Clavulanic Acid Biosynthesis Gene Cluster.
Biochem.J., 385, 2005
1VZ7
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ORNITHINE ACETYLTRANSFERASE (ORF6 GENE PRODUCT - CLAVULANIC ACID BIOSYNTHESIS) FROM STREPTOMYCES CLAVULIGERUS
Descriptor:ORNITHINE ACETYL-TRANSFERASE, SULFATE ION
Authors:Elkins, J.M., Kershaw, N.J., Schofield, C.J.
Deposit date:2004-05-14
Release date:2004-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-Ray Crystal Structure of Ornithine Acetyltransferase from the Clavulanic Acid Biosynthesis Gene Cluster.
Biochem.J., 385, 2005
1VZ8
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ORNITHINE ACETYLTRANSFERASE (ORF6 GENE PRODUCT - CLAVULANIC ACID BIOSYNTHESIS) FROM STREPTOMYCES CLAVULIGERUS (SEMET STRUCTURE)
Descriptor:ORNITHINE ACETYL-TRANSFERASE, SULFATE ION
Authors:Elkins, J.M., Kershaw, N.J., Schofield, C.J.
Deposit date:2004-05-14
Release date:2004-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:X-Ray Crystal Structure of Ornithine Acetyltransferase from the Clavulanic Acid Biosynthesis Gene Cluster.
Biochem.J., 385, 2005
2BYG
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2ND PDZ DOMAIN OF DISCS LARGE HOMOLOGUE 2
Descriptor:CHANNEL ASSOCIATED PROTEIN OF SYNAPSE-110
Authors:Elkins, J.M., Schoch, G.A., Smee, C.E.A., Berridge, G., Salah, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-08-01
Release date:2005-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extensions.
Protein Sci., 16, 2007
2IWN
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3RD PDZ DOMAIN OF MULTIPLE PDZ DOMAIN PROTEIN MPDZ (CASP TARGET)
Descriptor:MULTIPLE PDZ DOMAIN PROTEIN
Authors:Elkins, J.M., Gileadi, C., Savitsky, P., Berridge, G., Smee, C.E.A., Pike, A.C.W., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A.
Deposit date:2006-07-03
Release date:2006-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extension.
Protein Sci., 16, 2007
2IWO
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12TH PDZ DOMAIN OF MULTIPLE PDZ DOMAIN PROTEIN MPDZ (CASP TARGET)
Descriptor:MULTIPLE PDZ DOMAIN PROTEIN
Authors:Elkins, J.M., Yang, X., Gileadi, C., Schoch, G., Johansson, C., Savitsky, P., Berridge, G., Smee, C.E.A., Turnbull, A., Pike, A., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A.
Deposit date:2006-07-03
Release date:2006-07-26
Last modified:2012-10-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extensions.
Protein Sci., 16, 2007
2IWP
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12TH PDZ DOMAIN OF MULTIPLE PDZ DOMAIN PROTEIN MPDZ (CASP TARGET)
Descriptor:MULTIPLE PDZ DOMAIN PROTEIN
Authors:Elkins, J.M., Yang, X., Gileadi, C., Schoch, G., Johansson, C., Savitsky, P., Berridge, G., Smee, C.E.A., Turnbull, A., Pike, A., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A.
Deposit date:2006-07-03
Release date:2006-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extension.
Protein Sci., 16, 2007
2IWQ
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7TH PDZ DOMAIN OF MULTIPLE PDZ DOMAIN PROTEIN MPDZ
Descriptor:MULTIPLE PDZ DOMAIN PROTEIN
Authors:Elkins, J.M., Berridge, G., Savitsky, P., Smee, C.E.A., Turnbull, A., Ugochukwu, E., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A.
Deposit date:2006-07-03
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extensions.
Protein Sci., 16, 2007
2VAC
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STRUCTURE OF N-TERMINAL ACTIN DEPOLYMERIZING FACTOR HOMOLOGY (ADF-H) DOMAIN OF HUMAN TWINFILIN-2
Descriptor:TWINFILIN-2, ZINC ION, 1,2-ETHANEDIOL
Authors:Elkins, J.M., Pike, A.C.W., King, O., Salah, E., Savitsky, P., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C.H., Sundstrom, M., Knapp, S.
Deposit date:2007-08-30
Release date:2007-10-16
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of N-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain of Human Twinfilin-2
To be Published
2W0I
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STRUCTURE OF C-TERMINAL ACTIN DEPOLYMERIZING FACTOR HOMOLOGY (ADF-H) DOMAIN OF HUMAN TWINFILIN-2
Descriptor:TWINFILIN-2
Authors:Elkins, J.M., Pike, A.C.W., Salah, E., Savitsky, P., Murray, J.W., Roos, A., von Delft, F., Edwards, A., Arrowsmith, C.H., Wikstrom, M., Bountra, C., Knapp, S.
Deposit date:2008-08-18
Release date:2008-09-30
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of C-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain of Human Twinfilin- 2
To be Published
3ZON
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HUMAN TYK2 PSEUDOKINASE DOMAIN BOUND TO A KINASE INHIBITOR
Descriptor:NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2, 5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE
Authors:Elkins, J.M., Wang, J., Krojer, T., Savitsky, P., Chalk, R., Daga, N., Salah, E., Berridge, G., Picaud, S., von Delft, F., Bountra, C., Edwards, A., Knapp, S.
Deposit date:2013-02-22
Release date:2013-04-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Human Tyk2 Pseudokinase Domain Bound to a Kinase Inhibitor
To be Published
4AF3
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HUMAN AURORA B KINASE IN COMPLEX WITH INCENP AND VX-680
Descriptor:AURORA KINASE B, INNER CENTROMERE PROTEIN, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE
Authors:Elkins, J.M., Vollmar, M., Wang, J., Picaud, S., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Knapp, S.
Deposit date:2012-01-16
Release date:2012-04-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal Structure of Human Aurora B in Complex with Incenp and Vx-680.
J.Med.Chem., 55, 2012
4AOT
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CRYSTAL STRUCTURE OF HUMAN SERINE THREONINE KINASE-10 (LOK) BOUND TO GW830263A
Descriptor:Serine/threonine-protein kinase 10, CHLORIDE ION, 1-(4-{methyl[2-({4-[(methylsulfonyl)methyl]phenyl}amino)pyrimidin-4-yl]amino}phenyl)-3-{3-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea
Authors:Elkins, J.M., Salah, E., Szklarz, M., Canning, P., von Delft, F., Yue, W., Liu, Y., Bountra, C., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2012-03-29
Release date:2012-04-11
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Crystal Structure of Human Serine Threonine Kinase-10 (Lok) Bound to Gw830263A
To be Published
4APC
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CRYSTAL STRUCTURE OF HUMAN NIMA-RELATED KINASE 1 (NEK1)
Descriptor:SERINE/THREONINE-PROTEIN KINASE NEK1, CHLORIDE ION
Authors:Elkins, J.M., Hanchuk, T.D.M., Lovato, D.V., Basei, F.L., Meirelles, G.V., Kobarg, J., Szklarz, M., Vollmar, M., Mahajan, P., Rellos, P., Zhang, Y., Krojer, T., Pike, A.C.W., Bountra, C., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2012-04-02
Release date:2012-04-25
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Human Nima-Related Kinase 1
To be Published