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2C21
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SPECIFICITY OF THE TRYPANOTHIONE-DEPENDEDNT LEISHMANIA MAJOR GLYOXALASE I: STRUCTURE AND BIOCHEMICAL COMPARISON WITH THE HUMAN ENZYME
Descriptor:TRYPANOTHIONE-DEPENDENT GLYOXALASE I, NICKEL (II) ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Ariza, A., Vickers, T.J., Greig, N., Armour, K.A., Eggleston, I.M., Fairlamb, A.H., Bond, C.S.
Deposit date:2005-09-23
Release date:2006-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Specificity of the Trypanothione-Dependent Leishmania Major Glyoxalase I: Structure and Biochemical Comparison with the Human Enzyme.
Mol.Microbiol., 59, 2006
2CBI
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STRUCTURE OF THE CLOSTRIDIUM PERFRINGENS NAGJ FAMILY 84 GLYCOSIDE HYDROLASE, A HOMOLOGUE OF HUMAN O-GLCNACASE
Descriptor:HYALURONIDASE, SULFATE ION, CHLORIDE ION, ...
Authors:Rao, F.V., Dorfmueller, H.C., Villa, F., Allwood, M., Eggleston, I.M., van Aalten, D.M.F.
Deposit date:2006-01-04
Release date:2006-02-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis.
EMBO J., 25, 2006
2CBJ
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STRUCTURE OF THE CLOSTRIDIUM PERFRINGENS NAGJ FAMILY 84 GLYCOSIDE HYDROLASE, A HOMOLOGUE OF HUMAN O-GLCNACASE IN COMPLEX WITH PUGNAC
Descriptor:HYALURONIDASE, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE, CHLORIDE ION
Authors:Rao, F.V., Dorfmueller, H.C., Villa, F., Allwood, M., Eggleston, I.M., van Aalten, D.M.F.
Deposit date:2006-01-05
Release date:2006-02-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis.
EMBO J., 25, 2006
2IUZ
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CHITINASE B1 IN COMPLEX WITH C2-DICAFFEINE
Descriptor:CHITINASE, SULFATE ION, 1,1'-ETHANE-1,2-DIYLBIS(3,7-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE)
Authors:Schuttelkopf, A.W., Andersen, O.A., Rao, F.V., Allwood, M., Lloyd, C.M., Eggleston, I.M., Van Aalten, D.M.F.
Deposit date:2006-06-08
Release date:2006-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Screening-Based Discovery and Structural Dissection of a Novel Family 18 Chitinase Inhibitor
J.Biol.Chem., 281, 2006
2XUC
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NATURAL PRODUCT-GUIDED DISCOVERY OF A FUNGAL CHITINASE INHIBITOR
Descriptor:CHITINASE, 1-methyl-3-(N-methylcarbamimidoyl)urea, PHOSPHATE ION, ...
Authors:Rush, C.L., Schuttelkopf, A.W., Hurtado-Guerrero, R., Blair, D.E., Ibrahim, A.F.M., Desvergnes, S., Eggleston, I.M., van Aalten, D.M.F.
Deposit date:2010-10-18
Release date:2010-10-27
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Natural Product-Guided Discovery of a Fungal Chitinase Inhibitor.
Chem.Biol., 17, 2010
2XVN
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A. FUMIGATUS CHITINASE A1 PHENYL-METHYLGUANYLUREA COMPLEX
Descriptor:ASPERGILLUS FUMIGATUS CHITINASE A1, 1-METHYL-3-(N-PHENYLCARBAMIMIDOYL)UREA, CHLORIDE ION
Authors:Rush, C.L., Schuttelkopf, A.W., Hurtado-Guerrero, R., Blair, D.E., Ibrahim, A.F.M., Desvergnes, S., Eggleston, I.M., van Aalten, D.M.F.
Deposit date:2010-10-26
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Natural Product-Guided Discovery of a Fungal Chitinase Inhibitor.
Chem.Biol., 17, 2010
2YBT
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CRYSTAL STRUCTURE OF HUMAN ACIDIC CHITINASE IN COMPLEX WITH BISDIONIN C
Descriptor:ACIDIC MAMMALIAN CHITINASE, GLYCEROL, 1,1'-PROPANE-1,3-DIYLBIS(3,7-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE)
Authors:Sutherland, T.E., Andersen, O.A., Betou, M., Eggleston, I.M., Maizels, R.M., van Aalten, D., Allen, J.E.
Deposit date:2011-03-10
Release date:2011-06-08
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor.
Chem. Biol., 18, 2011
2YBU
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CRYSTAL STRUCTURE OF HUMAN ACIDIC CHITINASE IN COMPLEX WITH BISDIONIN F
Descriptor:ACIDIC MAMMALIAN CHITINASE, GLYCEROL, 3,7-DIMETHYL-1-[3-(3-METHYL-2,6-DIOXO-9H-PURIN-1-YL)PROPYL]PURINE-2,6-DIONE
Authors:Sutherland, T.E., Andersen, O.A., Betou, M., Eggleston, I.M., Maizels, R.M., van Aalten, D., Allen, J.E.
Deposit date:2011-03-10
Release date:2011-06-08
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor.
Chem. Biol., 18, 2011
4AY1
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HUMAN YKL-39 IS A PSEUDO-CHITINASE WITH RETAINED CHITOOLIGOSACCHARIDE BINDING PROPERTIES
Descriptor:CHITINASE-3-LIKE PROTEIN 2, N-ACETYL-D-GLUCOSAMINE
Authors:Schimpl, M., Rush, C.L., Betou, M., Eggleston, I.M., Penman, G.A., Recklies, A.D., van Aalten, D.M.F.
Deposit date:2012-06-17
Release date:2012-08-08
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Human Ykl-39 is a Pseudo-Chitinase with Retained Chitooligosaccharide-Binding Properties.
Biochem.J., 446, 2012
2XVP
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CHIA1 FROM ASPERGILLUS FUMIGATUS, APOSTRUCTURE
Descriptor:CLASS III CHITINASE CHIA1, PHOSPHATE ION
Authors:Schuettelkopf, A.W., van Aalten, D.M.F.
Deposit date:2010-10-27
Release date:2011-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Natural Product-Guided Discovery of a Fungal Chitinase Inhibitor.
Chem.Biol., 17, 2010
3CH9
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CHITINASE B1 IN COMPLEX WITH DIMETHYLGUANYLUREA
Descriptor:Chitinase, SULFATE ION, 1-methyl-3-(N-methylcarbamimidoyl)urea
Authors:Andersen, O.A., van Aalten, D.M.F.
Deposit date:2008-03-09
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.
Chem.Biol., 15, 2008
3CHC
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CHITINASE B1 IN COMPLEX WITH MONOPEPTIDE
Descriptor:Chitinase, SULFATE ION, (2S)-2-acetamido-N-methyl-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]pentanamide
Authors:Andersen, O.A., van Aalten, D.M.F.
Deposit date:2008-03-09
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.
Chem.Biol., 15, 2008
3CHD
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CHITINASE B1 IN COMPLEX WITH DIPEPTIDE
Descriptor:Chitinase, (2S)-2-[[(2S)-2-acetamido-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]pentanoyl]-methyl-amino]-3-phenyl-propanoic acid, SULFATE ION
Authors:Andersen, O.A., van Aalten, D.M.F.
Deposit date:2008-03-09
Release date:2008-03-25
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.
Chem.Biol., 15, 2008
3CHE
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CHITINASE B1 IN COMPLEX WITH TRIPEPTIDE
Descriptor:Chitinase, Peptide inhibitor, SULFATE ION
Authors:Andersen, O.A., van Aalten, D.M.F.
Deposit date:2008-03-09
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.
Chem.Biol., 15, 2008
3CHF
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CHITINASE B1 IN COMPLEX WITH TETRAPEPTIDE
Descriptor:Chitinase, Argifin, SULFATE ION
Authors:Andersen, O.A., van Aalten, D.M.F.
Deposit date:2008-03-09
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.
Chem.Biol., 15, 2008