2C21

Specificity of the Trypanothione-dependednt Leishmania major Glyoxalase I: Structure and biochemical comparison with the human enzyme

Summary for 2C21

Entry DOI	10.2210/pdb2c21/pdb
Descriptor	TRYPANOTHIONE-DEPENDENT GLYOXALASE I, NICKEL (II) ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (6 entities in total)
Functional Keywords	glyoxalase i, lyase, leishmania major, trypanothione, glutathionylspermidine, methylglyoxal, detoxification
Biological source	LEISHMANIA MAJOR
Total number of polymer chains	6
Total formula weight	101074.91
Authors	Ariza, A.,Vickers, T.J.,Greig, N.,Armour, K.A.,Eggleston, I.M.,Fairlamb, A.H.,Bond, C.S. (deposition date: 2005-09-23, release date: 2006-02-01, Last modification date: 2023-12-13)
Primary citation	Ariza, A.,Vickers, T.J.,Greig, N.,Armour, K.A.,Dixon, M.J.,Eggleston, I.M.,Fairlamb, A.H.,Bond, C.S. Specificity of the Trypanothione-Dependent Leishmania Major Glyoxalase I: Structure and Biochemical Comparison with the Human Enzyme. Mol.Microbiol., 59:1239-, 2006 Cited by PubMed: 16430697 DOI: 10.1111/J.1365-2958.2006.05022.X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation