2C21

Specificity of the Trypanothione-dependednt Leishmania major Glyoxalase I: Structure and biochemical comparison with the human enzyme

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	TRYPANOTHIONE-DEPENDENT GLYOXALASE I	polymer	144	16621.9	6	UniProt (Q68RJ8) Pfam (PF00903)	LEISHMANIA MAJOR
2	G, H, M, N, T... (A, C, E)	NICKEL (II) ION	non-polymer		58.7	6	Chemie (NI)
3	I, K, O, P, R... (A, B, C, D, E)	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	6	Chemie (MPD)
4	J, Q (A, D)	(4R)-2-METHYLPENTANE-2,4-DIOL	non-polymer		118.2	2	Chemie (MRD)
5	L, S (B, D)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
6	AA, BA, W, X, Y... (E, F, A, B, C...)	water	water		18.0	839	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: -2 - 0 (PDB: 2C21)
A, B, C, D, E, F: 1 - 141 (UniProt: Q68RJ8)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	99731.4
Non-Polymers*	Number of molecules	16
	Total formula weight	1343.5
All*	Total formula weight	101074.9

*Water molecules are not included.