Author results

6IQW
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CRYO-EM STRUCTURE OF CSM EFFECTOR COMPLEX
Descriptor:Csm1, Csm2, Csm3, ...
Authors:Huo, Y., Li, T., Wang, N., Dong, Q., Wang, X., Jiang, T.
Deposit date:2018-11-09
Release date:2019-01-16
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Cryo-EM structure of Type III-A CRISPR effector complex.
Cell Res., 28, 2018
5Y26
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CRYSTAL STRUCTURE OF NATIVE DPB4-DPB3
Descriptor:DNA polymerase epsilon subunit D, Putative transcription factor C16C4.22, GLYCEROL
Authors:Chen, Y.H., Li, Y., Gao, F.
Deposit date:2017-07-24
Release date:2018-01-24
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Coordinated regulation of heterochromatin inheritance by Dpb3-Dpb4 complex.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5Y27
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CRYSTAL STRUCTURE OF SE-MET DPB4-DPB3
Descriptor:DNA polymerase epsilon subunit D, Putative transcription factor C16C4.22, GLYCEROL
Authors:Li, Y., Gao, F., Su, M., Zhang, F.B., Chen, Y.H.
Deposit date:2017-07-24
Release date:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Coordinated regulation of heterochromatin inheritance by Dpb3-Dpb4 complex.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5TT7
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DISCOVERY OF TAK-659, AN ORALLY AVAILABLE INVESTIGATIONAL INHIBITOR OF SPLEEN TYROSINE KINASE (SYK)
Descriptor:Tyrosine-protein kinase SYK, 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one
Authors:Yano, J., Jennings, A., Lam, B., Hoffman, I.D.
Deposit date:2016-11-01
Release date:2016-11-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK).
Bioorg. Med. Chem. Lett., 26, 2016
5TR6
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DISCOVERY OF TAK-659, AN ORALLY AVAILABLE INVESTIGATIONAL INHIBITOR OF SPLEEN TYROSINE KINASE (SYK)
Descriptor:Tyrosine-protein kinase SYK, 6-{[(1R,2S)-2-aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one, 1,2-ETHANEDIOL
Authors:Yano, J., Jennings, A., Lam, B., Hoffman, I.D.
Deposit date:2016-10-25
Release date:2016-11-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK).
Bioorg. Med. Chem. Lett., 26, 2016
5GPK
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CRYSTAL STRUCTURE OF CCP1 MUTANT
Descriptor:Putative nucleosome assembly protein C36B7.08c
Authors:Yin, F., Gao, F., Chen, Y.
Deposit date:2016-08-03
Release date:2016-11-30
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading
Mol.Cell, 64, 2016
5GPL
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CRYSTAL STRUCTURE OF CCP1
Descriptor:Putative nucleosome assembly protein C36B7.08c
Authors:Yin, F., Gao, F., Chen, Y.
Deposit date:2016-08-03
Release date:2016-11-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading
Mol.Cell, 64, 2016
2MNA
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THE STRUCTURAL BASIS OF DNA BINDING BY THE SINGLE-STRANDED DNA-BINDING PROTEIN FROM SULFOLOBUS SOLFATARICUS
Descriptor:ssDNA, Single-stranded DNA binding protein (SSB)
Authors:Gamsjaeger, R., Kariawasam, R., Gimenez, A.X., Touma, C.F., McIlwain, E., Bernardo, R.E., Shepherd, N.E., Ataide, S.F., Dong, A.Q., Richard, D.J., White, M.F., Cubeddu, L.
Deposit date:2014-04-02
Release date:2014-12-17
Method:SOLUTION NMR
Cite:The structural basis of DNA binding by the single-stranded DNA-binding protein from Sulfolobus solfataricus
Biochem.J., 465, 2015
4NFT
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CRYSTAL STRUCTURE OF HUMAN LNKH2B-H2A.Z-ANP32E
Descriptor:Histone H2B type 2-E, Histone H2A.Z, Acidic leucine-rich nuclear phosphoprotein 32 family member E
Authors:Shan, S., Pan, L., Mao, Z., Wang, W., Sun, J., Dong, Q., Liang, X., Ding, X., Chen, S., Dai, L., Zhang, Z., Zhu, B., Zhou, Z.
Deposit date:2013-11-01
Release date:2014-04-09
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z
Cell Res., 24, 2014
3PP1
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CRYSTAL STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK 1) IN COMPLEX WITH LIGAND AND MGATP
Descriptor:Dual specificity mitogen-activated protein kinase kinase 1, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Dougan, D.R.
Deposit date:2010-11-23
Release date:2011-02-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer.
Bioorg.Med.Chem.Lett., 21, 2011
3MBL
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CRYSTAL STRUCTURE OF THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MEK 1) IN COMPLEX WITH LIGAND AND MGADP
Descriptor:Dual specificity mitogen-activated protein kinase kinase 1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Dougan, D.R., Mol, C.D.
Deposit date:2010-03-25
Release date:2010-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010