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2XE0
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MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:I-CREI V2V3 VARIANT, 24MER DNA, ACETATE ION, ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Redondo, P., Villate, M., Merino, N., Marenchino, M., D'Abramo, M., Gervasio, F.L., Grizot, S., Daboussi, F., Smith, J., Chion-Sotine, I., Paques, F., Duchateau, P., Alibes, A., Stricher, F., Serrano, L., Blanco, F.J., Montoya, G.
Deposit date:2010-05-10
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Molecular Basis of Engineered Meganuclease Targeting of the Endogenous Human Rag1 Locus
Nucleic Acids Res., 39, 2011
4AQU
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CRYSTAL STRUCTURE OF I-CREI COMPLEXED WITH ITS TARGET METHYLATED AT POSITION PLUS 2 (IN THE B STRAND) IN THE PRESENCE OF CALCIUM
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*DTP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*DAP *GP*AP*CP*AP*GP*TP*TP*TP*GP*G)-3', 5'-D(*DCP*CP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*5CMP *GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3', ...
Authors:Valton, J., Daboussi, F., Leduc, S., Redondo, P., Macmaster, R., Molina, R., Montoya, G., Duchateau, P.
Deposit date:2012-04-19
Release date:2012-07-04
Last modified:2012-09-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:5'-Cytosine-Phosphoguanine (Cpg) Methylation Impacts the Activity of Natural and Engineered Meganucleases.
J.Biol.Chem., 287, 2012
4AQX
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CRYSTAL STRUCTURE OF I-CREI COMPLEXED WITH ITS TARGET METHYLATED AT POSITION PLUS 2 (IN THE B STRAND) IN THE PRESENCE OF MAGNESIUM
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP)-3', 5'-D(*GP*AP*CP*AP*GP*TP*TP*TP*GP*GP)-3', ...
Authors:Valton, J., Daboussi, F., Leduc, S., Redondo, P., Macmaster, R., Molina, R., Montoya, G., Duchateau, P.
Deposit date:2012-04-19
Release date:2012-07-04
Last modified:2012-09-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:5'-Cytosine-Phosphoguanine (Cpg) Methylation Impacts the Activity of Natural and Engineered Meganucleases.
J.Biol.Chem., 287, 2012
2VBJ
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MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP*AP*GP*GP*AP*TP*CP*CP*TP*AP*A)-3', 5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP*AP*AP*AP*AP*GP*GP*CP*AP*GP*A)-3', ...
Authors:Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
2VBL
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MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*DT*DC*DT*DG*DC*DC*DT*DT*DT*DT*DT*DT *DGP*DAP)-3', 5'-D(*DT*DT*DA*DG*DG*DA*DT*DC*DC*DT*DT*DC *DAP*DAP)-3', ...
Authors:Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
2VBN
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MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP)-3', 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP)-3', ...
Authors:Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
2VBO
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MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS
Descriptor:DNA ENDONUCLEASE I-CREI, 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP*AP*GP*GP*AP*TP*CP*CP*TP*AP*A)-3', 5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP*AP*AP*AP*AP*GP*GP*CP*AP*GP*A)-3', ...
Authors:Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G.
Deposit date:2007-09-14
Release date:2008-10-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
3MX9
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MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:Protein scV3V2(G19S), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*CP*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*GP*CP*TP*GP*AP*GP*GP*TP*AP*CP*CP*TP*GP*AP*GP*AP*AP*CP*AP*A)-3'), ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
3MXA
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MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:scV3V2(G19S), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*C)-3'), DNA (5'-D(P*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
3MXB
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MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:V3(E8K), V2(K7E-G19S), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*CP*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
4CJ9
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BURRH DNA-BINDING PROTEIN FROM BURKHOLDERIA RHIZOXINICA IN ITS APO FORM
Descriptor:BURRH, SELENIUM ATOM
Authors:Stella, S., Molina, R., Lopez-Mendez, B., Campos-Olivas, R., Duchateau, P., Montoya, G.
Deposit date:2013-12-19
Release date:2014-07-09
Last modified:2014-07-23
Method:X-RAY DIFFRACTION (2.214 Å)
Cite:Bud, a Helix-Loop-Helix DNA-Binding Domain for Genome Modification
Acta Crystallogr.,Sect.D, 70, 2014
4CJA
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BURRH DNA-BINDING PROTEIN FROM BURKHOLDERIA RHIZOXINICA IN COMPLEX WITH ITS TARGET DNA
Descriptor:BURRH, 5'-D(*DTP*TP*AP*AP*GP*AP*GP*AP*AP*GP*CP*AP*AP*DP *TP*AP*CP*GP*TP*TP*AP*TP*AP)-3', 5'-D(*DTP*AP*TP*AP*AP*CP*GP*TP*AP*TP*TP*TP*GP*CP *TP*TP*CP*TP*CP*TP*TP*AP*AP)-3'
Authors:Stella, S., Molina, R., Lopez-Mendez, B., Campos-Olivas, R., Duchateau, P., Montoya, G.
Deposit date:2013-12-19
Release date:2014-07-09
Last modified:2014-07-23
Method:X-RAY DIFFRACTION (2.651 Å)
Cite:Bud, a Helix-Loop-Helix DNA-Binding Domain for Genome Modification
Acta Crystallogr.,Sect.D, 70, 2014