Author results

1NND
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ARGININE 116 IS ESSENTIAL FOR NUCLEIC ACID RECOGNITION BY THE FINGERS DOMAIN OF MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE
Descriptor:Reverse Transcriptase
Authors:Crowther, R.L., Remeta, D.P., Minetti, C.A., Das, D., Montano, S.P., Georgiadis, M.M.
Deposit date:2003-01-13
Release date:2004-01-27
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and energetic characterization of nucleic acid-binding to the fingers domain of Moloney murine leukemia virus reverse transcriptase
Proteins, 57, 2004
1XRU
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CRYSTAL STRUCTURE OF 5-KETO-4-DEOXYURONATE ISOMERASE FROM ESCHERICIA COLI
Descriptor:4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, ZINC ION, PENTAETHYLENE GLYCOL
Authors:Crowther, R.L., Georgiadis, M.M.
Deposit date:2004-10-15
Release date:2005-04-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:The crystal structure of 5-keto-4-deoxyuronate isomerase from Escherichia coli
Proteins, 61, 2005
1HGD
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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY
Descriptor:HEMAGGLUTININ, CHAIN HA1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S.-J., Skehel, J.J., Wiley, D.C.
Deposit date:1991-11-01
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
1HGE
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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY
Descriptor:HEMAGGLUTININ, (G135R), HA1 CHAIN, ...
Authors:Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S.-J., Skehel, J.J., Wiley, D.C.
Deposit date:1991-11-01
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
1HGF
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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY
Descriptor:HEMAGGLUTININ, CHAIN HA1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S.-J., Skehel, J.J., Wiley, D.C.
Deposit date:1991-11-01
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
1HGG
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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY
Descriptor:HEMAGGLUTININ, CHAIN HA1, CHAIN HA2, ...
Authors:Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S.-J., Skehel, J.J., Wiley, D.C.
Deposit date:1991-11-01
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
1HGH
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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY
Descriptor:HEMAGGLUTININ, CHAIN HA1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S.-J., Skehel, J.J., Wiley, D.C.
Deposit date:1991-11-01
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
1HGI
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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY
Descriptor:HEMAGGLUTININ, CHAIN HA1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S.-J., Skehel, J.J., Wiley, D.C.
Deposit date:1991-11-01
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
1HGJ
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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY
Descriptor:HEMAGGLUTININ, CHAIN HA1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S.-J., Skehel, J.J., Wiley, D.C.
Deposit date:1991-11-01
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Biochemistry, 31, 1992
1C3I
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HUMAN STROMELYSIN-1 CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812
Descriptor:STROMELYSIN-1, ZINC ION, CALCIUM ION, ...
Authors:Steele, D.L., Kammlott, R.U., Crowther, R.L., Birktoft, J.J., Dunten, P., Engler, J.E.
Deposit date:1999-07-27
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1.
Protein Eng., 13, 2000
1C8T
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HUMAN STROMELYSIN-1 (E202Q) CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812
Descriptor:STROMELYSIN-1, ZINC ION, CALCIUM ION, ...
Authors:Steele, D.L., el-Kabbani, O., Dunten, P., Crowther, R.L.
Deposit date:1999-07-29
Release date:2000-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1.
Protein Eng., 13, 2000
1ESL
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INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS
Descriptor:HUMAN E-SELECTIN, CALCIUM ION, CHLORIDE ION
Authors:Graves, B.J., Crowther, R.L.
Deposit date:1994-06-03
Release date:1994-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains.
Nature, 367, 1994
1Z8D
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CRYSTAL STRUCTURE OF HUMAN MUSCLE GLYCOGEN PHOSPHORYLASE A WITH AMP AND GLUCOSE
Descriptor:Glycogen phosphorylase, muscle form, ALPHA-D-GLUCOSE, ...
Authors:Lukacs, C.M., Oikonomakos, N.G., Crowther, R.L., Hong, L.N., Kammlott, R.U., Levin, W., Li, S., Liu, C.M., Lucas-McGady, D., Pietranico, S., Reik, L.
Deposit date:2005-03-30
Release date:2006-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of human muscle glycogen phosphorylase a with bound glucose and AMP: An intermediate conformation with T-state and R-state features.
Proteins, 63, 2006
2FVD
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CYCLIN DEPENDENT KINASE 2 (CDK2) WITH DIAMINOPYRIMIDINE INHIBITOR
Descriptor:Cell division protein kinase 2, (4-AMINO-2-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIMIDIN-5-YL)(2,3-DIFLUORO-6-METHOXYPHENYL)METHANONE
Authors:Crowther, R.L., Lukacs, C.M., Kammlott, R.U.
Deposit date:2006-01-30
Release date:2006-10-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity.
J.Med.Chem., 49, 2006
1HXB
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HIV-1 PROTEINASE COMPLEXED WITH RO 31-8959
Descriptor:HIV-1 PROTEASE, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide
Authors:Graves, B.J., Hatada, M.H., Crowther, R.L.
Deposit date:1996-09-13
Release date:1997-03-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere.
J.Med.Chem., 34, 1991
3LE6
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THE STRUCTURE OF CYCLIN DEPENDENT KINASE 2 (CKD2) WITH A PYRAZOLOBENZODIAZEPINE INHIBITOR
Descriptor:Cell division protein kinase 2, 5-(2-chlorophenyl)-3-methyl-7-nitropyrazolo[3,4-b][1,4]benzodiazepine
Authors:Lukacs, C.M., Swain, A., Crowther, R.L., Kammlott, R.U., Liu, J.J.
Deposit date:2010-01-14
Release date:2010-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Pyrazolobenzodiazepines: part I. Synthesis and SAR of a potent class of kinase inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010