Author results

5EHI
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND MOLECULE BF287
Descriptor:NS5 methyltransferase dengue virus, S-ADENOSYLMETHIONINE, 4-[[3-[(2-azanyl-4-chloranyl-phenyl)carbamoylamino]phenyl]sulfonylamino]benzoic acid
Authors:Barral, K., Bricogne, G., Sharff, A.
Deposit date:2015-10-28
Release date:2016-10-26
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.303 Å)
Cite:Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Eur.J.Med.Chem., 125, 2016
3Q3Y
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COMPLEX STRUCTURE OF HEVB EV93 MAIN PROTEASE 3C WITH COMPOUND 1 (AG7404)
Descriptor:HEVB EV93 3C protease, ethyl (4R)-4-({(2S)-2-[3-{[(5-methyl-1,2-oxazol-3-yl)carbonyl]amino}-2-oxopyridin-1(2H)-yl]pent-4-ynoyl}amino)-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate, 1,2-ETHANEDIOL, ...
Authors:Costenaro, L., Kaczmarska, Z., Arnan, C., Sola, M., Coutard, B., Norder, H., Canard, B., Coll, M.
Deposit date:2010-12-22
Release date:2011-09-07
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93.
J.Virol., 85, 2011
4CTJ
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 3A9
Descriptor:NON-STRUCTURAL PROTEIN 5, S-ADENOSYLMETHIONINE, 2,3-dihydro-1-benzofuran-5-carboxylic acid, ...
Authors:Barral, K., Bricogne, G., Sharff, A.
Deposit date:2014-03-14
Release date:2014-04-16
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Assessment of Dengue Virus Helicase and Methyltransferase as Targets for Fragment-Based Drug Discovery.
Antiviral Res., 106, 2014
3RUO
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COMPLEX STRUCTURE OF HEVB EV93 MAIN PROTEASE 3C WITH RUPINTRIVIR (AG7088)
Descriptor:HEVB EV93 3C PROTEASE, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, MAGNESIUM ION, ...
Authors:Kaczmarska, Z., Janowski, R., Costenaro, L., Coutard, B., Norder, H., Canard, B., Coll, M.
Deposit date:2011-05-05
Release date:2011-09-07
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93.
J.Virol., 85, 2011
5EIF
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT NB2C3
Descriptor:Genome polyprotein, S-ADENOSYLMETHIONINE, 2-azanyl-4-methyl-benzoic acid
Authors:Barral, K., Bricogne, G., Sharff, A.
Deposit date:2015-10-29
Release date:2016-10-26
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Eur.J.Med.Chem., 125, 2016
4CTK
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 2A4
Descriptor:POLYPROTEIN, S-ADENOSYLMETHIONINE, thieno[2,3-b]pyrazin-7-amine, ...
Authors:Barral, K., Bricogne, G., Sharff, A.
Deposit date:2014-03-14
Release date:2014-04-16
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Assessment of Dengue Virus Helicase and Methyltransferase as Targets for Fragment-Based Drug Discovery.
Antiviral Res., 106, 2014
3OV9
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STRUCTURE OF THE NUCLEOPROTEIN FROM RIFT VALLEY FEVER VIRUS
Descriptor:Nucleoprotein, NITRITE ION, SODIUM ION
Authors:Ferron, F., Danek, E.I., Li, Z., Luo, D., Wong, Y.H., Coutard, B., Lantez, V., Charrel, R., Canard, B., Walz, T., Lescar, J.
Deposit date:2010-09-16
Release date:2011-05-25
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes
Plos Pathog., 7, 2011
5EIW
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT NB3C2
Descriptor:NS5 methyltransferase, S-ADENOSYLMETHIONINE, 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE
Authors:Barral, K., Bricogne, G., Sharff, A.
Deposit date:2015-10-30
Release date:2016-10-26
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.611 Å)
Cite:Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Eur.J.Med.Chem., 125, 2016
3GPG
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CRYSTAL STRUCTURE OF MACRO DOMAIN OF CHIKUNGUNYA VIRUS
Descriptor:Non-structural protein 3
Authors:Malet, H., Jamal, S., Coutard, B., Canard, B.
Deposit date:2009-03-23
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
J.Virol., 83, 2009
5EC8
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND COMPOUND BF175
Descriptor:Genome polyprotein, S-ADENOSYLMETHIONINE, 2-[(2-azanyl-4-chloranyl-phenyl)carbamoylamino]-4-methyl-benzoic acid
Authors:Barral, K., Bricogne, G., Sharff, A.
Deposit date:2015-10-20
Release date:2016-10-26
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.714 Å)
Cite:Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Eur.J.Med.Chem., 125, 2016
5EKX
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYLMETHIONINE AND FRAGMENT NB2E11
Descriptor:NS5 METHYLTRANSFERASE, S-ADENOSYLMETHIONINE, 4-chloro-5-methylbenzene-1,2-diamine
Authors:Barral, K., Bricogne, G., Sharff, A.
Deposit date:2015-11-04
Release date:2016-10-26
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Eur.J.Med.Chem., 125, 2016
5E9Q
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND MOLECULE BF174
Descriptor:Genome polyprotein, S-ADENOSYLMETHIONINE, 2-({[2-amino-4-(trifluoromethyl)phenyl]carbamoyl}amino)-4-methylbenzoic acid
Authors:Barral, K., Bricogne, G., Sharff, A.
Deposit date:2015-10-15
Release date:2016-10-26
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Eur.J.Med.Chem., 125, 2016
2WA2
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STRUCTURE OF THE METHYLTRANSFERASE DOMAIN FROM MODOC VIRUS, A FLAVIVIRUS WITH NO KNOWN VECTOR (NKV)
Descriptor:NON-STRUCTURAL PROTEIN 5, S-ADENOSYLMETHIONINE, SULFATE ION
Authors:Jansson, A.M., Johansson, P., Jones, T.A.
Deposit date:2009-02-02
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the Methyltransferase Domain from the Modoc Virus, a Flavivirus with No Known Vector.
Acta Crystallogr.,Sect.D, 65, 2009
3ZVE
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3C PROTEASE OF ENTEROVIRUS 68 COMPLEXED WITH MICHAEL RECEPTOR INHIBITOR 84
Descriptor:3C PROTEASE, O-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide
Authors:Tan, J., Perbandt, M., Mesters, J.R., Hilgenfeld, R.
Deposit date:2011-07-24
Release date:2012-08-08
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses.
J.Virol., 87, 2013
3ELD
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WESSELSBRON METHYLTRANSFERASE IN COMPLEX WITH SINEFUNGIN
Descriptor:Methyltransferase, SINEFUNGIN, SULFATE ION
Authors:Bollati, M., Milani, M., Mastrangelo, E., Ricagno, S., Bolognesi, M.
Deposit date:2008-09-22
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELW
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH ADOMET AND GPPPG
Descriptor:Methyltransferase, SULFATE ION, S-ADENOSYLMETHIONINE, ...
Authors:Bollati, M., Ricagno, S., Milani, M., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-23
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3GPO
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CRYSTAL STRUCTURE OF MACRO DOMAIN OF CHIKUNGUNYA VIRUS IN COMPLEX WITH ADP-RIBOSE
Descriptor:Non-structural protein 3, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Malet, H., Jamal, S., Coutard, B., Canard, B.
Deposit date:2009-03-23
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
J.Virol., 83, 2009
3Q3X
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CRYSTAL STRUCTURE OF THE MAIN PROTEASE (3C) FROM HUMAN ENTEROVIRUS B EV93
Descriptor:HEVB EV93 3C protease, GLYCEROL, MAGNESIUM ION
Authors:Costenaro, L., Sola, M., Coutard, B., Norder, H., Canard, B., Coll, M.
Deposit date:2010-12-22
Release date:2011-09-07
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93.
J.Virol., 85, 2011
6G13
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C-TERMINAL DOMAIN OF MERS-COV NUCLEOCAPSID
Descriptor:Nucleoprotein, trimethylamine oxide, DI(HYDROXYETHYL)ETHER, ...
Authors:Nguyen, T.H.V., Ferron, F.P., Lichiere, J., Canard, B., Papageorgiou, N., Coutard, B.
Deposit date:2018-03-20
Release date:2019-02-27
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein.
Acta Crystallogr D Struct Biol, 75, 2019
2W5E
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STRUCTURAL AND BIOCHEMICAL ANALYSIS OF HUMAN PATHOGENIC ASTROVIRUS SERINE PROTEASE AT 2.0 ANGSTROM RESOLUTION
Descriptor:PUTATIVE SERINE PROTEASE, CADMIUM ION, CHLORIDE ION
Authors:Speroni, S., Rohayem, J., Nenci, S., Bonivento, D., Robel, I., Barthel, J., Coutard, B., Canard, B., Mattevi, A.
Deposit date:2008-12-10
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Biochemical Analysis of Human Pathogenic Astrovirus Serine Protease at 2.0 A Resolution.
J.Mol.Biol., 387, 2009
2WA1
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STRUCTURE OF THE METHYLTRANSFERASE DOMAIN FROM MODOC VIRUS, A FLAVIVIRUS WITH NO KNOWN VECTOR (NKV)
Descriptor:NON-STRUCTURAL PROTEIN 5, SULFATE ION
Authors:Jansson, A.M., Johansson, P., Jones, T.A.
Deposit date:2009-02-02
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Methyltransferase Domain from the Modoc Virus, a Flavivirus with No Known Vector.
Acta Crystallogr.,Sect.D, 65, 2009
2XYQ
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CRYSTAL STRUCTURE OF THE NSP16 NSP10 SARS CORONAVIRUS COMPLEX
Descriptor:PUTATIVE 2'-O-METHYL TRANSFERASE, NON-STRUCTURAL PROTEIN 10, CHLORIDE ION, ...
Authors:Decroly, E., Debarnot, C., Ferron, F., Bouvet, M., Coutard, B., Imbert, I., Gluais, L., Papageorgiou, N., Ortiz-Lombardia, M., Lescar, J., Canard, B.
Deposit date:2010-11-18
Release date:2011-10-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex.
Plos Pathog., 7, 2011
3ELU
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH ADOMET
Descriptor:Methyltransferase, S-ADENOSYLMETHIONINE, SULFATE ION
Authors:Bollati, M., Ricagno, S., Milani, M., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-23
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3EMD
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH SINEFUNGIN AND 7MEGPPPA
Descriptor:methyltransferase, SINEFUNGIN, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ...
Authors:Bollati, M., Milani, M., Ricagno, S., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-24
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3GPQ
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CRYSTAL STRUCTURE OF MACRO DOMAIN OF CHIKUNGUNYA VIRUS IN COMPLEX WITH RNA
Descriptor:Non-structural protein 3, RNA (5'-R(*AP*AP*A)-3')
Authors:Malet, H., Jamal, S., Coutard, B., Canard, B.
Deposit date:2009-03-23
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
J.Virol., 83, 2009
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