Author results

3PXA
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IMPACT OF BRCA1 BRCT DOMAIN MISSENSE SUBSTITUTIONS ON PHOSPHO-PEPTIDE RECOGNITION: G1656D
Descriptor:Breast cancer type 1 susceptibility protein, NICKEL (II) ION, SULFATE ION
Authors:Coquelle, N., Green, R., Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
3PXB
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IMPACT OF BRCA1 BRCT DOMAIN MISSENSE SUBSTITUTIONS ON PHOSPHO-PEPTIDE RECOGNITION: T1700A
Descriptor:Breast cancer type 1 susceptibility protein, SULFATE ION, NICKEL (II) ION
Authors:Coquelle, N., Green, R., Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
3PXC
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IMPACT OF BRCA1 BRCT DOMAIN MISSENSE SUBSTITUTIONS ON PHOSPHO-PEPTIDE RECOGNITION: R1699Q
Descriptor:Breast cancer type 1 susceptibility protein, SULFATE ION, NICKEL (II) ION
Authors:Coquelle, N., Green, R., Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
3PXD
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IMPACT OF BRCA1 BRCT DOMAIN MISSENSE SUBSTITUTIONS ON PHOSPHO-PEPTIDE RECOGNITION: R1835P
Descriptor:Breast cancer type 1 susceptibility protein, SULFATE ION, NICKEL (II) ION
Authors:Coquelle, N., Green, R., Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
3PXE
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IMPACT OF BRCA1 BRCT DOMAIN MISSENSE SUBSTITUTIONS ON PHOSPHO-PEPTIDE RECOGNITION: E1836K
Descriptor:Breast cancer type 1 susceptibility protein, phospho peptide
Authors:Coquelle, N., Green, R., Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
3U7E
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CRYSTAL STRUCTURE OF MPNKP CATALYTIC FRAGMENT (D170A)
Descriptor:Bifunctional polynucleotide phosphatase/kinase, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Coquelle, N., Havali, Z., Bernstein, N., Green, R., Glover, J.N.M.
Deposit date:2011-10-13
Release date:2011-12-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates.
Proc.Natl.Acad.Sci.USA, 108, 2011
3U7F
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CRYSTAL STRUCTURE OF MPNKP CATALYTIC FRAGMENT (D170A) BOUND TO SINGLE-STRANDED DNA (TCCTCP)
Descriptor:Bifunctional polynucleotide phosphatase/kinase, DNA, MAGNESIUM ION, ...
Authors:Coquelle, N., Havali, Z., Bernstein, N., Green, R., Glover, J.N.M.
Deposit date:2011-10-13
Release date:2011-12-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates.
Proc.Natl.Acad.Sci.USA, 108, 2011
3U7G
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CRYSTAL STRUCTURE OF MPNKP CATALYTIC FRAGMENT (D170A) BOUND TO SINGLE-STRANDED DNA (TCCTAP)
Descriptor:Bifunctional polynucleotide phosphatase/kinase, DNA, GLYCEROL, ...
Authors:Coquelle, N., Havali, Z., Bernstein, N., Green, R., Glover, J.N.M.
Deposit date:2011-10-13
Release date:2011-12-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates.
Proc.Natl.Acad.Sci.USA, 108, 2011
3U7H
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CRYSTAL STRUCTURE OF MPNKP CATALYTIC FRAGMENT (D170A) BOUND TO SINGLE-STRANDED DNA (TCCTTP)
Descriptor:Bifunctional polynucleotide phosphatase/kinase, DNA, GLYCEROL, ...
Authors:Coquelle, N., Havali, Z., Bernstein, N., Green, R., Glover, J.N.M.
Deposit date:2011-10-13
Release date:2011-12-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates.
Proc.Natl.Acad.Sci.USA, 108, 2011
2V65
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APO LDH FROM THE PSYCHROPHILE C. GUNNARI
Descriptor:L-LACTATE DEHYDROGENASE A CHAIN
Authors:Coquelle, N., Madern, D., Vellieux, F.
Deposit date:2007-07-13
Release date:2007-09-25
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Activity, Stability and Structural Studies of Lactate Dehydrogenases Adapted to Extreme Thermal Environments.
J.Mol.Biol., 374, 2007
2V6B
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CRYSTAL STRUCTURE OF LACTATE DEHYDROGENASE FROM DEINOCOCCUS RADIODURANS (APO FORM)
Descriptor:L-LACTATE DEHYDROGENASE
Authors:Coquelle, N., Fioravanti, E., Weik, M., Vellieux, F.
Deposit date:2007-07-16
Release date:2007-09-25
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments.
J. Mol. Biol., 374, 2007
2V6M
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CRYSTAL STRUCTURE OF LACTATE DEHYDROGENASE FROM THERMUS THERMOPHILUS HB8 (APO FORM)
Descriptor:L-LACTATE DEHYDROGENASE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Coquelle, N., Fioravanti, E., Weik, M., Vellieux, F.
Deposit date:2007-07-19
Release date:2007-09-25
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments.
J. Mol. Biol., 374, 2007
2V7P
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CRYSTAL STRUCTURE OF LACTATE DEHYDROGENASE FROM THERMUS THERMOPHILUS HB8 (HOLO FORM)
Descriptor:L-LACTATE DEHYDROGENASE, OXAMIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Coquelle, N., Fioravanti, E., Weik, M., Vellieux, F.
Deposit date:2007-07-31
Release date:2007-09-25
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments.
J. Mol. Biol., 374, 2007
3NEP
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1.55A RESOLUTION STRUCTURE OF MALATE DEHYDROGENASE FROM SALINIBACTER RUBER
Descriptor:Malate dehydrogenase
Authors:Coquelle, N., Madern, D.
Deposit date:2010-06-09
Release date:2010-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.551 Å)
Cite:Gradual adaptive changes of a protein facing high salt concentrations.
J.Mol.Biol., 404, 2010
4WG1
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ROOM TEMPERATURE CRYSTAL STRUCTURE OF LYSOZYME DETERMINED BY SERIAL SYNCHROTRON CRYSTALLOGRAPHY (MICRO FOCUSED BEAM - CRYSTFEL)
Descriptor:Lysozyme C, CHLORIDE ION
Authors:Coquelle, N., Brewster, A.S., Kapp, U., Shilova, A., Weimhausen, B., Sauter, N.K., Burghammer, M., Colletier, J.P.
Deposit date:2014-09-17
Release date:2015-05-06
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Raster-scanning serial protein crystallography using micro- and nano-focused synchrotron beams.
Acta Crystallogr.,Sect.D, 71, 2015
4WG7
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ROOM-TEMPERATURE CRYSTAL STRUCTURE OF LYSOZYME DETERMINED BY SERIAL SYNCHROTRON CRYSTALLOGRAPHY USING A NANO FOCUSED BEAM.
Descriptor:Lysozyme C, CHLORIDE ION
Authors:Coquelle, N., Brewster, A.S., Kappe, U., Shilova, A., Weinhausen, B., Burghammer, M., Colletier, J.P.
Deposit date:2014-09-18
Release date:2015-05-06
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Raster-scanning serial protein crystallography using micro- and nano-focused synchrotron beams.
Acta Crystallogr.,Sect.D, 71, 2015
4WL6
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RASTER-SCANNING PROTEIN CRYSTALLOGRAPHY USING MICRO AND NANO-FOCUSED SYNCHROTRON BEAMS
Descriptor:Lysozyme C, CHLORIDE ION
Authors:Coquelle, N., Kapp, U., Shilova, A., Weinhausen, B., Burghammer, M., Colletier, J.P.
Deposit date:2014-10-06
Release date:2015-05-06
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Raster-scanning serial protein crystallography using micro- and nano-focused synchrotron beams.
Acta Crystallogr.,Sect.D, 71, 2015
4WL7
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ROOM-TEMPERATURE CRYSTAL STRUCTURE OF LYSOZYME DETERMINED BY SERIAL SYNCHROTRON CRYSTALLOGRAPHY USING A MICRO FOCUSED BEAM (CONVENTIONAL RESOLUTION CUT-OFF)
Descriptor:Lysozyme C, CHLORIDE ION
Authors:Coquelle, N., Brewster, A.S., Kapp, U., Shilova, A., Weinhausen, B., Burghammer, M., Colletier, J.P.
Deposit date:2014-10-06
Release date:2015-05-06
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Raster-scanning serial protein crystallography using micro- and nano-focused synchrotron beams.
Acta Crystallogr.,Sect.D, 71, 2015
5O89
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CRYSTAL STRUCTURE OF RSEGFP2 IN THE FLUORESCENT ON-STATE DETERMINED BY SFX
Descriptor:Green fluorescent protein
Authors:Coquelle, N., Sliwa, M., Woodhouse, J., Schiro, G., Adam, V., Aquila, A., Barends, T.R.M., Boutet, S., Byrdin, M., Carbajo, S., De la Mora, E., Doak, R.B., Feliks, M., Fieschi, F., Foucar, L., Guillon, V., Hilpert, M., Hunter, M., Jakobs, S., Koglin, J.E., Kovacsova, G., Lane, T.J., Levy, B., Liang, M., Nass, K., Ridard, J., Robinson, J.S., Roome, C.M., Ruckebusch, C., Seaberg, M., Thepaut, M., Cammarata, M., Demachy, I., Field, M., Shoeman, R.L., Bourgeois, D., Colletier, J.P., Schlichting, I., Weik, M.
Deposit date:2017-06-12
Release date:2017-12-13
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography.
Nat Chem, 10, 2018
5O8A
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CRYSTAL STRUCTURE OF RSEGFP2 IN THE NON-FLUORESCENT OFF-STATE DETERMINED BY SFX
Descriptor:Green fluorescent protein
Authors:Coquelle, N., Sliwa, M., Woodhouse, J., Schiro, G., Adam, V., Aquila, A., Barends, T.R.M., Boutet, S., Byrdin, M., Carbajo, S., De la Mora, E., Doak, R.B., Feliks, M., Fieschi, F., Foucar, L., Guillon, V., Hilpert, M., Hunter, M., Jakobs, S., Koglin, J.E., Kovacsova, G., Lane, T.J., Levy, B., Liang, M., Nass, K., Ridard, J., Robinson, J.S., Roome, C.M., Ruckebusch, C., Seaberg, M., Thepaut, M., Cammarata, M., Demachy, I., Field, M., Shoeman, R.L., Bourgeois, D., Colletier, J.P., Schlichting, I., Weik, M.
Deposit date:2017-06-12
Release date:2017-09-27
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography.
Nat Chem, 10, 2018
5O8B
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DIFFERENCE-REFINED EXCITED-STATE STRUCTURE OF RSEGFP2 1PS FOLLOWING 400NM-LASER IRRADIATION OF THE OFF-STATE.
Descriptor:Green fluorescent protein
Authors:Coquelle, N., Sliwa, M., Woodhouse, J., Schiro, G., Adam, V., Aquila, A., Barends, T.R.M., Boutet, S., Byrdin, M., Carbajo, S., De la Mora, E., Doak, R.B., Feliks, M., Fieschi, F., Foucar, L., Guillon, V., Hilpert, M., Hunter, M., Jakobs, S., Koglin, J.E., Kovacsova, G., Lane, T.J., Levy, B., Liang, M., Nass, K., Ridard, J., Robinson, J.S., Roome, C.M., Ruckebusch, C., Seaberg, M., Thepaut, M., Cammarata, M., Demachy, I., Field, M., Shoeman, R.L., Bourgeois, D., Colletier, J.P., Schlichting, I., Weik, M.
Deposit date:2017-06-12
Release date:2018-01-24
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography.
Nat Chem, 10, 2018
5O8C
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COMPOSITE STRUCTURE OF RSEGFP2 1PS FOLLOWING 400NM-LASER IRRADIATION OF THE OFF-STATE.
Descriptor:Green fluorescent protein
Authors:Coquelle, N., Sliwa, M., Woodhouse, J., Schiro, G., Adam, V., Aquila, A., Barends, T.R.M., Boutet, S., Byrdin, M., Carbajo, S., De la Mora, E., Doak, R.B., Feliks, M., Fieschi, F., Foucar, L., Guillon, V., Hilpert, M., Hunter, M., Jakobs, S., Koglin, J.E., Kovacsova, G., Lane, T.J., Levy, B., Liang, M., Nass, K., Ridard, J., Robinson, J.S., Roome, C.M., Ruckebusch, C., Seaberg, M., Thepaut, M., Cammarata, M., Demachy, I., Field, M., Shoeman, R.L., Bourgeois, D., Colletier, J.P., Schlichting, I., Weik, M.
Deposit date:2017-06-12
Release date:2017-12-06
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography.
Nat Chem, 10, 2018
6H12
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CRYSTAL STRUCTURE OF TCACHE COMPLEXED TO 1-(6-OXO-1,2,3,4,6,10B-HEXAHYDROPYRIDO[2,1-A]ISOINDOL-10-YL)-3-(4-(((1-(2-((1,2,3,4-TETRAHYDROACRIDIN-9-YL)AMINO)ETHYL)-1H-1,2,3-TRIAZOL-4-YL)METHOXY)METHYL)PYRIDIN-2-YL)UREA
Descriptor:Acetylcholinesterase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, ...
Authors:Coquelle, N., Colletier, J.P.
Deposit date:2018-07-10
Release date:2019-05-15
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.
Eur.J.Med.Chem., 168, 2019
6H13
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CRYSTAL STRUCTURE OF TCACHE COMPLEXED TO1-(4-((METHYL((1-(2-((1,2,3,4-TETRAHYDROACRIDIN-9-YL)AMINO)ETHYL)-1H-1,2,3-TRIAZOL-4-YL)METHYL)AMINO)METHYL)PYRIDIN-2-YL)-3-(6-OXO-1,2,3,4,6,10B-HEXAHYDROPYRIDO[2,1-A]ISOINDOL-10-YL)UREA
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, [1-[2-(1,2,3,4,4~{a},9~{a}-hexahydroacridin-9-ylamino)ethyl]-1,2,3-triazol-4-yl]methyl-[[2-[[(10~{b}~{S})-6-oxidanylidene-2,3,4,10~{b}-tetrahydro-1~{H}-pyrido[2,1-a]isoindol-10-yl]carbamoylamino]pyridin-4-yl]methyl]-methyl-azanium, ...
Authors:Coquelle, N., Colletier, J.P.
Deposit date:2018-07-10
Release date:2019-05-15
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.
Eur.J.Med.Chem., 168, 2019
6H14
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CRYSTAL STRUCTURE OF TCACHE COMPLEXED TO 1-(6-OXO-1,2,3,4,6,10B-HEXAHYDROPYRIDO[2,1-A]ISOINDOL-10-YL)-3-(4-(1-(2-((1,2,3,4-TETRAHYDROACRIDIN-9-YL)AMINO)ETHYL)-1H-1,2,3-TRIAZOL-4-YL)PYRIDIN-2-YL)UREA
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, 1,2-ETHANEDIOL, ...
Authors:Coquelle, N., Colletier, J.P.
Deposit date:2018-07-10
Release date:2019-05-15
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.
Eur.J.Med.Chem., 168, 2019
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