Author results

2GMS
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E COLI GDP-4-KETO-6-DEOXY-D-MANNOSE-3-DEHYDRATASE WITH BOUND HYDRATED PLP
Descriptor:Putative pyridoxamine 5-phosphate-dependent dehydrase, Wbdk, MAGNESIUM ION, ...
Authors:Cook, P.D., Thoden, J.B., Holden, H.M.
Deposit date:2006-04-07
Release date:2006-09-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: a unique coenzyme B6-dependent enzyme.
Protein Sci., 15, 2006
2GMU
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CRYSTAL STRUCTURE OF E COLI GDP-4-KETO-6-DEOXY-D-MANNOSE-3-DEHYDRATASE COMPLEXED WITH PLP-GLUTAMATE KETIMINE INTERMEDIATE
Descriptor:Putative pyridoxamine 5-phosphate-dependent dehydrase, WbdK, MAGNESIUM ION, ...
Authors:Cook, P.D., Thoden, J.B., Holden, H.M.
Deposit date:2006-04-07
Release date:2006-09-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structure of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: a unique coenzyme B6-dependent enzyme.
Protein Sci., 15, 2006
2R0T
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CRYSTAL STRUCTURE OF GDP-4-KETO-6-DEOXYMANNOSE-3-DEHYDRATASE WITH A TRAPPED PLP-GLUTAMATE GEMINAL DIAMINE
Descriptor:Pyridoxamine 5-phosphate-dependent dehydrase, N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid
Authors:Cook, P.D., Holden, H.M.
Deposit date:2007-08-21
Release date:2007-12-18
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Structural Study of GDP-4-Keto-6-Deoxy-d-Mannose-3-Dehydratase: Caught in the Act of Geminal Diamine Formation
Biochemistry, 46, 2007
3B8X
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CRYSTAL STRUCTURE OF GDP-4-KETO-6-DEOXYMANNOSE-3-DEHYDRATASE (COLD) H188N MUTANT WITH BOUND GDP-PEROSAMINE
Descriptor:Pyridoxamine 5-phosphate-dependent dehydrase, SODIUM ION, [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S,5S,6R)-3,4-dihydroxy-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate, ...
Authors:Cook, P.D., Holden, H.M.
Deposit date:2007-11-02
Release date:2007-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:GDP-4-Keto-6-deoxy-D-mannose 3-Dehydratase, Accommodating a Sugar Substrate in the Active Site.
J.Biol.Chem., 283, 2008
3BN1
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CRYSTAL STRUCTURE OF GDP-PEROSAMINE SYNTHASE
Descriptor:Perosamine synthetase, ACETATE ION, SODIUM ION, ...
Authors:Cook, P.D., Holden, H.M.
Deposit date:2007-12-13
Release date:2008-03-18
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:GDP-Perosamine Synthase: Structural Analysis and Production of a Novel Trideoxysugar
Biochemistry, 47, 2008
5D00
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CRYSTAL STRUCTURE OF BSHA FROM B. SUBTILIS COMPLEXED WITH N-ACETYLGLUCOSAMINYL-MALATE AND UMP
Descriptor:N-acetyl-alpha-D-glucosaminyl L-malate synthase, (2S)-2-{[2-(acetylamino)-2-deoxy-alpha-D-glucopyranosyl]oxy}butanedioic acid, PHOSPHATE ION, ...
Authors:Cook, P.D., Winchell, K.R.
Deposit date:2015-08-01
Release date:2016-09-07
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Complexed with N-acetylglucosaminyl-malate
to be published
5D01
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CRYSTAL STRUCTURE OF BSHA FROM B. SUBTILIS COMPLEXED WITH N-ACETYLGLUCOSAMINYL-MALATE
Descriptor:N-acetyl-alpha-D-glucosaminyl L-malate synthase, (2S)-2-{[2-(acetylamino)-2-deoxy-alpha-D-glucopyranosyl]oxy}butanedioic acid
Authors:Cook, P.D., Winchell, K.R.
Deposit date:2015-08-02
Release date:2016-09-07
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Complexed with N-acetylglucosaminyl-malate
to be published
3DR4
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GDP-PEROSAMINE SYNTHASE K186A MUTANT FROM CAULOBACTER CRESCENTUS WITH BOUND SUGAR LIGAND
Descriptor:Putative perosamine synthetase, [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S,5S,6R)-3,4-dihydroxy-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate, 1,2-ETHANEDIOL
Authors:Holden, H.M., Cook, P.D., Carney, A.E.
Deposit date:2008-07-10
Release date:2008-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase
Biochemistry, 47, 2008
3DR7
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GDP-PEROSAMINE SYNTHASE FROM CAULOBACTER CRESCENTUS WITH BOUND GDP-3-DEOXYPEROSAMINE
Descriptor:Putative perosamine synthetase, (2R,3S,5S,6R)-5-amino-3-hydroxy-6-methyl-oxan-2-yl, 1,2-ETHANEDIOL
Authors:Holden, H.M., Cook, P.D., Carney, A.E.
Deposit date:2008-07-10
Release date:2008-10-14
Last modified:2017-05-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase
Biochemistry, 47, 2008
3GR9
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CRYSTAL STRUCTURE OF COLD H188K S187N
Descriptor:ColD, 2-OXOGLUTARIC ACID
Authors:Holden, H.M., Cook, P.D., Kubiak, R.L., Toomey, D.P.
Deposit date:2009-03-25
Release date:2009-06-16
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Two Site-Directed Mutations Are Required for the Conversion of a Sugar Dehydratase into an Aminotransferase.
Biochemistry, 48, 2009
4NB1
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CRYSTAL STRUCTURE OF FOSB FROM STAPHYLOCOCCUS AUREUS AT 1.80 ANGSTROM RESOLUTION WITH L-CYSTEINE-CYS9 DISULFIDE
Descriptor:Metallothiol transferase FosB, CYSTEINE, SULFATE ION
Authors:Cook, P.D., Thompson, M.K., Goodman, M.C., Jagessar, K., Harp, J., Keithly, M.E., Armstrong, R.N.
Deposit date:2013-10-22
Release date:2014-02-26
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and Function of the Genomically Encoded Fosfomycin Resistance Enzyme, FosB, from Staphylococcus aureus.
Biochemistry, 53, 2014
4NB2
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CRYSTAL STRUCTURE OF FOSB FROM STAPHYLOCOCCUS AUREUS AT 1.89 ANGSTROM RESOLUTION - APO STRUCTURE
Descriptor:Metallothiol transferase FosB, SULFATE ION
Authors:Cook, P.D., Thompson, M.K., Goodman, M.C., Jagessar, K., Harp, J., Keithly, M.E., Armstrong, R.N.
Deposit date:2013-10-22
Release date:2014-02-26
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure and Function of the Genomically Encoded Fosfomycin Resistance Enzyme, FosB, from Staphylococcus aureus.
Biochemistry, 53, 2014
4WBD
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THE CRYSTAL STRUCTURE OF BSHC FROM BACILLUS SUBTILIS COMPLEXED WITH CITRATE AND ADP
Descriptor:BSHC, ADENOSINE-5'-DIPHOSPHATE, CITRIC ACID, ...
Authors:Cook, P.D., VanDuinen, A.J., Winchell, K.R.
Deposit date:2014-09-03
Release date:2014-12-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:X-ray Crystallographic Structure of BshC, a Unique Enzyme Involved in Bacillithiol Biosynthesis.
Biochemistry, 54, 2015
5WK0
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CRYSTAL STRUCTURE OF THE BACILLITHIOL TRANSFERASE BSTA FROM STAPHYLOCOCCUS AUREUS.
Descriptor:Damage-inducible protein DinB, NICKEL (II) ION
Authors:Cook, P.D., Francis, J.W.
Deposit date:2017-07-24
Release date:2018-02-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.335 Å)
Cite:Structure and function of the bacillithiol-S-transferase BstA from Staphylococcus aureus.
Protein Sci., 27, 2018
1D8Y
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CRYSTAL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH DNA
Descriptor:D(T)19 OLIGOMER, DNA POLYMERASE I, ZINC ION, ...
Authors:Teplova, M., Wallace, S.T., Tereshko, V., Minasov, G., Simons, A.M., Cook, P.D., Manoharan, M., Egli, M.
Deposit date:1999-10-26
Release date:1999-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural origins of the exonuclease resistance of a zwitterionic RNA.
Proc.Natl.Acad.Sci.USA, 96, 1999
1D9D
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CRYSTALL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH SHORT DNA FRAGMENT CARRYING 2'-0-AMINOPROPYL-RNA MODIFICATIONS 5'-D(TCG)-AP(AUC)-3'
Descriptor:5'-D(*TP*CP*GP)-R(AP*(U31)P*(C31))-3', DNA POLYMERASE I, ZINC ION, ...
Authors:Teplova, M., Wallace, S.T., Tereshko, V., Minasov, G., Simons, A.M., Cook, P.D., Manoharan, M., Egli, M.
Deposit date:1999-10-27
Release date:1999-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural origins of the exonuclease resistance of a zwitterionic RNA.
Proc.Natl.Acad.Sci.USA, 96, 1999
1D9F
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CRYSTAL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH DNA TETRAMER CARRYING 2'-O-(3-AMINOPROPYL)-RNA MODIFICATION 5'-D(TT)-AP(U)-D(T)-3'
Descriptor:DNA/RNA (5'-D(*TP*TP)-R(*(U31)P)-D(*T)-3'), DNA POLYMERASE I, ZINC ION, ...
Authors:Teplova, M., Wallace, S.T., Tereshko, V., Minasov, G., Simons, A.M., Cook, P.D., Manoharan, M., Egli, M.
Deposit date:1999-10-27
Release date:1999-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural origins of the exonuclease resistance of a zwitterionic RNA.
Proc.Natl.Acad.Sci.USA, 96, 1999
1D9H
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STRUCTURAL ORIGINS OF THE EXONUCLEASE RESISTANCE OF A ZWITTERIONIC RNA
Descriptor:DNA/RNA (5'-D(*GP*CP*GP*TP*AP)-R(*(U31)P)-D(*AP*CP*GP*C)-3')
Authors:Teplova, M., Wallace, S.T., Tereshko, V., Minasov, G., Simons, A.M., Cook, P.D., Manoharan, M., Egli, M.
Deposit date:1999-10-27
Release date:1999-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural origins of the exonuclease resistance of a zwitterionic RNA
Proc.Natl.Acad.Sci.USA, 96, 1999
3R3E
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THE GLUTATHIONE BOUND STRUCTURE OF YQJG, A GLUTATHIONE TRANSFERASE HOMOLOG FROM ESCHERICHIA COLI K-12
Descriptor:Uncharacterized protein yqjG, GLUTATHIONE, SULFATE ION
Authors:Branch, M.C., Cook, P.D., Harp, J.M., Armstrong, R.N.
Deposit date:2011-03-15
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.205 Å)
Cite:Crystal Structure Analysis of yqjG from Escherichia Coli K-12
To be Published
468D
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CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA
Descriptor:RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3'), MAGNESIUM ION
Authors:Teplova, M., Minasov, G., Tereshko, V., Inamati, G., Cook, P.D., Egli, M.
Deposit date:1999-04-29
Release date:1999-05-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nat.Struct.Biol., 6, 1999
469D
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CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA
Descriptor:RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3'), MAGNESIUM ION
Authors:Teplova, M., Minasov, G., Tereshko, V., Inamati, G., Cook, P.D., Egli, M.
Deposit date:1999-04-29
Release date:1999-05-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nat.Struct.Biol., 6, 1999
470D
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CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA
Descriptor:RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3'), MAGNESIUM ION
Authors:Teplova, M., Minasov, G., Tereshko, V., Inamati, G., Cook, P.D., Egli, M.
Deposit date:1999-04-29
Release date:1999-05-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nat.Struct.Biol., 6, 1999
471D
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CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA
Descriptor:RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3'), MAGNESIUM ION
Authors:Teplova, M., Minasov, G., Tereshko, V., Inamati, G., Cook, P.D., Egli, M.
Deposit date:1999-04-29
Release date:1999-05-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nat.Struct.Biol., 6, 1999
4EA7
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X-RAY CRYSTAL STRUCTURE OF PERB FROM CAULOBACTER CRESCENTUS IN COMPLEX WITH COA AND GDP-PEROSAMINE AT 1.0 ANGSTROM RESOLUTION
Descriptor:Perosamine N-acetyltransferase, COENZYME A, GDP-perosamine, ...
Authors:Thoden, J.B., Reinhardt, L.A., Cook, P.D., Menden, P., Cleland, W.W., Holden, H.M.
Deposit date:2012-03-22
Release date:2012-04-04
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (1 Å)
Cite:Catalytic Mechanism of Perosamine N-Acetyltransferase Revealed by High-Resolution X-ray Crystallographic Studies and Kinetic Analyses.
Biochemistry, 51, 2012
4EA8
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X-RAY CRYSTAL STRUCTURE OF PERB FROM CAULOBACTER CRESCENTUS IN COMPLEX WITH COENZYME A AND GDP-N-ACETYLPEROSAMINE AT 1 ANGSTROM RESOLUTION
Descriptor:Perosamine N-acetyltransferase, COENZYME A, GDP-N-acetylperosamine, ...
Authors:Thoden, J.B., Reinhardt, L.A., Cook, P.D., Menden, P., Cleland, W.W., Holden, H.M.
Deposit date:2012-03-22
Release date:2012-04-04
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (1 Å)
Cite:Catalytic Mechanism of Perosamine N-Acetyltransferase Revealed by High-Resolution X-ray Crystallographic Studies and Kinetic Analyses.
Biochemistry, 51, 2012
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